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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20434

FusionGeneSummary for LY6E_ZNF511

check button Fusion gene summary
Fusion gene informationFusion gene name: LY6E_ZNF511
Fusion gene ID: 20434
HgeneTgene
Gene symbol

LY6E

ZNF511

Gene ID

4061

118472

Gene namelymphocyte antigen 6 family member Ezinc finger protein 511
SynonymsRIG-E|RIGE|SCA-2|SCA2|TSA-1-
Cytomap

8q24.3

10q26.3

Type of geneprotein-codingprotein-coding
Descriptionlymphocyte antigen 6Ely-6Elymphocyte antigen 6 complex, locus Eretinoic acid induced gene Eretinoic acid-induced gene E proteinstem cell antigen 2thymic shared antigen 1zinc finger protein 511
Modification date2018052320180519
UniProtAcc

Q16553

Q8NB15

Ensembl transtripts involved in fusion geneENST00000517503, ENST00000292494, 
ENST00000429120, ENST00000521699, 
ENST00000520531, ENST00000520466, 
ENST00000521003, ENST00000522528, 
ENST00000522971, ENST00000519611, 
ENST00000521182, ENST00000519546, 
ENST00000523847, ENST00000522024, 
ENST00000519615, 		ENST00000368554, 
ENST00000361518, ENST00000359035, 
ENST00000463816, 
Fusion gene scores* DoF score5 X 5 X 3=752 X 2 X 2=8
# samples 73
** MAII scorelog2(7/75*10)=-0.0995356735509144
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/8*10)=1.90689059560852
Context

PubMed: LY6E [Title/Abstract] AND ZNF511 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB164138LY6Echr8

144103623

-ZNF511chr10

135163622

+
ChiTaRS3.1CB164673LY6Echr8

144103623

-ZNF511chr10

135163622

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000517503ENST00000368554LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-intronENST00000517503ENST00000361518LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-intronENST00000517503ENST00000359035LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-intronENST00000517503ENST00000463816LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-3CDSENST00000292494ENST00000368554LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-intronENST00000292494ENST00000361518LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-intronENST00000292494ENST00000359035LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-intronENST00000292494ENST00000463816LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-3CDSENST00000429120ENST00000368554LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-intronENST00000429120ENST00000361518LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-intronENST00000429120ENST00000359035LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-intronENST00000429120ENST00000463816LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-3CDSENST00000521699ENST00000368554LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-intronENST00000521699ENST00000361518LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-intronENST00000521699ENST00000359035LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-intronENST00000521699ENST00000463816LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-3CDSENST00000520531ENST00000368554LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-intronENST00000520531ENST00000361518LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-intronENST00000520531ENST00000359035LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-intronENST00000520531ENST00000463816LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-3CDSENST00000520466ENST00000368554LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-intronENST00000520466ENST00000361518LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-intronENST00000520466ENST00000359035LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-intronENST00000520466ENST00000463816LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-3CDSENST00000521003ENST00000368554LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-intronENST00000521003ENST00000361518LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-intronENST00000521003ENST00000359035LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-intronENST00000521003ENST00000463816LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-3CDSENST00000522528ENST00000368554LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-intronENST00000522528ENST00000361518LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-intronENST00000522528ENST00000359035LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-intronENST00000522528ENST00000463816LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-3CDSENST00000522971ENST00000368554LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-intronENST00000522971ENST00000361518LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-intronENST00000522971ENST00000359035LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-intronENST00000522971ENST00000463816LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-3CDSENST00000519611ENST00000368554LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-intronENST00000519611ENST00000361518LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-intronENST00000519611ENST00000359035LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-intronENST00000519611ENST00000463816LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-3CDSENST00000521182ENST00000368554LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-intronENST00000521182ENST00000361518LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-intronENST00000521182ENST00000359035LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-intronENST00000521182ENST00000463816LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-3CDSENST00000519546ENST00000368554LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-intronENST00000519546ENST00000361518LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-intronENST00000519546ENST00000359035LY6Echr8

144103623

-ZNF511chr10

135163622

+
3UTR-intronENST00000519546ENST00000463816LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-3CDSENST00000523847ENST00000368554LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-intronENST00000523847ENST00000361518LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-intronENST00000523847ENST00000359035LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-intronENST00000523847ENST00000463816LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-3CDSENST00000522024ENST00000368554LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-intronENST00000522024ENST00000361518LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-intronENST00000522024ENST00000359035LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-intronENST00000522024ENST00000463816LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-3CDSENST00000519615ENST00000368554LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-intronENST00000519615ENST00000361518LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-intronENST00000519615ENST00000359035LY6Echr8

144103623

-ZNF511chr10

135163622

+
intron-intronENST00000519615ENST00000463816LY6Echr8

144103623

-ZNF511chr10

135163622

+

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FusionProtFeatures for LY6E_ZNF511


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LY6E

Q16553

ZNF511

Q8NB15

Involved in T-cell development. Believed to act as amodulator of nicotinic acetylcholine receptors (nAChRs) activity.In vitro inhibits alpha-3:beta-4-containing nAChRs maximumresponse. {ECO:0000250|UniProtKB:Q64253}. May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LY6E_ZNF511


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LY6E_ZNF511


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LY6E_ZNF511


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LY6E_ZNF511


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLY6EC0021400Influenza1CTD_human
HgeneLY6EC0030297Pancreatic Neoplasm1CTD_human