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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20422

FusionGeneSummary for LURAP1L_TYRP1

check button Fusion gene summary
Fusion gene informationFusion gene name: LURAP1L_TYRP1
Fusion gene ID: 20422
HgeneTgene
Gene symbol

LURAP1L

TYRP1

Gene ID

286343

7306

Gene nameleucine rich adaptor protein 1 liketyrosinase related protein 1
SynonymsC9orf150|HYST0841|LRAP35b|bA3L8.2CAS2|CATB|GP75|OCA3|TRP|TRP1|TYRP|b-PROTEIN
Cytomap

9p23

9p23

Type of geneprotein-codingprotein-coding
Descriptionleucine rich adaptor protein 1-likeleucine repeat adaptor protein 35b5,6-dihydroxyindole-2-carboxylic acid oxidaseDHICA oxidasecatalase Bglycoprotein 75melanoma antigen gp75
Modification date2018051920180523
UniProtAcc

Q8IV03

P17643

Ensembl transtripts involved in fusion geneENST00000319264, ENST00000489107, 
ENST00000381137, ENST00000388918, 
ENST00000381136, ENST00000473504, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 1 X 3=15
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/15*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LURAP1L [Title/Abstract] AND TYRP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A2-A0SX-01ALURAP1Lchr9

12776026

+TYRP1chr9

12693912

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000319264ENST00000381137LURAP1Lchr9

12776026

+TYRP1chr9

12693912

+
5CDS-5UTRENST00000319264ENST00000388918LURAP1Lchr9

12776026

+TYRP1chr9

12693912

+
5CDS-intronENST00000319264ENST00000381136LURAP1Lchr9

12776026

+TYRP1chr9

12693912

+
5CDS-intronENST00000319264ENST00000473504LURAP1Lchr9

12776026

+TYRP1chr9

12693912

+
3UTR-5UTRENST00000489107ENST00000381137LURAP1Lchr9

12776026

+TYRP1chr9

12693912

+
3UTR-5UTRENST00000489107ENST00000388918LURAP1Lchr9

12776026

+TYRP1chr9

12693912

+
3UTR-intronENST00000489107ENST00000381136LURAP1Lchr9

12776026

+TYRP1chr9

12693912

+
3UTR-intronENST00000489107ENST00000473504LURAP1Lchr9

12776026

+TYRP1chr9

12693912

+

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FusionProtFeatures for LURAP1L_TYRP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LURAP1L

Q8IV03

TYRP1

P17643

Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acidin the presence of bound Cu(2+) ions (PubMed:28661582). Mayregulate or influence the type of melanin synthesized(PubMed:22556244, PubMed:16704458). Also to a lower extent,capable of hydroxylating tyrosine and producing melanin (Bysimilarity). {ECO:0000250|UniProtKB:P07147,ECO:0000269|PubMed:28661582, ECO:0000305|PubMed:16704458,ECO:0000305|PubMed:22556244, ECO:0000305|PubMed:23504663}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LURAP1L_TYRP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LURAP1L_TYRP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LURAP1LAPP, KIAA1598, NEFM, SNTB2, CDC42BPA, CDC42BPB, FBXO28, HSF1, SNAP29, TP53RKTYRP1GIPC1, RAB11A, TF, RAB5A, HSPA4, RC3H1, ZNF431


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LURAP1L_TYRP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LURAP1L_TYRP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLURAP1LC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneTYRP1C0342683ALBINISM, OCULOCUTANEOUS, TYPE III2ORPHANET;UNIPROT
TgeneTYRP1C0001418Adenocarcinoma1CTD_human
TgeneTYRP1C0024121Lung Neoplasms1CTD_human
TgeneTYRP1C0025202melanoma1CTD_human