FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 20409

FusionGeneSummary for LUC7L3_MYCBPAP

check button Fusion gene summary
Fusion gene informationFusion gene name: LUC7L3_MYCBPAP
Fusion gene ID: 20409
HgeneTgene
Gene symbol

LUC7L3

MYCBPAP

Gene ID

51747

84073

Gene nameLUC7 like 3 pre-mRNA splicing factorMYCBP associated protein
SynonymsCRA|CREAP-1|CROP|LUC7A|OA48-18|hLuc7AAMAP-1|AMAP1
Cytomap

17q21.33

17q21.33

Type of geneprotein-codingprotein-coding
Descriptionluc7-like protein 3CRE-associated protein 1LUC7-like 3cAMP regulatory element-associated protein 1cisplatin resistance-associated-overexpressed proteinokadaic acid-inducible phosphoprotein OA48-18MYCBP-associated proteinAMAM-1AMY-1-binding protein 1AMY1-associating protein 1testis secretory sperm-binding protein Li 214e
Modification date2018052320180519
UniProtAcc

O95232

Q8TBZ2

Ensembl transtripts involved in fusion geneENST00000505658, ENST00000393227, 
ENST00000311571, ENST00000240304, 
ENST00000544170, ENST00000503798, 
ENST00000323776, ENST00000419930, 
ENST00000436259, ENST00000468821, 
Fusion gene scores* DoF score12 X 8 X 6=5762 X 2 X 2=8
# samples 142
** MAII scorelog2(14/576*10)=-2.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: LUC7L3 [Title/Abstract] AND MYCBPAP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCSTCGA-N8-A4PM-01ALUC7L3chr17

48797192

+MYCBPAPchr17

48593931

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000505658ENST00000323776LUC7L3chr17

48797192

+MYCBPAPchr17

48593931

+
5CDS-intronENST00000505658ENST00000419930LUC7L3chr17

48797192

+MYCBPAPchr17

48593931

+
5CDS-intronENST00000505658ENST00000436259LUC7L3chr17

48797192

+MYCBPAPchr17

48593931

+
5CDS-intronENST00000505658ENST00000468821LUC7L3chr17

48797192

+MYCBPAPchr17

48593931

+
Frame-shiftENST00000393227ENST00000323776LUC7L3chr17

48797192

+MYCBPAPchr17

48593931

+
5CDS-intronENST00000393227ENST00000419930LUC7L3chr17

48797192

+MYCBPAPchr17

48593931

+
5CDS-intronENST00000393227ENST00000436259LUC7L3chr17

48797192

+MYCBPAPchr17

48593931

+
5CDS-intronENST00000393227ENST00000468821LUC7L3chr17

48797192

+MYCBPAPchr17

48593931

+
Frame-shiftENST00000311571ENST00000323776LUC7L3chr17

48797192

+MYCBPAPchr17

48593931

+
5CDS-intronENST00000311571ENST00000419930LUC7L3chr17

48797192

+MYCBPAPchr17

48593931

+
5CDS-intronENST00000311571ENST00000436259LUC7L3chr17

48797192

+MYCBPAPchr17

48593931

+
5CDS-intronENST00000311571ENST00000468821LUC7L3chr17

48797192

+MYCBPAPchr17

48593931

+
Frame-shiftENST00000240304ENST00000323776LUC7L3chr17

48797192

+MYCBPAPchr17

48593931

+
5CDS-intronENST00000240304ENST00000419930LUC7L3chr17

48797192

+MYCBPAPchr17

48593931

+
5CDS-intronENST00000240304ENST00000436259LUC7L3chr17

48797192

+MYCBPAPchr17

48593931

+
5CDS-intronENST00000240304ENST00000468821LUC7L3chr17

48797192

+MYCBPAPchr17

48593931

+
5UTR-3CDSENST00000544170ENST00000323776LUC7L3chr17

48797192

+MYCBPAPchr17

48593931

+
5UTR-intronENST00000544170ENST00000419930LUC7L3chr17

48797192

+MYCBPAPchr17

48593931

+
5UTR-intronENST00000544170ENST00000436259LUC7L3chr17

48797192

+MYCBPAPchr17

48593931

+
5UTR-intronENST00000544170ENST00000468821LUC7L3chr17

48797192

+MYCBPAPchr17

48593931

+
intron-3CDSENST00000503798ENST00000323776LUC7L3chr17

48797192

+MYCBPAPchr17

48593931

+
intron-intronENST00000503798ENST00000419930LUC7L3chr17

48797192

+MYCBPAPchr17

48593931

+
intron-intronENST00000503798ENST00000436259LUC7L3chr17

48797192

+MYCBPAPchr17

48593931

+
intron-intronENST00000503798ENST00000468821LUC7L3chr17

48797192

+MYCBPAPchr17

48593931

+

Top

FusionProtFeatures for LUC7L3_MYCBPAP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LUC7L3

O95232

MYCBPAP

Q8TBZ2

Binds cAMP regulatory element DNA sequence. May play arole in RNA splicing. {ECO:0000269|PubMed:16462885}. May play a role in spermatogenesis. May be involved insynaptic processes (By similarity). {ECO:0000250|UniProtKB:Q69CM7,ECO:0000269|PubMed:12151104}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for LUC7L3_MYCBPAP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for LUC7L3_MYCBPAP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LUC7L3RNPS1, LUC7L3, SRSF1, CLK1, SRPK1, SRPK2, RRP1B, MEPCE, TADA2A, YWHAG, ITSN2, CUL2, CUL1, COPS5, CAND1, SRSF7, SART1, SMU1, HNRNPU, NXF1, VTN, TRMT112, BANF1, NFIA, RCC1, S100A9, ESR1, BARD1, WWOX, ENO1, SHMT2, MOV10, CUL7, OBSL1, SUZ12, EED, RNF2, BMI1, EAF1, ZRANB2, LUC7L, LUC7L2, UNK, SNRPD2, NTRK1, PTTG1, SYN1, AKAP5, NABP2, NLRP3, NF2, SNW1, EGFR, JMJD6, UHRF2, LMNAMYCBPAPMYCBP, CASP4, CDK19, FBF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for LUC7L3_MYCBPAP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for LUC7L3_MYCBPAP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource