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Fusion gene ID: 20395 |
FusionGeneSummary for LUC7L2_JAKMIP1 |
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Fusion gene information | Fusion gene name: LUC7L2_JAKMIP1 | Fusion gene ID: 20395 | Hgene | Tgene | Gene symbol | LUC7L2 | JAKMIP1 | Gene ID | 51631 | 152789 |
Gene name | LUC7 like 2, pre-mRNA splicing factor | janus kinase and microtubule interacting protein 1 | |
Synonyms | CGI-59|CGI-74|LUC7B2 | Gababrbp|JAMIP1|MARLIN1 | |
Cytomap | 7q34 | 4p16.1 | |
Type of gene | protein-coding | protein-coding | |
Description | putative RNA-binding protein Luc7-like 2LUC7-like 2 | janus kinase and microtubule-interacting protein 1GABA-B receptor-binding proteinJak and microtubule interacting protein 1marlin-1multiple alpha-helices and RNA-linker protein 1multiple coiled-coil GABABR1-binding protein | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q96N16 | ||
Ensembl transtripts involved in fusion gene | ENST00000541515, | ENST00000409021, ENST00000409371, ENST00000282924, ENST00000409831, ENST00000410077, ENST00000457227, | |
Fusion gene scores | * DoF score | 9 X 9 X 6=486 | 1 X 1 X 1=1 |
# samples | 11 | 1 | |
** MAII score | log2(11/486*10)=-2.14345279008112 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: LUC7L2 [Title/Abstract] AND JAKMIP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-D8-A27R-01A | LUC7L2 | chr7 | 139045068 | + | JAKMIP1 | chr4 | 6114724 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000541515 | ENST00000409021 | LUC7L2 | chr7 | 139045068 | + | JAKMIP1 | chr4 | 6114724 | - |
intron-5UTR | ENST00000541515 | ENST00000409371 | LUC7L2 | chr7 | 139045068 | + | JAKMIP1 | chr4 | 6114724 | - |
intron-5UTR | ENST00000541515 | ENST00000282924 | LUC7L2 | chr7 | 139045068 | + | JAKMIP1 | chr4 | 6114724 | - |
intron-5UTR | ENST00000541515 | ENST00000409831 | LUC7L2 | chr7 | 139045068 | + | JAKMIP1 | chr4 | 6114724 | - |
intron-5UTR | ENST00000541515 | ENST00000410077 | LUC7L2 | chr7 | 139045068 | + | JAKMIP1 | chr4 | 6114724 | - |
intron-intron | ENST00000541515 | ENST00000457227 | LUC7L2 | chr7 | 139045068 | + | JAKMIP1 | chr4 | 6114724 | - |
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FusionProtFeatures for LUC7L2_JAKMIP1 |
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Hgene | Tgene |
LUC7L2 | JAKMIP1 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LUC7L2_JAKMIP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LUC7L2_JAKMIP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LUC7L2 | RNPS1, YWHAG, YWHAQ, PTCD3, LUC7L2, PEA15, NKAP, SSFA2, SVIL, KLHL20, ALB, ATRX, LINC00341, NAT9, NDUFA4L2, LPL, UNC119, MAN2A2, MAP1LC3B, FAM173A, NAP1L5, NASP, NUTF2, OFD1, SAT1, ZCCHC10, CDK5RAP2, CCDC53, FXR1, CHD3, KIAA1377, PTN, NSF, ULK2, RRP1B, MEPCE, IKBKG, NEDD4, RBM39, NOP56, NDEL1, EXOC1, GSK3B, GADD45G, AIMP2, PDPK1, CDC37, CDK4, SETDB1, PIK3R3, JMJD6, ELAVL1, CUL3, COPS5, CAND1, HAP1, APP, RPL19, RPL15, RPL18A, RPL7A, RPS4X, SNRPD2, RPLP0P6, BARD1, PAXIP1, CD81, SRPK2, SRPK1, TARDBP, CARS, HSPA4L, ARFIP1, ATP6V1C1, PBDC1, IVNS1ABP, MAN2B1, STAT3, SHMT2, STAU1, HUWE1, NFYA, SRSF6, SRSF7, APPBP2, EZH2, SUZ12, RNF2, EAF1, TRA2A, ZRANB2, LUC7L, CSNK2A2, LARP7, ZC3H18, BCLAF1, THRAP3, PRPF4B, CCDC9, ACIN1, C17orf85, C1QBP, PABPC4, GPATCH8, U2AF2, PAIP1, UBE2O, RBM22, PNN, LARP1, LARP1B, SRSF1, SNW1, CLASRP, PAIP2B, SRRT, CSNK2A1, CCDC12, LUC7L3, MOV10, CDC40, DDX46, SF3A1, ZC3H14, CPSF6, SNRNP27, CLK3, IK, CASC3, FAM98A, FTL, SNRNP70, MKRN2, SCAF11, MKRN1, TRA2B, SRSF8, SRSF12, SRSF10, SREK1, CLK2, HNRNPR, DDX5, PABPC1, PRPF6, PRPF8, RBM8A, RPL22, SNRPD3, SRSF11, TIA1, SF3B3, SNRNP200, SNRPD1, SNRPE, SYNCRIP, U2AF1, SFN, NTRK1, CNTRL, OTUB1, RC3H1, CRBN, FTH1, PPIL4, ISY1, SRRM2, INO80B, RPAP3, FOXA1, TRIM25, UHRF2 | JAKMIP1 | GABBR1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LUC7L2_JAKMIP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LUC7L2_JAKMIP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | JAKMIP1 | C0004352 | Autistic Disorder | 1 | CTD_human |