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Fusion gene ID: 20367 |
FusionGeneSummary for LTBP2_NEK9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LTBP2_NEK9 | Fusion gene ID: 20367 | Hgene | Tgene | Gene symbol | LTBP2 | NEK9 | Gene ID | 4054 | 91754 |
| Gene name | latent transforming growth factor beta binding protein 3 | NIMA related kinase 9 | |
| Synonyms | DASS|GPHYSD3|LTBP-3|LTBP2|STHAG6|pp6425 | APUG|LCCS10|NC|NERCC|NERCC1 | |
| Cytomap | 11q13.1 | 14q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | latent-transforming growth factor beta-binding protein 3latent TGF beta binding protein 3 | serine/threonine-protein kinase Nek9NIMA (never in mitosis gene a)- related kinase 9nercc1 kinasenimA-related protein kinase 9 | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q14767 | Q8TD19 | |
| Ensembl transtripts involved in fusion gene | ENST00000261978, ENST00000556690, ENST00000557425, | ENST00000238616, ENST00000555763, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 2 X 5 X 2=20 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/32*10)=0.643856189774725 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/20*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: LTBP2 [Title/Abstract] AND NEK9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-25-1315-01A | LTBP2 | chr14 | 74999129 | - | NEK9 | chr14 | 75558181 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000261978 | ENST00000238616 | LTBP2 | chr14 | 74999129 | - | NEK9 | chr14 | 75558181 | - |
| 5CDS-intron | ENST00000261978 | ENST00000555763 | LTBP2 | chr14 | 74999129 | - | NEK9 | chr14 | 75558181 | - |
| In-frame | ENST00000556690 | ENST00000238616 | LTBP2 | chr14 | 74999129 | - | NEK9 | chr14 | 75558181 | - |
| 5CDS-intron | ENST00000556690 | ENST00000555763 | LTBP2 | chr14 | 74999129 | - | NEK9 | chr14 | 75558181 | - |
| intron-3CDS | ENST00000557425 | ENST00000238616 | LTBP2 | chr14 | 74999129 | - | NEK9 | chr14 | 75558181 | - |
| intron-intron | ENST00000557425 | ENST00000555763 | LTBP2 | chr14 | 74999129 | - | NEK9 | chr14 | 75558181 | - |
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FusionProtFeatures for LTBP2_NEK9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LTBP2 | NEK9 |
| May play an integral structural role in elastic-fiberarchitectural organization and/or assembly. | Pleiotropic regulator of mitotic progression,participating in the control of spindle dynamics and chromosomeseparation. Phosphorylates different histones, myelin basicprotein, beta-casein, and BICD2. Phosphorylates histone H3 onserine and threonine residues and beta-casein on serine residues.Important for G1/S transition and S phase progression.Phosphorylates NEK6 and NEK7 and stimulates their activity byreleasing the autoinhibitory functions of Tyr-108 and Tyr-97respectively. {ECO:0000269|PubMed:12840024,ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 187_219 | 662 | 1822 | Domain | EGF-like 1 |
| Hgene | LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 396_428 | 662 | 1822 | Domain | EGF-like 2 |
| Hgene | LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 552_604 | 662 | 1822 | Domain | TB 1 |
| Hgene | LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 622_662 | 662 | 1822 | Domain | EGF-like 3%3B calcium-binding |
| Hgene | LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 375_377 | 662 | 1822 | Motif | Cell attachment site |
| Hgene | LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 232_249 | 662 | 1822 | Region | Note=Heparin-binding |
| Hgene | LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 344_354 | 662 | 1822 | Region | Note=Heparin-binding |
| Hgene | LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 94_115 | 662 | 1822 | Region | Note=Heparin-binding |
| Tgene | >NEK9 | chr14:74999129 | chr14:75558181 | ENST00000238616 | - | 17 | 22 | 892_939 | 744 | 980 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >NEK9 | chr14:74999129 | chr14:75558181 | ENST00000238616 | - | 17 | 22 | 752_760 | 744 | 980 | Compositional bias | Note=Poly-Gly |
| Tgene | >NEK9 | chr14:74999129 | chr14:75558181 | ENST00000238616 | - | 17 | 22 | 765_888 | 744 | 980 | Compositional bias | Note=Pro/Ser/Thr-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 856_1372 | 662 | 1822 | Compositional bias | Note=Cys-rich |
| Hgene | >LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 1010_1050 | 662 | 1822 | Domain | EGF-like 8%3B calcium-binding |
| Hgene | >LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 1051_1092 | 662 | 1822 | Domain | EGF-like 9%3B calcium-binding |
| Hgene | >LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 1093_1134 | 662 | 1822 | Domain | EGF-like 10%3B calcium-binding |
| Hgene | >LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 1135_1175 | 662 | 1822 | Domain | EGF-like 11%3B calcium-binding |
| Hgene | >LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 1176_1217 | 662 | 1822 | Domain | EGF-like 12%3B calcium-binding |
| Hgene | >LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 1218_1258 | 662 | 1822 | Domain | EGF-like 13%3B calcium-binding |
| Hgene | >LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 1259_1302 | 662 | 1822 | Domain | EGF-like 14%3B calcium-binding |
| Hgene | >LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 1303_1344 | 662 | 1822 | Domain | EGF-like 15%3B calcium-binding |
| Hgene | >LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 1345_1387 | 662 | 1822 | Domain | EGF-like 16%3B calcium-binding |
| Hgene | >LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 1411_1463 | 662 | 1822 | Domain | TB 3 |
| Hgene | >LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 1485_1527 | 662 | 1822 | Domain | EGF-like 17%3B calcium-binding |
| Hgene | >LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 1528_1567 | 662 | 1822 | Domain | EGF-like 18%3B calcium-binding |
| Hgene | >LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 1584_1636 | 662 | 1822 | Domain | TB 4 |
| Hgene | >LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 1733_1773 | 662 | 1822 | Domain | EGF-like 19%3B calcium-binding |
| Hgene | >LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 1774_1818 | 662 | 1822 | Domain | EGF-like 20%3B calcium-binding |
| Hgene | >LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 672_724 | 662 | 1822 | Domain | TB 2 |
| Hgene | >LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 844_886 | 662 | 1822 | Domain | EGF-like 4 |
| Hgene | >LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 887_929 | 662 | 1822 | Domain | EGF-like 5%3B calcium-binding |
| Hgene | >LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 930_969 | 662 | 1822 | Domain | EGF-like 6%3B calcium-binding |
| Hgene | >LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 970_1009 | 662 | 1822 | Domain | EGF-like 7%3B calcium-binding |
| Hgene | >LTBP2 | chr14:74999129 | chr14:75558181 | ENST00000261978 | - | 10 | 36 | 1639_1821 | 662 | 1822 | Region | C-terminal domain |
| Tgene | NEK9 | chr14:74999129 | chr14:75558181 | ENST00000238616 | - | 17 | 22 | 52_308 | 744 | 980 | Domain | Protein kinase |
| Tgene | NEK9 | chr14:74999129 | chr14:75558181 | ENST00000238616 | - | 17 | 22 | 58_66 | 744 | 980 | Nucleotide binding | ATP |
| Tgene | NEK9 | chr14:74999129 | chr14:75558181 | ENST00000238616 | - | 17 | 22 | 388_444 | 744 | 980 | Repeat | Note=RCC1 1 |
| Tgene | NEK9 | chr14:74999129 | chr14:75558181 | ENST00000238616 | - | 17 | 22 | 445_498 | 744 | 980 | Repeat | Note=RCC1 2 |
| Tgene | NEK9 | chr14:74999129 | chr14:75558181 | ENST00000238616 | - | 17 | 22 | 499_550 | 744 | 980 | Repeat | Note=RCC1 3 |
| Tgene | NEK9 | chr14:74999129 | chr14:75558181 | ENST00000238616 | - | 17 | 22 | 551_615 | 744 | 980 | Repeat | Note=RCC1 4 |
| Tgene | NEK9 | chr14:74999129 | chr14:75558181 | ENST00000238616 | - | 17 | 22 | 616_668 | 744 | 980 | Repeat | Note=RCC1 5 |
| Tgene | NEK9 | chr14:74999129 | chr14:75558181 | ENST00000238616 | - | 17 | 22 | 669_726 | 744 | 980 | Repeat | Note=RCC1 6 |
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FusionGeneSequence for LTBP2_NEK9 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_LTBP2_ENST00000261978_chr14_74999129_-_NEK9_ENST00000238616_chr14_75558181_-_898aa MRPRTKARSPGRALRNPWRGFLPLTLALFVGAGHAQRDPVGRYEPAGGDANRLRRPGGSYPAAAAAKVYSLFREQDAPVAGLQPVERAQP GWGSPRRPTEAEARRPSRAQQSRRVQPPAQTRRSTPLGQQQPAPRTRAAPALPRLGTPQRSGAAPPTPPRGRLTGRNVCGGQCCPGWTTA NSTNHCIKPVCEPPCQNRGSCSRPQLCVCRSGFRGARCEEVIPDEEFDPQNSRLAPRRWAERSPNLRRSSAAGEGTLARAQPPAPQSPPA PQSPPAGTLSGLSQTHPSQQHVGLSRTVRLHPTATASSQLSSNALPPGPGLEQRDGTQQAVPLEHPSSPWGLNLTEKIKKIKIVFTPTIC KQTCARGHCANSCERGDTTTLYSQGGHGHDPKSGFRIYFCQIPCLNGGRCIGRDECWCPANSTGKFCHLPIPQPDREPPGRGSRPRALLE APLKQSTFTLPLSNQLASVNPSLVKVHIHHPPEASVQIHQVAQVRGGVEEALVENSVETRPPPWLPASPGHSLWDSNNIPARSGEPPRPL PPAAPRPRGLLGRCYLNTVNGQCANPLLELTTQEDCCGSVGAFWGVTLCAPCPPRPASPVIENGQLECPQGYKRLNLTHCQDINECLTLG LCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVLFQSSSPGGGGGGGGGEEEDSQQESETPDPSGGFRGTMEADRGMEGLISPTEAMGNSN GASSSCPGWLRKELENAEFIPMPDSPSPLSAAFSESEKDTLPYEELQGLKVASEAPLEHKPQVEASSPRLNPAVTCAGKGTPLTPPACAC >In-frame_LTBP2_ENST00000556690_chr14_74999129_-_NEK9_ENST00000238616_chr14_75558181_-_898aa MRPRTKARSPGRALRNPWRGFLPLTLALFVGAGHAQRDPVGRYEPAGGDANRLRRPGGSYPAAAAAKVYSLFREQDAPVAGLQPVERAQP GWGSPRRPTEAEARRPSRAQQSRRVQPPAQTRRSTPLGQQQPAPRTRAAPALPRLGTPQRSGAAPPTPPRGRLTGRNVCGGQCCPGWTTA NSTNHCIKPVCEPPCQNRGSCSRPQLCVCRSGFRGARCEEVIPDEEFDPQNSRLAPRRWAERSPNLRRSSAAGEGTLARAQPPAPQSPPA PQSPPAGTLSGLSQTHPSQQHVGLSRTVRLHPTATASSQLSSNALPPGPGLEQRDGTQQAVPLEHPSSPWGLNLTEKIKKIKIVFTPTIC KQTCARGHCANSCERGDTTTLYSQGGHGHDPKSGFRIYFCQIPCLNGGRCIGRDECWCPANSTGKFCHLPIPQPDREPPGRGSRPRALLE APLKQSTFTLPLSNQLASVNPSLVKVHIHHPPEASVQIHQVAQVRGGVEEALVENSVETRPPPWLPASPGHSLWDSNNIPARSGEPPRPL PPAAPRPRGLLGRCYLNTVNGQCANPLLELTTQEDCCGSVGAFWGVTLCAPCPPRPASPVIENGQLECPQGYKRLNLTHCQDINECLTLG LCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVLFQSSSPGGGGGGGGGEEEDSQQESETPDPSGGFRGTMEADRGMEGLISPTEAMGNSN GASSSCPGWLRKELENAEFIPMPDSPSPLSAAFSESEKDTLPYEELQGLKVASEAPLEHKPQVEASSPRLNPAVTCAGKGTPLTPPACAC |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_LTBP2_ENST00000261978_chr14_74999129_-_NEK9_ENST00000238616_chr14_75558181_-_2694nt ATGAGGCCGCGGACCAAAGCCCGCAGCCCGGGGCGCGCCCTGCGGAACCCCTGGAGAGGCTTCCTGCCGCTCACCCTGGCTCTCTTCGTG GGCGCGGGTCATGCCCAAAGGGACCCCGTAGGGAGATACGAGCCGGCTGGTGGAGACGCGAATCGACTGCGGCGCCCTGGGGGCAGCTAC CCGGCAGCGGCTGCAGCCAAGGTGTACAGTCTGTTCCGGGAGCAGGACGCGCCTGTCGCGGGCTTGCAGCCCGTGGAGCGGGCCCAGCCG GGCTGGGGGAGCCCCAGGAGGCCCACCGAGGCGGAGGCCAGGAGGCCGTCCCGCGCGCAGCAGTCGCGGCGTGTCCAGCCACCTGCGCAG ACCCGGAGAAGCACTCCCCTGGGCCAGCAGCAACCAGCACCCCGGACCCGGGCCGCGCCGGCTCTCCCACGCCTGGGGACCCCACAGCGG TCTGGGGCTGCGCCCCCAACCCCGCCGCGAGGGCGGCTCACGGGGAGGAACGTCTGCGGGGGACAGTGCTGCCCAGGATGGACAACAGCA AACAGCACCAACCACTGTATCAAACCCGTTTGCGAGCCGCCGTGCCAGAACCGGGGCTCCTGCAGCCGCCCGCAGCTCTGTGTCTGCCGC TCTGGTTTCCGTGGAGCCCGCTGCGAGGAGGTCATTCCCGATGAGGAATTTGACCCCCAGAACTCCAGGCTGGCACCTCGACGCTGGGCC GAGCGTTCACCCAACCTGCGCAGGAGCAGTGCGGCTGGAGAGGGCACCTTGGCCAGAGCACAGCCGCCAGCACCACAGTCGCCGCCCGCA CCACAGTCGCCACCAGCTGGGACCCTGAGTGGCCTCAGCCAGACCCACCCTTCCCAGCAGCACGTGGGGTTGTCCCGCACTGTCCGACTT CACCCGACTGCCACGGCCAGTAGCCAGCTCTCTTCCAACGCCCTGCCCCCGGGACCAGGCCTTGAGCAGAGAGATGGCACCCAACAGGCG GTACCTCTGGAGCACCCCTCATCCCCCTGGGGGCTGAACCTCACGGAGAAAATCAAGAAGATCAAGATCGTCTTCACTCCCACCATCTGC AAGCAGACCTGTGCCCGTGGACACTGTGCCAACAGCTGTGAGAGGGGCGACACCACCACCCTGTACAGCCAGGGCGGCCATGGGCACGAT CCCAAGTCTGGCTTCCGCATCTATTTCTGCCAGATCCCCTGCCTGAACGGAGGCCGCTGCATCGGCAGGGACGAATGCTGGTGCCCCGCC AACTCCACCGGGAAGTTCTGCCACCTGCCTATCCCGCAGCCGGACAGGGAGCCTCCAGGGAGGGGGTCCCGCCCCAGGGCCTTGCTGGAA GCCCCACTGAAGCAGTCCACTTTCACACTGCCGCTCTCCAACCAGCTGGCCTCCGTGAACCCCTCCCTGGTGAAGGTGCACATTCACCAC CCACCCGAGGCCTCAGTGCAGATCCACCAGGTGGCCCAGGTGCGGGGCGGGGTGGAGGAGGCCCTAGTGGAGAACAGCGTGGAGACCAGA CCCCCGCCCTGGCTGCCTGCCAGCCCTGGCCACAGCCTCTGGGACAGCAACAACATCCCTGCTCGGTCTGGAGAGCCCCCTCGGCCACTG CCCCCAGCAGCACCCAGGCCTCGAGGACTGCTGGGCCGGTGTTACCTGAACACTGTGAACGGACAGTGTGCCAACCCTCTGCTGGAGCTG ACTACCCAGGAGGACTGCTGTGGCAGTGTGGGAGCCTTCTGGGGGGTGACTTTGTGTGCCCCATGCCCACCCAGACCAGCCTCCCCGGTG ATTGAGAATGGCCAGCTGGAGTGTCCTCAGGGGTACAAGAGACTGAACCTCACTCACTGCCAAGATATCAACGAGTGCTTGACCCTGGGC CTGTGCAAGGACGCGGAGTGTGTGAATACCAGGGGCAGCTACCTGTGCACATGCAGACCTGGCCTCATGCTGGATCCATCGCGGAGCCGC TGTGTGTTGTTTCAGAGCTCTAGCCCGGGAGGAGGCGGCGGGGGCGGCGGTGGTGAAGAAGAGGACAGTCAGCAGGAATCTGAAACTCCT GACCCAAGTGGAGGCTTCCGAGGAACAATGGAAGCAGACCGAGGAATGGAAGGTTTAATCAGTCCCACAGAGGCCATGGGGAACAGTAAT GGGGCCAGCAGCTCCTGTCCTGGCTGGCTTCGAAAGGAGCTGGAAAATGCAGAATTTATCCCCATGCCTGACAGCCCATCTCCTCTCAGT GCAGCGTTTTCAGAATCTGAGAAAGATACCCTGCCCTATGAAGAGCTGCAAGGACTCAAAGTGGCCTCTGAAGCTCCTTTGGAACACAAA CCCCAAGTAGAAGCCTCGTCACCTCGGCTGAATCCTGCAGTAACCTGTGCTGGGAAGGGAACACCACTGACTCCTCCTGCGTGTGCGTGC AGCTCTCTGCAGGTGGAGGTTGAGAGATTGCAGGGTCTGGTGTTAAAGTGTCTGGCTGAACAACAGAAGCTACAGCAAGAAAACCTCCAG ATTTTTACCCAACTGCAGAAGTTGAACAAGAAATTAGAAGGAGGGCAGCAGGTGGGGATGCATTCCAAAGGAACTCAGACAGCAAAGGAA >In-frame_LTBP2_ENST00000556690_chr14_74999129_-_NEK9_ENST00000238616_chr14_75558181_-_2694nt ATGAGGCCGCGGACCAAAGCCCGCAGCCCGGGGCGCGCCCTGCGGAACCCCTGGAGAGGCTTCCTGCCGCTCACCCTGGCTCTCTTCGTG GGCGCGGGTCATGCCCAAAGGGACCCCGTAGGGAGATACGAGCCGGCTGGTGGAGACGCGAATCGACTGCGGCGCCCTGGGGGCAGCTAC CCGGCAGCGGCTGCAGCCAAGGTGTACAGTCTGTTCCGGGAGCAGGACGCGCCTGTCGCGGGCTTGCAGCCCGTGGAGCGGGCCCAGCCG GGCTGGGGGAGCCCCAGGAGGCCCACCGAGGCGGAGGCCAGGAGGCCGTCCCGCGCGCAGCAGTCGCGGCGTGTCCAGCCACCTGCGCAG ACCCGGAGAAGCACTCCCCTGGGCCAGCAGCAACCAGCACCCCGGACCCGGGCCGCGCCGGCTCTCCCACGCCTGGGGACCCCACAGCGG TCTGGGGCTGCGCCCCCAACCCCGCCGCGAGGGCGGCTCACGGGGAGGAACGTCTGCGGGGGACAGTGCTGCCCAGGATGGACAACAGCA AACAGCACCAACCACTGTATCAAACCCGTTTGCGAGCCGCCGTGCCAGAACCGGGGCTCCTGCAGCCGCCCGCAGCTCTGTGTCTGCCGC TCTGGTTTCCGTGGAGCCCGCTGCGAGGAGGTCATTCCCGATGAGGAATTTGACCCCCAGAACTCCAGGCTGGCACCTCGACGCTGGGCC GAGCGTTCACCCAACCTGCGCAGGAGCAGTGCGGCTGGAGAGGGCACCTTGGCCAGAGCACAGCCGCCAGCACCACAGTCGCCGCCCGCA CCACAGTCGCCACCAGCTGGGACCCTGAGTGGCCTCAGCCAGACCCACCCTTCCCAGCAGCACGTGGGGTTGTCCCGCACTGTCCGACTT CACCCGACTGCCACGGCCAGTAGCCAGCTCTCTTCCAACGCCCTGCCCCCGGGACCAGGCCTTGAGCAGAGAGATGGCACCCAACAGGCG GTACCTCTGGAGCACCCCTCATCCCCCTGGGGGCTGAACCTCACGGAGAAAATCAAGAAGATCAAGATCGTCTTCACTCCCACCATCTGC AAGCAGACCTGTGCCCGTGGACACTGTGCCAACAGCTGTGAGAGGGGCGACACCACCACCCTGTACAGCCAGGGCGGCCATGGGCACGAT CCCAAGTCTGGCTTCCGCATCTATTTCTGCCAGATCCCCTGCCTGAACGGAGGCCGCTGCATCGGCAGGGACGAATGCTGGTGCCCCGCC AACTCCACCGGGAAGTTCTGCCACCTGCCTATCCCGCAGCCGGACAGGGAGCCTCCAGGGAGGGGGTCCCGCCCCAGGGCCTTGCTGGAA GCCCCACTGAAGCAGTCCACTTTCACACTGCCGCTCTCCAACCAGCTGGCCTCCGTGAACCCCTCCCTGGTGAAGGTGCACATTCACCAC CCACCCGAGGCCTCAGTGCAGATCCACCAGGTGGCCCAGGTGCGGGGCGGGGTGGAGGAGGCCCTAGTGGAGAACAGCGTGGAGACCAGA CCCCCGCCCTGGCTGCCTGCCAGCCCTGGCCACAGCCTCTGGGACAGCAACAACATCCCTGCTCGGTCTGGAGAGCCCCCTCGGCCACTG CCCCCAGCAGCACCCAGGCCTCGAGGACTGCTGGGCCGGTGTTACCTGAACACTGTGAACGGACAGTGTGCCAACCCTCTGCTGGAGCTG ACTACCCAGGAGGACTGCTGTGGCAGTGTGGGAGCCTTCTGGGGGGTGACTTTGTGTGCCCCATGCCCACCCAGACCAGCCTCCCCGGTG ATTGAGAATGGCCAGCTGGAGTGTCCTCAGGGGTACAAGAGACTGAACCTCACTCACTGCCAAGATATCAACGAGTGCTTGACCCTGGGC CTGTGCAAGGACGCGGAGTGTGTGAATACCAGGGGCAGCTACCTGTGCACATGCAGACCTGGCCTCATGCTGGATCCATCGCGGAGCCGC TGTGTGTTGTTTCAGAGCTCTAGCCCGGGAGGAGGCGGCGGGGGCGGCGGTGGTGAAGAAGAGGACAGTCAGCAGGAATCTGAAACTCCT GACCCAAGTGGAGGCTTCCGAGGAACAATGGAAGCAGACCGAGGAATGGAAGGTTTAATCAGTCCCACAGAGGCCATGGGGAACAGTAAT GGGGCCAGCAGCTCCTGTCCTGGCTGGCTTCGAAAGGAGCTGGAAAATGCAGAATTTATCCCCATGCCTGACAGCCCATCTCCTCTCAGT GCAGCGTTTTCAGAATCTGAGAAAGATACCCTGCCCTATGAAGAGCTGCAAGGACTCAAAGTGGCCTCTGAAGCTCCTTTGGAACACAAA CCCCAAGTAGAAGCCTCGTCACCTCGGCTGAATCCTGCAGTAACCTGTGCTGGGAAGGGAACACCACTGACTCCTCCTGCGTGTGCGTGC AGCTCTCTGCAGGTGGAGGTTGAGAGATTGCAGGGTCTGGTGTTAAAGTGTCTGGCTGAACAACAGAAGCTACAGCAAGAAAACCTCCAG ATTTTTACCCAACTGCAGAAGTTGAACAAGAAATTAGAAGGAGGGCAGCAGGTGGGGATGCATTCCAAAGGAACTCAGACAGCAAAGGAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_LTBP2_ENST00000261978_chr14_74999129_-_NEK9_ENST00000238616_chr14_75558181_-_5526nt CCTCGCTCCCTCTCCGGTAATGAGGGGGCTGAGCTGTCCCTCCGAGGAGGGGGCCTGGTGTGGATAAAAGAGACGAAAAAGCCGGGGGAG GTTTCCAAAAATAAAACCGTCCGGGTCCCCTTCAGACGGCTGCAGGCACAGGGAGGAGGCGCGAAGGTGCAGCAGCCGTGCGAGCCCAGC TGGAGTAGGAGCGCGGACTCGAGGCTCGGGGCGCGCAGCCCTCGTTCCGCCGAGAGCCGGGCCCCCAGTCGGCCGCTTCAGGGCCCCCTA GACTCAGAGAAGCTGGCCGCCGGGCGGGGCCGGGAGAACAGCCCGCGGGCGTCCAGCGTGCCGACCACAAAGCTCTTCGCGGTGCCCGCG CGCACCACTCTCCAGCCGCCCCGCGCCATGAGGCCGCGGACCAAAGCCCGCAGCCCGGGGCGCGCCCTGCGGAACCCCTGGAGAGGCTTC CTGCCGCTCACCCTGGCTCTCTTCGTGGGCGCGGGTCATGCCCAAAGGGACCCCGTAGGGAGATACGAGCCGGCTGGTGGAGACGCGAAT CGACTGCGGCGCCCTGGGGGCAGCTACCCGGCAGCGGCTGCAGCCAAGGTGTACAGTCTGTTCCGGGAGCAGGACGCGCCTGTCGCGGGC TTGCAGCCCGTGGAGCGGGCCCAGCCGGGCTGGGGGAGCCCCAGGAGGCCCACCGAGGCGGAGGCCAGGAGGCCGTCCCGCGCGCAGCAG TCGCGGCGTGTCCAGCCACCTGCGCAGACCCGGAGAAGCACTCCCCTGGGCCAGCAGCAACCAGCACCCCGGACCCGGGCCGCGCCGGCT CTCCCACGCCTGGGGACCCCACAGCGGTCTGGGGCTGCGCCCCCAACCCCGCCGCGAGGGCGGCTCACGGGGAGGAACGTCTGCGGGGGA CAGTGCTGCCCAGGATGGACAACAGCAAACAGCACCAACCACTGTATCAAACCCGTTTGCGAGCCGCCGTGCCAGAACCGGGGCTCCTGC AGCCGCCCGCAGCTCTGTGTCTGCCGCTCTGGTTTCCGTGGAGCCCGCTGCGAGGAGGTCATTCCCGATGAGGAATTTGACCCCCAGAAC TCCAGGCTGGCACCTCGACGCTGGGCCGAGCGTTCACCCAACCTGCGCAGGAGCAGTGCGGCTGGAGAGGGCACCTTGGCCAGAGCACAG CCGCCAGCACCACAGTCGCCGCCCGCACCACAGTCGCCACCAGCTGGGACCCTGAGTGGCCTCAGCCAGACCCACCCTTCCCAGCAGCAC GTGGGGTTGTCCCGCACTGTCCGACTTCACCCGACTGCCACGGCCAGTAGCCAGCTCTCTTCCAACGCCCTGCCCCCGGGACCAGGCCTT GAGCAGAGAGATGGCACCCAACAGGCGGTACCTCTGGAGCACCCCTCATCCCCCTGGGGGCTGAACCTCACGGAGAAAATCAAGAAGATC AAGATCGTCTTCACTCCCACCATCTGCAAGCAGACCTGTGCCCGTGGACACTGTGCCAACAGCTGTGAGAGGGGCGACACCACCACCCTG TACAGCCAGGGCGGCCATGGGCACGATCCCAAGTCTGGCTTCCGCATCTATTTCTGCCAGATCCCCTGCCTGAACGGAGGCCGCTGCATC GGCAGGGACGAATGCTGGTGCCCCGCCAACTCCACCGGGAAGTTCTGCCACCTGCCTATCCCGCAGCCGGACAGGGAGCCTCCAGGGAGG GGGTCCCGCCCCAGGGCCTTGCTGGAAGCCCCACTGAAGCAGTCCACTTTCACACTGCCGCTCTCCAACCAGCTGGCCTCCGTGAACCCC TCCCTGGTGAAGGTGCACATTCACCACCCACCCGAGGCCTCAGTGCAGATCCACCAGGTGGCCCAGGTGCGGGGCGGGGTGGAGGAGGCC CTAGTGGAGAACAGCGTGGAGACCAGACCCCCGCCCTGGCTGCCTGCCAGCCCTGGCCACAGCCTCTGGGACAGCAACAACATCCCTGCT CGGTCTGGAGAGCCCCCTCGGCCACTGCCCCCAGCAGCACCCAGGCCTCGAGGACTGCTGGGCCGGTGTTACCTGAACACTGTGAACGGA CAGTGTGCCAACCCTCTGCTGGAGCTGACTACCCAGGAGGACTGCTGTGGCAGTGTGGGAGCCTTCTGGGGGGTGACTTTGTGTGCCCCA TGCCCACCCAGACCAGCCTCCCCGGTGATTGAGAATGGCCAGCTGGAGTGTCCTCAGGGGTACAAGAGACTGAACCTCACTCACTGCCAA GATATCAACGAGTGCTTGACCCTGGGCCTGTGCAAGGACGCGGAGTGTGTGAATACCAGGGGCAGCTACCTGTGCACATGCAGACCTGGC CTCATGCTGGATCCATCGCGGAGCCGCTGTGTGTTGTTTCAGAGCTCTAGCCCGGGAGGAGGCGGCGGGGGCGGCGGTGGTGAAGAAGAG GACAGTCAGCAGGAATCTGAAACTCCTGACCCAAGTGGAGGCTTCCGAGGAACAATGGAAGCAGACCGAGGAATGGAAGGTTTAATCAGT CCCACAGAGGCCATGGGGAACAGTAATGGGGCCAGCAGCTCCTGTCCTGGCTGGCTTCGAAAGGAGCTGGAAAATGCAGAATTTATCCCC ATGCCTGACAGCCCATCTCCTCTCAGTGCAGCGTTTTCAGAATCTGAGAAAGATACCCTGCCCTATGAAGAGCTGCAAGGACTCAAAGTG GCCTCTGAAGCTCCTTTGGAACACAAACCCCAAGTAGAAGCCTCGTCACCTCGGCTGAATCCTGCAGTAACCTGTGCTGGGAAGGGAACA CCACTGACTCCTCCTGCGTGTGCGTGCAGCTCTCTGCAGGTGGAGGTTGAGAGATTGCAGGGTCTGGTGTTAAAGTGTCTGGCTGAACAA CAGAAGCTACAGCAAGAAAACCTCCAGATTTTTACCCAACTGCAGAAGTTGAACAAGAAATTAGAAGGAGGGCAGCAGGTGGGGATGCAT TCCAAAGGAACTCAGACAGCAAAGGAAGAGATGGAAATGGATCCAAAGCCTGACTTAGATTCAGATTCCTGGTGCCTCCTGGGAACAGAC TCCTGTAGACCCAGCCTCTAGTCTCCTGAGCCTGTAGAGCCCCCAGGAGACTGGGACCCAAAGAACTTCACAGCACACTTACCGAATGCA GAGAGCAGCTTTCCTGGCTTTGTTCACTTGCAGAAAAGGAGCGCAAGGCAGAGGCTCTGAAGCACTTTCCTTGTACATTTGGAGAGTGGC ATTGCCTTTTAGATAGGATCTAGGAGTGATTTTATTGTTTTGGAGAATGGAAGGGCCCCCATGGCCCTGGCTTTGTCATCAGTGACTGCC ATAGCAACAGCAGCTCTGTACCTCATCTGTTGATCCCACCTTTGAAGAGGAGACACAGTGCTCACCTTAATTGCGCTGGTAGCAGCTTAT ATCCCATGTATCATTTTCACCATTGATTGGAAGCTGCCTTGGGAATTCAGTACCAGGCATTACCCCTCTGGGTGGGAGAGGGAGAAGTGT AAAGTTGGAGTGGGCTGGAATCAGGTGTGGCCCGCCCAGTGTCCTCTGCAGAGTGGTGAAGTAGTCTGGCCCTCTTGGGAGCCCTGAGTC CAGGAAAATATGTCTGATGGAGTCAATCTAGGGCTTGTTTCGAAAAAGTTCAGTTACTCTGTGCAGCTAAATGCTTTAGGAGGAAAGGTA GGCTTAGGTTGCTTTTCCTCTGAGGGTTGATTGAAATTTCTTCAGTGAGGAATAGAGAAAGGGCAGGACCCTCCTCATCACACAGCTGGT GTTTCAGGCTGTGACCAATGCAGGGTGGGATTTCCTAACTGTGGATGAGGGGATGAGGTGTCTCTGAGGGATGAGGTGTCTCAGAGAATT GAGTCCATGGGGCAGTCAGAATAGCCTTAAGAGAAAATCATGAAGGAGAAGAGGTCCTCCTTTAGCTGCCTCTACTTGGTATCTTAGAGA GGGCTTAGAGGGCTCTCAGTCTTCTGCCCATGAAAAGACTTCTTTGAGCCTCTGCCTTCATGGCTCTTAGGGTTCTGATCTTGATATCAG CAGCCCCAACCACTTTCTTTCTGAATGTCTAGTCAGTATTTTTCCCCTTTTGGTGTTTTATGAAGCCATGTGGTAACGAATGAATCTGTA TCATTTTTCCTACCTGAGTGGCCCAAAGCCAGCACCAAACCCTGGGAGTCCCTGAAGCCTAACAGAACAGGTAGAACTTGCAAAAGGAAT TTGGCTGAGAGCTCACTTCTAATCCTGTACTCACTGTGTCTTTGTAGATAGAAACAAGCTAGCTTTACCAAAGAGAAATAGTGTCATAGA AGAACAAAACTTCATATAGAAAGTTCTAGGCAAGTATTTGATGGTTTCCTTAAGGATGTGAGCTTTGTATTTCCACCTAGCCTTGTAAAA TGTTCCTGTGGTATTTTGTGTCACACATCCTACCTTTGATGAGTCTCACATCCCACCTTCCTATAAACAGCTAAATTAATTTTGTTTCAT CTTCCCCAGACCAAAATGTTTGATAATCTTATCAACATTGTGGGAGGTCTTGTGCAATGGAAATTTTGCCATTTCTCCAAAACTGGTGGC ATAAAGGCTGATGCTTGGGGAGAACCCCATTGCTCGGGACAGGCAACTCTGTTCAATGGGATCTTCTTTGGTTTGATGTTCCCATTGTTT TCTCAGTTCTGGGAAGCCTAGTACATTAGTACTAATGTAATCACTGAAACCTTTTCTTGAAATAAGGGAAGCAGCCAAACTTTGATTAAA GTTGCAAGTTCTGGGGACTTGCGGGGGTTGTCATAAACTGTAACAGTGGGTTTTGGTTCAGCATGTAAATGCAACTTTGATTTTCTTGAG GACCGATTGACCTGTCATGTCCCTGTATCCTCATGCTCATCATCTCAGCAGGCCTGAGAGGCTGGGTCAGTTTGGGTGTTCATCATGAGG ATTGCTTCTGCCATGGAGCTGATGGACATGGGCAGGTTGCTGAGAAGGTGGGGTGAAAGTGAGTGCCGGGGGTGGGTGAGTGCCCTGGTC TTGTTCATAGGGGAGCCTTTCCCTAGCAGTGGAACGCTGTGGTCATTTTCTCTAGCATATTCCCTTGGGAAGTCTAGATTTGCTATTAAT CTGGCTGAGAATCTAAGTTCTGTGCCTTAGAGACAGTTTGCACTTTCCCATATTGTGCCTGGGACAGCCATATGATTTTTTTTCCCACCA AACAAGTATGCAAACAGAAACCAGTTCAAAGGGGGATGGAGTAAAAGATGAGGCAGTAGAAATGCCTTTGAATGGTTTTCTGTAGCTAAT TCTCTTTAAATTTTGTCCTGCTTTTTTTCTTTATGCAGTGCTAGGTGTTTTAAGTTTTCTAGTAGTATTGCTTTTGAGTTACAGTATAAC CTGAGTTACTCCTCTGCTCTAACATTGTTGCAGAAGAACTAGTTTATTGTTAGCCAGGTTGCTTGAAAGGTTGAGAGTGGAGTGGTTTGG >In-frame_LTBP2_ENST00000556690_chr14_74999129_-_NEK9_ENST00000238616_chr14_75558181_-_5267nt AGGGCCCCCTAGACTCAGAGAAGCTGGCCGCCGGGCGGGGCCGGGAGAACAGCCCGCGGGCGTCCAGCGTGCCGACCACAAAGCTCTTCG CGGTGCCCGCGCGCACCACTCTCCAGCCGCCCCGCGCCATGAGGCCGCGGACCAAAGCCCGCAGCCCGGGGCGCGCCCTGCGGAACCCCT GGAGAGGCTTCCTGCCGCTCACCCTGGCTCTCTTCGTGGGCGCGGGTCATGCCCAAAGGGACCCCGTAGGGAGATACGAGCCGGCTGGTG GAGACGCGAATCGACTGCGGCGCCCTGGGGGCAGCTACCCGGCAGCGGCTGCAGCCAAGGTGTACAGTCTGTTCCGGGAGCAGGACGCGC CTGTCGCGGGCTTGCAGCCCGTGGAGCGGGCCCAGCCGGGCTGGGGGAGCCCCAGGAGGCCCACCGAGGCGGAGGCCAGGAGGCCGTCCC GCGCGCAGCAGTCGCGGCGTGTCCAGCCACCTGCGCAGACCCGGAGAAGCACTCCCCTGGGCCAGCAGCAACCAGCACCCCGGACCCGGG CCGCGCCGGCTCTCCCACGCCTGGGGACCCCACAGCGGTCTGGGGCTGCGCCCCCAACCCCGCCGCGAGGGCGGCTCACGGGGAGGAACG TCTGCGGGGGACAGTGCTGCCCAGGATGGACAACAGCAAACAGCACCAACCACTGTATCAAACCCGTTTGCGAGCCGCCGTGCCAGAACC GGGGCTCCTGCAGCCGCCCGCAGCTCTGTGTCTGCCGCTCTGGTTTCCGTGGAGCCCGCTGCGAGGAGGTCATTCCCGATGAGGAATTTG ACCCCCAGAACTCCAGGCTGGCACCTCGACGCTGGGCCGAGCGTTCACCCAACCTGCGCAGGAGCAGTGCGGCTGGAGAGGGCACCTTGG CCAGAGCACAGCCGCCAGCACCACAGTCGCCGCCCGCACCACAGTCGCCACCAGCTGGGACCCTGAGTGGCCTCAGCCAGACCCACCCTT CCCAGCAGCACGTGGGGTTGTCCCGCACTGTCCGACTTCACCCGACTGCCACGGCCAGTAGCCAGCTCTCTTCCAACGCCCTGCCCCCGG GACCAGGCCTTGAGCAGAGAGATGGCACCCAACAGGCGGTACCTCTGGAGCACCCCTCATCCCCCTGGGGGCTGAACCTCACGGAGAAAA TCAAGAAGATCAAGATCGTCTTCACTCCCACCATCTGCAAGCAGACCTGTGCCCGTGGACACTGTGCCAACAGCTGTGAGAGGGGCGACA CCACCACCCTGTACAGCCAGGGCGGCCATGGGCACGATCCCAAGTCTGGCTTCCGCATCTATTTCTGCCAGATCCCCTGCCTGAACGGAG GCCGCTGCATCGGCAGGGACGAATGCTGGTGCCCCGCCAACTCCACCGGGAAGTTCTGCCACCTGCCTATCCCGCAGCCGGACAGGGAGC CTCCAGGGAGGGGGTCCCGCCCCAGGGCCTTGCTGGAAGCCCCACTGAAGCAGTCCACTTTCACACTGCCGCTCTCCAACCAGCTGGCCT CCGTGAACCCCTCCCTGGTGAAGGTGCACATTCACCACCCACCCGAGGCCTCAGTGCAGATCCACCAGGTGGCCCAGGTGCGGGGCGGGG TGGAGGAGGCCCTAGTGGAGAACAGCGTGGAGACCAGACCCCCGCCCTGGCTGCCTGCCAGCCCTGGCCACAGCCTCTGGGACAGCAACA ACATCCCTGCTCGGTCTGGAGAGCCCCCTCGGCCACTGCCCCCAGCAGCACCCAGGCCTCGAGGACTGCTGGGCCGGTGTTACCTGAACA CTGTGAACGGACAGTGTGCCAACCCTCTGCTGGAGCTGACTACCCAGGAGGACTGCTGTGGCAGTGTGGGAGCCTTCTGGGGGGTGACTT TGTGTGCCCCATGCCCACCCAGACCAGCCTCCCCGGTGATTGAGAATGGCCAGCTGGAGTGTCCTCAGGGGTACAAGAGACTGAACCTCA CTCACTGCCAAGATATCAACGAGTGCTTGACCCTGGGCCTGTGCAAGGACGCGGAGTGTGTGAATACCAGGGGCAGCTACCTGTGCACAT GCAGACCTGGCCTCATGCTGGATCCATCGCGGAGCCGCTGTGTGTTGTTTCAGAGCTCTAGCCCGGGAGGAGGCGGCGGGGGCGGCGGTG GTGAAGAAGAGGACAGTCAGCAGGAATCTGAAACTCCTGACCCAAGTGGAGGCTTCCGAGGAACAATGGAAGCAGACCGAGGAATGGAAG GTTTAATCAGTCCCACAGAGGCCATGGGGAACAGTAATGGGGCCAGCAGCTCCTGTCCTGGCTGGCTTCGAAAGGAGCTGGAAAATGCAG AATTTATCCCCATGCCTGACAGCCCATCTCCTCTCAGTGCAGCGTTTTCAGAATCTGAGAAAGATACCCTGCCCTATGAAGAGCTGCAAG GACTCAAAGTGGCCTCTGAAGCTCCTTTGGAACACAAACCCCAAGTAGAAGCCTCGTCACCTCGGCTGAATCCTGCAGTAACCTGTGCTG GGAAGGGAACACCACTGACTCCTCCTGCGTGTGCGTGCAGCTCTCTGCAGGTGGAGGTTGAGAGATTGCAGGGTCTGGTGTTAAAGTGTC TGGCTGAACAACAGAAGCTACAGCAAGAAAACCTCCAGATTTTTACCCAACTGCAGAAGTTGAACAAGAAATTAGAAGGAGGGCAGCAGG TGGGGATGCATTCCAAAGGAACTCAGACAGCAAAGGAAGAGATGGAAATGGATCCAAAGCCTGACTTAGATTCAGATTCCTGGTGCCTCC TGGGAACAGACTCCTGTAGACCCAGCCTCTAGTCTCCTGAGCCTGTAGAGCCCCCAGGAGACTGGGACCCAAAGAACTTCACAGCACACT TACCGAATGCAGAGAGCAGCTTTCCTGGCTTTGTTCACTTGCAGAAAAGGAGCGCAAGGCAGAGGCTCTGAAGCACTTTCCTTGTACATT TGGAGAGTGGCATTGCCTTTTAGATAGGATCTAGGAGTGATTTTATTGTTTTGGAGAATGGAAGGGCCCCCATGGCCCTGGCTTTGTCAT CAGTGACTGCCATAGCAACAGCAGCTCTGTACCTCATCTGTTGATCCCACCTTTGAAGAGGAGACACAGTGCTCACCTTAATTGCGCTGG TAGCAGCTTATATCCCATGTATCATTTTCACCATTGATTGGAAGCTGCCTTGGGAATTCAGTACCAGGCATTACCCCTCTGGGTGGGAGA GGGAGAAGTGTAAAGTTGGAGTGGGCTGGAATCAGGTGTGGCCCGCCCAGTGTCCTCTGCAGAGTGGTGAAGTAGTCTGGCCCTCTTGGG AGCCCTGAGTCCAGGAAAATATGTCTGATGGAGTCAATCTAGGGCTTGTTTCGAAAAAGTTCAGTTACTCTGTGCAGCTAAATGCTTTAG GAGGAAAGGTAGGCTTAGGTTGCTTTTCCTCTGAGGGTTGATTGAAATTTCTTCAGTGAGGAATAGAGAAAGGGCAGGACCCTCCTCATC ACACAGCTGGTGTTTCAGGCTGTGACCAATGCAGGGTGGGATTTCCTAACTGTGGATGAGGGGATGAGGTGTCTCTGAGGGATGAGGTGT CTCAGAGAATTGAGTCCATGGGGCAGTCAGAATAGCCTTAAGAGAAAATCATGAAGGAGAAGAGGTCCTCCTTTAGCTGCCTCTACTTGG TATCTTAGAGAGGGCTTAGAGGGCTCTCAGTCTTCTGCCCATGAAAAGACTTCTTTGAGCCTCTGCCTTCATGGCTCTTAGGGTTCTGAT CTTGATATCAGCAGCCCCAACCACTTTCTTTCTGAATGTCTAGTCAGTATTTTTCCCCTTTTGGTGTTTTATGAAGCCATGTGGTAACGA ATGAATCTGTATCATTTTTCCTACCTGAGTGGCCCAAAGCCAGCACCAAACCCTGGGAGTCCCTGAAGCCTAACAGAACAGGTAGAACTT GCAAAAGGAATTTGGCTGAGAGCTCACTTCTAATCCTGTACTCACTGTGTCTTTGTAGATAGAAACAAGCTAGCTTTACCAAAGAGAAAT AGTGTCATAGAAGAACAAAACTTCATATAGAAAGTTCTAGGCAAGTATTTGATGGTTTCCTTAAGGATGTGAGCTTTGTATTTCCACCTA GCCTTGTAAAATGTTCCTGTGGTATTTTGTGTCACACATCCTACCTTTGATGAGTCTCACATCCCACCTTCCTATAAACAGCTAAATTAA TTTTGTTTCATCTTCCCCAGACCAAAATGTTTGATAATCTTATCAACATTGTGGGAGGTCTTGTGCAATGGAAATTTTGCCATTTCTCCA AAACTGGTGGCATAAAGGCTGATGCTTGGGGAGAACCCCATTGCTCGGGACAGGCAACTCTGTTCAATGGGATCTTCTTTGGTTTGATGT TCCCATTGTTTTCTCAGTTCTGGGAAGCCTAGTACATTAGTACTAATGTAATCACTGAAACCTTTTCTTGAAATAAGGGAAGCAGCCAAA CTTTGATTAAAGTTGCAAGTTCTGGGGACTTGCGGGGGTTGTCATAAACTGTAACAGTGGGTTTTGGTTCAGCATGTAAATGCAACTTTG ATTTTCTTGAGGACCGATTGACCTGTCATGTCCCTGTATCCTCATGCTCATCATCTCAGCAGGCCTGAGAGGCTGGGTCAGTTTGGGTGT TCATCATGAGGATTGCTTCTGCCATGGAGCTGATGGACATGGGCAGGTTGCTGAGAAGGTGGGGTGAAAGTGAGTGCCGGGGGTGGGTGA GTGCCCTGGTCTTGTTCATAGGGGAGCCTTTCCCTAGCAGTGGAACGCTGTGGTCATTTTCTCTAGCATATTCCCTTGGGAAGTCTAGAT TTGCTATTAATCTGGCTGAGAATCTAAGTTCTGTGCCTTAGAGACAGTTTGCACTTTCCCATATTGTGCCTGGGACAGCCATATGATTTT TTTTCCCACCAAACAAGTATGCAAACAGAAACCAGTTCAAAGGGGGATGGAGTAAAAGATGAGGCAGTAGAAATGCCTTTGAATGGTTTT CTGTAGCTAATTCTCTTTAAATTTTGTCCTGCTTTTTTTCTTTATGCAGTGCTAGGTGTTTTAAGTTTTCTAGTAGTATTGCTTTTGAGT TACAGTATAACCTGAGTTACTCCTCTGCTCTAACATTGTTGCAGAAGAACTAGTTTATTGTTAGCCAGGTTGCTTGAAAGGTTGAGAGTG |
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FusionGenePPI for LTBP2_NEK9 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LTBP2 | NEK9 | NEK6, GABARAPL2, SSRP1, NEK7, RAN, GABARAPL1, DYNLL1, CHEK1, NSMAF, MYC, HSP90AA1, CAP1, SPDL1, MCM5, REPIN1, MDM2, HUWE1, MAFF, NTRK1, CSN2, NEK8, BICD2, MED4, XPO1, BAG3, TUBA1C, ATOH1, RNF19B, DYNLL2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | NEK9 | chr14:74999129 | chr14:75558181 | ENST00000238616 | - | 17 | 22 | 732_891 | 744 | 980 | NEK6 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LTBP2_NEK9 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LTBP2_NEK9 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | LTBP2 | C0017601 | Glaucoma | 2 | CTD_human;HPO |
| Hgene | LTBP2 | C3553785 | WEILL-MARCHESANI SYNDROME 3 | 1 | UNIPROT |
| Tgene | NEK9 | C3280309 | ARTHROGRYPOSIS, PERTHES DISEASE, AND UPWARD GAZE PALSY | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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