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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2036

FusionGeneSummary for AP1M1_ZNF93

check button Fusion gene summary
Fusion gene informationFusion gene name: AP1M1_ZNF93
Fusion gene ID: 2036
HgeneTgene
Gene symbol

AP1M1

ZNF93

Gene ID

8907

81931

Gene nameadaptor related protein complex 1 subunit mu 1zinc finger protein 93
SynonymsAP47|CLAPM2|CLTNM|MU-1AHPF34|HTF34|TF34|ZNF505
Cytomap

19p13.11

19p12

Type of geneprotein-codingprotein-coding
DescriptionAP-1 complex subunit mu-1AP-mu chain family member mu1AHA1 47 kDa subunitadapter-related protein complex 1 subunit mu-1adaptor protein complex AP-1 mu-1 subunitadaptor protein complex AP-1 subunit mu-1adaptor related protein complex 1 mu 1 subunitczinc finger protein 93zinc finger protein 505zinc finger protein HTF34
Modification date2018051920180522
UniProtAcc

Q9BXS5

P35789

Ensembl transtripts involved in fusion geneENST00000291439, ENST00000541844, 
ENST00000590756, ENST00000429941, 
ENST00000444449, 
ENST00000592613, 
ENST00000591366, ENST00000592160, 
ENST00000343769, 
Fusion gene scores* DoF score4 X 1 X 3=123 X 2 X 3=18
# samples 43
** MAII scorelog2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: AP1M1 [Title/Abstract] AND ZNF93 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneZNF93

GO:0045892

negative regulation of transcription, DNA-templated

25274305

TgeneZNF93

GO:0070895

negative regulation of transposon integration

25274305


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-BH-A0BR-01AAP1M1chr19

16319988

+ZNF93chr19

20043991

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000291439ENST00000592613AP1M1chr19

16319988

+ZNF93chr19

20043991

+
5CDS-intronENST00000291439ENST00000591366AP1M1chr19

16319988

+ZNF93chr19

20043991

+
5CDS-intronENST00000291439ENST00000592160AP1M1chr19

16319988

+ZNF93chr19

20043991

+
5CDS-intronENST00000291439ENST00000343769AP1M1chr19

16319988

+ZNF93chr19

20043991

+
5CDS-intronENST00000541844ENST00000592613AP1M1chr19

16319988

+ZNF93chr19

20043991

+
5CDS-intronENST00000541844ENST00000591366AP1M1chr19

16319988

+ZNF93chr19

20043991

+
5CDS-intronENST00000541844ENST00000592160AP1M1chr19

16319988

+ZNF93chr19

20043991

+
5CDS-intronENST00000541844ENST00000343769AP1M1chr19

16319988

+ZNF93chr19

20043991

+
5CDS-intronENST00000590756ENST00000592613AP1M1chr19

16319988

+ZNF93chr19

20043991

+
5CDS-intronENST00000590756ENST00000591366AP1M1chr19

16319988

+ZNF93chr19

20043991

+
5CDS-intronENST00000590756ENST00000592160AP1M1chr19

16319988

+ZNF93chr19

20043991

+
5CDS-intronENST00000590756ENST00000343769AP1M1chr19

16319988

+ZNF93chr19

20043991

+
5CDS-intronENST00000429941ENST00000592613AP1M1chr19

16319988

+ZNF93chr19

20043991

+
5CDS-intronENST00000429941ENST00000591366AP1M1chr19

16319988

+ZNF93chr19

20043991

+
5CDS-intronENST00000429941ENST00000592160AP1M1chr19

16319988

+ZNF93chr19

20043991

+
5CDS-intronENST00000429941ENST00000343769AP1M1chr19

16319988

+ZNF93chr19

20043991

+
5CDS-intronENST00000444449ENST00000592613AP1M1chr19

16319988

+ZNF93chr19

20043991

+
5CDS-intronENST00000444449ENST00000591366AP1M1chr19

16319988

+ZNF93chr19

20043991

+
5CDS-intronENST00000444449ENST00000592160AP1M1chr19

16319988

+ZNF93chr19

20043991

+
5CDS-intronENST00000444449ENST00000343769AP1M1chr19

16319988

+ZNF93chr19

20043991

+

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FusionProtFeatures for AP1M1_ZNF93


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AP1M1

Q9BXS5

ZNF93

P35789

Subunit of clathrin-associated adaptor protein complex 1that plays a role in protein sorting in the trans-Golgi network(TGN) and endosomes. The AP complexes mediate the recruitment ofclathrin to membranes and the recognition of sorting signalswithin the cytosolic tails of transmembrane cargo molecules. Transcription factor specifically required to represslong interspersed nuclear element 1 (L1) retrotransposons:recognizes and binds L1 sequences and repress their expression byrecruiting a repressive complex containing TRIM28/KAP1(PubMed:25274305). Not able to repress expression of all subtypesof L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or oldersubtypes nor at the most recently evolved L1PA2 and L1Hs. 50% ofL1PA3 elements have lost the ZNF93-binding site, explaining whyZNF93 is not able to repress their expression (PubMed:25274305).{ECO:0000269|PubMed:25274305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AP1M1_ZNF93


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AP1M1_ZNF93


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AP1M1VAMP4, TIFA, FXR2, AP2B1, MTF1, RUNDC3A, DVL2, HNRNPC, LDOC1, ZBTB8A, AP1G1, SELP, KIF13A, AP1B1, TGOLN2, AP1S2, AP1S1, ALB, EGFR, HEXIM1, DCP2, GPRASP2, PHC2, ETV6, ZBTB14, DZIP3, TNIP1, IKZF1, SDCCAG3, ZBTB43, ZBTB44, HOOK2, LZTS2, PNMA5, SSX2IP, KRT40, FAM9B, CEP57L1, KRTAP10-7, KRTAP10-3, CORO7, BRCA1, MPZL2, NECAP2, SPACA1, CA14, DCPS, PRKAB1, RNASEH2A, RNASEH2B, UBA1, NTRK1, SRPK2, XPO1, NCBP1, GTSE1, SLC2A4, FBXO4, RNF19B, CPD, TLR2, DLD, UBE2AZNF93FBL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AP1M1_ZNF93


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AP1M1_ZNF93


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource