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Fusion gene ID: 20353 |
FusionGeneSummary for LTA4H_LAMA2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LTA4H_LAMA2 | Fusion gene ID: 20353 | Hgene | Tgene | Gene symbol | LTA4H | LAMA2 | Gene ID | 4048 | 3908 |
| Gene name | leukotriene A4 hydrolase | laminin subunit alpha 2 | |
| Synonyms | - | LAMM | |
| Cytomap | 12q23.1 | 6q22.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | leukotriene A-4 hydrolaseLTA-4 hydrolasetesticular secretory protein Li 27 | laminin subunit alpha-2laminin M chainlaminin, alpha 2laminin-12 subunit alphalaminin-2 subunit alphalaminin-4 subunit alphamerosin heavy chainmutant laminin subunit alpha 2 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P09960 | P24043 | |
| Ensembl transtripts involved in fusion gene | ENST00000228740, ENST00000552789, ENST00000413268, ENST00000548375, | ENST00000421865, ENST00000498257, | |
| Fusion gene scores | * DoF score | 6 X 5 X 3=90 | 10 X 9 X 6=540 |
| # samples | 6 | 9 | |
| ** MAII score | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/540*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LTA4H [Title/Abstract] AND LAMA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LTA4H | GO:0019370 | leukotriene biosynthetic process | 9774412|15078870 |
| Hgene | LTA4H | GO:0043171 | peptide catabolic process | 9774412|15078870|18804029 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-3B-A9HS-01A | LTA4H | chr12 | 96429139 | - | LAMA2 | chr6 | 129571257 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000228740 | ENST00000421865 | LTA4H | chr12 | 96429139 | - | LAMA2 | chr6 | 129571257 | + |
| 5CDS-intron | ENST00000228740 | ENST00000498257 | LTA4H | chr12 | 96429139 | - | LAMA2 | chr6 | 129571257 | + |
| intron-3CDS | ENST00000552789 | ENST00000421865 | LTA4H | chr12 | 96429139 | - | LAMA2 | chr6 | 129571257 | + |
| intron-intron | ENST00000552789 | ENST00000498257 | LTA4H | chr12 | 96429139 | - | LAMA2 | chr6 | 129571257 | + |
| intron-3CDS | ENST00000413268 | ENST00000421865 | LTA4H | chr12 | 96429139 | - | LAMA2 | chr6 | 129571257 | + |
| intron-intron | ENST00000413268 | ENST00000498257 | LTA4H | chr12 | 96429139 | - | LAMA2 | chr6 | 129571257 | + |
| intron-3CDS | ENST00000548375 | ENST00000421865 | LTA4H | chr12 | 96429139 | - | LAMA2 | chr6 | 129571257 | + |
| intron-intron | ENST00000548375 | ENST00000498257 | LTA4H | chr12 | 96429139 | - | LAMA2 | chr6 | 129571257 | + |
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FusionProtFeatures for LTA4H_LAMA2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LTA4H | LAMA2 |
| Epoxide hydrolase that catalyzes the final step in thebiosynthesis of the proinflammatory mediator leukotriene B4. Hasalso aminopeptidase activity. {ECO:0000269|PubMed:11917124,ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870,ECO:0000269|PubMed:18804029, ECO:0000269|PubMed:1897988,ECO:0000269|PubMed:1975494, ECO:0000269|PubMed:2244921}. | Binding to cells via a high affinity receptor, lamininis thought to mediate the attachment, migration and organizationof cells into tissues during embryonic development by interactingwith other extracellular matrix components. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 1630_2150 | 594 | 3123 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 1014_1059 | 594 | 3123 | Domain | Laminin EGF-like 11 |
| Tgene | >LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 1060_1105 | 594 | 3123 | Domain | Laminin EGF-like 12 |
| Tgene | >LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 1106_1165 | 594 | 3123 | Domain | Laminin EGF-like 13 |
| Tgene | >LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 1166_1175 | 594 | 3123 | Domain | Laminin EGF-like 14%3B first part |
| Tgene | >LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 1176_1379 | 594 | 3123 | Domain | Laminin IV type A 2 |
| Tgene | >LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 1380_1419 | 594 | 3123 | Domain | Laminin EGF-like 14%3B second part |
| Tgene | >LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 1420_1468 | 594 | 3123 | Domain | Laminin EGF-like 15 |
| Tgene | >LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 1469_1526 | 594 | 3123 | Domain | Laminin EGF-like 16 |
| Tgene | >LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 1527_1573 | 594 | 3123 | Domain | Laminin EGF-like 17 |
| Tgene | >LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 2145_2328 | 594 | 3123 | Domain | Laminin G-like 1 |
| Tgene | >LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 2340_2521 | 594 | 3123 | Domain | Laminin G-like 2 |
| Tgene | >LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 2526_2710 | 594 | 3123 | Domain | Laminin G-like 3 |
| Tgene | >LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 2763_2934 | 594 | 3123 | Domain | Laminin G-like 4 |
| Tgene | >LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 2939_3110 | 594 | 3123 | Domain | Laminin G-like 5 |
| Tgene | >LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 724_756 | 594 | 3123 | Domain | Laminin EGF-like 5%3B second part |
| Tgene | >LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 757_806 | 594 | 3123 | Domain | Laminin EGF-like 6 |
| Tgene | >LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 807_864 | 594 | 3123 | Domain | Laminin EGF-like 7 |
| Tgene | >LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 865_917 | 594 | 3123 | Domain | Laminin EGF-like 8 |
| Tgene | >LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 918_966 | 594 | 3123 | Domain | Laminin EGF-like 9 |
| Tgene | >LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 967_1013 | 594 | 3123 | Domain | Laminin EGF-like 10 |
| Tgene | >LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 1574_2144 | 594 | 3123 | Region | Note=Domain II and I |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >LTA4H | chr12:96429139 | chr6:129571257 | ENST00000228740 | - | 1 | 19 | 135_137 | 53 | 612 | Region | Substrate binding |
| Hgene | >LTA4H | chr12:96429139 | chr6:129571257 | ENST00000228740 | - | 1 | 19 | 267_272 | 53 | 612 | Region | Substrate binding |
| Hgene | >LTA4H | chr12:96429139 | chr6:129571257 | ENST00000228740 | - | 1 | 19 | 564_566 | 53 | 612 | Region | Substrate binding |
| Hgene | >LTA4H | chr12:96429139 | chr6:129571257 | ENST00000413268 | - | 1 | 18 | 135_137 | -49 | 489 | Region | Substrate binding |
| Hgene | >LTA4H | chr12:96429139 | chr6:129571257 | ENST00000413268 | - | 1 | 18 | 267_272 | -49 | 489 | Region | Substrate binding |
| Hgene | >LTA4H | chr12:96429139 | chr6:129571257 | ENST00000413268 | - | 1 | 18 | 564_566 | -49 | 489 | Region | Substrate binding |
| Hgene | >LTA4H | chr12:96429139 | chr6:129571257 | ENST00000552789 | - | 1 | 19 | 135_137 | -34 | 588 | Region | Substrate binding |
| Hgene | >LTA4H | chr12:96429139 | chr6:129571257 | ENST00000552789 | - | 1 | 19 | 267_272 | -34 | 588 | Region | Substrate binding |
| Hgene | >LTA4H | chr12:96429139 | chr6:129571257 | ENST00000552789 | - | 1 | 19 | 564_566 | -34 | 588 | Region | Substrate binding |
| Tgene | LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 287_343 | 594 | 3123 | Domain | Laminin EGF-like 1 |
| Tgene | LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 344_413 | 594 | 3123 | Domain | Laminin EGF-like 2 |
| Tgene | LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 35_286 | 594 | 3123 | Domain | Laminin N-terminal |
| Tgene | LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 414_468 | 594 | 3123 | Domain | Laminin EGF-like 3 |
| Tgene | LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 469_517 | 594 | 3123 | Domain | Laminin EGF-like 4 |
| Tgene | LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 518_527 | 594 | 3123 | Domain | Laminin EGF-like 5%3B first part |
| Tgene | LAMA2 | chr12:96429139 | chr6:129571257 | ENST00000421865 | + | 11 | 65 | 531_723 | 594 | 3123 | Domain | Laminin IV type A 1 |
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FusionGeneSequence for LTA4H_LAMA2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_LTA4H_ENST00000228740_chr12_96429139_-_LAMA2_ENST00000421865_chr6_129571257_+_2582aa MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLLPAVGGQLTFTISYDLEEEEEDTERVLQLMIILEGND LSISTAQDEVYLHPSEEHTNVLLLKEESFTIHGTHFPVRRKEFMTVLANLKRVLLQITYSFGMDAIFRLSSVNLESAVSYPTDGSIAAAV EVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPL NIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELC ADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQSARGCVPCNCNSFGSKSFDCEESGQCWCQPGV TGKKCDRCAHGYFNFQEGGCTACECSHLGNNCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNC HPKFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYCFGT TTQCSEAKGLIRTWVTLKAEQTILPLVDEALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIYFEA REETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEWKYYGDDPRVHRTVTREDFLDILYDIHYILIKATYGNFMRQ SRISEISMEVAEQGRGTTMTPPADLIEKCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNCQH HTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDP YGSLPVPCDPVTGFCTCRPGATGRKCDGCKHWHAREGWECVFCGDECTGLLLGDLARLEQMVMSINLTGPLPAPYKMLYGLENMTQELKH LLSPQRAPERLIQLAEGNLNTLVTEMNELLTRATKVTADGEQTGQDAERTNTRAKSLGEFIKELARDAEAVNEKAIKLNETLGTRDEAFE RNLEGLQKEIDQMIKELRRKNLETQKEIAEDELVAAEALLKKVKKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREAN RLFAVNQKNMTALEKKKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQTKLPPMSEELNDKIDDLSQEIKDRKLAEKVS QAESHAAQLNDSSAVLDGILDEAKNISFNATAAFKAYSNIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNEA KKLANDVKENEDHLNGLKTRIENADARNGDLLRTLNDTLGKLSAIPNDTAAKLQAVKDKARQANDTAKDVLAQITELHQNLDGLKKNYNK LADSVAKTNAVVKDPSKNKIIADADATVKNLEQEADRLIDKLKPIKELEDNLKKNISEIKELINQARKQANSIKVSVSSGGDCIRTYKPE IKKGSYNNIVVNVKTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRALDGP KASIVPSTHHSTSPPGYTILDVDANAMLFVGGLTGKLKKADAVRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTVSPQVEDSEGTI QFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLRDFMSVELTDGHIKVSYDLGSGMASVVSNQNHNDGKWKSFTLSRIQ KQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLKDIEISRTPYNILSSPDYVGVTKGC SLENVYTVSFPKPGFVELSPVPIDVGTEINLSFSTKNESGIILLGSGGTPAPPRRKRRQTGQAYYAILLNRGRLEVHLSTGARTMRKIVI RPEPNLFHDGREHSVHVERTRGIFTVQVDENRRYMQNLTVEQPIEVKKLFVGGAPPEFQPSPLRNIPPFEGCIWNLVINSVPMDFARPVS FKNADIGRCAHQKLREDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALLIGSKQFGLSRNSHIAIAFDDTKVKNRLTIEL EVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRTISPKKADILDV VGMLYVGGLPINYTTRRIGPVTYSIDGCVRNLHMAEAPADLEQPTSSFHVGTCFANAQRGTYFDGTGFAKAVGGFKVGLDLLVEFEFRTT TTTGVLLGISSQKMDGMGIEMIDEKLMFHVDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_LTA4H_ENST00000228740_chr12_96429139_-_LAMA2_ENST00000421865_chr6_129571257_+_7746nt ATGCCCGAGATAGTGGATACCTGTTCGTTGGCCTCTCCGGCTTCCGTCTGCCGGACCAAGCACCTGCACCTGCGCTGCAGCGTCGACTTT ACTCGCCGGACGCTGACCGGGACTGCTGCTCTCACGGTCCAGTCTCAGGAGGACAATCTGCGCAGCCTGCTCCCAGCAGTAGGAGGACAG TTGACATTTACCATATCATATGACCTTGAAGAAGAGGAAGAAGATACAGAACGTGTTCTCCAGCTTATGATTATCTTAGAGGGTAATGAC TTGAGCATCAGCACAGCCCAAGATGAGGTGTACCTGCACCCATCTGAAGAACATACTAATGTATTGTTACTTAAAGAAGAATCATTTACC ATACATGGCACACATTTTCCAGTCCGTAGAAAGGAATTTATGACAGTGCTTGCGAATTTGAAGAGAGTCCTCCTACAAATCACATACAGC TTTGGGATGGATGCCATCTTCAGGTTGAGCTCTGTTAACCTTGAATCCGCTGTCTCCTATCCTACTGATGGAAGCATTGCAGCAGCTGTA GAAGTGTGTCAGTGCCCACCAGGGTATACTGGCTCCTCTTGTGAATCTTGTTGGCCTAGGCACAGGCGAGTTAACGGCACTATTTTTGGT GGCATCTGTGAGCCATGTCAGTGCTTTGGTCATGCGGAGTCCTGTGATGACGTCACTGGAGAATGCCTGAACTGTAAGGATCACACAGGT GGCCCATATTGTGATAAATGTCTTCCTGGTTTCTATGGCGAGCCTACTAAAGGAACCTCTGAAGACTGTCAACCCTGTGCCTGTCCACTC AATATCCCATCCAATAACTTTAGCCCAACGTGCCATTTAGACCGGAGTCTTGGATTGATCTGTGATGGATGCCCTGTCGGGTACACAGGA CCACGCTGTGAGAGGTGTGCAGAAGGCTATTTTGGACAACCCTCTGTACCTGGAGGATCATGTCAGCCATGCCAATGCAATGACAACCTT GACTTCTCCATCCCTGGCAGCTGTGACAGCTTGTCTGGCTCCTGTCTGATATGTAAACCAGGTACAACAGGCCGGTACTGTGAGCTCTGT GCTGATGGATATTTTGGAGATGCAGTTGATGCGAAGAACTGTCAGCCCTGTCGCTGTAATGCCGGTGGCTCTTTCTCTGAGGTTTGCCAC AGTCAAACTGGACAGTGTGAGTGCAGAGCCAACGTTCAGGGTCAGAGATGTGACAAATGCAAGGCTGGGACCTTTGGCCTACAATCAGCA AGGGGCTGTGTTCCCTGCAACTGCAATTCTTTTGGGTCTAAGTCATTCGACTGTGAAGAGAGTGGACAATGTTGGTGCCAACCTGGAGTC ACAGGGAAGAAATGTGACCGCTGTGCCCACGGCTATTTCAACTTCCAAGAAGGAGGCTGCACAGCTTGTGAATGTTCTCATCTGGGTAAT AATTGTGACCCAAAGACTGGGCGATGCATTTGCCCTCCCAATACCATTGGAGAGAAATGTTCTAAATGTGCACCCAATACCTGGGGCCAC AGCATTACCACTGGTTGTAAGGCTTGTAACTGCAGCACAGTGGGATCCTTGGATTTCCAATGCAATGTAAATACAGGCCAATGCAACTGT CATCCAAAATTCTCTGGTGCAAAATGTACAGAGTGCAGTCGAGGTCACTGGAACTACCCTCGCTGCAATCTCTGTGACTGCTTCCTCCCT GGGACAGATGCCACAACCTGTGATTCAGAGACTAAAAAATGCTCCTGTAGTGATCAAACTGGGCAGTGCACTTGTAAGGTGAATGTGGAA GGCATCCACTGTGACAGATGCCGGCCTGGCAAATTCGGACTCGATGCCAAGAATCCACTTGGCTGCAGCAGCTGCTATTGCTTCGGCACT ACTACCCAGTGCTCTGAAGCAAAAGGACTGATCCGGACGTGGGTGACTCTGAAGGCTGAGCAGACCATTCTACCCCTGGTAGATGAGGCT CTGCAGCACACGACCACCAAGGGCATTGTTTTTCAACATCCAGAGATTGTTGCCCACATGGACCTGATGAGAGAAGATCTCCATTTGGAA CCTTTTTATTGGAAACTTCCAGAACAATTTGAAGGAAAGAAGTTGATGGCCTATGGGGGCAAACTCAAGTATGCAATCTATTTCGAGGCT CGGGAAGAAACAGGTTTCTCTACATATAATCCTCAAGTGATCATTCGAGGTGGGACACCTACTCATGCTAGAATTATCGTCAGGCATATG GCTGCTCCTCTGATTGGCCAATTGACAAGGCATGAAATTGAAATGACAGAGAAAGAATGGAAATATTATGGGGATGATCCTCGAGTCCAT AGAACTGTGACCCGAGAAGACTTCTTGGATATACTATATGATATTCATTACATTCTTATCAAAGCTACTTATGGAAATTTCATGCGACAA AGCAGGATTTCTGAAATCTCAATGGAGGTAGCTGAACAAGGACGTGGAACAACAATGACTCCTCCAGCTGACTTGATTGAAAAATGTGAT TGTCCCCTGGGCTATTCTGGCCTGTCCTGTGAGGCATGCTTGCCGGGATTTTATCGACTGCGTTCTCAACCAGGTGGCCGCACCCCTGGA CCAACCCTGGGCACCTGTGTTCCATGTCAATGTAATGGACACAGCAGCCTGTGTGACCCTGAAACATCGATATGCCAGAATTGTCAACAT CACACTGCTGGTGACTTCTGTGAACGATGTGCTCTTGGATACTATGGAATTGTCAAGGGATTGCCAAATGACTGTCAGCAATGTGCCTGC CCTCTGATTTCTTCCAGTAACAATTTCAGCCCCTCTTGTGTCGCAGAAGGACTTGACGACTACCGCTGCACGGCTTGTCCACGGGGATAT GAAGGCCAGTACTGTGAAAGGTGTGCCCCTGGCTATACTGGCAGTCCAGGCAACCCTGGAGGCTCCTGCCAAGAATGTGAGTGTGATCCC TATGGCTCACTGCCTGTGCCCTGTGACCCTGTCACAGGATTCTGCACGTGCCGACCTGGAGCCACGGGAAGGAAGTGTGACGGCTGCAAG CACTGGCATGCACGCGAGGGCTGGGAGTGTGTTTTTTGTGGAGATGAGTGCACTGGCCTTCTTCTCGGTGACTTGGCTCGCCTGGAGCAG ATGGTCATGAGCATCAACCTCACTGGTCCGCTGCCTGCGCCATATAAAATGCTGTATGGTCTTGAAAATATGACTCAGGAGCTAAAGCAC TTGCTGTCACCTCAGCGGGCCCCAGAGAGGCTTATTCAGCTGGCAGAGGGCAATCTGAATACACTCGTGACCGAAATGAACGAGCTGCTG ACCAGGGCTACCAAAGTGACAGCAGATGGCGAGCAGACCGGACAGGATGCTGAGAGGACCAACACAAGAGCAAAGTCCCTGGGAGAATTC ATTAAGGAGCTTGCCCGGGATGCAGAAGCTGTAAATGAAAAAGCTATAAAACTAAATGAAACTCTAGGAACTCGAGACGAGGCCTTTGAG AGAAATTTGGAAGGGCTTCAGAAAGAGATTGACCAGATGATTAAAGAACTGAGGAGGAAAAATCTAGAGACACAAAAGGAAATTGCTGAA GATGAGTTGGTAGCTGCAGAAGCCCTTCTGAAAAAAGTGAAGAAGCTGTTTGGAGAGTCCCGGGGGGAAAATGAAGAAATGGAGAAGGAT CTCCGGGAAAAACTGGCTGACTACAAAAACAAAGTTGATGATGCTTGGGACCTTTTGAGAGAAGCCACAGATAAAATCAGAGAAGCTAAT CGCCTATTTGCAGTAAATCAGAAAAACATGACTGCATTGGAGAAAAAGAAGGAGGCTGTTGAAAGCGGCAAACGACAAATTGAGAACACT TTAAAAGAGGGCAATGACATACTCGATGAAGCCAACCGTCTTGCAGATGAAATCAACTCCATCATAGACTATGTTGAAGACATCCAAACT AAATTGCCACCTATGTCTGAGGAGCTTAATGATAAAATAGATGACCTCTCCCAAGAAATAAAGGACAGGAAGCTTGCTGAGAAGGTGTCC CAGGCTGAGAGCCACGCAGCTCAGTTGAATGACTCATCTGCTGTCCTTGATGGAATCCTTGATGAGGCTAAAAACATCTCCTTCAATGCC ACTGCAGCCTTCAAAGCTTACAGCAATATTAAGGACTATATTGATGAAGCTGAGAAAGTTGCCAAAGAAGCCAAAGATCTTGCACATGAA GCTACAAAACTGGCAACAGGTCCTCGGGGTTTATTAAAGGAAGATGCCAAAGGCTGTCTTCAGAAAAGCTTCAGGATTCTTAACGAAGCC AAGAAGTTAGCAAATGATGTAAAAGAAAATGAAGACCATCTAAATGGCTTAAAAACCAGGATAGAAAATGCTGATGCTAGAAATGGGGAT CTCTTGAGAACTTTGAATGACACTTTGGGAAAGTTATCAGCTATTCCAAATGATACAGCTGCTAAACTGCAAGCTGTTAAGGACAAAGCC AGACAAGCCAACGACACAGCTAAAGATGTACTGGCACAGATTACAGAGCTCCACCAGAACCTCGATGGCCTGAAGAAGAATTACAATAAA CTAGCAGACAGCGTCGCCAAAACGAATGCTGTGGTTAAAGATCCTTCCAAGAACAAAATCATTGCCGATGCAGATGCCACTGTCAAAAAT TTAGAACAGGAAGCTGACCGGCTAATAGATAAACTCAAACCCATCAAGGAACTTGAGGATAACCTAAAGAAAAACATCTCTGAGATAAAG GAATTGATAAACCAAGCTCGGAAACAAGCCAATTCTATCAAAGTATCTGTGTCTTCAGGAGGTGACTGCATTCGAACATACAAACCAGAA ATCAAGAAAGGAAGTTACAATAATATTGTTGTCAACGTAAAGACAGCTGTTGCTGATAACCTCCTCTTTTATCTTGGAAGTGCCAAATTT ATTGACTTTCTGGCTATAGAAATGCGTAAAGGCAAAGTCAGCTTCCTCTGGGATGTTGGATCTGGAGTTGGACGTGTAGAGTACCCAGAT TTGACTATTGATGACTCATATTGGTACCGTATCGTAGCATCAAGAACTGGGAGAAATGGAACTATTTCTGTGAGAGCCCTGGATGGACCC AAAGCCAGCATTGTGCCCAGCACACACCATTCGACGTCTCCTCCAGGGTACACGATTCTAGATGTGGATGCAAATGCAATGCTGTTTGTT GGTGGCCTGACTGGGAAATTAAAGAAGGCTGATGCTGTACGTGTGATTACATTCACTGGCTGCATGGGAGAAACATACTTTGACAACAAA CCTATAGGTTTGTGGAATTTCCGAGAAAAAGAAGGTGACTGCAAAGGATGCACTGTCAGTCCTCAGGTGGAAGATAGTGAGGGGACTATT CAATTTGATGGAGAAGGTTATGCATTGGTCAGCCGTCCCATTCGCTGGTACCCCAACATCTCCACTGTCATGTTCAAGTTCAGAACATTT TCTTCGAGTGCTCTTCTGATGTATCTTGCCACACGAGACCTGAGAGATTTCATGAGTGTGGAGCTCACTGATGGGCACATAAAAGTCAGT TACGATCTGGGCTCAGGAATGGCTTCCGTTGTCAGCAATCAAAACCATAATGATGGGAAATGGAAATCATTCACTCTGTCAAGAATTCAA AAACAAGCCAATATATCAATTGTAGATATAGATACTAATCAGGAGGAGAATATAGCAACTTCGTCTTCTGGAAACAACTTTGGTCTTGAC TTGAAAGCAGATGACAAAATATATTTTGGTGGCCTGCCAACGCTGAGAAACTTGAGTATGAAAGCAAGGCCAGAAGTAAATCTGAAGAAA TATTCCGGCTGCCTCAAAGATATTGAAATTTCAAGAACTCCGTACAATATACTCAGTAGTCCCGATTATGTTGGTGTTACCAAAGGATGT TCCCTGGAGAATGTTTACACAGTTAGCTTTCCTAAGCCTGGTTTTGTGGAGCTCTCCCCTGTGCCAATTGATGTAGGAACAGAAATCAAC CTGTCATTCAGCACCAAGAATGAGTCCGGCATCATTCTTTTGGGAAGTGGAGGGACACCAGCACCACCTAGGAGAAAACGAAGGCAGACT GGACAGGCCTATTATGCAATACTCCTCAACAGGGGCCGTCTGGAAGTGCATCTCTCCACAGGGGCACGAACAATGAGGAAAATTGTGATC AGACCAGAGCCGAATCTGTTTCATGATGGAAGAGAACATTCCGTTCATGTAGAGCGAACTAGAGGCATCTTTACAGTTCAAGTGGATGAA AACAGAAGATACATGCAAAACCTGACAGTTGAACAGCCTATCGAAGTTAAAAAGCTTTTCGTTGGGGGTGCTCCACCTGAATTTCAACCT TCCCCACTCAGAAATATTCCTCCTTTTGAAGGCTGCATATGGAATCTTGTTATTAACTCTGTCCCCATGGACTTTGCAAGGCCTGTGTCC TTCAAAAATGCTGACATTGGTCGCTGTGCCCATCAGAAACTCCGTGAAGATGAAGATGGAGCAGCTCCAGCTGAAATAGTTATCCAGCCT GAGCCAGTTCCCACCCCAGCCTTTCCTACGCCCACCCCAGTTCTGACACATGGTCCTTGTGCTGCAGAATCAGAACCAGCTCTTTTGATA GGGAGCAAGCAGTTCGGGCTTTCAAGAAACAGTCACATTGCAATTGCATTTGATGACACCAAAGTTAAAAACCGTCTCACAATTGAGTTG GAAGTAAGAACCGAAGCTGAATCCGGCTTGCTTTTTTACATGGCTCGCATCAATCATGCTGATTTTGCAACAGTTCAGCTGAGAAATGGA TTGCCCTACTTCAGCTATGACTTGGGGAGTGGGGACACCCACACCATGATCCCCACCAAAATCAATGATGGCCAGTGGCACAAGATTAAG ATAATGAGAAGTAAGCAAGAAGGAATTCTTTATGTAGATGGGGCTTCCAACAGAACCATCAGTCCCAAAAAAGCCGACATCCTGGATGTC GTGGGAATGCTGTATGTTGGTGGGTTACCCATCAACTACACTACCCGAAGAATTGGTCCAGTGACCTATAGCATTGATGGCTGCGTCAGG AATCTCCACATGGCAGAGGCCCCTGCCGATCTGGAACAACCCACCTCCAGCTTCCATGTTGGGACATGTTTTGCAAATGCTCAGAGGGGA ACATATTTTGACGGAACCGGTTTTGCCAAAGCAGTTGGTGGATTCAAAGTGGGATTGGACCTTCTTGTAGAATTTGAATTCCGCACAACT ACAACGACTGGAGTTCTTCTGGGGATCAGTAGTCAAAAAATGGATGGAATGGGTATTGAAATGATTGATGAAAAGTTGATGTTTCATGTG GACAATGGTGCGGGCAGATTCACTGCTGTCTATGATGCTGGGGTTCCAGGGCATTTGTGTGATGGACAATGGCATAAAGTCACTGCCAAC AAGATCAAACACCGCATTGAGCTCACAGTCGATGGGAACCAGGTGGAAGCCCAAAGCCCAAACCCAGCATCTACATCAGCTGACACAAAT GACCCTGTGTTTGTTGGAGGCTTCCCAGATGACCTCAAGCAGTTTGGCCTAACAACCAGTATTCCGTTCCGAGGTTGCATCAGATCCCTG AAGCTCACCAAAGGCACAGGCAAGCCACTGGAGGTTAATTTTGCCAAGGCCCTGGAACTGAGGGGCGTTCAACCTGTATCATGCCCAGCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_LTA4H_ENST00000228740_chr12_96429139_-_LAMA2_ENST00000421865_chr6_129571257_+_8110nt AAGAAACTTCCTTTCCCGGCGTGCACCGCGAATCCCTCCTCCTCTTCTTTACCTCTCTCCCTCCTCCTCAGGTTCTCTATCGACGAGTCT GGTAGCTGAGCGTTGGGCTGTAGGTCGCTGTGCTGTGTGATCCCCCAGAGCCATGCCCGAGATAGTGGATACCTGTTCGTTGGCCTCTCC GGCTTCCGTCTGCCGGACCAAGCACCTGCACCTGCGCTGCAGCGTCGACTTTACTCGCCGGACGCTGACCGGGACTGCTGCTCTCACGGT CCAGTCTCAGGAGGACAATCTGCGCAGCCTGCTCCCAGCAGTAGGAGGACAGTTGACATTTACCATATCATATGACCTTGAAGAAGAGGA AGAAGATACAGAACGTGTTCTCCAGCTTATGATTATCTTAGAGGGTAATGACTTGAGCATCAGCACAGCCCAAGATGAGGTGTACCTGCA CCCATCTGAAGAACATACTAATGTATTGTTACTTAAAGAAGAATCATTTACCATACATGGCACACATTTTCCAGTCCGTAGAAAGGAATT TATGACAGTGCTTGCGAATTTGAAGAGAGTCCTCCTACAAATCACATACAGCTTTGGGATGGATGCCATCTTCAGGTTGAGCTCTGTTAA CCTTGAATCCGCTGTCTCCTATCCTACTGATGGAAGCATTGCAGCAGCTGTAGAAGTGTGTCAGTGCCCACCAGGGTATACTGGCTCCTC TTGTGAATCTTGTTGGCCTAGGCACAGGCGAGTTAACGGCACTATTTTTGGTGGCATCTGTGAGCCATGTCAGTGCTTTGGTCATGCGGA GTCCTGTGATGACGTCACTGGAGAATGCCTGAACTGTAAGGATCACACAGGTGGCCCATATTGTGATAAATGTCTTCCTGGTTTCTATGG CGAGCCTACTAAAGGAACCTCTGAAGACTGTCAACCCTGTGCCTGTCCACTCAATATCCCATCCAATAACTTTAGCCCAACGTGCCATTT AGACCGGAGTCTTGGATTGATCTGTGATGGATGCCCTGTCGGGTACACAGGACCACGCTGTGAGAGGTGTGCAGAAGGCTATTTTGGACA ACCCTCTGTACCTGGAGGATCATGTCAGCCATGCCAATGCAATGACAACCTTGACTTCTCCATCCCTGGCAGCTGTGACAGCTTGTCTGG CTCCTGTCTGATATGTAAACCAGGTACAACAGGCCGGTACTGTGAGCTCTGTGCTGATGGATATTTTGGAGATGCAGTTGATGCGAAGAA CTGTCAGCCCTGTCGCTGTAATGCCGGTGGCTCTTTCTCTGAGGTTTGCCACAGTCAAACTGGACAGTGTGAGTGCAGAGCCAACGTTCA GGGTCAGAGATGTGACAAATGCAAGGCTGGGACCTTTGGCCTACAATCAGCAAGGGGCTGTGTTCCCTGCAACTGCAATTCTTTTGGGTC TAAGTCATTCGACTGTGAAGAGAGTGGACAATGTTGGTGCCAACCTGGAGTCACAGGGAAGAAATGTGACCGCTGTGCCCACGGCTATTT CAACTTCCAAGAAGGAGGCTGCACAGCTTGTGAATGTTCTCATCTGGGTAATAATTGTGACCCAAAGACTGGGCGATGCATTTGCCCTCC CAATACCATTGGAGAGAAATGTTCTAAATGTGCACCCAATACCTGGGGCCACAGCATTACCACTGGTTGTAAGGCTTGTAACTGCAGCAC AGTGGGATCCTTGGATTTCCAATGCAATGTAAATACAGGCCAATGCAACTGTCATCCAAAATTCTCTGGTGCAAAATGTACAGAGTGCAG TCGAGGTCACTGGAACTACCCTCGCTGCAATCTCTGTGACTGCTTCCTCCCTGGGACAGATGCCACAACCTGTGATTCAGAGACTAAAAA ATGCTCCTGTAGTGATCAAACTGGGCAGTGCACTTGTAAGGTGAATGTGGAAGGCATCCACTGTGACAGATGCCGGCCTGGCAAATTCGG ACTCGATGCCAAGAATCCACTTGGCTGCAGCAGCTGCTATTGCTTCGGCACTACTACCCAGTGCTCTGAAGCAAAAGGACTGATCCGGAC GTGGGTGACTCTGAAGGCTGAGCAGACCATTCTACCCCTGGTAGATGAGGCTCTGCAGCACACGACCACCAAGGGCATTGTTTTTCAACA TCCAGAGATTGTTGCCCACATGGACCTGATGAGAGAAGATCTCCATTTGGAACCTTTTTATTGGAAACTTCCAGAACAATTTGAAGGAAA GAAGTTGATGGCCTATGGGGGCAAACTCAAGTATGCAATCTATTTCGAGGCTCGGGAAGAAACAGGTTTCTCTACATATAATCCTCAAGT GATCATTCGAGGTGGGACACCTACTCATGCTAGAATTATCGTCAGGCATATGGCTGCTCCTCTGATTGGCCAATTGACAAGGCATGAAAT TGAAATGACAGAGAAAGAATGGAAATATTATGGGGATGATCCTCGAGTCCATAGAACTGTGACCCGAGAAGACTTCTTGGATATACTATA TGATATTCATTACATTCTTATCAAAGCTACTTATGGAAATTTCATGCGACAAAGCAGGATTTCTGAAATCTCAATGGAGGTAGCTGAACA AGGACGTGGAACAACAATGACTCCTCCAGCTGACTTGATTGAAAAATGTGATTGTCCCCTGGGCTATTCTGGCCTGTCCTGTGAGGCATG CTTGCCGGGATTTTATCGACTGCGTTCTCAACCAGGTGGCCGCACCCCTGGACCAACCCTGGGCACCTGTGTTCCATGTCAATGTAATGG ACACAGCAGCCTGTGTGACCCTGAAACATCGATATGCCAGAATTGTCAACATCACACTGCTGGTGACTTCTGTGAACGATGTGCTCTTGG ATACTATGGAATTGTCAAGGGATTGCCAAATGACTGTCAGCAATGTGCCTGCCCTCTGATTTCTTCCAGTAACAATTTCAGCCCCTCTTG TGTCGCAGAAGGACTTGACGACTACCGCTGCACGGCTTGTCCACGGGGATATGAAGGCCAGTACTGTGAAAGGTGTGCCCCTGGCTATAC TGGCAGTCCAGGCAACCCTGGAGGCTCCTGCCAAGAATGTGAGTGTGATCCCTATGGCTCACTGCCTGTGCCCTGTGACCCTGTCACAGG ATTCTGCACGTGCCGACCTGGAGCCACGGGAAGGAAGTGTGACGGCTGCAAGCACTGGCATGCACGCGAGGGCTGGGAGTGTGTTTTTTG TGGAGATGAGTGCACTGGCCTTCTTCTCGGTGACTTGGCTCGCCTGGAGCAGATGGTCATGAGCATCAACCTCACTGGTCCGCTGCCTGC GCCATATAAAATGCTGTATGGTCTTGAAAATATGACTCAGGAGCTAAAGCACTTGCTGTCACCTCAGCGGGCCCCAGAGAGGCTTATTCA GCTGGCAGAGGGCAATCTGAATACACTCGTGACCGAAATGAACGAGCTGCTGACCAGGGCTACCAAAGTGACAGCAGATGGCGAGCAGAC CGGACAGGATGCTGAGAGGACCAACACAAGAGCAAAGTCCCTGGGAGAATTCATTAAGGAGCTTGCCCGGGATGCAGAAGCTGTAAATGA AAAAGCTATAAAACTAAATGAAACTCTAGGAACTCGAGACGAGGCCTTTGAGAGAAATTTGGAAGGGCTTCAGAAAGAGATTGACCAGAT GATTAAAGAACTGAGGAGGAAAAATCTAGAGACACAAAAGGAAATTGCTGAAGATGAGTTGGTAGCTGCAGAAGCCCTTCTGAAAAAAGT GAAGAAGCTGTTTGGAGAGTCCCGGGGGGAAAATGAAGAAATGGAGAAGGATCTCCGGGAAAAACTGGCTGACTACAAAAACAAAGTTGA TGATGCTTGGGACCTTTTGAGAGAAGCCACAGATAAAATCAGAGAAGCTAATCGCCTATTTGCAGTAAATCAGAAAAACATGACTGCATT GGAGAAAAAGAAGGAGGCTGTTGAAAGCGGCAAACGACAAATTGAGAACACTTTAAAAGAGGGCAATGACATACTCGATGAAGCCAACCG TCTTGCAGATGAAATCAACTCCATCATAGACTATGTTGAAGACATCCAAACTAAATTGCCACCTATGTCTGAGGAGCTTAATGATAAAAT AGATGACCTCTCCCAAGAAATAAAGGACAGGAAGCTTGCTGAGAAGGTGTCCCAGGCTGAGAGCCACGCAGCTCAGTTGAATGACTCATC TGCTGTCCTTGATGGAATCCTTGATGAGGCTAAAAACATCTCCTTCAATGCCACTGCAGCCTTCAAAGCTTACAGCAATATTAAGGACTA TATTGATGAAGCTGAGAAAGTTGCCAAAGAAGCCAAAGATCTTGCACATGAAGCTACAAAACTGGCAACAGGTCCTCGGGGTTTATTAAA GGAAGATGCCAAAGGCTGTCTTCAGAAAAGCTTCAGGATTCTTAACGAAGCCAAGAAGTTAGCAAATGATGTAAAAGAAAATGAAGACCA TCTAAATGGCTTAAAAACCAGGATAGAAAATGCTGATGCTAGAAATGGGGATCTCTTGAGAACTTTGAATGACACTTTGGGAAAGTTATC AGCTATTCCAAATGATACAGCTGCTAAACTGCAAGCTGTTAAGGACAAAGCCAGACAAGCCAACGACACAGCTAAAGATGTACTGGCACA GATTACAGAGCTCCACCAGAACCTCGATGGCCTGAAGAAGAATTACAATAAACTAGCAGACAGCGTCGCCAAAACGAATGCTGTGGTTAA AGATCCTTCCAAGAACAAAATCATTGCCGATGCAGATGCCACTGTCAAAAATTTAGAACAGGAAGCTGACCGGCTAATAGATAAACTCAA ACCCATCAAGGAACTTGAGGATAACCTAAAGAAAAACATCTCTGAGATAAAGGAATTGATAAACCAAGCTCGGAAACAAGCCAATTCTAT CAAAGTATCTGTGTCTTCAGGAGGTGACTGCATTCGAACATACAAACCAGAAATCAAGAAAGGAAGTTACAATAATATTGTTGTCAACGT AAAGACAGCTGTTGCTGATAACCTCCTCTTTTATCTTGGAAGTGCCAAATTTATTGACTTTCTGGCTATAGAAATGCGTAAAGGCAAAGT CAGCTTCCTCTGGGATGTTGGATCTGGAGTTGGACGTGTAGAGTACCCAGATTTGACTATTGATGACTCATATTGGTACCGTATCGTAGC ATCAAGAACTGGGAGAAATGGAACTATTTCTGTGAGAGCCCTGGATGGACCCAAAGCCAGCATTGTGCCCAGCACACACCATTCGACGTC TCCTCCAGGGTACACGATTCTAGATGTGGATGCAAATGCAATGCTGTTTGTTGGTGGCCTGACTGGGAAATTAAAGAAGGCTGATGCTGT ACGTGTGATTACATTCACTGGCTGCATGGGAGAAACATACTTTGACAACAAACCTATAGGTTTGTGGAATTTCCGAGAAAAAGAAGGTGA CTGCAAAGGATGCACTGTCAGTCCTCAGGTGGAAGATAGTGAGGGGACTATTCAATTTGATGGAGAAGGTTATGCATTGGTCAGCCGTCC CATTCGCTGGTACCCCAACATCTCCACTGTCATGTTCAAGTTCAGAACATTTTCTTCGAGTGCTCTTCTGATGTATCTTGCCACACGAGA CCTGAGAGATTTCATGAGTGTGGAGCTCACTGATGGGCACATAAAAGTCAGTTACGATCTGGGCTCAGGAATGGCTTCCGTTGTCAGCAA TCAAAACCATAATGATGGGAAATGGAAATCATTCACTCTGTCAAGAATTCAAAAACAAGCCAATATATCAATTGTAGATATAGATACTAA TCAGGAGGAGAATATAGCAACTTCGTCTTCTGGAAACAACTTTGGTCTTGACTTGAAAGCAGATGACAAAATATATTTTGGTGGCCTGCC AACGCTGAGAAACTTGAGTATGAAAGCAAGGCCAGAAGTAAATCTGAAGAAATATTCCGGCTGCCTCAAAGATATTGAAATTTCAAGAAC TCCGTACAATATACTCAGTAGTCCCGATTATGTTGGTGTTACCAAAGGATGTTCCCTGGAGAATGTTTACACAGTTAGCTTTCCTAAGCC TGGTTTTGTGGAGCTCTCCCCTGTGCCAATTGATGTAGGAACAGAAATCAACCTGTCATTCAGCACCAAGAATGAGTCCGGCATCATTCT TTTGGGAAGTGGAGGGACACCAGCACCACCTAGGAGAAAACGAAGGCAGACTGGACAGGCCTATTATGCAATACTCCTCAACAGGGGCCG TCTGGAAGTGCATCTCTCCACAGGGGCACGAACAATGAGGAAAATTGTGATCAGACCAGAGCCGAATCTGTTTCATGATGGAAGAGAACA TTCCGTTCATGTAGAGCGAACTAGAGGCATCTTTACAGTTCAAGTGGATGAAAACAGAAGATACATGCAAAACCTGACAGTTGAACAGCC TATCGAAGTTAAAAAGCTTTTCGTTGGGGGTGCTCCACCTGAATTTCAACCTTCCCCACTCAGAAATATTCCTCCTTTTGAAGGCTGCAT ATGGAATCTTGTTATTAACTCTGTCCCCATGGACTTTGCAAGGCCTGTGTCCTTCAAAAATGCTGACATTGGTCGCTGTGCCCATCAGAA ACTCCGTGAAGATGAAGATGGAGCAGCTCCAGCTGAAATAGTTATCCAGCCTGAGCCAGTTCCCACCCCAGCCTTTCCTACGCCCACCCC AGTTCTGACACATGGTCCTTGTGCTGCAGAATCAGAACCAGCTCTTTTGATAGGGAGCAAGCAGTTCGGGCTTTCAAGAAACAGTCACAT TGCAATTGCATTTGATGACACCAAAGTTAAAAACCGTCTCACAATTGAGTTGGAAGTAAGAACCGAAGCTGAATCCGGCTTGCTTTTTTA CATGGCTCGCATCAATCATGCTGATTTTGCAACAGTTCAGCTGAGAAATGGATTGCCCTACTTCAGCTATGACTTGGGGAGTGGGGACAC CCACACCATGATCCCCACCAAAATCAATGATGGCCAGTGGCACAAGATTAAGATAATGAGAAGTAAGCAAGAAGGAATTCTTTATGTAGA TGGGGCTTCCAACAGAACCATCAGTCCCAAAAAAGCCGACATCCTGGATGTCGTGGGAATGCTGTATGTTGGTGGGTTACCCATCAACTA CACTACCCGAAGAATTGGTCCAGTGACCTATAGCATTGATGGCTGCGTCAGGAATCTCCACATGGCAGAGGCCCCTGCCGATCTGGAACA ACCCACCTCCAGCTTCCATGTTGGGACATGTTTTGCAAATGCTCAGAGGGGAACATATTTTGACGGAACCGGTTTTGCCAAAGCAGTTGG TGGATTCAAAGTGGGATTGGACCTTCTTGTAGAATTTGAATTCCGCACAACTACAACGACTGGAGTTCTTCTGGGGATCAGTAGTCAAAA AATGGATGGAATGGGTATTGAAATGATTGATGAAAAGTTGATGTTTCATGTGGACAATGGTGCGGGCAGATTCACTGCTGTCTATGATGC TGGGGTTCCAGGGCATTTGTGTGATGGACAATGGCATAAAGTCACTGCCAACAAGATCAAACACCGCATTGAGCTCACAGTCGATGGGAA CCAGGTGGAAGCCCAAAGCCCAAACCCAGCATCTACATCAGCTGACACAAATGACCCTGTGTTTGTTGGAGGCTTCCCAGATGACCTCAA GCAGTTTGGCCTAACAACCAGTATTCCGTTCCGAGGTTGCATCAGATCCCTGAAGCTCACCAAAGGCACAGGCAAGCCACTGGAGGTTAA TTTTGCCAAGGCCCTGGAACTGAGGGGCGTTCAACCTGTATCATGCCCAGCCAACTAATAAAAATAAGTGTAACCCCAGGAAGAGTCTGT CAAAACAAGTATATCAAGTAAAACAAACAAATATATTTTACCTATATATGTTAATTAAACTAATTTGTGCATGTACATAGAATTCTTTCT GTATTCAGATGGTGCTAATTCAGACTCCAGACTGAATTTTAATTCAAGTTCTTTCTCAAGTCTATAAATAATATTAAACTGATTATTTCA |
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FusionGenePPI for LTA4H_LAMA2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LTA4H | GH1, MCC, TMEM62, DDA1, UBA5, HDAC5, ELAVL1, SIRT7, TINF2, SIRT1, ZNF593, ALDOA, FKBP2, GALK2, IDH1, PGM1, PRPF4, SPR, TRAP1, NAPRT, TAGLN2, NTRK1, KRAS | LAMA2 | DAG1, SMC6, ENTHD2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LTA4H_LAMA2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | LTA4H | P09960 | DB01197 | Captopril | Leukotriene A-4 hydrolase | small molecule | approved |
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RelatedDiseases for LTA4H_LAMA2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | LTA4H | C0004153 | Atherosclerosis | 1 | CTD_human |
| Hgene | LTA4H | C0011570 | Mental Depression | 1 | PSYGENET |
| Hgene | LTA4H | C0011581 | Depressive disorder | 1 | PSYGENET |
| Hgene | LTA4H | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | LAMA2 | C1263858 | Muscular dystrophy congenital, merosin negative | 3 | CTD_human;ORPHANET;UNIPROT |
| Tgene | LAMA2 | C0026850 | Muscular Dystrophy | 2 | CTD_human;HPO |
| Tgene | LAMA2 | C0036341 | Schizophrenia | 2 | CTD_human |
| Tgene | LAMA2 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Tgene | LAMA2 | C0027092 | Myopia | 1 | CTD_human |
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