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Fusion gene ID: 20344 |
FusionGeneSummary for LSM4_TRHDE |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LSM4_TRHDE | Fusion gene ID: 20344 | Hgene | Tgene | Gene symbol | LSM4 | TRHDE | Gene ID | 25804 | 29953 |
| Gene name | LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated | thyrotropin releasing hormone degrading enzyme | |
| Synonyms | GRP|YER112W | PAP-II|PGPEP2|TRH-DE | |
| Cytomap | 19p13.11 | 12q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | U6 snRNA-associated Sm-like protein LSm4LSM4 U6 small nuclear RNA and mRNA degradation associatedLSM4 homolog, U6 small nuclear RNA associatedglycine-rich protein | thyrotropin-releasing hormone-degrading ectoenzymeTRH-degrading ectoenzymeTRH-specific aminopeptidasepyroglutamyl aminopeptidase IIpyroglutamyl-peptidase IIthyroliberinase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y4Z0 | Q9UKU6 | |
| Ensembl transtripts involved in fusion gene | ENST00000593829, ENST00000252816, | ENST00000261180, ENST00000549138, | |
| Fusion gene scores | * DoF score | 6 X 3 X 5=90 | 14 X 6 X 5=420 |
| # samples | 6 | 13 | |
| ** MAII score | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/420*10)=-1.69187770463767 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LSM4 [Title/Abstract] AND TRHDE [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AC-A7VB-01A | LSM4 | chr19 | 18433828 | - | TRHDE | chr12 | 72771775 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000593829 | ENST00000261180 | LSM4 | chr19 | 18433828 | - | TRHDE | chr12 | 72771775 | + |
| 5CDS-intron | ENST00000593829 | ENST00000549138 | LSM4 | chr19 | 18433828 | - | TRHDE | chr12 | 72771775 | + |
| In-frame | ENST00000252816 | ENST00000261180 | LSM4 | chr19 | 18433828 | - | TRHDE | chr12 | 72771775 | + |
| 5CDS-intron | ENST00000252816 | ENST00000549138 | LSM4 | chr19 | 18433828 | - | TRHDE | chr12 | 72771775 | + |
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FusionProtFeatures for LSM4_TRHDE |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LSM4 | TRHDE |
| Binds specifically to the 3'-terminal U-tract of U6snRNA. | Specific inactivation of TRH after its release. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >TRHDE | chr19:18433828 | chr12:72771775 | ENST00000261180 | + | 1 | 19 | 404_408 | 351 | 1025 | Region | Substrate binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | TRHDE | chr19:18433828 | chr12:72771775 | ENST00000261180 | + | 1 | 19 | 1_40 | 351 | 1025 | Topological domain | Cytoplasmic |
| Tgene | TRHDE | chr19:18433828 | chr12:72771775 | ENST00000261180 | + | 1 | 19 | 62_1024 | 351 | 1025 | Topological domain | Extracellular |
| Tgene | TRHDE | chr19:18433828 | chr12:72771775 | ENST00000261180 | + | 1 | 19 | 41_61 | 351 | 1025 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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FusionGeneSequence for LSM4_TRHDE |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_LSM4_ENST00000593829_chr19_18433828_-_TRHDE_ENST00000261180_chr12_72771775_+_675aa MVRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVH EICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKG AALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFI YDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHE VLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFN GSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLE ALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKN >In-frame_LSM4_ENST00000252816_chr19_18433828_-_TRHDE_ENST00000261180_chr12_72771775_+_675aa MVRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVH EICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKG AALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFI YDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHE VLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFN GSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLE ALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_LSM4_ENST00000593829_chr19_18433828_-_TRHDE_ENST00000261180_chr12_72771775_+_2025nt ATGGTACGATTATATGCAAGACCTGATGCTATCAGAAGAGGATCCGGGGACTATGCTCTCCATATAACAAAGAGATTAATAGAATTTTAT GAAGACTACTTTAAAGTGCCCTATTCCTTGCCAAAACTAGATCTTTTAGCTGTGCCTAAGCATCCGTATGCTGCTATGGAGAACTGGGGA CTAAGTATTTTTGTGGAACAAAGAATACTGCTGGATCCCAGTGTTTCATCTATTTCTTATTTGCTGGATGTCACCATGGTCATTGTTCAT GAGATATGTCACCAGTGGTTTGGTGACCTTGTGACGCCTGTGTGGTGGGAAGACGTGTGGCTGAAGGAAGGGTTTGCTCACTACTTTGAA TTTGTTGGTACAGACTACCTCTATCCTGGCTGGAACATGGAAAAGCAGAGGTTTCTGACCGATGTTCTGCATGAAGTGATGCTGCTGGAC GGTTTGGCCAGTTCCCATCCAGTATCACAGGAAGTGCTGCAGGCAACAGATATTGACAGGGTGTTTGACTGGATCGCATATAAAAAGGGT GCTGCTTTAATAAGAATGCTGGCTAATTTTATGGGCCATTCAGTTTTCCAGAGGGGTTTGCAAGATTATTTAACCATTCATAAGTATGGT AATGCAGCCAGAAATGATCTCTGGAATACATTATCGGAGGCTTTAAAAAGAAATGGGAAATATGTAAATATACAAGAAGTAATGGATCAG TGGACACTCCAGATGGGTTATCCTGTTATCACCATCTTGGGAAACACAACAGCAGAAAATAGAATAATAATTACCCAACAGCATTTTATC TATGATATCAGTGCTAAAACTAAAGCACTTAAACTTCAGAATAACAGTTACCTGTGGCAGATTCCATTAACTATTGTGGTAGGAAATAGA AGCCATGTGTCTTCAGAAGCAATTATTTGGGTGTCTAACAAATCAGAGCACCACAGAATAACTTATTTGGACAAAGGAAGCTGGCTGCTG GGGAACATCAATCAAACTGGCTATTTTAGAGTCAACTATGACCTAAGGAACTGGAGATTATTAATTGATCAATTAATCCGGAATCATGAG GTTCTTTCTGTCAGTAACCGAGCGGGCTTGATCGATGATGCCTTCAGCCTAGCCAGGGCTGGCTATTTGCCTCAGAATATTCCTCTGGAG ATTATCAGATACCTGTCTGAGGAGAAGGATTTTCTTCCTTGGCATGCTGCCAGCCGAGCTCTTTATCCTCTAGATAAATTACTGGACCGC ATGGAAAACTACAACATTTTCAATGAATATATTTTAAAGCAAGTTGCAACAACATATATCAAGCTTGGGTGGCCGAAAAATAATTTTAAT GGATCTCTTGTTCAAGCATCCTACCAACATGAAGAACTACGTAGAGAAGTTATAATGCTGGCCTGCAGTTTTGGCAACAAGCACTGTCAC CAACAGGCATCAACACTTATTTCAGATTGGATTTCCAGCAACAGGAACAGAATACCACTAAATGTTAGAGACATCGTATACTGTACAGGA GTGTCACTACTGGATGAGGATGTCTGGGAATTCATATGGATGAAATTCCATTCCACCACAGCAGTTTCTGAGAAGAAAATATTATTGGAA GCCTTAACTTGCAGTGATGACAGGAATTTATTAAACAGGCTTCTAAATCTGTCACTGAATTCTGAGGTGGTGCTGGATCAAGATGCAATT GATGTCATAATCCATGTAGCTCGAAATCCACATGGTCGAGACCTTGCCTGGAAGTTTTTCAGGGATAAATGGAAGATATTAAATACCAGG TATGGAGAAGCATTGTTTATGAATTCCAAACTCATCAGTGGTGTCACAGAATTTCTTAATACTGAAGGTGAACTCAAAGAGCTCAAGAAC TTCATGAAAAACTATGATGGGGTAGCTGCTGCTTCTTTCTCACGAGCTGTGGAAACTGTCGAAGCCAATGTGCGCTGGAAAATGCTTTAC >In-frame_LSM4_ENST00000252816_chr19_18433828_-_TRHDE_ENST00000261180_chr12_72771775_+_2025nt ATGGTACGATTATATGCAAGACCTGATGCTATCAGAAGAGGATCCGGGGACTATGCTCTCCATATAACAAAGAGATTAATAGAATTTTAT GAAGACTACTTTAAAGTGCCCTATTCCTTGCCAAAACTAGATCTTTTAGCTGTGCCTAAGCATCCGTATGCTGCTATGGAGAACTGGGGA CTAAGTATTTTTGTGGAACAAAGAATACTGCTGGATCCCAGTGTTTCATCTATTTCTTATTTGCTGGATGTCACCATGGTCATTGTTCAT GAGATATGTCACCAGTGGTTTGGTGACCTTGTGACGCCTGTGTGGTGGGAAGACGTGTGGCTGAAGGAAGGGTTTGCTCACTACTTTGAA TTTGTTGGTACAGACTACCTCTATCCTGGCTGGAACATGGAAAAGCAGAGGTTTCTGACCGATGTTCTGCATGAAGTGATGCTGCTGGAC GGTTTGGCCAGTTCCCATCCAGTATCACAGGAAGTGCTGCAGGCAACAGATATTGACAGGGTGTTTGACTGGATCGCATATAAAAAGGGT GCTGCTTTAATAAGAATGCTGGCTAATTTTATGGGCCATTCAGTTTTCCAGAGGGGTTTGCAAGATTATTTAACCATTCATAAGTATGGT AATGCAGCCAGAAATGATCTCTGGAATACATTATCGGAGGCTTTAAAAAGAAATGGGAAATATGTAAATATACAAGAAGTAATGGATCAG TGGACACTCCAGATGGGTTATCCTGTTATCACCATCTTGGGAAACACAACAGCAGAAAATAGAATAATAATTACCCAACAGCATTTTATC TATGATATCAGTGCTAAAACTAAAGCACTTAAACTTCAGAATAACAGTTACCTGTGGCAGATTCCATTAACTATTGTGGTAGGAAATAGA AGCCATGTGTCTTCAGAAGCAATTATTTGGGTGTCTAACAAATCAGAGCACCACAGAATAACTTATTTGGACAAAGGAAGCTGGCTGCTG GGGAACATCAATCAAACTGGCTATTTTAGAGTCAACTATGACCTAAGGAACTGGAGATTATTAATTGATCAATTAATCCGGAATCATGAG GTTCTTTCTGTCAGTAACCGAGCGGGCTTGATCGATGATGCCTTCAGCCTAGCCAGGGCTGGCTATTTGCCTCAGAATATTCCTCTGGAG ATTATCAGATACCTGTCTGAGGAGAAGGATTTTCTTCCTTGGCATGCTGCCAGCCGAGCTCTTTATCCTCTAGATAAATTACTGGACCGC ATGGAAAACTACAACATTTTCAATGAATATATTTTAAAGCAAGTTGCAACAACATATATCAAGCTTGGGTGGCCGAAAAATAATTTTAAT GGATCTCTTGTTCAAGCATCCTACCAACATGAAGAACTACGTAGAGAAGTTATAATGCTGGCCTGCAGTTTTGGCAACAAGCACTGTCAC CAACAGGCATCAACACTTATTTCAGATTGGATTTCCAGCAACAGGAACAGAATACCACTAAATGTTAGAGACATCGTATACTGTACAGGA GTGTCACTACTGGATGAGGATGTCTGGGAATTCATATGGATGAAATTCCATTCCACCACAGCAGTTTCTGAGAAGAAAATATTATTGGAA GCCTTAACTTGCAGTGATGACAGGAATTTATTAAACAGGCTTCTAAATCTGTCACTGAATTCTGAGGTGGTGCTGGATCAAGATGCAATT GATGTCATAATCCATGTAGCTCGAAATCCACATGGTCGAGACCTTGCCTGGAAGTTTTTCAGGGATAAATGGAAGATATTAAATACCAGG TATGGAGAAGCATTGTTTATGAATTCCAAACTCATCAGTGGTGTCACAGAATTTCTTAATACTGAAGGTGAACTCAAAGAGCTCAAGAAC TTCATGAAAAACTATGATGGGGTAGCTGCTGCTTCTTTCTCACGAGCTGTGGAAACTGTCGAAGCCAATGTGCGCTGGAAAATGCTTTAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_LSM4_ENST00000593829_chr19_18433828_-_TRHDE_ENST00000261180_chr12_72771775_+_4726nt ATTACAAGCCGCGGCACTTTACGGCTCTCGTCCTCGTTCCTCCGGCGGGAACACGGCCCGCCCCGCCCTTTCGCCCAGCGGGCCCCGCCC TACTCCGCGTGGATTGGTTGACCGCCCTTCGAGCCCGGTGCTGACTGGCTTGCGTCTCTGCCACTTTCTTTCAGCTTAGTGGCGCGCGGC GCGGCGACGACCGCCGGGAGCGTGTGCAGCGGCGGCGGCGGAAGTGGCCGGCGAGCCCGGTCCCCGCCGGCACCATGGTACGATTATATG CAAGACCTGATGCTATCAGAAGAGGATCCGGGGACTATGCTCTCCATATAACAAAGAGATTAATAGAATTTTATGAAGACTACTTTAAAG TGCCCTATTCCTTGCCAAAACTAGATCTTTTAGCTGTGCCTAAGCATCCGTATGCTGCTATGGAGAACTGGGGACTAAGTATTTTTGTGG AACAAAGAATACTGCTGGATCCCAGTGTTTCATCTATTTCTTATTTGCTGGATGTCACCATGGTCATTGTTCATGAGATATGTCACCAGT GGTTTGGTGACCTTGTGACGCCTGTGTGGTGGGAAGACGTGTGGCTGAAGGAAGGGTTTGCTCACTACTTTGAATTTGTTGGTACAGACT ACCTCTATCCTGGCTGGAACATGGAAAAGCAGAGGTTTCTGACCGATGTTCTGCATGAAGTGATGCTGCTGGACGGTTTGGCCAGTTCCC ATCCAGTATCACAGGAAGTGCTGCAGGCAACAGATATTGACAGGGTGTTTGACTGGATCGCATATAAAAAGGGTGCTGCTTTAATAAGAA TGCTGGCTAATTTTATGGGCCATTCAGTTTTCCAGAGGGGTTTGCAAGATTATTTAACCATTCATAAGTATGGTAATGCAGCCAGAAATG ATCTCTGGAATACATTATCGGAGGCTTTAAAAAGAAATGGGAAATATGTAAATATACAAGAAGTAATGGATCAGTGGACACTCCAGATGG GTTATCCTGTTATCACCATCTTGGGAAACACAACAGCAGAAAATAGAATAATAATTACCCAACAGCATTTTATCTATGATATCAGTGCTA AAACTAAAGCACTTAAACTTCAGAATAACAGTTACCTGTGGCAGATTCCATTAACTATTGTGGTAGGAAATAGAAGCCATGTGTCTTCAG AAGCAATTATTTGGGTGTCTAACAAATCAGAGCACCACAGAATAACTTATTTGGACAAAGGAAGCTGGCTGCTGGGGAACATCAATCAAA CTGGCTATTTTAGAGTCAACTATGACCTAAGGAACTGGAGATTATTAATTGATCAATTAATCCGGAATCATGAGGTTCTTTCTGTCAGTA ACCGAGCGGGCTTGATCGATGATGCCTTCAGCCTAGCCAGGGCTGGCTATTTGCCTCAGAATATTCCTCTGGAGATTATCAGATACCTGT CTGAGGAGAAGGATTTTCTTCCTTGGCATGCTGCCAGCCGAGCTCTTTATCCTCTAGATAAATTACTGGACCGCATGGAAAACTACAACA TTTTCAATGAATATATTTTAAAGCAAGTTGCAACAACATATATCAAGCTTGGGTGGCCGAAAAATAATTTTAATGGATCTCTTGTTCAAG CATCCTACCAACATGAAGAACTACGTAGAGAAGTTATAATGCTGGCCTGCAGTTTTGGCAACAAGCACTGTCACCAACAGGCATCAACAC TTATTTCAGATTGGATTTCCAGCAACAGGAACAGAATACCACTAAATGTTAGAGACATCGTATACTGTACAGGAGTGTCACTACTGGATG AGGATGTCTGGGAATTCATATGGATGAAATTCCATTCCACCACAGCAGTTTCTGAGAAGAAAATATTATTGGAAGCCTTAACTTGCAGTG ATGACAGGAATTTATTAAACAGGCTTCTAAATCTGTCACTGAATTCTGAGGTGGTGCTGGATCAAGATGCAATTGATGTCATAATCCATG TAGCTCGAAATCCACATGGTCGAGACCTTGCCTGGAAGTTTTTCAGGGATAAATGGAAGATATTAAATACCAGGTATGGAGAAGCATTGT TTATGAATTCCAAACTCATCAGTGGTGTCACAGAATTTCTTAATACTGAAGGTGAACTCAAAGAGCTCAAGAACTTCATGAAAAACTATG ATGGGGTAGCTGCTGCTTCTTTCTCACGAGCTGTGGAAACTGTCGAAGCCAATGTGCGCTGGAAAATGCTTTACCAAGACGAGCTTTTCC AATGGTTAGGAAAAGCTCTAAGACACTAATATATGTATCTTATAAACAAACAATTCAACTCAGAAGTTTATGAGAAGACACGCTTTTTGT GGAATGAGGAAAATGTACTACCTAGAAAATGGCCAGATTTTCAGTGTTAACGTGTGGGAGGAATTTTTTTTTTAGTTTTTATTTTTTGGT TTTGGGGGATATTTTTTATTTGTTTCATTCATTCTGTTCTGTTTCTCTACTGGGTGTTCCTCTCTAAAGAAACTCTTGCAAGTGAAACTA GCCATGATTGCTTCAGCTGTACATTCCTTGCTGTACAGGACCAAATATGATAGTGATGCATGTTGATGTTACAGTCAATTTGGAAAAACA TATTCAGAATATCTGTGCATGGATATATTGTCCTGCCTGTGTTCCAGCATGCTTATTTCAAACGTCCAGTGTTGTGTGTGAATATGTGTT ACACCTAGGATGGGCATTATGCAAAAGCACAAAGATTATATATGACAATCAGTATTGCAATGAAAGAAAAACTAAAAACAGAAATGATAT TCTCAATTTTGGGCAATGTGAGAGGTAAAATAGCCCTTGACATGATGAACATCACTTATTTCAGCACTTGGATTGTCTGGCAATGATTAC TGTGTTGCTAACTCATTTTCTTTGAGTTAAAGCTGTGTATACATTTTAAAAGGCATATAGATAGTGTATGCATATGTATATGTACATAGG GAAGCCCCATATGTATATAGTATGTTGTACACTGCACATGTACAAAGAATGTCTTCAGATCAAAGAAAATTTATCTCTTTTTATAAACTT AAGGACAGTTGCAAAAGGCTTCAAGGAATTTATCTCAACATTATTCTTTCTATGTCCTAACTAAATTTCTCAACTGTTATGAATTTTTCA TCTACTTCTTGAACAGTGGTCTATTCTGCTACATGAAGATGAATACAAACAAAATTTTTGTATAAACTACTATTCCAGTTCTCCTGTGTC AGTCTTGCCTATAGATTTTGCCATCGTTTTCTGTCAAAGTTCCTTTTGCATGAAACAATTATGCAAACTTATAATTATTAGTGCTGAAAA AGAGTTTATTTTCCATCTTGTTTGTTTTCCTACCTTATGCTGAGTAGTCCAGAGAGTTAAAAAAATTCTCTGCATGTTGGTCTTTTAAGT CTGTTTTGCTCTAATCCTCCATTAAGCGAGCATACCTCAAGTGGGTCTATTAGCATTTAATGACCTTTTGTGCCAGTTGTGCCATCCCTT AAGATGAAAAGTTCCTTTTCTTGTGTTAATGTACAAAGCTTTTCTTTTGGCACTGACAACTGTGTTCTACCTGGGAATTTTGAATAGCCA TTTTCATGGCTGTGTGTTGTGTAACACAAATGTTTTTAAATGGTATTCTCACCCAGTAGGCCAGCTCTCCAAACGTTGCTTAGATGCTTC AAAATTAGCATATTTTAAGTTTACCAGTATAAAATACCAATGCAACTACTCTACATAGCCAAATGTTTGTAAATCACGTCTTATTTTCCT GAGGTTTTTCACTCCACCAAATCTTACAAATCATTGAAAGAAATATATTCTAACAGTACGCACTGAATAGTGAAAATAATTAGACATTTT AAGAACCAGAGCCATAGAATTATTTTAAATTAGTAGAAAAGAGGAGCTATTTCCGAATCTATAGAATAAAGTACCACCTAAAACTGAATT TTATCATATAAGCAAGTAATACCTATTAGTCATACCTAAATTTTTCAGCACTTCATTCAATTAAAATACATGAATTTTAAATATTTTACA TGATGTGAATAGGCATGATAATACTTTTAGTATAAAATCTAAACTTTTTCCATTTATCAGAAATGATAAAATCCAGTTACCACATATCAC GTTTATAAAATCCTTAATTAAATGAGTAACTTCTAAAATATAACAATACTAAATATCACACTGCGATGGAGGTCCCAAATATGTGGTCTA TCACCACTGAATTCATGTAATAGATAAGAAAAAAATTAGAGGTGGATGTCTTGTTTTGTGTCATGAATTACTAAAATCTCTTAGTAGTTG TGGTATATTTTTGAGTAAAATTACCATTTCCAGATTTGAGTTTGAAGGGCTTTTATAGTTGTATTTTCCTCCTCACTGTTAATAATCATA ATCCTTTTTCAGTATTTTAGTGGCCTTGAACAACTGGTTTATCTACAATCTCAAATCCTAAGTGTATAATTATGTGCAATGTTCAATACC TCATATAATACTTGCTCAACAGTATAGTGGTACCAATGGCATTAAGATGGTGTTTTTGTTCTACATATTTTTCAATAATTTATTCTTTCT AATGTTGAAATTATATCAGGCTTTACCGGTTTTTTTAGTTGTTTAAATAAGTAATATTTTCAAAAGAATAAAATAACCAATGATATCTCT >In-frame_LSM4_ENST00000252816_chr19_18433828_-_TRHDE_ENST00000261180_chr12_72771775_+_4523nt GTGCAGCGGCGGCGGCGGAAGTGGCCGGCGAGCCCGGTCCCCGCCGGCACCATGGTACGATTATATGCAAGACCTGATGCTATCAGAAGA GGATCCGGGGACTATGCTCTCCATATAACAAAGAGATTAATAGAATTTTATGAAGACTACTTTAAAGTGCCCTATTCCTTGCCAAAACTA GATCTTTTAGCTGTGCCTAAGCATCCGTATGCTGCTATGGAGAACTGGGGACTAAGTATTTTTGTGGAACAAAGAATACTGCTGGATCCC AGTGTTTCATCTATTTCTTATTTGCTGGATGTCACCATGGTCATTGTTCATGAGATATGTCACCAGTGGTTTGGTGACCTTGTGACGCCT GTGTGGTGGGAAGACGTGTGGCTGAAGGAAGGGTTTGCTCACTACTTTGAATTTGTTGGTACAGACTACCTCTATCCTGGCTGGAACATG GAAAAGCAGAGGTTTCTGACCGATGTTCTGCATGAAGTGATGCTGCTGGACGGTTTGGCCAGTTCCCATCCAGTATCACAGGAAGTGCTG CAGGCAACAGATATTGACAGGGTGTTTGACTGGATCGCATATAAAAAGGGTGCTGCTTTAATAAGAATGCTGGCTAATTTTATGGGCCAT TCAGTTTTCCAGAGGGGTTTGCAAGATTATTTAACCATTCATAAGTATGGTAATGCAGCCAGAAATGATCTCTGGAATACATTATCGGAG GCTTTAAAAAGAAATGGGAAATATGTAAATATACAAGAAGTAATGGATCAGTGGACACTCCAGATGGGTTATCCTGTTATCACCATCTTG GGAAACACAACAGCAGAAAATAGAATAATAATTACCCAACAGCATTTTATCTATGATATCAGTGCTAAAACTAAAGCACTTAAACTTCAG AATAACAGTTACCTGTGGCAGATTCCATTAACTATTGTGGTAGGAAATAGAAGCCATGTGTCTTCAGAAGCAATTATTTGGGTGTCTAAC AAATCAGAGCACCACAGAATAACTTATTTGGACAAAGGAAGCTGGCTGCTGGGGAACATCAATCAAACTGGCTATTTTAGAGTCAACTAT GACCTAAGGAACTGGAGATTATTAATTGATCAATTAATCCGGAATCATGAGGTTCTTTCTGTCAGTAACCGAGCGGGCTTGATCGATGAT GCCTTCAGCCTAGCCAGGGCTGGCTATTTGCCTCAGAATATTCCTCTGGAGATTATCAGATACCTGTCTGAGGAGAAGGATTTTCTTCCT TGGCATGCTGCCAGCCGAGCTCTTTATCCTCTAGATAAATTACTGGACCGCATGGAAAACTACAACATTTTCAATGAATATATTTTAAAG CAAGTTGCAACAACATATATCAAGCTTGGGTGGCCGAAAAATAATTTTAATGGATCTCTTGTTCAAGCATCCTACCAACATGAAGAACTA CGTAGAGAAGTTATAATGCTGGCCTGCAGTTTTGGCAACAAGCACTGTCACCAACAGGCATCAACACTTATTTCAGATTGGATTTCCAGC AACAGGAACAGAATACCACTAAATGTTAGAGACATCGTATACTGTACAGGAGTGTCACTACTGGATGAGGATGTCTGGGAATTCATATGG ATGAAATTCCATTCCACCACAGCAGTTTCTGAGAAGAAAATATTATTGGAAGCCTTAACTTGCAGTGATGACAGGAATTTATTAAACAGG CTTCTAAATCTGTCACTGAATTCTGAGGTGGTGCTGGATCAAGATGCAATTGATGTCATAATCCATGTAGCTCGAAATCCACATGGTCGA GACCTTGCCTGGAAGTTTTTCAGGGATAAATGGAAGATATTAAATACCAGGTATGGAGAAGCATTGTTTATGAATTCCAAACTCATCAGT GGTGTCACAGAATTTCTTAATACTGAAGGTGAACTCAAAGAGCTCAAGAACTTCATGAAAAACTATGATGGGGTAGCTGCTGCTTCTTTC TCACGAGCTGTGGAAACTGTCGAAGCCAATGTGCGCTGGAAAATGCTTTACCAAGACGAGCTTTTCCAATGGTTAGGAAAAGCTCTAAGA CACTAATATATGTATCTTATAAACAAACAATTCAACTCAGAAGTTTATGAGAAGACACGCTTTTTGTGGAATGAGGAAAATGTACTACCT AGAAAATGGCCAGATTTTCAGTGTTAACGTGTGGGAGGAATTTTTTTTTTAGTTTTTATTTTTTGGTTTTGGGGGATATTTTTTATTTGT TTCATTCATTCTGTTCTGTTTCTCTACTGGGTGTTCCTCTCTAAAGAAACTCTTGCAAGTGAAACTAGCCATGATTGCTTCAGCTGTACA TTCCTTGCTGTACAGGACCAAATATGATAGTGATGCATGTTGATGTTACAGTCAATTTGGAAAAACATATTCAGAATATCTGTGCATGGA TATATTGTCCTGCCTGTGTTCCAGCATGCTTATTTCAAACGTCCAGTGTTGTGTGTGAATATGTGTTACACCTAGGATGGGCATTATGCA AAAGCACAAAGATTATATATGACAATCAGTATTGCAATGAAAGAAAAACTAAAAACAGAAATGATATTCTCAATTTTGGGCAATGTGAGA GGTAAAATAGCCCTTGACATGATGAACATCACTTATTTCAGCACTTGGATTGTCTGGCAATGATTACTGTGTTGCTAACTCATTTTCTTT GAGTTAAAGCTGTGTATACATTTTAAAAGGCATATAGATAGTGTATGCATATGTATATGTACATAGGGAAGCCCCATATGTATATAGTAT GTTGTACACTGCACATGTACAAAGAATGTCTTCAGATCAAAGAAAATTTATCTCTTTTTATAAACTTAAGGACAGTTGCAAAAGGCTTCA AGGAATTTATCTCAACATTATTCTTTCTATGTCCTAACTAAATTTCTCAACTGTTATGAATTTTTCATCTACTTCTTGAACAGTGGTCTA TTCTGCTACATGAAGATGAATACAAACAAAATTTTTGTATAAACTACTATTCCAGTTCTCCTGTGTCAGTCTTGCCTATAGATTTTGCCA TCGTTTTCTGTCAAAGTTCCTTTTGCATGAAACAATTATGCAAACTTATAATTATTAGTGCTGAAAAAGAGTTTATTTTCCATCTTGTTT GTTTTCCTACCTTATGCTGAGTAGTCCAGAGAGTTAAAAAAATTCTCTGCATGTTGGTCTTTTAAGTCTGTTTTGCTCTAATCCTCCATT AAGCGAGCATACCTCAAGTGGGTCTATTAGCATTTAATGACCTTTTGTGCCAGTTGTGCCATCCCTTAAGATGAAAAGTTCCTTTTCTTG TGTTAATGTACAAAGCTTTTCTTTTGGCACTGACAACTGTGTTCTACCTGGGAATTTTGAATAGCCATTTTCATGGCTGTGTGTTGTGTA ACACAAATGTTTTTAAATGGTATTCTCACCCAGTAGGCCAGCTCTCCAAACGTTGCTTAGATGCTTCAAAATTAGCATATTTTAAGTTTA CCAGTATAAAATACCAATGCAACTACTCTACATAGCCAAATGTTTGTAAATCACGTCTTATTTTCCTGAGGTTTTTCACTCCACCAAATC TTACAAATCATTGAAAGAAATATATTCTAACAGTACGCACTGAATAGTGAAAATAATTAGACATTTTAAGAACCAGAGCCATAGAATTAT TTTAAATTAGTAGAAAAGAGGAGCTATTTCCGAATCTATAGAATAAAGTACCACCTAAAACTGAATTTTATCATATAAGCAAGTAATACC TATTAGTCATACCTAAATTTTTCAGCACTTCATTCAATTAAAATACATGAATTTTAAATATTTTACATGATGTGAATAGGCATGATAATA CTTTTAGTATAAAATCTAAACTTTTTCCATTTATCAGAAATGATAAAATCCAGTTACCACATATCACGTTTATAAAATCCTTAATTAAAT GAGTAACTTCTAAAATATAACAATACTAAATATCACACTGCGATGGAGGTCCCAAATATGTGGTCTATCACCACTGAATTCATGTAATAG ATAAGAAAAAAATTAGAGGTGGATGTCTTGTTTTGTGTCATGAATTACTAAAATCTCTTAGTAGTTGTGGTATATTTTTGAGTAAAATTA CCATTTCCAGATTTGAGTTTGAAGGGCTTTTATAGTTGTATTTTCCTCCTCACTGTTAATAATCATAATCCTTTTTCAGTATTTTAGTGG CCTTGAACAACTGGTTTATCTACAATCTCAAATCCTAAGTGTATAATTATGTGCAATGTTCAATACCTCATATAATACTTGCTCAACAGT ATAGTGGTACCAATGGCATTAAGATGGTGTTTTTGTTCTACATATTTTTCAATAATTTATTCTTTCTAATGTTGAAATTATATCAGGCTT TACCGGTTTTTTTAGTTGTTTAAATAAGTAATATTTTCAAAAGAATAAAATAACCAATGATATCTCTTGGAATAATCTGTAAAACGTAGT |
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FusionGenePPI for LSM4_TRHDE |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LSM4 | SNRPE, XRN1, CALCOCO2, LSM1, LSM2, LSM3, LSM6, LSM7, LSM8, SMN1, USP15, USP4, PRPF4, SART3, MEPCE, RNU4ATAC, RNU6ATAC, TOP1, LSM5, DDX39B, PRPF18, VAC14, TCEA2, WDR44, PYROXD1, MTR, RMI2, GTF2B, RAD23A, SGTA, PPIB, PPIP5K1, HUWE1, SMU1, TOE1, SLC22A2, SMIM14, NMI, RHOXF2, COX5B, PLEKHA5, WWOX, PSTPIP1, IKZF1, ZBTB10, L3MBTL3, HNRNPR, KLC2, LRPPRC, PKN2, NAA38, SF3A3, SF3B3, SYNCRIP, ZMAT2, XPO1, SIN3B, PRPF3, SNRPN, ALYREF, RPL26L1, PPIH, OLA1, RPL32 | TRHDE | AKT1, EGFR, MUL1, TSPAN3, DNAJB9, LEMD3, EMILIN2, MANEA, FKBP14, KIRREL, CANX, TMTC3, MESDC2, MAN1A2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LSM4_TRHDE |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LSM4_TRHDE |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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