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Fusion gene ID: 20313 |
FusionGeneSummary for LSAMP_COL4A5 |
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Fusion gene information | Fusion gene name: LSAMP_COL4A5 | Fusion gene ID: 20313 | Hgene | Tgene | Gene symbol | LSAMP | COL4A5 | Gene ID | 4045 | 1287 |
Gene name | limbic system associated membrane protein | collagen type IV alpha 5 chain | |
Synonyms | IGLON3|LAMP | ASLN|ATS|CA54 | |
Cytomap | 3q13.31 | Xq22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | limbic system-associated membrane proteinIgLON family member 3 | collagen alpha-5(IV) chaincollagen IV, alpha-5 polypeptidecollagen of basement membrane, alpha-5 chaincollagen, type IV, alpha 5dA149D17.3dA24A23.1 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q13449 | P29400 | |
Ensembl transtripts involved in fusion gene | ENST00000539563, ENST00000490035, ENST00000498645, | ENST00000328300, ENST00000361603, ENST00000477429, | |
Fusion gene scores | * DoF score | 6 X 7 X 4=168 | 2 X 2 X 2=8 |
# samples | 8 | 2 | |
** MAII score | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: LSAMP [Title/Abstract] AND COL4A5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-FS-A1ZJ-06A | LSAMP | chr3 | 115738362 | - | COL4A5 | chrX | 107811989 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000539563 | ENST00000328300 | LSAMP | chr3 | 115738362 | - | COL4A5 | chrX | 107811989 | + |
Frame-shift | ENST00000539563 | ENST00000361603 | LSAMP | chr3 | 115738362 | - | COL4A5 | chrX | 107811989 | + |
5CDS-intron | ENST00000539563 | ENST00000477429 | LSAMP | chr3 | 115738362 | - | COL4A5 | chrX | 107811989 | + |
Frame-shift | ENST00000490035 | ENST00000328300 | LSAMP | chr3 | 115738362 | - | COL4A5 | chrX | 107811989 | + |
Frame-shift | ENST00000490035 | ENST00000361603 | LSAMP | chr3 | 115738362 | - | COL4A5 | chrX | 107811989 | + |
5CDS-intron | ENST00000490035 | ENST00000477429 | LSAMP | chr3 | 115738362 | - | COL4A5 | chrX | 107811989 | + |
5UTR-3CDS | ENST00000498645 | ENST00000328300 | LSAMP | chr3 | 115738362 | - | COL4A5 | chrX | 107811989 | + |
5UTR-3CDS | ENST00000498645 | ENST00000361603 | LSAMP | chr3 | 115738362 | - | COL4A5 | chrX | 107811989 | + |
5UTR-intron | ENST00000498645 | ENST00000477429 | LSAMP | chr3 | 115738362 | - | COL4A5 | chrX | 107811989 | + |
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FusionProtFeatures for LSAMP_COL4A5 |
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Hgene | Tgene |
LSAMP | COL4A5 |
Mediates selective neuronal growth and axon targeting.Contributes to the guidance of developing axons and remodeling ofmature circuits in the limbic system. Essential for normal growthof the hyppocampal mossy fiber projection (By similarity).{ECO:0000250}. | Type IV collagen is the major structural component ofglomerular basement membranes (GBM), forming a 'chicken-wire'meshwork together with laminins, proteoglycans andentactin/nidogen. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LSAMP_COL4A5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LSAMP_COL4A5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LSAMP | NTM, LSAMP, NEGR1, DNAAF2 | COL4A5 | DAZAP2, TK1, CDKN1A, SMN1, NR1H2, ANXA7, VHL, ELAVL1, ANTXR2, STRN3, PDK1, DAP3, KIF21B, CASC5, VPS26B, CEP170P1, PLOD1, COL8A2, COLGALT2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LSAMP_COL4A5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LSAMP_COL4A5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | LSAMP | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | LSAMP | C0041696 | Unipolar Depression | 1 | PSYGENET |
Hgene | LSAMP | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Tgene | COL4A5 | C1567742 | Alport Syndrome, X-Linked | 17 | CTD_human;ORPHANET;UNIPROT |
Tgene | COL4A5 | C0086533 | Leiomyoma, Epithelioid | 1 | CTD_human |