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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20313

FusionGeneSummary for LSAMP_COL4A5

check button Fusion gene summary
Fusion gene informationFusion gene name: LSAMP_COL4A5
Fusion gene ID: 20313
HgeneTgene
Gene symbol

LSAMP

COL4A5

Gene ID

4045

1287

Gene namelimbic system associated membrane proteincollagen type IV alpha 5 chain
SynonymsIGLON3|LAMPASLN|ATS|CA54
Cytomap

3q13.31

Xq22.3

Type of geneprotein-codingprotein-coding
Descriptionlimbic system-associated membrane proteinIgLON family member 3collagen alpha-5(IV) chaincollagen IV, alpha-5 polypeptidecollagen of basement membrane, alpha-5 chaincollagen, type IV, alpha 5dA149D17.3dA24A23.1
Modification date2018052220180523
UniProtAcc

Q13449

P29400

Ensembl transtripts involved in fusion geneENST00000539563, ENST00000490035, 
ENST00000498645, 
ENST00000328300, 
ENST00000361603, ENST00000477429, 
Fusion gene scores* DoF score6 X 7 X 4=1682 X 2 X 2=8
# samples 82
** MAII scorelog2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: LSAMP [Title/Abstract] AND COL4A5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-FS-A1ZJ-06ALSAMPchr3

115738362

-COL4A5chrX

107811989

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000539563ENST00000328300LSAMPchr3

115738362

-COL4A5chrX

107811989

+
Frame-shiftENST00000539563ENST00000361603LSAMPchr3

115738362

-COL4A5chrX

107811989

+
5CDS-intronENST00000539563ENST00000477429LSAMPchr3

115738362

-COL4A5chrX

107811989

+
Frame-shiftENST00000490035ENST00000328300LSAMPchr3

115738362

-COL4A5chrX

107811989

+
Frame-shiftENST00000490035ENST00000361603LSAMPchr3

115738362

-COL4A5chrX

107811989

+
5CDS-intronENST00000490035ENST00000477429LSAMPchr3

115738362

-COL4A5chrX

107811989

+
5UTR-3CDSENST00000498645ENST00000328300LSAMPchr3

115738362

-COL4A5chrX

107811989

+
5UTR-3CDSENST00000498645ENST00000361603LSAMPchr3

115738362

-COL4A5chrX

107811989

+
5UTR-intronENST00000498645ENST00000477429LSAMPchr3

115738362

-COL4A5chrX

107811989

+

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FusionProtFeatures for LSAMP_COL4A5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LSAMP

Q13449

COL4A5

P29400

Mediates selective neuronal growth and axon targeting.Contributes to the guidance of developing axons and remodeling ofmature circuits in the limbic system. Essential for normal growthof the hyppocampal mossy fiber projection (By similarity).{ECO:0000250}. Type IV collagen is the major structural component ofglomerular basement membranes (GBM), forming a 'chicken-wire'meshwork together with laminins, proteoglycans andentactin/nidogen.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LSAMP_COL4A5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LSAMP_COL4A5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LSAMPNTM, LSAMP, NEGR1, DNAAF2COL4A5DAZAP2, TK1, CDKN1A, SMN1, NR1H2, ANXA7, VHL, ELAVL1, ANTXR2, STRN3, PDK1, DAP3, KIF21B, CASC5, VPS26B, CEP170P1, PLOD1, COL8A2, COLGALT2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LSAMP_COL4A5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LSAMP_COL4A5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLSAMPC0036341Schizophrenia1PSYGENET
HgeneLSAMPC0041696Unipolar Depression1PSYGENET
HgeneLSAMPC1269683Major Depressive Disorder1PSYGENET
TgeneCOL4A5C1567742Alport Syndrome, X-Linked17CTD_human;ORPHANET;UNIPROT
TgeneCOL4A5C0086533Leiomyoma, Epithelioid1CTD_human