	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 2031

FusionGeneSummary for AP1G2_HLA-F

Fusion gene summary

Fusion gene information	Fusion gene name: AP1G2_HLA-F
	Fusion gene ID: 2031
		Hgene	Tgene
	Gene symbol	AP1G2	HLA-F
	Gene ID	8906	3134
	Gene name	adaptor related protein complex 1 subunit gamma 2	major histocompatibility complex, class I, F
	Synonyms	G2AD	CDA12\|HLA-5.4\|HLA-CDA12\|HLAF
	Cytomap	14q11.2	6p22.1
	Type of gene	protein-coding	protein-coding
	Description	AP-1 complex subunit gamma-like 2adaptor related protein complex 1 gamma 2 subunitclathrin-associated/assembly/adaptor protein, large, gamma-2gamma2-adaptin	HLA class I histocompatibility antigen, alpha chain FHLA F antigenMHC class I antigen Fleukocyte antigen F
	Modification date	20180519	20180523
	UniProtAcc	O75843	P30511
	Ensembl transtripts involved in fusion gene	ENST00000308724, ENST00000397120, ENST00000556277,	ENST00000376861, ENST00000334668, ENST00000259951, ENST00000440587, ENST00000434407, ENST00000475996, ENST00000342322, ENST00000552082, ENST00000551026, ENST00000383516, ENST00000383515, ENST00000496199, ENST00000422711, ENST00000551832, ENST00000549067, ENST00000428296, ENST00000420067, ENST00000485297, ENST00000422439, ENST00000490874, ENST00000383626, ENST00000550932, ENST00000547132, ENST00000383627, ENST00000359076, ENST00000489167, ENST00000435058, ENST00000551780, ENST00000551347, ENST00000445657, ENST00000440590, ENST00000490259, ENST00000444891, ENST00000549422, ENST00000552880, ENST00000549254, ENST00000430472, ENST00000376848, ENST00000463731,
Fusion gene scores	* DoF score	2 X 2 X 1=4	3 X 3 X 3=27
	# samples	2	3
	** MAII score	log2(2/4*10)=2.32192809488736	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: AP1G2 [Title/Abstract] AND HLA-F [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BF917628	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000308724	ENST00000376861	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000334668	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000259951	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000440587	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000434407	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000475996	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000342322	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000552082	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000551026	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000383516	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000383515	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000496199	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000422711	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000551832	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000549067	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000428296	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000420067	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000485297	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000422439	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000490874	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000383626	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000550932	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000547132	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000383627	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000359076	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000489167	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000435058	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000551780	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000551347	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000445657	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000440590	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000490259	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000444891	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000549422	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000552880	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000549254	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000430472	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000376848	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000308724	ENST00000463731	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000376861	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000334668	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000259951	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000440587	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000434407	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000475996	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000342322	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000552082	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000551026	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000383516	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000383515	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000496199	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000422711	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000551832	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000549067	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000428296	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000420067	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000485297	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000422439	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000490874	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000383626	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000550932	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000547132	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000383627	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000359076	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000489167	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000435058	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000551780	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000551347	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000445657	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000440590	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000490259	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000444891	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000549422	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000552880	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000549254	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000430472	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000376848	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000397120	ENST00000463731	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000376861	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000334668	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000259951	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000440587	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000434407	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000475996	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000342322	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000552082	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000551026	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000383516	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000383515	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000496199	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000422711	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000551832	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000549067	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000428296	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000420067	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000485297	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000422439	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000490874	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000383626	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000550932	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000547132	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000383627	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000359076	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000489167	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000435058	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000551780	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000551347	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000445657	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000440590	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000490259	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000444891	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000549422	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000552880	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000549254	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000430472	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000376848	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+
intron-intron	ENST00000556277	ENST00000463731	AP1G2	chr14	24030630	+	HLA-F	chr6	1029924	+

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FusionProtFeatures for AP1G2_HLA-F

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AP1G2 O75843	HLA-F P30511
May function in protein sorting in late endosomes ormultivesucular bodies (MVBs). {ECO:0000269\|PubMed:9733768}. (Microbial infection) Involved in MVB-assistedmaturation of hepatitis B virus (HBV).{ECO:0000269\|PubMed:16867982, ECO:0000269\|PubMed:17553870}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for AP1G2_HLA-F

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AP1G2_HLA-F

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for AP1G2_HLA-F

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for AP1G2_HLA-F

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 2031

FusionGeneSummary for AP1G2_HLA-F

FusionProtFeatures for AP1G2_HLA-F

FusionGeneSequence for AP1G2_HLA-F

FusionGenePPI for AP1G2_HLA-F

RelatedDrugs for AP1G2_HLA-F

RelatedDiseases for AP1G2_HLA-F