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Fusion gene ID: 20254 |
FusionGeneSummary for LRRC61_PTPN13 |
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Fusion gene information | Fusion gene name: LRRC61_PTPN13 | Fusion gene ID: 20254 | Hgene | Tgene | Gene symbol | LRRC61 | PTPN13 | Gene ID | 65999 | 5783 |
Gene name | leucine rich repeat containing 61 | protein tyrosine phosphatase, non-receptor type 13 | |
Synonyms | HSPC295 | FAP-1|PNP1|PTP-BAS|PTP-BL|PTP1E|PTPL1|PTPLE|hPTP1E | |
Cytomap | 7q36.1 | 4q21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | leucine-rich repeat-containing protein 61 | tyrosine-protein phosphatase non-receptor type 13fas-associated protein-tyrosine phosphatase 1hPTPE1protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)protein-tyrosine phosphatase 1Eprotein-tyrosine phosphatas | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9BV99 | Q12923 | |
Ensembl transtripts involved in fusion gene | ENST00000463441, ENST00000323078, ENST00000359623, ENST00000493307, | ENST00000427191, ENST00000436978, ENST00000502971, ENST00000411767, ENST00000316707, ENST00000511467, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 5 X 8 X 6=240 |
# samples | 3 | 11 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/240*10)=-1.12553088208386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LRRC61 [Title/Abstract] AND PTPN13 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PTPN13 | GO:0006470 | protein dephosphorylation | 17657516 |
Tgene | PTPN13 | GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling | 23604317 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BU676031 | LRRC61 | chr7 | 150035158 | - | PTPN13 | chr4 | 87612505 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000463441 | ENST00000427191 | LRRC61 | chr7 | 150035158 | - | PTPN13 | chr4 | 87612505 | + |
intron-intron | ENST00000463441 | ENST00000436978 | LRRC61 | chr7 | 150035158 | - | PTPN13 | chr4 | 87612505 | + |
intron-intron | ENST00000463441 | ENST00000502971 | LRRC61 | chr7 | 150035158 | - | PTPN13 | chr4 | 87612505 | + |
intron-intron | ENST00000463441 | ENST00000411767 | LRRC61 | chr7 | 150035158 | - | PTPN13 | chr4 | 87612505 | + |
intron-intron | ENST00000463441 | ENST00000316707 | LRRC61 | chr7 | 150035158 | - | PTPN13 | chr4 | 87612505 | + |
intron-intron | ENST00000463441 | ENST00000511467 | LRRC61 | chr7 | 150035158 | - | PTPN13 | chr4 | 87612505 | + |
3UTR-intron | ENST00000323078 | ENST00000427191 | LRRC61 | chr7 | 150035158 | - | PTPN13 | chr4 | 87612505 | + |
3UTR-intron | ENST00000323078 | ENST00000436978 | LRRC61 | chr7 | 150035158 | - | PTPN13 | chr4 | 87612505 | + |
3UTR-intron | ENST00000323078 | ENST00000502971 | LRRC61 | chr7 | 150035158 | - | PTPN13 | chr4 | 87612505 | + |
3UTR-intron | ENST00000323078 | ENST00000411767 | LRRC61 | chr7 | 150035158 | - | PTPN13 | chr4 | 87612505 | + |
3UTR-intron | ENST00000323078 | ENST00000316707 | LRRC61 | chr7 | 150035158 | - | PTPN13 | chr4 | 87612505 | + |
3UTR-intron | ENST00000323078 | ENST00000511467 | LRRC61 | chr7 | 150035158 | - | PTPN13 | chr4 | 87612505 | + |
3UTR-intron | ENST00000359623 | ENST00000427191 | LRRC61 | chr7 | 150035158 | - | PTPN13 | chr4 | 87612505 | + |
3UTR-intron | ENST00000359623 | ENST00000436978 | LRRC61 | chr7 | 150035158 | - | PTPN13 | chr4 | 87612505 | + |
3UTR-intron | ENST00000359623 | ENST00000502971 | LRRC61 | chr7 | 150035158 | - | PTPN13 | chr4 | 87612505 | + |
3UTR-intron | ENST00000359623 | ENST00000411767 | LRRC61 | chr7 | 150035158 | - | PTPN13 | chr4 | 87612505 | + |
3UTR-intron | ENST00000359623 | ENST00000316707 | LRRC61 | chr7 | 150035158 | - | PTPN13 | chr4 | 87612505 | + |
3UTR-intron | ENST00000359623 | ENST00000511467 | LRRC61 | chr7 | 150035158 | - | PTPN13 | chr4 | 87612505 | + |
intron-intron | ENST00000493307 | ENST00000427191 | LRRC61 | chr7 | 150035158 | - | PTPN13 | chr4 | 87612505 | + |
intron-intron | ENST00000493307 | ENST00000436978 | LRRC61 | chr7 | 150035158 | - | PTPN13 | chr4 | 87612505 | + |
intron-intron | ENST00000493307 | ENST00000502971 | LRRC61 | chr7 | 150035158 | - | PTPN13 | chr4 | 87612505 | + |
intron-intron | ENST00000493307 | ENST00000411767 | LRRC61 | chr7 | 150035158 | - | PTPN13 | chr4 | 87612505 | + |
intron-intron | ENST00000493307 | ENST00000316707 | LRRC61 | chr7 | 150035158 | - | PTPN13 | chr4 | 87612505 | + |
intron-intron | ENST00000493307 | ENST00000511467 | LRRC61 | chr7 | 150035158 | - | PTPN13 | chr4 | 87612505 | + |
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FusionProtFeatures for LRRC61_PTPN13 |
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Hgene | Tgene |
LRRC61 | PTPN13 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LRRC61_PTPN13 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LRRC61_PTPN13 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LRRC61_PTPN13 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LRRC61_PTPN13 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |