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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20254

FusionGeneSummary for LRRC61_PTPN13

check button Fusion gene summary
Fusion gene informationFusion gene name: LRRC61_PTPN13
Fusion gene ID: 20254
HgeneTgene
Gene symbol

LRRC61

PTPN13

Gene ID

65999

5783

Gene nameleucine rich repeat containing 61protein tyrosine phosphatase, non-receptor type 13
SynonymsHSPC295FAP-1|PNP1|PTP-BAS|PTP-BL|PTP1E|PTPL1|PTPLE|hPTP1E
Cytomap

7q36.1

4q21.3

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeat-containing protein 61tyrosine-protein phosphatase non-receptor type 13fas-associated protein-tyrosine phosphatase 1hPTPE1protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)protein-tyrosine phosphatase 1Eprotein-tyrosine phosphatas
Modification date2018052320180519
UniProtAcc

Q9BV99

Q12923

Ensembl transtripts involved in fusion geneENST00000463441, ENST00000323078, 
ENST00000359623, ENST00000493307, 
ENST00000427191, ENST00000436978, 
ENST00000502971, ENST00000411767, 
ENST00000316707, ENST00000511467, 
Fusion gene scores* DoF score3 X 2 X 3=185 X 8 X 6=240
# samples 311
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(11/240*10)=-1.12553088208386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRRC61 [Title/Abstract] AND PTPN13 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePTPN13

GO:0006470

protein dephosphorylation

17657516

TgenePTPN13

GO:0014066

regulation of phosphatidylinositol 3-kinase signaling

23604317


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU676031LRRC61chr7

150035158

-PTPN13chr4

87612505

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000463441ENST00000427191LRRC61chr7

150035158

-PTPN13chr4

87612505

+
intron-intronENST00000463441ENST00000436978LRRC61chr7

150035158

-PTPN13chr4

87612505

+
intron-intronENST00000463441ENST00000502971LRRC61chr7

150035158

-PTPN13chr4

87612505

+
intron-intronENST00000463441ENST00000411767LRRC61chr7

150035158

-PTPN13chr4

87612505

+
intron-intronENST00000463441ENST00000316707LRRC61chr7

150035158

-PTPN13chr4

87612505

+
intron-intronENST00000463441ENST00000511467LRRC61chr7

150035158

-PTPN13chr4

87612505

+
3UTR-intronENST00000323078ENST00000427191LRRC61chr7

150035158

-PTPN13chr4

87612505

+
3UTR-intronENST00000323078ENST00000436978LRRC61chr7

150035158

-PTPN13chr4

87612505

+
3UTR-intronENST00000323078ENST00000502971LRRC61chr7

150035158

-PTPN13chr4

87612505

+
3UTR-intronENST00000323078ENST00000411767LRRC61chr7

150035158

-PTPN13chr4

87612505

+
3UTR-intronENST00000323078ENST00000316707LRRC61chr7

150035158

-PTPN13chr4

87612505

+
3UTR-intronENST00000323078ENST00000511467LRRC61chr7

150035158

-PTPN13chr4

87612505

+
3UTR-intronENST00000359623ENST00000427191LRRC61chr7

150035158

-PTPN13chr4

87612505

+
3UTR-intronENST00000359623ENST00000436978LRRC61chr7

150035158

-PTPN13chr4

87612505

+
3UTR-intronENST00000359623ENST00000502971LRRC61chr7

150035158

-PTPN13chr4

87612505

+
3UTR-intronENST00000359623ENST00000411767LRRC61chr7

150035158

-PTPN13chr4

87612505

+
3UTR-intronENST00000359623ENST00000316707LRRC61chr7

150035158

-PTPN13chr4

87612505

+
3UTR-intronENST00000359623ENST00000511467LRRC61chr7

150035158

-PTPN13chr4

87612505

+
intron-intronENST00000493307ENST00000427191LRRC61chr7

150035158

-PTPN13chr4

87612505

+
intron-intronENST00000493307ENST00000436978LRRC61chr7

150035158

-PTPN13chr4

87612505

+
intron-intronENST00000493307ENST00000502971LRRC61chr7

150035158

-PTPN13chr4

87612505

+
intron-intronENST00000493307ENST00000411767LRRC61chr7

150035158

-PTPN13chr4

87612505

+
intron-intronENST00000493307ENST00000316707LRRC61chr7

150035158

-PTPN13chr4

87612505

+
intron-intronENST00000493307ENST00000511467LRRC61chr7

150035158

-PTPN13chr4

87612505

+

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FusionProtFeatures for LRRC61_PTPN13


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRRC61

Q9BV99

PTPN13

Q12923


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LRRC61_PTPN13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LRRC61_PTPN13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LRRC61_PTPN13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LRRC61_PTPN13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource