![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 20241 |
FusionGeneSummary for LRRC4_LTA4H |
![]() |
Fusion gene information | Fusion gene name: LRRC4_LTA4H | Fusion gene ID: 20241 | Hgene | Tgene | Gene symbol | LRRC4 | LTA4H | Gene ID | 64101 | 4048 |
Gene name | leucine rich repeat containing 4 | leukotriene A4 hydrolase | |
Synonyms | NAG14|NGL-2 | - | |
Cytomap | 7q32.1 | 12q23.1 | |
Type of gene | protein-coding | protein-coding | |
Description | leucine-rich repeat-containing protein 4brain tumor associated protein LRRC4brain tumor-associated protein BAGnasopharyngeal carcinoma-associated gene 14 proteinnetrin-G2 ligand | leukotriene A-4 hydrolaseLTA-4 hydrolasetesticular secretory protein Li 27 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9HBW1 | P09960 | |
Ensembl transtripts involved in fusion gene | ENST00000249363, | ENST00000228740, ENST00000552789, ENST00000413268, ENST00000548375, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 6 X 3=108 |
# samples | 1 | 5 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/108*10)=-1.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LRRC4 [Title/Abstract] AND LTA4H [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | LTA4H | GO:0019370 | leukotriene biosynthetic process | 9774412|15078870 |
Tgene | LTA4H | GO:0043171 | peptide catabolic process | 9774412|15078870|18804029 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-DX-A3LS-01A | LRRC4 | chr7 | 127668920 | - | LTA4H | chr12 | 96412681 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000249363 | ENST00000228740 | LRRC4 | chr7 | 127668920 | - | LTA4H | chr12 | 96412681 | - |
intron-3CDS | ENST00000249363 | ENST00000552789 | LRRC4 | chr7 | 127668920 | - | LTA4H | chr12 | 96412681 | - |
intron-3CDS | ENST00000249363 | ENST00000413268 | LRRC4 | chr7 | 127668920 | - | LTA4H | chr12 | 96412681 | - |
intron-intron | ENST00000249363 | ENST00000548375 | LRRC4 | chr7 | 127668920 | - | LTA4H | chr12 | 96412681 | - |
Top |
FusionProtFeatures for LRRC4_LTA4H |
![]() |
Hgene | Tgene |
LRRC4 | LTA4H |
Synaptic adhesion protein. Regulates the formation ofexitatory synapses through the recruitment of pre-and-postsynapticproteins. Organize the lamina/pathway-specific differentiation ofdendrites. Plays a important role for auditory synaptic responses.Involved in the suppression of glioma (By similarity).{ECO:0000250}. | Epoxide hydrolase that catalyzes the final step in thebiosynthesis of the proinflammatory mediator leukotriene B4. Hasalso aminopeptidase activity. {ECO:0000269|PubMed:11917124,ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870,ECO:0000269|PubMed:18804029, ECO:0000269|PubMed:1897988,ECO:0000269|PubMed:1975494, ECO:0000269|PubMed:2244921}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for LRRC4_LTA4H |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for LRRC4_LTA4H |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LRRC4 | SPP1, LRRC4C, FAM114A2, TBCD, XPO4, DPP9, KIAA1524, POMT2, TNPO2, MID1, ITGB5, FBXL13 | LTA4H | GH1, MCC, TMEM62, DDA1, UBA5, HDAC5, ELAVL1, SIRT7, TINF2, SIRT1, ZNF593, ALDOA, FKBP2, GALK2, IDH1, PGM1, PRPF4, SPR, TRAP1, NAPRT, TAGLN2, NTRK1, KRAS |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for LRRC4_LTA4H |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | LTA4H | P09960 | DB01197 | Captopril | Leukotriene A-4 hydrolase | small molecule | approved |
Top |
RelatedDiseases for LRRC4_LTA4H |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | LTA4H | C0004153 | Atherosclerosis | 1 | CTD_human |
Tgene | LTA4H | C0011570 | Mental Depression | 1 | PSYGENET |
Tgene | LTA4H | C0011581 | Depressive disorder | 1 | PSYGENET |
Tgene | LTA4H | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |