FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 20241

FusionGeneSummary for LRRC4_LTA4H

check button Fusion gene summary
Fusion gene informationFusion gene name: LRRC4_LTA4H
Fusion gene ID: 20241
HgeneTgene
Gene symbol

LRRC4

LTA4H

Gene ID

64101

4048

Gene nameleucine rich repeat containing 4leukotriene A4 hydrolase
SynonymsNAG14|NGL-2-
Cytomap

7q32.1

12q23.1

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeat-containing protein 4brain tumor associated protein LRRC4brain tumor-associated protein BAGnasopharyngeal carcinoma-associated gene 14 proteinnetrin-G2 ligandleukotriene A-4 hydrolaseLTA-4 hydrolasetesticular secretory protein Li 27
Modification date2018051920180523
UniProtAcc

Q9HBW1

P09960

Ensembl transtripts involved in fusion geneENST00000249363, ENST00000228740, 
ENST00000552789, ENST00000413268, 
ENST00000548375, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 6 X 3=108
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/108*10)=-1.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRRC4 [Title/Abstract] AND LTA4H [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLTA4H

GO:0019370

leukotriene biosynthetic process

9774412|15078870

TgeneLTA4H

GO:0043171

peptide catabolic process

9774412|15078870|18804029


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A3LS-01ALRRC4chr7

127668920

-LTA4Hchr12

96412681

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000249363ENST00000228740LRRC4chr7

127668920

-LTA4Hchr12

96412681

-
intron-3CDSENST00000249363ENST00000552789LRRC4chr7

127668920

-LTA4Hchr12

96412681

-
intron-3CDSENST00000249363ENST00000413268LRRC4chr7

127668920

-LTA4Hchr12

96412681

-
intron-intronENST00000249363ENST00000548375LRRC4chr7

127668920

-LTA4Hchr12

96412681

-

Top

FusionProtFeatures for LRRC4_LTA4H


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRRC4

Q9HBW1

LTA4H

P09960

Synaptic adhesion protein. Regulates the formation ofexitatory synapses through the recruitment of pre-and-postsynapticproteins. Organize the lamina/pathway-specific differentiation ofdendrites. Plays a important role for auditory synaptic responses.Involved in the suppression of glioma (By similarity).{ECO:0000250}. Epoxide hydrolase that catalyzes the final step in thebiosynthesis of the proinflammatory mediator leukotriene B4. Hasalso aminopeptidase activity. {ECO:0000269|PubMed:11917124,ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870,ECO:0000269|PubMed:18804029, ECO:0000269|PubMed:1897988,ECO:0000269|PubMed:1975494, ECO:0000269|PubMed:2244921}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for LRRC4_LTA4H


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for LRRC4_LTA4H


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LRRC4SPP1, LRRC4C, FAM114A2, TBCD, XPO4, DPP9, KIAA1524, POMT2, TNPO2, MID1, ITGB5, FBXL13LTA4HGH1, MCC, TMEM62, DDA1, UBA5, HDAC5, ELAVL1, SIRT7, TINF2, SIRT1, ZNF593, ALDOA, FKBP2, GALK2, IDH1, PGM1, PRPF4, SPR, TRAP1, NAPRT, TAGLN2, NTRK1, KRAS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for LRRC4_LTA4H


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneLTA4HP09960DB01197CaptoprilLeukotriene A-4 hydrolasesmall moleculeapproved

Top

RelatedDiseases for LRRC4_LTA4H


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLTA4HC0004153Atherosclerosis1CTD_human
TgeneLTA4HC0011570Mental Depression1PSYGENET
TgeneLTA4HC0011581Depressive disorder1PSYGENET
TgeneLTA4HC0023893Liver Cirrhosis, Experimental1CTD_human