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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20236

FusionGeneSummary for LRRC41_TAL1

check button Fusion gene summary
Fusion gene informationFusion gene name: LRRC41_TAL1
Fusion gene ID: 20236
HgeneTgene
Gene symbol

LRRC41

TAL1

Gene ID

10489

6886

Gene nameleucine rich repeat containing 41TAL bHLH transcription factor 1, erythroid differentiation factor
SynonymsMUF1|PP7759SCL|TCL5|bHLHa17|tal-1
Cytomap

1p34.1-p33

1p33

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeat-containing protein 41MUF1 protein (MUF1)elongin BC-interacting leucine-rich repeat proteinprotein Muf1T-cell acute lymphocytic leukemia protein 1T-cell acute lymphocytic leukemia 1T-cell leukemia/lymphoma protein 5class A basic helix-loop-helix protein 17stem cell proteintal-1 product
Modification date2018052320180523
UniProtAcc

Q15345

P17542

Ensembl transtripts involved in fusion geneENST00000343304, ENST00000472710, 
ENST00000371884, ENST00000371883, 
ENST00000294339, ENST00000459729, 
Fusion gene scores* DoF score3 X 2 X 3=182 X 2 X 2=8
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: LRRC41 [Title/Abstract] AND TAL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTAL1

GO:0031334

positive regulation of protein complex assembly

20855495

TgeneTAL1

GO:0045648

positive regulation of erythrocyte differentiation

20028976

TgeneTAL1

GO:0045893

positive regulation of transcription, DNA-templated

20028976

TgeneTAL1

GO:0045944

positive regulation of transcription by RNA polymerase II

20855495


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-2026-01ALRRC41chr1

46763235

-TAL1chr1

47695023

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000343304ENST00000371884LRRC41chr1

46763235

-TAL1chr1

47695023

-
5CDS-5UTRENST00000343304ENST00000371883LRRC41chr1

46763235

-TAL1chr1

47695023

-
5CDS-5UTRENST00000343304ENST00000294339LRRC41chr1

46763235

-TAL1chr1

47695023

-
5CDS-intronENST00000343304ENST00000459729LRRC41chr1

46763235

-TAL1chr1

47695023

-
5UTR-5UTRENST00000472710ENST00000371884LRRC41chr1

46763235

-TAL1chr1

47695023

-
5UTR-5UTRENST00000472710ENST00000371883LRRC41chr1

46763235

-TAL1chr1

47695023

-
5UTR-5UTRENST00000472710ENST00000294339LRRC41chr1

46763235

-TAL1chr1

47695023

-
5UTR-intronENST00000472710ENST00000459729LRRC41chr1

46763235

-TAL1chr1

47695023

-

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FusionProtFeatures for LRRC41_TAL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRRC41

Q15345

TAL1

P17542

Probable substrate recognition component of an ECS(Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complexwhich mediates the ubiquitination and subsequent proteasomaldegradation of target proteins. {ECO:0000269|PubMed:15601820}. Implicated in the genesis of hemopoietic malignancies.It may play an important role in hemopoietic differentiation.Serves as a positive regulator of erythroid differentiation (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:1396592}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LRRC41_TAL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LRRC41_TAL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LRRC41RBPMS, MYO9B, TCEB2, TCEB1, CUL5, DCUN1D1, BARD1, NXF1, DRG1, FBL, LIPH, PPP3CC, NTRK1, CPSF3, TEAD2, POU5F1, EXOC8, UNC5CL, ERCC3, TRIM25TAL1LMO2, NCAPG2, EP300, LMO1, PRKCQ, TCF4, GATA3, TCF3, TCF12, GATA1, SSBP1, SSBP2, SSBP3, CBFA2T3, CBFA2T2, HDAC1, HDAC2, TRRAP, BRD1, RCC1, XRCC6, TOP1, PARP1, LDB1, SP1, GATA2, SIN3A, SKP2, STUB1, TRIM27, SUV39H1, SATB1, TRIM33, TAL1, SUPT16H, CDK9, KDM1A, RCOR1, RBBP7, CHD4, CHD3, RB1, RUNX1, LYL1, ZHX1, DRG1, KAT2B, ELSPBP1, HOXB9


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LRRC41_TAL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LRRC41_TAL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTAL1C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma2CTD_human