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Fusion gene ID: 20236 |
FusionGeneSummary for LRRC41_TAL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LRRC41_TAL1 | Fusion gene ID: 20236 | Hgene | Tgene | Gene symbol | LRRC41 | TAL1 | Gene ID | 10489 | 6886 |
| Gene name | leucine rich repeat containing 41 | TAL bHLH transcription factor 1, erythroid differentiation factor | |
| Synonyms | MUF1|PP7759 | SCL|TCL5|bHLHa17|tal-1 | |
| Cytomap | 1p34.1-p33 | 1p33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | leucine-rich repeat-containing protein 41MUF1 protein (MUF1)elongin BC-interacting leucine-rich repeat proteinprotein Muf1 | T-cell acute lymphocytic leukemia protein 1T-cell acute lymphocytic leukemia 1T-cell leukemia/lymphoma protein 5class A basic helix-loop-helix protein 17stem cell proteintal-1 product | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q15345 | P17542 | |
| Ensembl transtripts involved in fusion gene | ENST00000343304, ENST00000472710, | ENST00000371884, ENST00000371883, ENST00000294339, ENST00000459729, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: LRRC41 [Title/Abstract] AND TAL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TAL1 | GO:0031334 | positive regulation of protein complex assembly | 20855495 |
| Tgene | TAL1 | GO:0045648 | positive regulation of erythrocyte differentiation | 20028976 |
| Tgene | TAL1 | GO:0045893 | positive regulation of transcription, DNA-templated | 20028976 |
| Tgene | TAL1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 20855495 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-24-2026-01A | LRRC41 | chr1 | 46763235 | - | TAL1 | chr1 | 47695023 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000343304 | ENST00000371884 | LRRC41 | chr1 | 46763235 | - | TAL1 | chr1 | 47695023 | - |
| 5CDS-5UTR | ENST00000343304 | ENST00000371883 | LRRC41 | chr1 | 46763235 | - | TAL1 | chr1 | 47695023 | - |
| 5CDS-5UTR | ENST00000343304 | ENST00000294339 | LRRC41 | chr1 | 46763235 | - | TAL1 | chr1 | 47695023 | - |
| 5CDS-intron | ENST00000343304 | ENST00000459729 | LRRC41 | chr1 | 46763235 | - | TAL1 | chr1 | 47695023 | - |
| 5UTR-5UTR | ENST00000472710 | ENST00000371884 | LRRC41 | chr1 | 46763235 | - | TAL1 | chr1 | 47695023 | - |
| 5UTR-5UTR | ENST00000472710 | ENST00000371883 | LRRC41 | chr1 | 46763235 | - | TAL1 | chr1 | 47695023 | - |
| 5UTR-5UTR | ENST00000472710 | ENST00000294339 | LRRC41 | chr1 | 46763235 | - | TAL1 | chr1 | 47695023 | - |
| 5UTR-intron | ENST00000472710 | ENST00000459729 | LRRC41 | chr1 | 46763235 | - | TAL1 | chr1 | 47695023 | - |
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FusionProtFeatures for LRRC41_TAL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LRRC41 | TAL1 |
| Probable substrate recognition component of an ECS(Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complexwhich mediates the ubiquitination and subsequent proteasomaldegradation of target proteins. {ECO:0000269|PubMed:15601820}. | Implicated in the genesis of hemopoietic malignancies.It may play an important role in hemopoietic differentiation.Serves as a positive regulator of erythroid differentiation (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:1396592}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LRRC41_TAL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LRRC41_TAL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LRRC41 | RBPMS, MYO9B, TCEB2, TCEB1, CUL5, DCUN1D1, BARD1, NXF1, DRG1, FBL, LIPH, PPP3CC, NTRK1, CPSF3, TEAD2, POU5F1, EXOC8, UNC5CL, ERCC3, TRIM25 | TAL1 | LMO2, NCAPG2, EP300, LMO1, PRKCQ, TCF4, GATA3, TCF3, TCF12, GATA1, SSBP1, SSBP2, SSBP3, CBFA2T3, CBFA2T2, HDAC1, HDAC2, TRRAP, BRD1, RCC1, XRCC6, TOP1, PARP1, LDB1, SP1, GATA2, SIN3A, SKP2, STUB1, TRIM27, SUV39H1, SATB1, TRIM33, TAL1, SUPT16H, CDK9, KDM1A, RCOR1, RBBP7, CHD4, CHD3, RB1, RUNX1, LYL1, ZHX1, DRG1, KAT2B, ELSPBP1, HOXB9 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LRRC41_TAL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LRRC41_TAL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | TAL1 | C1961099 | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 2 | CTD_human |
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