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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20221

FusionGeneSummary for LRRC29_TMC5

check button Fusion gene summary
Fusion gene informationFusion gene name: LRRC29_TMC5
Fusion gene ID: 20221
HgeneTgene
Gene symbol

LRRC29

TMC5

Gene ID

26231

79838

Gene nameleucine rich repeat containing 29transmembrane channel like 5
SynonymsFBL9|FBXL9-
Cytomap

16q22.1

16p12.3

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeat-containing protein 29F-box and leucine-rich repeat protein 9F-box protein FBL9F-box/LRR-repeat protein 9transmembrane channel-like protein 5
Modification date2018052320180523
UniProtAcc

Q8WV35

Q6UXY8

Ensembl transtripts involved in fusion geneENST00000409509, ENST00000409037, 
ENST00000393992, ENST00000341546, 
ENST00000462169, 		ENST00000563675, 
ENST00000541464, ENST00000381414, 
ENST00000396229, ENST00000542583, 
ENST00000219821, ENST00000561503, 
ENST00000564959, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 8 X 3=144
# samples 17
** MAII scorelog2(1/1*10)=3.32192809488736log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRRC29 [Title/Abstract] AND TMC5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF372779LRRC29chr16

67259805

-TMC5chr16

19490317

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000409509ENST00000563675LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000409509ENST00000541464LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000409509ENST00000381414LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000409509ENST00000396229LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000409509ENST00000542583LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000409509ENST00000219821LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000409509ENST00000561503LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000409509ENST00000564959LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000409037ENST00000563675LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000409037ENST00000541464LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000409037ENST00000381414LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000409037ENST00000396229LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000409037ENST00000542583LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000409037ENST00000219821LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000409037ENST00000561503LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000409037ENST00000564959LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000393992ENST00000563675LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000393992ENST00000541464LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000393992ENST00000381414LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000393992ENST00000396229LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000393992ENST00000542583LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000393992ENST00000219821LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000393992ENST00000561503LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000393992ENST00000564959LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000341546ENST00000563675LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000341546ENST00000541464LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000341546ENST00000381414LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000341546ENST00000396229LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000341546ENST00000542583LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000341546ENST00000219821LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000341546ENST00000561503LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000341546ENST00000564959LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000462169ENST00000563675LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000462169ENST00000541464LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000462169ENST00000381414LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000462169ENST00000396229LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000462169ENST00000542583LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000462169ENST00000219821LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000462169ENST00000561503LRRC29chr16

67259805

-TMC5chr16

19490317

+
intron-intronENST00000462169ENST00000564959LRRC29chr16

67259805

-TMC5chr16

19490317

+

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FusionProtFeatures for LRRC29_TMC5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRRC29

Q8WV35

TMC5

Q6UXY8

Probably recognizes and binds to some phosphorylatedproteins and promotes their ubiquitination and degradation. Probable ion channel. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LRRC29_TMC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LRRC29_TMC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LRRC29_TMC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LRRC29_TMC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource