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Fusion gene ID: 20185 |
FusionGeneSummary for LRPAP1_LRPAP1 |
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Fusion gene information | Fusion gene name: LRPAP1_LRPAP1 | Fusion gene ID: 20185 | Hgene | Tgene | Gene symbol | LRPAP1 | LRPAP1 | Gene ID | 4043 | 4043 |
Gene name | LDL receptor related protein associated protein 1 | LDL receptor related protein associated protein 1 | |
Synonyms | A2MRAP|A2RAP|HBP44|MRAP|MYP23|RAP|alpha-2-MRAP | A2MRAP|A2RAP|HBP44|MRAP|MYP23|RAP|alpha-2-MRAP | |
Cytomap | 4p16.3 | 4p16.3 | |
Type of gene | protein-coding | protein-coding | |
Description | alpha-2-macroglobulin receptor-associated protein39 kDa receptor-associated proteinlow density lipoprotein receptor-related protein associated protein 1low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associa | alpha-2-macroglobulin receptor-associated protein39 kDa receptor-associated proteinlow density lipoprotein receptor-related protein associated protein 1low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associa | |
Modification date | 20180522 | 20180522 | |
UniProtAcc | P30533 | P30533 | |
Ensembl transtripts involved in fusion gene | ENST00000500728, ENST00000296325, | ENST00000500728, ENST00000296325, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 2 X 2 X 2=8 |
# samples | 3 | 2 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: LRPAP1 [Title/Abstract] AND LRPAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LRPAP1 | GO:0010916 | negative regulation of very-low-density lipoprotein particle clearance | 8083232 |
Hgene | LRPAP1 | GO:0032091 | negative regulation of protein binding | 8083232 |
Hgene | LRPAP1 | GO:0048259 | regulation of receptor-mediated endocytosis | 7774585 |
Tgene | LRPAP1 | GO:0010916 | negative regulation of very-low-density lipoprotein particle clearance | 8083232 |
Tgene | LRPAP1 | GO:0032091 | negative regulation of protein binding | 8083232 |
Tgene | LRPAP1 | GO:0048259 | regulation of receptor-mediated endocytosis | 7774585 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI470190 | LRPAP1 | chr4 | 3514450 | + | LRPAP1 | chr4 | 3514563 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000500728 | ENST00000500728 | LRPAP1 | chr4 | 3514450 | + | LRPAP1 | chr4 | 3514563 | - |
intron-intron | ENST00000500728 | ENST00000296325 | LRPAP1 | chr4 | 3514450 | + | LRPAP1 | chr4 | 3514563 | - |
intron-3UTR | ENST00000296325 | ENST00000500728 | LRPAP1 | chr4 | 3514450 | + | LRPAP1 | chr4 | 3514563 | - |
intron-intron | ENST00000296325 | ENST00000296325 | LRPAP1 | chr4 | 3514450 | + | LRPAP1 | chr4 | 3514563 | - |
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FusionProtFeatures for LRPAP1_LRPAP1 |
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Hgene | Tgene |
LRPAP1 | LRPAP1 |
Molecular chaperone for LDL receptor-related proteinsthat may regulate their ligand binding activity along thesecretory pathway. {ECO:0000269|PubMed:7774585}. | Molecular chaperone for LDL receptor-related proteinsthat may regulate their ligand binding activity along thesecretory pathway. {ECO:0000269|PubMed:7774585}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LRPAP1_LRPAP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LRPAP1_LRPAP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LRPAP1_LRPAP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LRPAP1_LRPAP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |