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Fusion gene ID: 20184 |
FusionGeneSummary for LRPAP1_HNRNPM |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LRPAP1_HNRNPM | Fusion gene ID: 20184 | Hgene | Tgene | Gene symbol | LRPAP1 | HNRNPM | Gene ID | 4043 | 4670 |
| Gene name | LDL receptor related protein associated protein 1 | heterogeneous nuclear ribonucleoprotein M | |
| Synonyms | A2MRAP|A2RAP|HBP44|MRAP|MYP23|RAP|alpha-2-MRAP | CEAR|HNRNPM4|HNRPM|HNRPM4|HTGR1|NAGR1|hnRNP M | |
| Cytomap | 4p16.3 | 19p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | alpha-2-macroglobulin receptor-associated protein39 kDa receptor-associated proteinlow density lipoprotein receptor-related protein associated protein 1low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associa | heterogeneous nuclear ribonucleoprotein MCEA receptorN-acetylglucosamine receptor 1heterogenous nuclear ribonucleoprotein M4hnRNA-binding protein M4 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P30533 | P52272 | |
| Ensembl transtripts involved in fusion gene | ENST00000500728, ENST00000296325, | ENST00000348943, ENST00000325495, ENST00000602219, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 12 X 13 X 4=624 |
| # samples | 3 | 14 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(14/624*10)=-2.15611920191728 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LRPAP1 [Title/Abstract] AND HNRNPM [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LRPAP1 | GO:0010916 | negative regulation of very-low-density lipoprotein particle clearance | 8083232 |
| Hgene | LRPAP1 | GO:0032091 | negative regulation of protein binding | 8083232 |
| Hgene | LRPAP1 | GO:0048259 | regulation of receptor-mediated endocytosis | 7774585 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AL046867 | LRPAP1 | chr4 | 3514690 | - | HNRNPM | chr19 | 8551251 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000500728 | ENST00000348943 | LRPAP1 | chr4 | 3514690 | - | HNRNPM | chr19 | 8551251 | + |
| intron-3CDS | ENST00000500728 | ENST00000325495 | LRPAP1 | chr4 | 3514690 | - | HNRNPM | chr19 | 8551251 | + |
| intron-intron | ENST00000500728 | ENST00000602219 | LRPAP1 | chr4 | 3514690 | - | HNRNPM | chr19 | 8551251 | + |
| intron-3CDS | ENST00000296325 | ENST00000348943 | LRPAP1 | chr4 | 3514690 | - | HNRNPM | chr19 | 8551251 | + |
| intron-3CDS | ENST00000296325 | ENST00000325495 | LRPAP1 | chr4 | 3514690 | - | HNRNPM | chr19 | 8551251 | + |
| intron-intron | ENST00000296325 | ENST00000602219 | LRPAP1 | chr4 | 3514690 | - | HNRNPM | chr19 | 8551251 | + |
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FusionProtFeatures for LRPAP1_HNRNPM |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LRPAP1 | HNRNPM |
| Molecular chaperone for LDL receptor-related proteinsthat may regulate their ligand binding activity along thesecretory pathway. {ECO:0000269|PubMed:7774585}. | Pre-mRNA binding protein in vivo, binds avidly topoly(G) and poly(U) RNA homopolymers in vitro. Involved insplicing. Acts as a receptor for carcinoembryonic antigen inKupffer cells, may initiate a series of signaling events leadingto tyrosine phosphorylation of proteins and induction of IL-1alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LRPAP1_HNRNPM |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LRPAP1_HNRNPM |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LRPAP1_HNRNPM |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LRPAP1_HNRNPM |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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