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Fusion gene ID: 20167 |
FusionGeneSummary for LRP5_VPS26B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LRP5_VPS26B | Fusion gene ID: 20167 | Hgene | Tgene | Gene symbol | LRP5 | VPS26B | Gene ID | 4041 | 112936 |
| Gene name | LDL receptor related protein 5 | VPS26, retromer complex component B | |
| Synonyms | BMND1|EVR1|EVR4|HBM|LR3|LRP-5|LRP7|OPPG|OPS|OPTA1|PCLD4|VBCH2 | Pep8b | |
| Cytomap | 11q13.2 | 11q25 | |
| Type of gene | protein-coding | protein-coding | |
| Description | low-density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 7 | vacuolar protein sorting-associated protein 26Bvesicle protein sorting 26B | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O75197 | Q4G0F5 | |
| Ensembl transtripts involved in fusion gene | ENST00000294304, ENST00000529481, | ENST00000281187, ENST00000525095, ENST00000530402, | |
| Fusion gene scores | * DoF score | 21 X 16 X 9=3024 | 3 X 3 X 2=18 |
| # samples | 22 | 3 | |
| ** MAII score | log2(22/3024*10)=-3.78088271069641 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: LRP5 [Title/Abstract] AND VPS26B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LRP5 | GO:0008284 | positive regulation of cell proliferation | 9790987 |
| Hgene | LRP5 | GO:0016055 | Wnt signaling pathway | 17955262 |
| Hgene | LRP5 | GO:0044332 | Wnt signaling pathway involved in dorsal/ventral axis specification | 11029007 |
| Hgene | LRP5 | GO:0045840 | positive regulation of mitotic nuclear division | 9790987 |
| Hgene | LRP5 | GO:0045893 | positive regulation of transcription, DNA-templated | 15035989|17955262 |
| Hgene | LRP5 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12857724 |
| Hgene | LRP5 | GO:0060070 | canonical Wnt signaling pathway | 12121999|12857724|15035989 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-73-4658-01A | LRP5 | chr11 | 68181480 | + | VPS26B | chr11 | 134114832 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000294304 | ENST00000281187 | LRP5 | chr11 | 68181480 | + | VPS26B | chr11 | 134114832 | + |
| In-frame | ENST00000294304 | ENST00000525095 | LRP5 | chr11 | 68181480 | + | VPS26B | chr11 | 134114832 | + |
| 5CDS-intron | ENST00000294304 | ENST00000530402 | LRP5 | chr11 | 68181480 | + | VPS26B | chr11 | 134114832 | + |
| intron-3CDS | ENST00000529481 | ENST00000281187 | LRP5 | chr11 | 68181480 | + | VPS26B | chr11 | 134114832 | + |
| intron-3CDS | ENST00000529481 | ENST00000525095 | LRP5 | chr11 | 68181480 | + | VPS26B | chr11 | 134114832 | + |
| intron-intron | ENST00000529481 | ENST00000530402 | LRP5 | chr11 | 68181480 | + | VPS26B | chr11 | 134114832 | + |
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FusionProtFeatures for LRP5_VPS26B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LRP5 | VPS26B |
| Component of the Wnt-Fzd-LRP5-LRP6 complex that triggersbeta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surfacecoreceptor of Wnt/beta-catenin signaling, which plays a pivotalrole in bone formation. Plays a role in norrin (NDP) signaltransduction (PubMed:27228167). The Wnt-induced Fzd/LRP6coreceptor complex recruits DVL1 polymers to the plasma membranewhich, in turn, recruits the AXIN1/GSK3B-complex to the cellsurface promoting the formation of signalsomes and inhibitingAXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascularregression in the eye (By similarity). Required for posteriorpatterning of the epiblast during gastrulation (By similarity).{ECO:0000250|UniProtKB:Q91VN0, ECO:0000269|PubMed:11336703,ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:14727154,ECO:0000269|PubMed:14731402, ECO:0000269|PubMed:15778503,ECO:0000269|PubMed:27228167}. | Acts as component of the retromer cargo-selectivecomplex (CSC). The CSC is believed to be the core functionalcomponent of retromer or respective retromer complex variantsacting to prevent missorting of selected transmembrane cargoproteins into the lysosomal degradation pathway. The recruitmentof the CSC to the endosomal membrane involves RAB7A and SNX3. TheSNX-BAR retromer mediates retrograde transport of cargo proteinsfrom endosomes to the trans-Golgi network (TGN) and is involved inendosome-to-plasma membrane transport for cargo protein recycling.The SNX3-retromer mediates the retrograde transport of WLSdistinct from the SNX-BAR retromer pathway. The SNX27-retromer isbelieved to be involved in endosome-to-plasma membrane traffickingand recycling of a broad spectrum of cargo proteins. The CSC seemsto act as recruitment hub for other proteins, such as the WASHcomplex and TBC1D5. May be involved in retrograde transport ofSORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27mediated endocytic recycling of SLC2A1/GLUT1 (By similarity).{ECO:0000250|UniProtKB:O75436, ECO:0000250|UniProtKB:Q8C0E2}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 295_337 | 942 | 1616 | Domain | Note=EGF-like 1 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 601_641 | 942 | 1616 | Domain | Note=EGF-like 2 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 902_942 | 942 | 1616 | Domain | Note=EGF-like 3 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 32_288 | 942 | 1616 | Region | Note=Beta-propeller 1 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 341_602 | 942 | 1616 | Region | Note=Beta-propeller 2 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 644_903 | 942 | 1616 | Region | Note=Beta-propeller 3 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 120_162 | 942 | 1616 | Repeat | Note=LDL-receptor class B 2 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 123_126 | 942 | 1616 | Repeat | Note=YWTD 2 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 163_206 | 942 | 1616 | Repeat | Note=LDL-receptor class B 3 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 166_169 | 942 | 1616 | Repeat | Note=YWTD 3 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 207_247 | 942 | 1616 | Repeat | Note=LDL-receptor class B 4 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 248_290 | 942 | 1616 | Repeat | Note=LDL-receptor class B 5 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 251_254 | 942 | 1616 | Repeat | Note=YWTD 4 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 385_427 | 942 | 1616 | Repeat | Note=LDL-receptor class B 6 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 388_391 | 942 | 1616 | Repeat | Note=YWTD 5 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 428_470 | 942 | 1616 | Repeat | Note=LDL-receptor class B 7 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 431_434 | 942 | 1616 | Repeat | Note=YWTD 6 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 471_514 | 942 | 1616 | Repeat | Note=LDL-receptor class B 8 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 474_477 | 942 | 1616 | Repeat | Note=YWTD 7 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 515_557 | 942 | 1616 | Repeat | Note=LDL-receptor class B 9 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 558_600 | 942 | 1616 | Repeat | Note=LDL-receptor class B 10 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 559_562 | 942 | 1616 | Repeat | Note=YWTD 8 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 687_729 | 942 | 1616 | Repeat | Note=LDL-receptor class B 11 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 690_693 | 942 | 1616 | Repeat | Note=YWTD 9 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 730_772 | 942 | 1616 | Repeat | Note=LDL-receptor class B 12 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 75_119 | 942 | 1616 | Repeat | Note=LDL-receptor class B 1 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 773_815 | 942 | 1616 | Repeat | Note=LDL-receptor class B 13 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 78_81 | 942 | 1616 | Repeat | Note=YWTD 1 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 816_855 | 942 | 1616 | Repeat | Note=LDL-receptor class B 14 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 819_822 | 942 | 1616 | Repeat | Note=YWTD 10 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 856_898 | 942 | 1616 | Repeat | Note=LDL-receptor class B 15 |
| Hgene | LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 859_862 | 942 | 1616 | Repeat | Note=YWTD 11 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 1495_1610 | 942 | 1616 | Compositional bias | Note=Pro-rich |
| Hgene | >LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 1213_1254 | 942 | 1616 | Domain | Note=EGF-like 4 |
| Hgene | >LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 1258_1296 | 942 | 1616 | Domain | LDL-receptor class A 1 |
| Hgene | >LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 1297_1333 | 942 | 1616 | Domain | LDL-receptor class A 2 |
| Hgene | >LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 1335_1371 | 942 | 1616 | Domain | LDL-receptor class A 3 |
| Hgene | >LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 1500_1506 | 942 | 1616 | Motif | Note=PPPSP motif A |
| Hgene | >LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 1538_1545 | 942 | 1616 | Motif | Note=PPPSP motif B |
| Hgene | >LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 1574_1581 | 942 | 1616 | Motif | Note=PPPSP motif C |
| Hgene | >LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 1591_1596 | 942 | 1616 | Motif | Note=PPPSP motif D |
| Hgene | >LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 1605_1612 | 942 | 1616 | Motif | Note=PPPSP motif E |
| Hgene | >LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 945_1212 | 942 | 1616 | Region | Note=Beta-propeller 4 |
| Hgene | >LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 1036_1078 | 942 | 1616 | Repeat | Note=LDL-receptor class B 17 |
| Hgene | >LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 1079_1123 | 942 | 1616 | Repeat | Note=LDL-receptor class B 18 |
| Hgene | >LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 1124_1164 | 942 | 1616 | Repeat | Note=LDL-receptor class B 19 |
| Hgene | >LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 1165_1207 | 942 | 1616 | Repeat | Note=LDL-receptor class B 20 |
| Hgene | >LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 989_1035 | 942 | 1616 | Repeat | Note=LDL-receptor class B 16 |
| Hgene | >LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 1408_1615 | 942 | 1616 | Topological domain | Cytoplasmic |
| Hgene | >LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 32_1384 | 942 | 1616 | Topological domain | Extracellular |
| Hgene | >LRP5 | chr11:68181480 | chr11:134114832 | ENST00000294304 | + | 12 | 23 | 1385_1407 | 942 | 1616 | Transmembrane | Helical |
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FusionGeneSequence for LRP5_VPS26B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_LRP5_ENST00000294304_chr11_68181480_+_VPS26B_ENST00000281187_chr11_134114832_+_1039aa MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQT YLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAG MDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGK RKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTP DFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR KILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTL LEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIG LELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYP EGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLT IDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ DGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSRESIPIRLFLAGYELTPTMRDINKKFSVRYYLNLVLIDEEERRYFKQQ >In-frame_LRP5_ENST00000294304_chr11_68181480_+_VPS26B_ENST00000525095_chr11_134114832_+_1039aa MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQT YLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAG MDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGK RKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTP DFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR KILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTL LEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIG LELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYP EGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLT IDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ DGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSRESIPIRLFLAGYELTPTMRDINKKFSVRYYLNLVLIDEEERRYFKQQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_LRP5_ENST00000294304_chr11_68181480_+_VPS26B_ENST00000281187_chr11_134114832_+_3117nt ATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTGCCCGGCCCCCGCCGCG GCCTCGCCGCTCCTGCTATTTGCCAACCGCCGGGACGTACGGCTGGTGGACGCCGGCGGAGTCAAGCTGGAGTCCACCATCGTGGTCAGC GGCCTGGAGGATGCGGCCGCAGTGGACTTCCAGTTTTCCAAGGGAGCCGTGTACTGGACAGACGTGAGCGAGGAGGCCATCAAGCAGACC TACCTGAACCAGACGGGGGCCGCCGTGCAGAACGTGGTCATCTCCGGCCTGGTCTCTCCCGACGGCCTCGCCTGCGACTGGGTGGGCAAG AAGCTGTACTGGACGGACTCAGAGACCAACCGCATCGAGGTGGCCAACCTCAATGGCACATCCCGGAAGGTGCTCTTCTGGCAGGACCTT GACCAGCCGAGGGCCATCGCCTTGGACCCCGCTCACGGGTACATGTACTGGACAGACTGGGGTGAGACGCCCCGGATTGAGCGGGCAGGG ATGGATGGCAGCACCCGGAAGATCATTGTGGACTCGGACATTTACTGGCCCAATGGACTGACCATCGACCTGGAGGAGCAGAAGCTCTAC TGGGCTGACGCCAAGCTCAGCTTCATCCACCGTGCCAACCTGGACGGCTCGTTCCGGCAGAAGGTGGTGGAGGGCAGCCTGACGCACCCC TTCGCCCTGACGCTCTCCGGGGACACTCTGTACTGGACAGACTGGCAGACCCGCTCCATCCATGCCTGCAACAAGCGCACTGGGGGGAAG AGGAAGGAGATCCTGAGTGCCCTCTACTCACCCATGGACATCCAGGTGCTGAGCCAGGAGCGGCAGCCTTTCTTCCACACTCGCTGTGAG GAGGACAATGGCGGCTGCTCCCACCTGTGCCTGCTGTCCCCAAGCGAGCCTTTCTACACATGCGCCTGCCCCACGGGTGTGCAGCTGCAG GACAACGGCAGGACGTGTAAGGCAGGAGCCGAGGAGGTGCTGCTGCTGGCCCGGCGGACGGACCTACGGAGGATCTCGCTGGACACGCCG GACTTCACCGACATCGTGCTGCAGGTGGACGACATCCGGCACGCCATTGCCATCGACTACGACCCGCTAGAGGGCTATGTCTACTGGACA GATGACGAGGTGCGGGCCATCCGCAGGGCGTACCTGGACGGGTCTGGGGCGCAGACGCTGGTCAACACCGAGATCAACGACCCCGATGGC ATCGCGGTCGACTGGGTGGCCCGAAACCTCTACTGGACCGACACGGGCACGGACCGCATCGAGGTGACGCGCCTCAACGGCACCTCCCGC AAGATCCTGGTGTCGGAGGACCTGGACGAGCCCCGAGCCATCGCACTGCACCCCGTGATGGGCCTCATGTACTGGACAGACTGGGGAGAG AACCCTAAAATCGAGTGTGCCAACTTGGATGGGCAGGAGCGGCGTGTGCTGGTCAATGCCTCCCTCGGGTGGCCCAACGGCCTGGCCCTG GACCTGCAGGAGGGGAAGCTCTACTGGGGAGACGCCAAGACAGACAAGATCGAGGTGATCAATGTTGATGGGACGAAGAGGCGGACCCTC CTGGAGGACAAGCTCCCGCACATTTTTGGGTTCACGCTGCTGGGGGACTTCATCTACTGGACTGACTGGCAGCGCCGCAGCATCGAGCGG GTGCACAAGGTCAAGGCCAGCCGGGACGTCATCATTGACCAGCTGCCCGACCTGATGGGGCTCAAAGCTGTGAATGTGGCCAAGGTCGTC GGAACCAACCCGTGTGCGGACAGGAACGGGGGGTGCAGCCACCTGTGCTTCTTCACACCCCACGCAACCCGGTGTGGCTGCCCCATCGGC CTGGAGCTGCTGAGTGACATGAAGACCTGCATCGTGCCTGAGGCCTTCTTGGTCTTCACCAGCAGAGCCGCCATCCACAGGATCTCCCTC GAGACCAATAACAACGACGTGGCCATCCCGCTCACGGGCGTCAAGGAGGCCTCAGCCCTGGACTTTGATGTGTCCAACAACCACATCTAC TGGACAGACGTCAGCCTGAAGACCATCAGCCGCGCCTTCATGAACGGGAGCTCGGTGGAGCACGTGGTGGAGTTTGGCCTTGACTACCCC GAGGGCATGGCCGTTGACTGGATGGGCAAGAACCTCTACTGGGCCGACACTGGGACCAACAGAATCGAAGTGGCGCGGCTGGACGGGCAG TTCCGGCAAGTCCTCGTGTGGAGGGACTTGGACAACCCGAGGTCGCTGGCCCTGGATCCCACCAAGGGCTACATCTACTGGACCGAGTGG GGCGGCAAGCCGAGGATCGTGCGGGCCTTCATGGACGGGACCAACTGCATGACGCTGGTGGACAAGGTGGGCCGGGCCAACGACCTCACC ATTGACTACGCTGACCAGCGCCTCTACTGGACCGACCTGGACACCAACATGATCGAGTCGTCCAACATGCTGGGTCAGGAGCGGGTCGTG ATTGCCGACGATCTCCCGCACCCGTTCGGTCTGACGCAGTACAGCGATTATATCTACTGGACAGACTGGAATCTGCACAGCATTGAGCGG GCCGACAAGACTAGCGGCCGGAACCGCACCCTCATCCAGGGCCACCTGGACTTCGTGATGGACATCCTGGTGTTCCACTCCTCCCGCCAG GATGGCCTCAATGACTGTATGCACAACAACGGGCAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCGCTGCGGCTGCGCCTCA CACTACACCCTGGACCCCAGCAGCCGCAACTGCAGCCGAGAGTCCATCCCGATCCGGCTCTTCCTGGCCGGGTATGAGCTCACGCCCACC ATGCGGGACATCAACAAGAAGTTCTCTGTGCGCTATTACCTCAACCTGGTGCTGATAGACGAGGAGGAGCGGCGCTACTTCAAGCAGCAG GAAGTGGTGTTGTGGCGGAAGGGTGACATCGTACGGAAGAGCATGTCCCACCAGGCGGCCATCGCCTCACAGCGCTTTGAGGGCACCACC >In-frame_LRP5_ENST00000294304_chr11_68181480_+_VPS26B_ENST00000525095_chr11_134114832_+_3117nt ATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTGCCCGGCCCCCGCCGCG GCCTCGCCGCTCCTGCTATTTGCCAACCGCCGGGACGTACGGCTGGTGGACGCCGGCGGAGTCAAGCTGGAGTCCACCATCGTGGTCAGC GGCCTGGAGGATGCGGCCGCAGTGGACTTCCAGTTTTCCAAGGGAGCCGTGTACTGGACAGACGTGAGCGAGGAGGCCATCAAGCAGACC TACCTGAACCAGACGGGGGCCGCCGTGCAGAACGTGGTCATCTCCGGCCTGGTCTCTCCCGACGGCCTCGCCTGCGACTGGGTGGGCAAG AAGCTGTACTGGACGGACTCAGAGACCAACCGCATCGAGGTGGCCAACCTCAATGGCACATCCCGGAAGGTGCTCTTCTGGCAGGACCTT GACCAGCCGAGGGCCATCGCCTTGGACCCCGCTCACGGGTACATGTACTGGACAGACTGGGGTGAGACGCCCCGGATTGAGCGGGCAGGG ATGGATGGCAGCACCCGGAAGATCATTGTGGACTCGGACATTTACTGGCCCAATGGACTGACCATCGACCTGGAGGAGCAGAAGCTCTAC TGGGCTGACGCCAAGCTCAGCTTCATCCACCGTGCCAACCTGGACGGCTCGTTCCGGCAGAAGGTGGTGGAGGGCAGCCTGACGCACCCC TTCGCCCTGACGCTCTCCGGGGACACTCTGTACTGGACAGACTGGCAGACCCGCTCCATCCATGCCTGCAACAAGCGCACTGGGGGGAAG AGGAAGGAGATCCTGAGTGCCCTCTACTCACCCATGGACATCCAGGTGCTGAGCCAGGAGCGGCAGCCTTTCTTCCACACTCGCTGTGAG GAGGACAATGGCGGCTGCTCCCACCTGTGCCTGCTGTCCCCAAGCGAGCCTTTCTACACATGCGCCTGCCCCACGGGTGTGCAGCTGCAG GACAACGGCAGGACGTGTAAGGCAGGAGCCGAGGAGGTGCTGCTGCTGGCCCGGCGGACGGACCTACGGAGGATCTCGCTGGACACGCCG GACTTCACCGACATCGTGCTGCAGGTGGACGACATCCGGCACGCCATTGCCATCGACTACGACCCGCTAGAGGGCTATGTCTACTGGACA GATGACGAGGTGCGGGCCATCCGCAGGGCGTACCTGGACGGGTCTGGGGCGCAGACGCTGGTCAACACCGAGATCAACGACCCCGATGGC ATCGCGGTCGACTGGGTGGCCCGAAACCTCTACTGGACCGACACGGGCACGGACCGCATCGAGGTGACGCGCCTCAACGGCACCTCCCGC AAGATCCTGGTGTCGGAGGACCTGGACGAGCCCCGAGCCATCGCACTGCACCCCGTGATGGGCCTCATGTACTGGACAGACTGGGGAGAG AACCCTAAAATCGAGTGTGCCAACTTGGATGGGCAGGAGCGGCGTGTGCTGGTCAATGCCTCCCTCGGGTGGCCCAACGGCCTGGCCCTG GACCTGCAGGAGGGGAAGCTCTACTGGGGAGACGCCAAGACAGACAAGATCGAGGTGATCAATGTTGATGGGACGAAGAGGCGGACCCTC CTGGAGGACAAGCTCCCGCACATTTTTGGGTTCACGCTGCTGGGGGACTTCATCTACTGGACTGACTGGCAGCGCCGCAGCATCGAGCGG GTGCACAAGGTCAAGGCCAGCCGGGACGTCATCATTGACCAGCTGCCCGACCTGATGGGGCTCAAAGCTGTGAATGTGGCCAAGGTCGTC GGAACCAACCCGTGTGCGGACAGGAACGGGGGGTGCAGCCACCTGTGCTTCTTCACACCCCACGCAACCCGGTGTGGCTGCCCCATCGGC CTGGAGCTGCTGAGTGACATGAAGACCTGCATCGTGCCTGAGGCCTTCTTGGTCTTCACCAGCAGAGCCGCCATCCACAGGATCTCCCTC GAGACCAATAACAACGACGTGGCCATCCCGCTCACGGGCGTCAAGGAGGCCTCAGCCCTGGACTTTGATGTGTCCAACAACCACATCTAC TGGACAGACGTCAGCCTGAAGACCATCAGCCGCGCCTTCATGAACGGGAGCTCGGTGGAGCACGTGGTGGAGTTTGGCCTTGACTACCCC GAGGGCATGGCCGTTGACTGGATGGGCAAGAACCTCTACTGGGCCGACACTGGGACCAACAGAATCGAAGTGGCGCGGCTGGACGGGCAG TTCCGGCAAGTCCTCGTGTGGAGGGACTTGGACAACCCGAGGTCGCTGGCCCTGGATCCCACCAAGGGCTACATCTACTGGACCGAGTGG GGCGGCAAGCCGAGGATCGTGCGGGCCTTCATGGACGGGACCAACTGCATGACGCTGGTGGACAAGGTGGGCCGGGCCAACGACCTCACC ATTGACTACGCTGACCAGCGCCTCTACTGGACCGACCTGGACACCAACATGATCGAGTCGTCCAACATGCTGGGTCAGGAGCGGGTCGTG ATTGCCGACGATCTCCCGCACCCGTTCGGTCTGACGCAGTACAGCGATTATATCTACTGGACAGACTGGAATCTGCACAGCATTGAGCGG GCCGACAAGACTAGCGGCCGGAACCGCACCCTCATCCAGGGCCACCTGGACTTCGTGATGGACATCCTGGTGTTCCACTCCTCCCGCCAG GATGGCCTCAATGACTGTATGCACAACAACGGGCAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCGCTGCGGCTGCGCCTCA CACTACACCCTGGACCCCAGCAGCCGCAACTGCAGCCGAGAGTCCATCCCGATCCGGCTCTTCCTGGCCGGGTATGAGCTCACGCCCACC ATGCGGGACATCAACAAGAAGTTCTCTGTGCGCTATTACCTCAACCTGGTGCTGATAGACGAGGAGGAGCGGCGCTACTTCAAGCAGCAG GAAGTGGTGTTGTGGCGGAAGGGTGACATCGTACGGAAGAGCATGTCCCACCAGGCGGCCATCGCCTCACAGCGCTTTGAGGGCACCACC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_LRP5_ENST00000294304_chr11_68181480_+_VPS26B_ENST00000281187_chr11_134114832_+_5425nt GCCCGAGGGGGGAGGCGGAGGCGCCGGGAGCCGCGCGAGGAGCCGCCGCCGCCGCGCCATGGAGCCCGAGTGAGCGCGGCGCGGGCCCGT CCGGCCGCCGGACAACATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTG CCCGGCCCCCGCCGCGGCCTCGCCGCTCCTGCTATTTGCCAACCGCCGGGACGTACGGCTGGTGGACGCCGGCGGAGTCAAGCTGGAGTC CACCATCGTGGTCAGCGGCCTGGAGGATGCGGCCGCAGTGGACTTCCAGTTTTCCAAGGGAGCCGTGTACTGGACAGACGTGAGCGAGGA GGCCATCAAGCAGACCTACCTGAACCAGACGGGGGCCGCCGTGCAGAACGTGGTCATCTCCGGCCTGGTCTCTCCCGACGGCCTCGCCTG CGACTGGGTGGGCAAGAAGCTGTACTGGACGGACTCAGAGACCAACCGCATCGAGGTGGCCAACCTCAATGGCACATCCCGGAAGGTGCT CTTCTGGCAGGACCTTGACCAGCCGAGGGCCATCGCCTTGGACCCCGCTCACGGGTACATGTACTGGACAGACTGGGGTGAGACGCCCCG GATTGAGCGGGCAGGGATGGATGGCAGCACCCGGAAGATCATTGTGGACTCGGACATTTACTGGCCCAATGGACTGACCATCGACCTGGA GGAGCAGAAGCTCTACTGGGCTGACGCCAAGCTCAGCTTCATCCACCGTGCCAACCTGGACGGCTCGTTCCGGCAGAAGGTGGTGGAGGG CAGCCTGACGCACCCCTTCGCCCTGACGCTCTCCGGGGACACTCTGTACTGGACAGACTGGCAGACCCGCTCCATCCATGCCTGCAACAA GCGCACTGGGGGGAAGAGGAAGGAGATCCTGAGTGCCCTCTACTCACCCATGGACATCCAGGTGCTGAGCCAGGAGCGGCAGCCTTTCTT CCACACTCGCTGTGAGGAGGACAATGGCGGCTGCTCCCACCTGTGCCTGCTGTCCCCAAGCGAGCCTTTCTACACATGCGCCTGCCCCAC GGGTGTGCAGCTGCAGGACAACGGCAGGACGTGTAAGGCAGGAGCCGAGGAGGTGCTGCTGCTGGCCCGGCGGACGGACCTACGGAGGAT CTCGCTGGACACGCCGGACTTCACCGACATCGTGCTGCAGGTGGACGACATCCGGCACGCCATTGCCATCGACTACGACCCGCTAGAGGG CTATGTCTACTGGACAGATGACGAGGTGCGGGCCATCCGCAGGGCGTACCTGGACGGGTCTGGGGCGCAGACGCTGGTCAACACCGAGAT CAACGACCCCGATGGCATCGCGGTCGACTGGGTGGCCCGAAACCTCTACTGGACCGACACGGGCACGGACCGCATCGAGGTGACGCGCCT CAACGGCACCTCCCGCAAGATCCTGGTGTCGGAGGACCTGGACGAGCCCCGAGCCATCGCACTGCACCCCGTGATGGGCCTCATGTACTG GACAGACTGGGGAGAGAACCCTAAAATCGAGTGTGCCAACTTGGATGGGCAGGAGCGGCGTGTGCTGGTCAATGCCTCCCTCGGGTGGCC CAACGGCCTGGCCCTGGACCTGCAGGAGGGGAAGCTCTACTGGGGAGACGCCAAGACAGACAAGATCGAGGTGATCAATGTTGATGGGAC GAAGAGGCGGACCCTCCTGGAGGACAAGCTCCCGCACATTTTTGGGTTCACGCTGCTGGGGGACTTCATCTACTGGACTGACTGGCAGCG CCGCAGCATCGAGCGGGTGCACAAGGTCAAGGCCAGCCGGGACGTCATCATTGACCAGCTGCCCGACCTGATGGGGCTCAAAGCTGTGAA TGTGGCCAAGGTCGTCGGAACCAACCCGTGTGCGGACAGGAACGGGGGGTGCAGCCACCTGTGCTTCTTCACACCCCACGCAACCCGGTG TGGCTGCCCCATCGGCCTGGAGCTGCTGAGTGACATGAAGACCTGCATCGTGCCTGAGGCCTTCTTGGTCTTCACCAGCAGAGCCGCCAT CCACAGGATCTCCCTCGAGACCAATAACAACGACGTGGCCATCCCGCTCACGGGCGTCAAGGAGGCCTCAGCCCTGGACTTTGATGTGTC CAACAACCACATCTACTGGACAGACGTCAGCCTGAAGACCATCAGCCGCGCCTTCATGAACGGGAGCTCGGTGGAGCACGTGGTGGAGTT TGGCCTTGACTACCCCGAGGGCATGGCCGTTGACTGGATGGGCAAGAACCTCTACTGGGCCGACACTGGGACCAACAGAATCGAAGTGGC GCGGCTGGACGGGCAGTTCCGGCAAGTCCTCGTGTGGAGGGACTTGGACAACCCGAGGTCGCTGGCCCTGGATCCCACCAAGGGCTACAT CTACTGGACCGAGTGGGGCGGCAAGCCGAGGATCGTGCGGGCCTTCATGGACGGGACCAACTGCATGACGCTGGTGGACAAGGTGGGCCG GGCCAACGACCTCACCATTGACTACGCTGACCAGCGCCTCTACTGGACCGACCTGGACACCAACATGATCGAGTCGTCCAACATGCTGGG TCAGGAGCGGGTCGTGATTGCCGACGATCTCCCGCACCCGTTCGGTCTGACGCAGTACAGCGATTATATCTACTGGACAGACTGGAATCT GCACAGCATTGAGCGGGCCGACAAGACTAGCGGCCGGAACCGCACCCTCATCCAGGGCCACCTGGACTTCGTGATGGACATCCTGGTGTT CCACTCCTCCCGCCAGGATGGCCTCAATGACTGTATGCACAACAACGGGCAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCG CTGCGGCTGCGCCTCACACTACACCCTGGACCCCAGCAGCCGCAACTGCAGCCGAGAGTCCATCCCGATCCGGCTCTTCCTGGCCGGGTA TGAGCTCACGCCCACCATGCGGGACATCAACAAGAAGTTCTCTGTGCGCTATTACCTCAACCTGGTGCTGATAGACGAGGAGGAGCGGCG CTACTTCAAGCAGCAGGAAGTGGTGTTGTGGCGGAAGGGTGACATCGTACGGAAGAGCATGTCCCACCAGGCGGCCATCGCCTCACAGCG CTTTGAGGGCACCACCTCCCTGGGTGAGGTGCGGACCCCCAGCCAGCTGTCTGACAACAACTGCAGGCAGTAGGCCCCCAGGGCCGAGAA GATGCTGGGCACCCACCCAGCACCCCCATCTACCAACACCAGCGGCTGGGGGCGGGGGCGGACCTTGTGAGGCTCAGTTGACCCGTTACT TGCAACCTGAAAACAAATCATGTTTTTGACTTAAATTCTTTTCTCTGGAGAACCCAAGGGGCTTGGGGTGGGAAGCAGTCTCTCCTTGGG ATTCTGCGGCCGATGTGGGATAGAAGAGGTAGCATCCTGGAAGCCAGCCTCTCTGGGGAACATGAGCCCCCTTCCTCGGGGGGCTGCCTT GCGTCTTAGAGGAGGGAGAGCAGAGAGCACGCATCCTTGGCTCCTGGCTCTCTGAGCTTCCTGATACAGGATCTGAGCATGTCCCTGGGA TTCTGAGCTGCCAACAGGGCCCTGGGTAGTCACATCTTGTACTCCCCTTTGCTGTCCCGGAGGTAGTGGCAGGAGTTGGGCCAGCCCCCA CTAAGTGGCAGGGGAAGACTCACGATTGGGAAGCTACCTCTTTGGGAATCTTGGATGTGGTGATCTCAAGTTCCCACAGGCCACCTCCTT CTGGCCACTCACTGCTGGGACCCAGGCACCTCCCTTCTCCATCCTCTCTGGATTGTCAGTAATGTCCTGGAACAGAAGCCTGTGGGATGG CCTTGGGCACGGAGAAGCCCTGGGGTCAGTGTCGTGCACGGATGGCGGCAGTGTTGAACCCAGGAGGCTGAACCCGGCCCACCACGGAAG ATGAGTGCATGGCAACCGCCTGCCTTCACGTCGCTCCACTTGGTAACCCCAAGGTCTGGGCTGTTCTAGGTATTGCTTCACGTGCCCCAG CAAGCCCTTAACAAGAGGGCCTGGTTCCCTGAAGAACCAATCCCAGGAAGGGGCCTTGATCCCTCCGCCTTGCTGAGAGTGAACCCTCGT CTCTCCTCACCCTCCATTTCATTTCTGGGAATTGGGGCTTAGTTTCGAACCTTTGGCAAGGCTGTTCTTACTAATGCCCAAGCCCCTTTA CCCCTCTCCCTATAGGTTACACAGGGGAGACCAGGGCCTCGGCAGAAGACTGCTGCCACACTTCCGAATCATTCTGCTTGCCAAATAGGT CATCTTCACCAGTTGACTGACCCAAGTTTAGGACCATTGGTATCGTGTGTTTAAAAAACACATATAAAAAAACTCTTGTGAATATTCTTG TTATGCTAGAGAGGAAGGTACTTCTCCCTCTACGGCTCTGCGCTGGGGCCTATGGTAGTAAAGTTGTTTACTGTCCTTTTTCTGCTTCCC CTGGAAATGACAGGCATTACTCTCCCATTGGCCTCCCTTCCCTTTATAGAAAGACCAAGCAGGCCCCACTGGCCAAGAGGTACGGTATTT GGCAGTCTGAGTTCTCAGTAATTTGGAAAGTTAAGGAGTTGGTTCCTGTGTCACCTTTCAGTTAGTGTGGGAAAGGAAGACTTCTGTTTT CCTGAGATCAGTGCAGTCTCAGGCCTTTGGCAGGGCTCATGGATCAGAGCTGAGACTGGAGGGAGAGGCATTTTGGGTAGCCTAGGAGGG CGACTGGCGGCAGCAGAACCGAGGAAGGCAAGGTTGTTTCCCCCACGCTGTGTCCTGTGTTCAGGTGCGACACACAATCCTCATGGGAAC AGGATCACCCATGCGCTGCCCTTGATGATCAAGGTTGGGGCTTAAGTGGATAAGGGAGGCAAGTTCTGGGTTCCTTGCCTTTTCAGAGCA TGAGGTCAGGCTCTGTATCCCTCCTTTTCCTAGCTGATATTCTAACTAGAAGCATTTGTCAATTCCTTTGCCTCCCAACTGACAACACAC GTTCATTTTCCAACCTTCCTAACATCTTAAACCTTTCTTCTGGGAGAACTAGAAGACAGAATTTGCTTTGATTCTCTCAGGCGCTGTGCA CAAGCCAGGTCTTCTGTTTTCTCTTTCTTACTCTACCCACATTCTTGCCTTCTCTATCCAACTGTGAAAGTGAGGGGAGGCTCCTGTCCC CCTCTCTTAAGGTCCCCAAACCTGGGAGTGCATAGGTACTAAATCAAGCAGTGCAACTTGTAATTAAGCAGCTGCAGTGTTTACATGTTT CTTAATGTGTCATCTTTTCAATGGCTGTATTAAAAGAAGAACGTTTGTTTTAATGGTCTTTCTGATTAAAGAAAGCCCCTGTGGCTTTGG >In-frame_LRP5_ENST00000294304_chr11_68181480_+_VPS26B_ENST00000525095_chr11_134114832_+_3362nt GCCCGAGGGGGGAGGCGGAGGCGCCGGGAGCCGCGCGAGGAGCCGCCGCCGCCGCGCCATGGAGCCCGAGTGAGCGCGGCGCGGGCCCGT CCGGCCGCCGGACAACATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTG CCCGGCCCCCGCCGCGGCCTCGCCGCTCCTGCTATTTGCCAACCGCCGGGACGTACGGCTGGTGGACGCCGGCGGAGTCAAGCTGGAGTC CACCATCGTGGTCAGCGGCCTGGAGGATGCGGCCGCAGTGGACTTCCAGTTTTCCAAGGGAGCCGTGTACTGGACAGACGTGAGCGAGGA GGCCATCAAGCAGACCTACCTGAACCAGACGGGGGCCGCCGTGCAGAACGTGGTCATCTCCGGCCTGGTCTCTCCCGACGGCCTCGCCTG CGACTGGGTGGGCAAGAAGCTGTACTGGACGGACTCAGAGACCAACCGCATCGAGGTGGCCAACCTCAATGGCACATCCCGGAAGGTGCT CTTCTGGCAGGACCTTGACCAGCCGAGGGCCATCGCCTTGGACCCCGCTCACGGGTACATGTACTGGACAGACTGGGGTGAGACGCCCCG GATTGAGCGGGCAGGGATGGATGGCAGCACCCGGAAGATCATTGTGGACTCGGACATTTACTGGCCCAATGGACTGACCATCGACCTGGA GGAGCAGAAGCTCTACTGGGCTGACGCCAAGCTCAGCTTCATCCACCGTGCCAACCTGGACGGCTCGTTCCGGCAGAAGGTGGTGGAGGG CAGCCTGACGCACCCCTTCGCCCTGACGCTCTCCGGGGACACTCTGTACTGGACAGACTGGCAGACCCGCTCCATCCATGCCTGCAACAA GCGCACTGGGGGGAAGAGGAAGGAGATCCTGAGTGCCCTCTACTCACCCATGGACATCCAGGTGCTGAGCCAGGAGCGGCAGCCTTTCTT CCACACTCGCTGTGAGGAGGACAATGGCGGCTGCTCCCACCTGTGCCTGCTGTCCCCAAGCGAGCCTTTCTACACATGCGCCTGCCCCAC GGGTGTGCAGCTGCAGGACAACGGCAGGACGTGTAAGGCAGGAGCCGAGGAGGTGCTGCTGCTGGCCCGGCGGACGGACCTACGGAGGAT CTCGCTGGACACGCCGGACTTCACCGACATCGTGCTGCAGGTGGACGACATCCGGCACGCCATTGCCATCGACTACGACCCGCTAGAGGG CTATGTCTACTGGACAGATGACGAGGTGCGGGCCATCCGCAGGGCGTACCTGGACGGGTCTGGGGCGCAGACGCTGGTCAACACCGAGAT CAACGACCCCGATGGCATCGCGGTCGACTGGGTGGCCCGAAACCTCTACTGGACCGACACGGGCACGGACCGCATCGAGGTGACGCGCCT CAACGGCACCTCCCGCAAGATCCTGGTGTCGGAGGACCTGGACGAGCCCCGAGCCATCGCACTGCACCCCGTGATGGGCCTCATGTACTG GACAGACTGGGGAGAGAACCCTAAAATCGAGTGTGCCAACTTGGATGGGCAGGAGCGGCGTGTGCTGGTCAATGCCTCCCTCGGGTGGCC CAACGGCCTGGCCCTGGACCTGCAGGAGGGGAAGCTCTACTGGGGAGACGCCAAGACAGACAAGATCGAGGTGATCAATGTTGATGGGAC GAAGAGGCGGACCCTCCTGGAGGACAAGCTCCCGCACATTTTTGGGTTCACGCTGCTGGGGGACTTCATCTACTGGACTGACTGGCAGCG CCGCAGCATCGAGCGGGTGCACAAGGTCAAGGCCAGCCGGGACGTCATCATTGACCAGCTGCCCGACCTGATGGGGCTCAAAGCTGTGAA TGTGGCCAAGGTCGTCGGAACCAACCCGTGTGCGGACAGGAACGGGGGGTGCAGCCACCTGTGCTTCTTCACACCCCACGCAACCCGGTG TGGCTGCCCCATCGGCCTGGAGCTGCTGAGTGACATGAAGACCTGCATCGTGCCTGAGGCCTTCTTGGTCTTCACCAGCAGAGCCGCCAT CCACAGGATCTCCCTCGAGACCAATAACAACGACGTGGCCATCCCGCTCACGGGCGTCAAGGAGGCCTCAGCCCTGGACTTTGATGTGTC CAACAACCACATCTACTGGACAGACGTCAGCCTGAAGACCATCAGCCGCGCCTTCATGAACGGGAGCTCGGTGGAGCACGTGGTGGAGTT TGGCCTTGACTACCCCGAGGGCATGGCCGTTGACTGGATGGGCAAGAACCTCTACTGGGCCGACACTGGGACCAACAGAATCGAAGTGGC GCGGCTGGACGGGCAGTTCCGGCAAGTCCTCGTGTGGAGGGACTTGGACAACCCGAGGTCGCTGGCCCTGGATCCCACCAAGGGCTACAT CTACTGGACCGAGTGGGGCGGCAAGCCGAGGATCGTGCGGGCCTTCATGGACGGGACCAACTGCATGACGCTGGTGGACAAGGTGGGCCG GGCCAACGACCTCACCATTGACTACGCTGACCAGCGCCTCTACTGGACCGACCTGGACACCAACATGATCGAGTCGTCCAACATGCTGGG TCAGGAGCGGGTCGTGATTGCCGACGATCTCCCGCACCCGTTCGGTCTGACGCAGTACAGCGATTATATCTACTGGACAGACTGGAATCT GCACAGCATTGAGCGGGCCGACAAGACTAGCGGCCGGAACCGCACCCTCATCCAGGGCCACCTGGACTTCGTGATGGACATCCTGGTGTT CCACTCCTCCCGCCAGGATGGCCTCAATGACTGTATGCACAACAACGGGCAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCG CTGCGGCTGCGCCTCACACTACACCCTGGACCCCAGCAGCCGCAACTGCAGCCGAGAGTCCATCCCGATCCGGCTCTTCCTGGCCGGGTA TGAGCTCACGCCCACCATGCGGGACATCAACAAGAAGTTCTCTGTGCGCTATTACCTCAACCTGGTGCTGATAGACGAGGAGGAGCGGCG CTACTTCAAGCAGCAGGAAGTGGTGTTGTGGCGGAAGGGTGACATCGTACGGAAGAGCATGTCCCACCAGGCGGCCATCGCCTCACAGCG CTTTGAGGGCACCACCTCCCTGGGTGAGGTGCGGACCCCCAGCCAGCTGTCTGACAACAACTGCAGGCAGTAGGCCCCCAGGGCCGAGAA GATGCTGGGCACCCACCCAGCACCCCCATCTACCAACACCAGCGGCTGGGGGCGGGGGCGGACCTTGTGAGGCTCAGTTGACCCGTTACT |
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FusionGenePPI for LRP5_VPS26B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LRP5 | AXIN1, SMAD9, CAPRIN2, SOST, DKK1, FZD8, TAZ, RASD2, SUSD4, PARP16, POMK, B3GALT2, ETV6, CHST9, LIPH, PRSS37, CSNK1A1, TGIF2LY, DKKL1, SERPINA12, ST8SIA4, SCGB1D1, DKK4, MGAT4C, F9, FAM3B, C4orf26, FCGRT, PODN, ADAM33, BRINP3, LRRC4C, CLPSL1, NXPH2, TRIM25 | VPS26B | TBC1D5, VPS35, VPS29, UBA6, CAB39, ENO1, MOV10, NXF1, VPS26A, NEK1, SUPT5H, ATE1, C21orf2, BTBD9, SNX27, MRM1, SNX1, SNX2, NTRK1, ABCD1, COL4A5, ETV6, KIF5A, MYH1, TTF1, KIAA0196, SDCCAG3, MRPS30, MYCBP2, KIF1B, FKBP15, KIAA1033, PPIL2, MTO1, TXNDC11, SNX16, CCDC102B, CHD9, ACTL8, TRIM7, ANKRD27, CCDC102A, FAM21A, C9orf156, ZFC3H1, LOXL3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LRP5_VPS26B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LRP5_VPS26B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | LRP5 | C0432252 | Osteoporosis with pseudoglioma | 8 | CTD_human;ORPHANET;UNIPROT |
| Hgene | LRP5 | C1866176 | EXUDATIVE VITREORETINOPATHY 4 (disorder) | 8 | CTD_human;UNIPROT |
| Hgene | LRP5 | C1866079 | BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 1 | 5 | UNIPROT |
| Hgene | LRP5 | C0242852 | Proliferative vitreoretinopathy | 1 | CTD_human |
| Hgene | LRP5 | C0432273 | Worth disease | 1 | CTD_human;ORPHANET;UNIPROT |
| Hgene | LRP5 | C1843330 | OSTEOPETROSIS, AUTOSOMAL DOMINANT 1 | 1 | CTD_human;ORPHANET;UNIPROT |
| Hgene | LRP5 | C1851402 | Exudative vitreoretinopathy 1 | 1 | ORPHANET;UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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