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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 20157

FusionGeneSummary for LRP5_DLG2

check button Fusion gene summary
Fusion gene informationFusion gene name: LRP5_DLG2
Fusion gene ID: 20157
HgeneTgene
Gene symbol

LRP5

DLG2

Gene ID

4041

4355

Gene nameLDL receptor related protein 5membrane palmitoylated protein 2
SynonymsBMND1|EVR1|EVR4|HBM|LR3|LRP-5|LRP7|OPPG|OPS|OPTA1|PCLD4|VBCH2DLG2
Cytomap

11q13.2

17q21.31

Type of geneprotein-codingprotein-coding
Descriptionlow-density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 7MAGUK p55 subfamily member 2discs large, homolog 2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
Modification date2018052320180519
UniProtAcc

O75197

Q15700

Ensembl transtripts involved in fusion geneENST00000294304, ENST00000529481, 
ENST00000398309, ENST00000376104, 
ENST00000418306, ENST00000280241, 
ENST00000543673, ENST00000376106, 
ENST00000330014, ENST00000537455, 
ENST00000524982, ENST00000532653, 
ENST00000531015, ENST00000398301, 
ENST00000426717, ENST00000404783, 
ENST00000398304, ENST00000530800, 
ENST00000472545, 
Fusion gene scores* DoF score21 X 16 X 9=302416 X 15 X 6=1440
# samples 2220
** MAII scorelog2(22/3024*10)=-3.78088271069641
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/1440*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRP5 [Title/Abstract] AND DLG2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationKinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLRP5

GO:0008284

positive regulation of cell proliferation

9790987

HgeneLRP5

GO:0016055

Wnt signaling pathway

17955262

HgeneLRP5

GO:0044332

Wnt signaling pathway involved in dorsal/ventral axis specification

11029007

HgeneLRP5

GO:0045840

positive regulation of mitotic nuclear division

9790987

HgeneLRP5

GO:0045893

positive regulation of transcription, DNA-templated

15035989|17955262

HgeneLRP5

GO:0045944

positive regulation of transcription by RNA polymerase II

12857724

HgeneLRP5

GO:0060070

canonical Wnt signaling pathway

12121999|12857724|15035989


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A8-A09I-01ALRP5chr11

68157520

+DLG2chr11

83676511

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000294304ENST00000398309LRP5chr11

68157520

+DLG2chr11

83676511

-
In-frameENST00000294304ENST00000376104LRP5chr11

68157520

+DLG2chr11

83676511

-
In-frameENST00000294304ENST00000418306LRP5chr11

68157520

+DLG2chr11

83676511

-
In-frameENST00000294304ENST00000280241LRP5chr11

68157520

+DLG2chr11

83676511

-
In-frameENST00000294304ENST00000543673LRP5chr11

68157520

+DLG2chr11

83676511

-
5CDS-5UTRENST00000294304ENST00000376106LRP5chr11

68157520

+DLG2chr11

83676511

-
5CDS-5UTRENST00000294304ENST00000330014LRP5chr11

68157520

+DLG2chr11

83676511

-
5CDS-5UTRENST00000294304ENST00000537455LRP5chr11

68157520

+DLG2chr11

83676511

-
5CDS-5UTRENST00000294304ENST00000524982LRP5chr11

68157520

+DLG2chr11

83676511

-
5CDS-5UTRENST00000294304ENST00000532653LRP5chr11

68157520

+DLG2chr11

83676511

-
5CDS-5UTRENST00000294304ENST00000531015LRP5chr11

68157520

+DLG2chr11

83676511

-
5CDS-5UTRENST00000294304ENST00000398301LRP5chr11

68157520

+DLG2chr11

83676511

-
5CDS-intronENST00000294304ENST00000426717LRP5chr11

68157520

+DLG2chr11

83676511

-
5CDS-intronENST00000294304ENST00000404783LRP5chr11

68157520

+DLG2chr11

83676511

-
5CDS-intronENST00000294304ENST00000398304LRP5chr11

68157520

+DLG2chr11

83676511

-
5CDS-intronENST00000294304ENST00000530800LRP5chr11

68157520

+DLG2chr11

83676511

-
5CDS-intronENST00000294304ENST00000472545LRP5chr11

68157520

+DLG2chr11

83676511

-
intron-3CDSENST00000529481ENST00000398309LRP5chr11

68157520

+DLG2chr11

83676511

-
intron-3CDSENST00000529481ENST00000376104LRP5chr11

68157520

+DLG2chr11

83676511

-
intron-3CDSENST00000529481ENST00000418306LRP5chr11

68157520

+DLG2chr11

83676511

-
intron-3CDSENST00000529481ENST00000280241LRP5chr11

68157520

+DLG2chr11

83676511

-
intron-3CDSENST00000529481ENST00000543673LRP5chr11

68157520

+DLG2chr11

83676511

-
intron-5UTRENST00000529481ENST00000376106LRP5chr11

68157520

+DLG2chr11

83676511

-
intron-5UTRENST00000529481ENST00000330014LRP5chr11

68157520

+DLG2chr11

83676511

-
intron-5UTRENST00000529481ENST00000537455LRP5chr11

68157520

+DLG2chr11

83676511

-
intron-5UTRENST00000529481ENST00000524982LRP5chr11

68157520

+DLG2chr11

83676511

-
intron-5UTRENST00000529481ENST00000532653LRP5chr11

68157520

+DLG2chr11

83676511

-
intron-5UTRENST00000529481ENST00000531015LRP5chr11

68157520

+DLG2chr11

83676511

-
intron-5UTRENST00000529481ENST00000398301LRP5chr11

68157520

+DLG2chr11

83676511

-
intron-intronENST00000529481ENST00000426717LRP5chr11

68157520

+DLG2chr11

83676511

-
intron-intronENST00000529481ENST00000404783LRP5chr11

68157520

+DLG2chr11

83676511

-
intron-intronENST00000529481ENST00000398304LRP5chr11

68157520

+DLG2chr11

83676511

-
intron-intronENST00000529481ENST00000530800LRP5chr11

68157520

+DLG2chr11

83676511

-
intron-intronENST00000529481ENST00000472545LRP5chr11

68157520

+DLG2chr11

83676511

-

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FusionProtFeatures for LRP5_DLG2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRP5

O75197

DLG2

Q15700

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggersbeta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surfacecoreceptor of Wnt/beta-catenin signaling, which plays a pivotalrole in bone formation. Plays a role in norrin (NDP) signaltransduction (PubMed:27228167). The Wnt-induced Fzd/LRP6coreceptor complex recruits DVL1 polymers to the plasma membranewhich, in turn, recruits the AXIN1/GSK3B-complex to the cellsurface promoting the formation of signalsomes and inhibitingAXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascularregression in the eye (By similarity). Required for posteriorpatterning of the epiblast during gastrulation (By similarity).{ECO:0000250|UniProtKB:Q91VN0, ECO:0000269|PubMed:11336703,ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:14727154,ECO:0000269|PubMed:14731402, ECO:0000269|PubMed:15778503,ECO:0000269|PubMed:27228167}. Required for perception of chronic pain through NMDAreceptor signaling. Regulates surface expression of NMDA receptorsin dorsal horn neurons of the spinal cord. Interacts with thecytoplasmic tail of NMDA receptor subunits as well as inwardrectifying potassium channels. Involved in regulation of synapticstability at cholinergic synapses. Part of the postsynapticprotein scaffold of excitatory synapses (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723295_3375281616DomainNote=EGF-like 1
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+72332_2885281616RegionNote=Beta-propeller 1
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723120_1625281616RepeatNote=LDL-receptor class B 2
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723123_1265281616RepeatNote=YWTD 2
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723163_2065281616RepeatNote=LDL-receptor class B 3
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723166_1695281616RepeatNote=YWTD 3
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723207_2475281616RepeatNote=LDL-receptor class B 4
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723248_2905281616RepeatNote=LDL-receptor class B 5
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723251_2545281616RepeatNote=YWTD 4
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723385_4275281616RepeatNote=LDL-receptor class B 6
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723388_3915281616RepeatNote=YWTD 5
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723428_4705281616RepeatNote=LDL-receptor class B 7
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723431_4345281616RepeatNote=YWTD 6
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723471_5145281616RepeatNote=LDL-receptor class B 8
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723474_4775281616RepeatNote=YWTD 7
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+72375_1195281616RepeatNote=LDL-receptor class B 1
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+72378_815281616RepeatNote=YWTD 1
TgeneDLG2chr11:68157520chr11:83676511ENST00000280241-522421_501286910DomainPDZ 3
TgeneDLG2chr11:68157520chr11:83676511ENST00000280241-522536_606286910DomainSH3
TgeneDLG2chr11:68157520chr11:83676511ENST00000280241-522680_855286910DomainGuanylate kinase-like
TgeneDLG2chr11:68157520chr11:83676511ENST00000376104-1128421_501352976DomainPDZ 3
TgeneDLG2chr11:68157520chr11:83676511ENST00000376104-1128536_606352976DomainSH3
TgeneDLG2chr11:68157520chr11:83676511ENST00000376104-1128680_855352976DomainGuanylate kinase-like
TgeneDLG2chr11:68157520chr11:83676511ENST00000376106-522193_279-271335DomainPDZ 2
TgeneDLG2chr11:68157520chr11:83676511ENST00000376106-522421_501-271335DomainPDZ 3
TgeneDLG2chr11:68157520chr11:83676511ENST00000376106-522536_606-271335DomainSH3
TgeneDLG2chr11:68157520chr11:83676511ENST00000376106-522680_855-271335DomainGuanylate kinase-like
TgeneDLG2chr11:68157520chr11:83676511ENST00000376106-52298_184-271335DomainPDZ 1
TgeneDLG2chr11:68157520chr11:83676511ENST00000398309-623421_501247871DomainPDZ 3
TgeneDLG2chr11:68157520chr11:83676511ENST00000398309-623536_606247871DomainSH3
TgeneDLG2chr11:68157520chr11:83676511ENST00000398309-623680_855247871DomainGuanylate kinase-like
TgeneDLG2chr11:68157520chr11:83676511ENST00000418306-420193_279196750DomainPDZ 2
TgeneDLG2chr11:68157520chr11:83676511ENST00000418306-420421_501196750DomainPDZ 3
TgeneDLG2chr11:68157520chr11:83676511ENST00000418306-420536_606196750DomainSH3
TgeneDLG2chr11:68157520chr11:83676511ENST00000418306-420680_855196750DomainGuanylate kinase-like
TgeneDLG2chr11:68157520chr11:83676511ENST00000426717-011193_279-94335DomainPDZ 2
TgeneDLG2chr11:68157520chr11:83676511ENST00000426717-011421_501-94335DomainPDZ 3
TgeneDLG2chr11:68157520chr11:83676511ENST00000426717-011536_606-94335DomainSH3
TgeneDLG2chr11:68157520chr11:83676511ENST00000426717-011680_855-94335DomainGuanylate kinase-like
TgeneDLG2chr11:68157520chr11:83676511ENST00000426717-01198_184-94335DomainPDZ 1
TgeneDLG2chr11:68157520chr11:83676511ENST00000543673-926421_501352976DomainPDZ 3
TgeneDLG2chr11:68157520chr11:83676511ENST00000543673-926536_606352976DomainSH3
TgeneDLG2chr11:68157520chr11:83676511ENST00000543673-926680_855352976DomainGuanylate kinase-like

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+7231495_16105281616Compositional biasNote=Pro-rich
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+7231213_12545281616DomainNote=EGF-like 4
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+7231258_12965281616DomainLDL-receptor class A 1
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+7231297_13335281616DomainLDL-receptor class A 2
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+7231335_13715281616DomainLDL-receptor class A 3
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723601_6415281616DomainNote=EGF-like 2
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723902_9425281616DomainNote=EGF-like 3
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+7231500_15065281616MotifNote=PPPSP motif A
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+7231538_15455281616MotifNote=PPPSP motif B
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+7231574_15815281616MotifNote=PPPSP motif C
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+7231591_15965281616MotifNote=PPPSP motif D
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+7231605_16125281616MotifNote=PPPSP motif E
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723341_6025281616RegionNote=Beta-propeller 2
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723644_9035281616RegionNote=Beta-propeller 3
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723945_12125281616RegionNote=Beta-propeller 4
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+7231036_10785281616RepeatNote=LDL-receptor class B 17
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+7231079_11235281616RepeatNote=LDL-receptor class B 18
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+7231124_11645281616RepeatNote=LDL-receptor class B 19
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+7231165_12075281616RepeatNote=LDL-receptor class B 20
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723515_5575281616RepeatNote=LDL-receptor class B 9
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723558_6005281616RepeatNote=LDL-receptor class B 10
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723559_5625281616RepeatNote=YWTD 8
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723687_7295281616RepeatNote=LDL-receptor class B 11
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723690_6935281616RepeatNote=YWTD 9
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723730_7725281616RepeatNote=LDL-receptor class B 12
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723773_8155281616RepeatNote=LDL-receptor class B 13
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723816_8555281616RepeatNote=LDL-receptor class B 14
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723819_8225281616RepeatNote=YWTD 10
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723856_8985281616RepeatNote=LDL-receptor class B 15
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723859_8625281616RepeatNote=YWTD 11
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+723989_10355281616RepeatNote=LDL-receptor class B 16
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+7231408_16155281616Topological domainCytoplasmic
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+72332_13845281616Topological domainExtracellular
HgeneLRP5chr11:68157520chr11:83676511ENST00000294304+7231385_14075281616TransmembraneHelical
TgeneDLG2chr11:68157520chr11:83676511ENST00000280241-522193_279286910DomainPDZ 2
TgeneDLG2chr11:68157520chr11:83676511ENST00000280241-52298_184286910DomainPDZ 1
TgeneDLG2chr11:68157520chr11:83676511ENST00000376104-1128193_279352976DomainPDZ 2
TgeneDLG2chr11:68157520chr11:83676511ENST00000376104-112898_184352976DomainPDZ 1
TgeneDLG2chr11:68157520chr11:83676511ENST00000398309-623193_279247871DomainPDZ 2
TgeneDLG2chr11:68157520chr11:83676511ENST00000398309-62398_184247871DomainPDZ 1
TgeneDLG2chr11:68157520chr11:83676511ENST00000418306-42098_184196750DomainPDZ 1
TgeneDLG2chr11:68157520chr11:83676511ENST00000543673-926193_279352976DomainPDZ 2
TgeneDLG2chr11:68157520chr11:83676511ENST00000543673-92698_184352976DomainPDZ 1


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FusionGeneSequence for LRP5_DLG2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_LRP5_ENST00000294304_chr11_68157520_+_DLG2_ENST00000398309_chr11_83676511_-_1152aa
MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQT
YLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAG
MDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGK
RKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTP
DFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR
KILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVNNYSLEEVTHE
EAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYS
TVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGE
DGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSG
SLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKP
GVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCV
PHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPR

>In-frame_LRP5_ENST00000294304_chr11_68157520_+_DLG2_ENST00000376104_chr11_83676511_-_1152aa
MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQT
YLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAG
MDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGK
RKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTP
DFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR
KILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVNNYSLEEVTHE
EAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYS
TVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGE
DGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSG
SLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKP
GVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCV
PHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPR

>In-frame_LRP5_ENST00000294304_chr11_68157520_+_DLG2_ENST00000418306_chr11_83676511_-_1082aa
MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQT
YLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAG
MDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGK
RKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTP
DFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR
KILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVNNYSLEEVTHE
EAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTA
TRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAG
QTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQA
RRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGTKTLRGQEDLILSYEPVTRQEINYTRPVIILGPM
KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGN
AIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEK

>In-frame_LRP5_ENST00000294304_chr11_68157520_+_DLG2_ENST00000280241_chr11_83676511_-_1152aa
MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQT
YLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAG
MDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGK
RKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTP
DFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR
KILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVNNYSLEEVTHE
EAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYS
TVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGE
DGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSG
SLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKP
GVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCV
PHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPR

>In-frame_LRP5_ENST00000294304_chr11_68157520_+_DLG2_ENST00000543673_chr11_83676511_-_1152aa
MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQT
YLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAG
MDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGK
RKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTP
DFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR
KILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVNNYSLEEVTHE
EAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYS
TVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGE
DGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSG
SLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKP
GVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCV
PHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPR


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_LRP5_ENST00000294304_chr11_68157520_+_DLG2_ENST00000398309_chr11_83676511_-_3456nt
ATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTGCCCGGCCCCCGCCGCG
GCCTCGCCGCTCCTGCTATTTGCCAACCGCCGGGACGTACGGCTGGTGGACGCCGGCGGAGTCAAGCTGGAGTCCACCATCGTGGTCAGC
GGCCTGGAGGATGCGGCCGCAGTGGACTTCCAGTTTTCCAAGGGAGCCGTGTACTGGACAGACGTGAGCGAGGAGGCCATCAAGCAGACC
TACCTGAACCAGACGGGGGCCGCCGTGCAGAACGTGGTCATCTCCGGCCTGGTCTCTCCCGACGGCCTCGCCTGCGACTGGGTGGGCAAG
AAGCTGTACTGGACGGACTCAGAGACCAACCGCATCGAGGTGGCCAACCTCAATGGCACATCCCGGAAGGTGCTCTTCTGGCAGGACCTT
GACCAGCCGAGGGCCATCGCCTTGGACCCCGCTCACGGGTACATGTACTGGACAGACTGGGGTGAGACGCCCCGGATTGAGCGGGCAGGG
ATGGATGGCAGCACCCGGAAGATCATTGTGGACTCGGACATTTACTGGCCCAATGGACTGACCATCGACCTGGAGGAGCAGAAGCTCTAC
TGGGCTGACGCCAAGCTCAGCTTCATCCACCGTGCCAACCTGGACGGCTCGTTCCGGCAGAAGGTGGTGGAGGGCAGCCTGACGCACCCC
TTCGCCCTGACGCTCTCCGGGGACACTCTGTACTGGACAGACTGGCAGACCCGCTCCATCCATGCCTGCAACAAGCGCACTGGGGGGAAG
AGGAAGGAGATCCTGAGTGCCCTCTACTCACCCATGGACATCCAGGTGCTGAGCCAGGAGCGGCAGCCTTTCTTCCACACTCGCTGTGAG
GAGGACAATGGCGGCTGCTCCCACCTGTGCCTGCTGTCCCCAAGCGAGCCTTTCTACACATGCGCCTGCCCCACGGGTGTGCAGCTGCAG
GACAACGGCAGGACGTGTAAGGCAGGAGCCGAGGAGGTGCTGCTGCTGGCCCGGCGGACGGACCTACGGAGGATCTCGCTGGACACGCCG
GACTTCACCGACATCGTGCTGCAGGTGGACGACATCCGGCACGCCATTGCCATCGACTACGACCCGCTAGAGGGCTATGTCTACTGGACA
GATGACGAGGTGCGGGCCATCCGCAGGGCGTACCTGGACGGGTCTGGGGCGCAGACGCTGGTCAACACCGAGATCAACGACCCCGATGGC
ATCGCGGTCGACTGGGTGGCCCGAAACCTCTACTGGACCGACACGGGCACGGACCGCATCGAGGTGACGCGCCTCAACGGCACCTCCCGC
AAGATCCTGGTGTCGGAGGACCTGGACGAGCCCCGAGCCATCGCACTGCACCCCGTGATGGGCCTCATGTACTGGACAGACTGGGGAGAG
AACCCTAAAATCGAGTGTGCCAACTTGGATGGGCAGGAGCGGCGTGTGCTGGTCAATGCCTCCCTCGGGTGGCCCAACGGCCTGGCCCTG
GACCTGCAGGAGGGGAAGCTCTACTGGGGAGACGCCAAGACAGACAAGATCGAGGTAAACAACTACAGTTTAGAAGAAGTAACACACGAA
GAGGCAGTAGCAATATTAAAGAACACATCAGAGGTAGTTTATTTAAAAGTTGGCAAACCCACTACCATTTATATGACTGATCCTTATGGT
CCACCTGATATTACTCACTCTTATTCTCCACCAATGGAAAACCATCTACTCTCTGGCAACAATGGCACTTTAGAATATAAAACCTCCCTG
CCACCCATCTCTCCAGGAAGGTACTCACCAATTCCAAAGCACATGCTTGTTGACGACGACTACACCAGGCCTCCGGAACCTGTTTACAGC
ACTGTGAACAAACTATGTGATAAGCCTGCTTCTCCCAGGCACTATTCCCCTGTTGAGTGTGACAAAAGCTTCCTCCTCTCAGCTCCCTAT
TCCCACTACCACCTAGGCCTGCTACCTGACTCTGAGATGACCAGTCATTCCCAACATAGCACCGCAACTCGTCAGCCTTCAATGACTCTC
CAACGGGCCGTCTCCCTGGAAGGAGAGCCTCGCAAGGTAGTCCTGCACAAAGGCTCCACTGGCCTGGGCTTCAACATTGTCGGTGGGGAA
GATGGAGAAGGTATTTTTGTGTCCTTCATTCTGGCTGGTGGACCAGCAGACCTAAGTGGGGAGCTCCAGAGAGGAGACCAGATCCTATCG
GTGAATGGCATTGACCTCCGTGGTGCATCCCACGAGCAGGCAGCTGCTGCACTAAAGGGGGCTGGACAGACAGTGACGATTATAGCACAA
TATCAACCTGAAGATTACGCTCGATTTGAGGCCAAAATCCATGACCTACGAGAGCAGATGATGAACCACAGCATGAGCTCCGGGTCCGGA
TCCCTGCGAACCAATCAGAAACGCTCCCTCTACGTCAGAGCCATGTTCGACTACGACAAGAGCAAGGACAGTGGGCTGCCAAGTCAAGGA
CTTAGTTTTAAATATGGAGATATTCTCCACGTTATCAATGCCTCTGATGATGAGTGGTGGCAAGCCAGGAGAGTCATGCTGGAGGGAGAC
AGTGAGGAGATGGGGGTCATCCCCAGCAAAAGGAGGGTGGAAAGAAAGGAACGTGCCCGATTGAAGACAGTGAAGTTTAATGCCAAACCT
GGAGTGATTGATTCGAAAGGGTCATTCAATGACAAGCGTAAAAAGAGCTTCATCTTTTCACGAAAATTCCCATTCTACAAGAACAAGGAG
CAGAGTGAGCAGGAAACCAGTGATCCTGAACGAGGACAAGAAGACCTCATTCTTTCCTATGAGCCTGTTACAAGGCAGGAAATAAACTAC
ACCCGGCCGGTGATTATCCTGGGGCCCATGAAGGATCGGATCAATGACGACTTGATATCTGAATTCCCTGATAAATTTGGCTCCTGTGTG
CCTCATACTACGAGGCCAAAGCGAGACTACGAGGTGGATGGCAGAGACTATCACTTTGTCATTTCCAGAGAACAAATGGAGAAAGATATC
CAAGAGCACAAGTTTATAGAAGCCGGCCAGTACAATGACAATTTATATGGAACCAGTGTGCAGTCTGTGAGATTTGTAGCAGAAAGAGGC
AAACACTGTATACTTGATGTATCAGGAAATGCTATCAAGCGGTTACAAGTTGCCCAGCTCTATCCCATTGCCATCTTCATAAAACCCAGG
TCTCTGGAACCTCTTATGGAGATGAATAAGCGTCTAACAGAGGAACAAGCCAAGAAAACCTATGATCGAGCAATTAAGCTAGAACAAGAA
TTTGGAGAATATTTTACAGCTATTGTCCAAGGAGATACTTTAGAAGATATATATAACCAATGCAAGCTTGTTATTGAAGAGCAATCTGGG

>In-frame_LRP5_ENST00000294304_chr11_68157520_+_DLG2_ENST00000376104_chr11_83676511_-_3456nt
ATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTGCCCGGCCCCCGCCGCG
GCCTCGCCGCTCCTGCTATTTGCCAACCGCCGGGACGTACGGCTGGTGGACGCCGGCGGAGTCAAGCTGGAGTCCACCATCGTGGTCAGC
GGCCTGGAGGATGCGGCCGCAGTGGACTTCCAGTTTTCCAAGGGAGCCGTGTACTGGACAGACGTGAGCGAGGAGGCCATCAAGCAGACC
TACCTGAACCAGACGGGGGCCGCCGTGCAGAACGTGGTCATCTCCGGCCTGGTCTCTCCCGACGGCCTCGCCTGCGACTGGGTGGGCAAG
AAGCTGTACTGGACGGACTCAGAGACCAACCGCATCGAGGTGGCCAACCTCAATGGCACATCCCGGAAGGTGCTCTTCTGGCAGGACCTT
GACCAGCCGAGGGCCATCGCCTTGGACCCCGCTCACGGGTACATGTACTGGACAGACTGGGGTGAGACGCCCCGGATTGAGCGGGCAGGG
ATGGATGGCAGCACCCGGAAGATCATTGTGGACTCGGACATTTACTGGCCCAATGGACTGACCATCGACCTGGAGGAGCAGAAGCTCTAC
TGGGCTGACGCCAAGCTCAGCTTCATCCACCGTGCCAACCTGGACGGCTCGTTCCGGCAGAAGGTGGTGGAGGGCAGCCTGACGCACCCC
TTCGCCCTGACGCTCTCCGGGGACACTCTGTACTGGACAGACTGGCAGACCCGCTCCATCCATGCCTGCAACAAGCGCACTGGGGGGAAG
AGGAAGGAGATCCTGAGTGCCCTCTACTCACCCATGGACATCCAGGTGCTGAGCCAGGAGCGGCAGCCTTTCTTCCACACTCGCTGTGAG
GAGGACAATGGCGGCTGCTCCCACCTGTGCCTGCTGTCCCCAAGCGAGCCTTTCTACACATGCGCCTGCCCCACGGGTGTGCAGCTGCAG
GACAACGGCAGGACGTGTAAGGCAGGAGCCGAGGAGGTGCTGCTGCTGGCCCGGCGGACGGACCTACGGAGGATCTCGCTGGACACGCCG
GACTTCACCGACATCGTGCTGCAGGTGGACGACATCCGGCACGCCATTGCCATCGACTACGACCCGCTAGAGGGCTATGTCTACTGGACA
GATGACGAGGTGCGGGCCATCCGCAGGGCGTACCTGGACGGGTCTGGGGCGCAGACGCTGGTCAACACCGAGATCAACGACCCCGATGGC
ATCGCGGTCGACTGGGTGGCCCGAAACCTCTACTGGACCGACACGGGCACGGACCGCATCGAGGTGACGCGCCTCAACGGCACCTCCCGC
AAGATCCTGGTGTCGGAGGACCTGGACGAGCCCCGAGCCATCGCACTGCACCCCGTGATGGGCCTCATGTACTGGACAGACTGGGGAGAG
AACCCTAAAATCGAGTGTGCCAACTTGGATGGGCAGGAGCGGCGTGTGCTGGTCAATGCCTCCCTCGGGTGGCCCAACGGCCTGGCCCTG
GACCTGCAGGAGGGGAAGCTCTACTGGGGAGACGCCAAGACAGACAAGATCGAGGTAAACAACTACAGTTTAGAAGAAGTAACACACGAA
GAGGCAGTAGCAATATTAAAGAACACATCAGAGGTAGTTTATTTAAAAGTTGGCAAACCCACTACCATTTATATGACTGATCCTTATGGT
CCACCTGATATTACTCACTCTTATTCTCCACCAATGGAAAACCATCTACTCTCTGGCAACAATGGCACTTTAGAATATAAAACCTCCCTG
CCACCCATCTCTCCAGGAAGGTACTCACCAATTCCAAAGCACATGCTTGTTGACGACGACTACACCAGGCCTCCGGAACCTGTTTACAGC
ACTGTGAACAAACTATGTGATAAGCCTGCTTCTCCCAGGCACTATTCCCCTGTTGAGTGTGACAAAAGCTTCCTCCTCTCAGCTCCCTAT
TCCCACTACCACCTAGGCCTGCTACCTGACTCTGAGATGACCAGTCATTCCCAACATAGCACCGCAACTCGTCAGCCTTCAATGACTCTC
CAACGGGCCGTCTCCCTGGAAGGAGAGCCTCGCAAGGTAGTCCTGCACAAAGGCTCCACTGGCCTGGGCTTCAACATTGTCGGTGGGGAA
GATGGAGAAGGTATTTTTGTGTCCTTCATTCTGGCTGGTGGACCAGCAGACCTAAGTGGGGAGCTCCAGAGAGGAGACCAGATCCTATCG
GTGAATGGCATTGACCTCCGTGGTGCATCCCACGAGCAGGCAGCTGCTGCACTAAAGGGGGCTGGACAGACAGTGACGATTATAGCACAA
TATCAACCTGAAGATTACGCTCGATTTGAGGCCAAAATCCATGACCTACGAGAGCAGATGATGAACCACAGCATGAGCTCCGGGTCCGGA
TCCCTGCGAACCAATCAGAAACGCTCCCTCTACGTCAGAGCCATGTTCGACTACGACAAGAGCAAGGACAGTGGGCTGCCAAGTCAAGGA
CTTAGTTTTAAATATGGAGATATTCTCCACGTTATCAATGCCTCTGATGATGAGTGGTGGCAAGCCAGGAGAGTCATGCTGGAGGGAGAC
AGTGAGGAGATGGGGGTCATCCCCAGCAAAAGGAGGGTGGAAAGAAAGGAACGTGCCCGATTGAAGACAGTGAAGTTTAATGCCAAACCT
GGAGTGATTGATTCGAAAGGGTCATTCAATGACAAGCGTAAAAAGAGCTTCATCTTTTCACGAAAATTCCCATTCTACAAGAACAAGGAG
CAGAGTGAGCAGGAAACCAGTGATCCTGAACGAGGACAAGAAGACCTCATTCTTTCCTATGAGCCTGTTACAAGGCAGGAAATAAACTAC
ACCCGGCCGGTGATTATCCTGGGGCCCATGAAGGATCGGATCAATGACGACTTGATATCTGAATTCCCTGATAAATTTGGCTCCTGTGTG
CCTCATACTACGAGGCCAAAGCGAGACTACGAGGTGGATGGCAGAGACTATCACTTTGTCATTTCCAGAGAACAAATGGAGAAAGATATC
CAAGAGCACAAGTTTATAGAAGCCGGCCAGTACAATGACAATTTATATGGAACCAGTGTGCAGTCTGTGAGATTTGTAGCAGAAAGAGGC
AAACACTGTATACTTGATGTATCAGGAAATGCTATCAAGCGGTTACAAGTTGCCCAGCTCTATCCCATTGCCATCTTCATAAAACCCAGG
TCTCTGGAACCTCTTATGGAGATGAATAAGCGTCTAACAGAGGAACAAGCCAAGAAAACCTATGATCGAGCAATTAAGCTAGAACAAGAA
TTTGGAGAATATTTTACAGCTATTGTCCAAGGAGATACTTTAGAAGATATATATAACCAATGCAAGCTTGTTATTGAAGAGCAATCTGGG

>In-frame_LRP5_ENST00000294304_chr11_68157520_+_DLG2_ENST00000418306_chr11_83676511_-_3246nt
ATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTGCCCGGCCCCCGCCGCG
GCCTCGCCGCTCCTGCTATTTGCCAACCGCCGGGACGTACGGCTGGTGGACGCCGGCGGAGTCAAGCTGGAGTCCACCATCGTGGTCAGC
GGCCTGGAGGATGCGGCCGCAGTGGACTTCCAGTTTTCCAAGGGAGCCGTGTACTGGACAGACGTGAGCGAGGAGGCCATCAAGCAGACC
TACCTGAACCAGACGGGGGCCGCCGTGCAGAACGTGGTCATCTCCGGCCTGGTCTCTCCCGACGGCCTCGCCTGCGACTGGGTGGGCAAG
AAGCTGTACTGGACGGACTCAGAGACCAACCGCATCGAGGTGGCCAACCTCAATGGCACATCCCGGAAGGTGCTCTTCTGGCAGGACCTT
GACCAGCCGAGGGCCATCGCCTTGGACCCCGCTCACGGGTACATGTACTGGACAGACTGGGGTGAGACGCCCCGGATTGAGCGGGCAGGG
ATGGATGGCAGCACCCGGAAGATCATTGTGGACTCGGACATTTACTGGCCCAATGGACTGACCATCGACCTGGAGGAGCAGAAGCTCTAC
TGGGCTGACGCCAAGCTCAGCTTCATCCACCGTGCCAACCTGGACGGCTCGTTCCGGCAGAAGGTGGTGGAGGGCAGCCTGACGCACCCC
TTCGCCCTGACGCTCTCCGGGGACACTCTGTACTGGACAGACTGGCAGACCCGCTCCATCCATGCCTGCAACAAGCGCACTGGGGGGAAG
AGGAAGGAGATCCTGAGTGCCCTCTACTCACCCATGGACATCCAGGTGCTGAGCCAGGAGCGGCAGCCTTTCTTCCACACTCGCTGTGAG
GAGGACAATGGCGGCTGCTCCCACCTGTGCCTGCTGTCCCCAAGCGAGCCTTTCTACACATGCGCCTGCCCCACGGGTGTGCAGCTGCAG
GACAACGGCAGGACGTGTAAGGCAGGAGCCGAGGAGGTGCTGCTGCTGGCCCGGCGGACGGACCTACGGAGGATCTCGCTGGACACGCCG
GACTTCACCGACATCGTGCTGCAGGTGGACGACATCCGGCACGCCATTGCCATCGACTACGACCCGCTAGAGGGCTATGTCTACTGGACA
GATGACGAGGTGCGGGCCATCCGCAGGGCGTACCTGGACGGGTCTGGGGCGCAGACGCTGGTCAACACCGAGATCAACGACCCCGATGGC
ATCGCGGTCGACTGGGTGGCCCGAAACCTCTACTGGACCGACACGGGCACGGACCGCATCGAGGTGACGCGCCTCAACGGCACCTCCCGC
AAGATCCTGGTGTCGGAGGACCTGGACGAGCCCCGAGCCATCGCACTGCACCCCGTGATGGGCCTCATGTACTGGACAGACTGGGGAGAG
AACCCTAAAATCGAGTGTGCCAACTTGGATGGGCAGGAGCGGCGTGTGCTGGTCAATGCCTCCCTCGGGTGGCCCAACGGCCTGGCCCTG
GACCTGCAGGAGGGGAAGCTCTACTGGGGAGACGCCAAGACAGACAAGATCGAGGTAAACAACTACAGTTTAGAAGAAGTAACACACGAA
GAGGCAGTAGCAATATTAAAGAACACATCAGAGGTAGTTTATTTAAAAGTTGGCAAACCCACTACCATTTATATGACTGATCCTTATGGT
CCACCTGATATTACTCACTCTTATTCTCCACCAATGGAAAACCATCTACTCTCTGGCAACAATGGCACTTTAGAATATAAAACCTCCCTG
CCACCCATCTCTCCAGGAAGGTACTCACCAATTCCAAAGCACATGCTTGTTGACGACGACTACACCAGTCATTCCCAACATAGCACCGCA
ACTCGTCAGCCTTCAATGACTCTCCAACGGGCCGTCTCCCTGGAAGGAGAGCCTCGCAAGGTAGTCCTGCACAAAGGCTCCACTGGCCTG
GGCTTCAACATTGTCGGTGGGGAAGATGGAGAAGGTATTTTTGTGTCCTTCATTCTGGCTGGTGGACCAGCAGACCTAAGTGGGGAGCTC
CAGAGAGGAGACCAGATCCTATCGGTGAATGGCATTGACCTCCGTGGTGCATCCCACGAGCAGGCAGCTGCTGCACTAAAGGGGGCTGGA
CAGACAGTGACGATTATAGCACAATATCAACCTGAAGATTACGCTCGATTTGAGGCCAAAATCCATGACCTACGAGAGCAGATGATGAAC
CACAGCATGAGCTCCGGGTCCGGATCCCTGCGAACCAATCAGAAACGCTCCCTCTACGTCAGAGCCATGTTCGACTACGACAAGAGCAAG
GACAGTGGGCTGCCAAGTCAAGGACTTAGTTTTAAATATGGAGATATTCTCCACGTTATCAATGCCTCTGATGATGAGTGGTGGCAAGCC
AGGAGAGTCATGCTGGAGGGAGACAGTGAGGAGATGGGGGTCATCCCCAGCAAAAGGAGGGTGGAAAGAAAGGAACGTGCCCGATTGAAG
ACAGTGAAGTTTAATGCCAAACCTGGAGTGATTGATTCGAAAGGGGACATCCCCGGATTAGGTGACGACGGTTATGGAACAAAGACTCTG
AGAGGACAAGAAGACCTCATTCTTTCCTATGAGCCTGTTACAAGGCAGGAAATAAACTACACCCGGCCGGTGATTATCCTGGGGCCCATG
AAGGATCGGATCAATGACGACTTGATATCTGAATTCCCTGATAAATTTGGCTCCTGTGTGCCTCATACTACGAGGCCAAAGCGAGACTAC
GAGGTGGATGGCAGAGACTATCACTTTGTCATTTCCAGAGAACAAATGGAGAAAGATATCCAAGAGCACAAGTTTATAGAAGCCGGCCAG
TACAATGACAATTTATATGGAACCAGTGTGCAGTCTGTGAGATTTGTAGCAGAAAGAGGCAAACACTGTATACTTGATGTATCAGGAAAT
GCTATCAAGCGGTTACAAGTTGCCCAGCTCTATCCCATTGCCATCTTCATAAAACCCAGGTCTCTGGAACCTCTTATGGAGATGAATAAG
CGTCTAACAGAGGAACAAGCCAAGAAAACCTATGATCGAGCAATTAAGCTAGAACAAGAATTTGGAGAATATTTTACAGCTATTGTCCAA
GGAGATACTTTAGAAGATATATATAACCAATGCAAGCTTGTTATTGAAGAGCAATCTGGGCCTTTCATCTGGATTCCCTCAAAGGAAAAG

>In-frame_LRP5_ENST00000294304_chr11_68157520_+_DLG2_ENST00000280241_chr11_83676511_-_3456nt
ATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTGCCCGGCCCCCGCCGCG
GCCTCGCCGCTCCTGCTATTTGCCAACCGCCGGGACGTACGGCTGGTGGACGCCGGCGGAGTCAAGCTGGAGTCCACCATCGTGGTCAGC
GGCCTGGAGGATGCGGCCGCAGTGGACTTCCAGTTTTCCAAGGGAGCCGTGTACTGGACAGACGTGAGCGAGGAGGCCATCAAGCAGACC
TACCTGAACCAGACGGGGGCCGCCGTGCAGAACGTGGTCATCTCCGGCCTGGTCTCTCCCGACGGCCTCGCCTGCGACTGGGTGGGCAAG
AAGCTGTACTGGACGGACTCAGAGACCAACCGCATCGAGGTGGCCAACCTCAATGGCACATCCCGGAAGGTGCTCTTCTGGCAGGACCTT
GACCAGCCGAGGGCCATCGCCTTGGACCCCGCTCACGGGTACATGTACTGGACAGACTGGGGTGAGACGCCCCGGATTGAGCGGGCAGGG
ATGGATGGCAGCACCCGGAAGATCATTGTGGACTCGGACATTTACTGGCCCAATGGACTGACCATCGACCTGGAGGAGCAGAAGCTCTAC
TGGGCTGACGCCAAGCTCAGCTTCATCCACCGTGCCAACCTGGACGGCTCGTTCCGGCAGAAGGTGGTGGAGGGCAGCCTGACGCACCCC
TTCGCCCTGACGCTCTCCGGGGACACTCTGTACTGGACAGACTGGCAGACCCGCTCCATCCATGCCTGCAACAAGCGCACTGGGGGGAAG
AGGAAGGAGATCCTGAGTGCCCTCTACTCACCCATGGACATCCAGGTGCTGAGCCAGGAGCGGCAGCCTTTCTTCCACACTCGCTGTGAG
GAGGACAATGGCGGCTGCTCCCACCTGTGCCTGCTGTCCCCAAGCGAGCCTTTCTACACATGCGCCTGCCCCACGGGTGTGCAGCTGCAG
GACAACGGCAGGACGTGTAAGGCAGGAGCCGAGGAGGTGCTGCTGCTGGCCCGGCGGACGGACCTACGGAGGATCTCGCTGGACACGCCG
GACTTCACCGACATCGTGCTGCAGGTGGACGACATCCGGCACGCCATTGCCATCGACTACGACCCGCTAGAGGGCTATGTCTACTGGACA
GATGACGAGGTGCGGGCCATCCGCAGGGCGTACCTGGACGGGTCTGGGGCGCAGACGCTGGTCAACACCGAGATCAACGACCCCGATGGC
ATCGCGGTCGACTGGGTGGCCCGAAACCTCTACTGGACCGACACGGGCACGGACCGCATCGAGGTGACGCGCCTCAACGGCACCTCCCGC
AAGATCCTGGTGTCGGAGGACCTGGACGAGCCCCGAGCCATCGCACTGCACCCCGTGATGGGCCTCATGTACTGGACAGACTGGGGAGAG
AACCCTAAAATCGAGTGTGCCAACTTGGATGGGCAGGAGCGGCGTGTGCTGGTCAATGCCTCCCTCGGGTGGCCCAACGGCCTGGCCCTG
GACCTGCAGGAGGGGAAGCTCTACTGGGGAGACGCCAAGACAGACAAGATCGAGGTAAACAACTACAGTTTAGAAGAAGTAACACACGAA
GAGGCAGTAGCAATATTAAAGAACACATCAGAGGTAGTTTATTTAAAAGTTGGCAAACCCACTACCATTTATATGACTGATCCTTATGGT
CCACCTGATATTACTCACTCTTATTCTCCACCAATGGAAAACCATCTACTCTCTGGCAACAATGGCACTTTAGAATATAAAACCTCCCTG
CCACCCATCTCTCCAGGAAGGTACTCACCAATTCCAAAGCACATGCTTGTTGACGACGACTACACCAGGCCTCCGGAACCTGTTTACAGC
ACTGTGAACAAACTATGTGATAAGCCTGCTTCTCCCAGGCACTATTCCCCTGTTGAGTGTGACAAAAGCTTCCTCCTCTCAGCTCCCTAT
TCCCACTACCACCTAGGCCTGCTACCTGACTCTGAGATGACCAGTCATTCCCAACATAGCACCGCAACTCGTCAGCCTTCAATGACTCTC
CAACGGGCCGTCTCCCTGGAAGGAGAGCCTCGCAAGGTAGTCCTGCACAAAGGCTCCACTGGCCTGGGCTTCAACATTGTCGGTGGGGAA
GATGGAGAAGGTATTTTTGTGTCCTTCATTCTGGCTGGTGGACCAGCAGACCTAAGTGGGGAGCTCCAGAGAGGAGACCAGATCCTATCG
GTGAATGGCATTGACCTCCGTGGTGCATCCCACGAGCAGGCAGCTGCTGCACTAAAGGGGGCTGGACAGACAGTGACGATTATAGCACAA
TATCAACCTGAAGATTACGCTCGATTTGAGGCCAAAATCCATGACCTACGAGAGCAGATGATGAACCACAGCATGAGCTCCGGGTCCGGA
TCCCTGCGAACCAATCAGAAACGCTCCCTCTACGTCAGAGCCATGTTCGACTACGACAAGAGCAAGGACAGTGGGCTGCCAAGTCAAGGA
CTTAGTTTTAAATATGGAGATATTCTCCACGTTATCAATGCCTCTGATGATGAGTGGTGGCAAGCCAGGAGAGTCATGCTGGAGGGAGAC
AGTGAGGAGATGGGGGTCATCCCCAGCAAAAGGAGGGTGGAAAGAAAGGAACGTGCCCGATTGAAGACAGTGAAGTTTAATGCCAAACCT
GGAGTGATTGATTCGAAAGGGTCATTCAATGACAAGCGTAAAAAGAGCTTCATCTTTTCACGAAAATTCCCATTCTACAAGAACAAGGAG
CAGAGTGAGCAGGAAACCAGTGATCCTGAACGAGGACAAGAAGACCTCATTCTTTCCTATGAGCCTGTTACAAGGCAGGAAATAAACTAC
ACCCGGCCGGTGATTATCCTGGGGCCCATGAAGGATCGGATCAATGACGACTTGATATCTGAATTCCCTGATAAATTTGGCTCCTGTGTG
CCTCATACTACGAGGCCAAAGCGAGACTACGAGGTGGATGGCAGAGACTATCACTTTGTCATTTCCAGAGAACAAATGGAGAAAGATATC
CAAGAGCACAAGTTTATAGAAGCCGGCCAGTACAATGACAATTTATATGGAACCAGTGTGCAGTCTGTGAGATTTGTAGCAGAAAGAGGC
AAACACTGTATACTTGATGTATCAGGAAATGCTATCAAGCGGTTACAAGTTGCCCAGCTCTATCCCATTGCCATCTTCATAAAACCCAGG
TCTCTGGAACCTCTTATGGAGATGAATAAGCGTCTAACAGAGGAACAAGCCAAGAAAACCTATGATCGAGCAATTAAGCTAGAACAAGAA
TTTGGAGAATATTTTACAGCTATTGTCCAAGGAGATACTTTAGAAGATATATATAACCAATGCAAGCTTGTTATTGAAGAGCAATCTGGG

>In-frame_LRP5_ENST00000294304_chr11_68157520_+_DLG2_ENST00000543673_chr11_83676511_-_3456nt
ATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTGCCCGGCCCCCGCCGCG
GCCTCGCCGCTCCTGCTATTTGCCAACCGCCGGGACGTACGGCTGGTGGACGCCGGCGGAGTCAAGCTGGAGTCCACCATCGTGGTCAGC
GGCCTGGAGGATGCGGCCGCAGTGGACTTCCAGTTTTCCAAGGGAGCCGTGTACTGGACAGACGTGAGCGAGGAGGCCATCAAGCAGACC
TACCTGAACCAGACGGGGGCCGCCGTGCAGAACGTGGTCATCTCCGGCCTGGTCTCTCCCGACGGCCTCGCCTGCGACTGGGTGGGCAAG
AAGCTGTACTGGACGGACTCAGAGACCAACCGCATCGAGGTGGCCAACCTCAATGGCACATCCCGGAAGGTGCTCTTCTGGCAGGACCTT
GACCAGCCGAGGGCCATCGCCTTGGACCCCGCTCACGGGTACATGTACTGGACAGACTGGGGTGAGACGCCCCGGATTGAGCGGGCAGGG
ATGGATGGCAGCACCCGGAAGATCATTGTGGACTCGGACATTTACTGGCCCAATGGACTGACCATCGACCTGGAGGAGCAGAAGCTCTAC
TGGGCTGACGCCAAGCTCAGCTTCATCCACCGTGCCAACCTGGACGGCTCGTTCCGGCAGAAGGTGGTGGAGGGCAGCCTGACGCACCCC
TTCGCCCTGACGCTCTCCGGGGACACTCTGTACTGGACAGACTGGCAGACCCGCTCCATCCATGCCTGCAACAAGCGCACTGGGGGGAAG
AGGAAGGAGATCCTGAGTGCCCTCTACTCACCCATGGACATCCAGGTGCTGAGCCAGGAGCGGCAGCCTTTCTTCCACACTCGCTGTGAG
GAGGACAATGGCGGCTGCTCCCACCTGTGCCTGCTGTCCCCAAGCGAGCCTTTCTACACATGCGCCTGCCCCACGGGTGTGCAGCTGCAG
GACAACGGCAGGACGTGTAAGGCAGGAGCCGAGGAGGTGCTGCTGCTGGCCCGGCGGACGGACCTACGGAGGATCTCGCTGGACACGCCG
GACTTCACCGACATCGTGCTGCAGGTGGACGACATCCGGCACGCCATTGCCATCGACTACGACCCGCTAGAGGGCTATGTCTACTGGACA
GATGACGAGGTGCGGGCCATCCGCAGGGCGTACCTGGACGGGTCTGGGGCGCAGACGCTGGTCAACACCGAGATCAACGACCCCGATGGC
ATCGCGGTCGACTGGGTGGCCCGAAACCTCTACTGGACCGACACGGGCACGGACCGCATCGAGGTGACGCGCCTCAACGGCACCTCCCGC
AAGATCCTGGTGTCGGAGGACCTGGACGAGCCCCGAGCCATCGCACTGCACCCCGTGATGGGCCTCATGTACTGGACAGACTGGGGAGAG
AACCCTAAAATCGAGTGTGCCAACTTGGATGGGCAGGAGCGGCGTGTGCTGGTCAATGCCTCCCTCGGGTGGCCCAACGGCCTGGCCCTG
GACCTGCAGGAGGGGAAGCTCTACTGGGGAGACGCCAAGACAGACAAGATCGAGGTAAACAACTACAGTTTAGAAGAAGTAACACACGAA
GAGGCAGTAGCAATATTAAAGAACACATCAGAGGTAGTTTATTTAAAAGTTGGCAAACCCACTACCATTTATATGACTGATCCTTATGGT
CCACCTGATATTACTCACTCTTATTCTCCACCAATGGAAAACCATCTACTCTCTGGCAACAATGGCACTTTAGAATATAAAACCTCCCTG
CCACCCATCTCTCCAGGAAGGTACTCACCAATTCCAAAGCACATGCTTGTTGACGACGACTACACCAGGCCTCCGGAACCTGTTTACAGC
ACTGTGAACAAACTATGTGATAAGCCTGCTTCTCCCAGGCACTATTCCCCTGTTGAGTGTGACAAAAGCTTCCTCCTCTCAGCTCCCTAT
TCCCACTACCACCTAGGCCTGCTACCTGACTCTGAGATGACCAGTCATTCCCAACATAGCACCGCAACTCGTCAGCCTTCAATGACTCTC
CAACGGGCCGTCTCCCTGGAAGGAGAGCCTCGCAAGGTAGTCCTGCACAAAGGCTCCACTGGCCTGGGCTTCAACATTGTCGGTGGGGAA
GATGGAGAAGGTATTTTTGTGTCCTTCATTCTGGCTGGTGGACCAGCAGACCTAAGTGGGGAGCTCCAGAGAGGAGACCAGATCCTATCG
GTGAATGGCATTGACCTCCGTGGTGCATCCCACGAGCAGGCAGCTGCTGCACTAAAGGGGGCTGGACAGACAGTGACGATTATAGCACAA
TATCAACCTGAAGATTACGCTCGATTTGAGGCCAAAATCCATGACCTACGAGAGCAGATGATGAACCACAGCATGAGCTCCGGGTCCGGA
TCCCTGCGAACCAATCAGAAACGCTCCCTCTACGTCAGAGCCATGTTCGACTACGACAAGAGCAAGGACAGTGGGCTGCCAAGTCAAGGA
CTTAGTTTTAAATATGGAGATATTCTCCACGTTATCAATGCCTCTGATGATGAGTGGTGGCAAGCCAGGAGAGTCATGCTGGAGGGAGAC
AGTGAGGAGATGGGGGTCATCCCCAGCAAAAGGAGGGTGGAAAGAAAGGAACGTGCCCGATTGAAGACAGTGAAGTTTAATGCCAAACCT
GGAGTGATTGATTCGAAAGGGTCATTCAATGACAAGCGTAAAAAGAGCTTCATCTTTTCACGAAAATTCCCATTCTACAAGAACAAGGAG
CAGAGTGAGCAGGAAACCAGTGATCCTGAACGAGGACAAGAAGACCTCATTCTTTCCTATGAGCCTGTTACAAGGCAGGAAATAAACTAC
ACCCGGCCGGTGATTATCCTGGGGCCCATGAAGGATCGGATCAATGACGACTTGATATCTGAATTCCCTGATAAATTTGGCTCCTGTGTG
CCTCATACTACGAGGCCAAAGCGAGACTACGAGGTGGATGGCAGAGACTATCACTTTGTCATTTCCAGAGAACAAATGGAGAAAGATATC
CAAGAGCACAAGTTTATAGAAGCCGGCCAGTACAATGACAATTTATATGGAACCAGTGTGCAGTCTGTGAGATTTGTAGCAGAAAGAGGC
AAACACTGTATACTTGATGTATCAGGAAATGCTATCAAGCGGTTACAAGTTGCCCAGCTCTATCCCATTGCCATCTTCATAAAACCCAGG
TCTCTGGAACCTCTTATGGAGATGAATAAGCGTCTAACAGAGGAACAAGCCAAGAAAACCTATGATCGAGCAATTAAGCTAGAACAAGAA
TTTGGAGAATATTTTACAGCTATTGTCCAAGGAGATACTTTAGAAGATATATATAACCAATGCAAGCTTGTTATTGAAGAGCAATCTGGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_LRP5_ENST00000294304_chr11_68157520_+_DLG2_ENST00000398309_chr11_83676511_-_8368nt
GCCCGAGGGGGGAGGCGGAGGCGCCGGGAGCCGCGCGAGGAGCCGCCGCCGCCGCGCCATGGAGCCCGAGTGAGCGCGGCGCGGGCCCGT
CCGGCCGCCGGACAACATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTG
CCCGGCCCCCGCCGCGGCCTCGCCGCTCCTGCTATTTGCCAACCGCCGGGACGTACGGCTGGTGGACGCCGGCGGAGTCAAGCTGGAGTC
CACCATCGTGGTCAGCGGCCTGGAGGATGCGGCCGCAGTGGACTTCCAGTTTTCCAAGGGAGCCGTGTACTGGACAGACGTGAGCGAGGA
GGCCATCAAGCAGACCTACCTGAACCAGACGGGGGCCGCCGTGCAGAACGTGGTCATCTCCGGCCTGGTCTCTCCCGACGGCCTCGCCTG
CGACTGGGTGGGCAAGAAGCTGTACTGGACGGACTCAGAGACCAACCGCATCGAGGTGGCCAACCTCAATGGCACATCCCGGAAGGTGCT
CTTCTGGCAGGACCTTGACCAGCCGAGGGCCATCGCCTTGGACCCCGCTCACGGGTACATGTACTGGACAGACTGGGGTGAGACGCCCCG
GATTGAGCGGGCAGGGATGGATGGCAGCACCCGGAAGATCATTGTGGACTCGGACATTTACTGGCCCAATGGACTGACCATCGACCTGGA
GGAGCAGAAGCTCTACTGGGCTGACGCCAAGCTCAGCTTCATCCACCGTGCCAACCTGGACGGCTCGTTCCGGCAGAAGGTGGTGGAGGG
CAGCCTGACGCACCCCTTCGCCCTGACGCTCTCCGGGGACACTCTGTACTGGACAGACTGGCAGACCCGCTCCATCCATGCCTGCAACAA
GCGCACTGGGGGGAAGAGGAAGGAGATCCTGAGTGCCCTCTACTCACCCATGGACATCCAGGTGCTGAGCCAGGAGCGGCAGCCTTTCTT
CCACACTCGCTGTGAGGAGGACAATGGCGGCTGCTCCCACCTGTGCCTGCTGTCCCCAAGCGAGCCTTTCTACACATGCGCCTGCCCCAC
GGGTGTGCAGCTGCAGGACAACGGCAGGACGTGTAAGGCAGGAGCCGAGGAGGTGCTGCTGCTGGCCCGGCGGACGGACCTACGGAGGAT
CTCGCTGGACACGCCGGACTTCACCGACATCGTGCTGCAGGTGGACGACATCCGGCACGCCATTGCCATCGACTACGACCCGCTAGAGGG
CTATGTCTACTGGACAGATGACGAGGTGCGGGCCATCCGCAGGGCGTACCTGGACGGGTCTGGGGCGCAGACGCTGGTCAACACCGAGAT
CAACGACCCCGATGGCATCGCGGTCGACTGGGTGGCCCGAAACCTCTACTGGACCGACACGGGCACGGACCGCATCGAGGTGACGCGCCT
CAACGGCACCTCCCGCAAGATCCTGGTGTCGGAGGACCTGGACGAGCCCCGAGCCATCGCACTGCACCCCGTGATGGGCCTCATGTACTG
GACAGACTGGGGAGAGAACCCTAAAATCGAGTGTGCCAACTTGGATGGGCAGGAGCGGCGTGTGCTGGTCAATGCCTCCCTCGGGTGGCC
CAACGGCCTGGCCCTGGACCTGCAGGAGGGGAAGCTCTACTGGGGAGACGCCAAGACAGACAAGATCGAGGTAAACAACTACAGTTTAGA
AGAAGTAACACACGAAGAGGCAGTAGCAATATTAAAGAACACATCAGAGGTAGTTTATTTAAAAGTTGGCAAACCCACTACCATTTATAT
GACTGATCCTTATGGTCCACCTGATATTACTCACTCTTATTCTCCACCAATGGAAAACCATCTACTCTCTGGCAACAATGGCACTTTAGA
ATATAAAACCTCCCTGCCACCCATCTCTCCAGGAAGGTACTCACCAATTCCAAAGCACATGCTTGTTGACGACGACTACACCAGGCCTCC
GGAACCTGTTTACAGCACTGTGAACAAACTATGTGATAAGCCTGCTTCTCCCAGGCACTATTCCCCTGTTGAGTGTGACAAAAGCTTCCT
CCTCTCAGCTCCCTATTCCCACTACCACCTAGGCCTGCTACCTGACTCTGAGATGACCAGTCATTCCCAACATAGCACCGCAACTCGTCA
GCCTTCAATGACTCTCCAACGGGCCGTCTCCCTGGAAGGAGAGCCTCGCAAGGTAGTCCTGCACAAAGGCTCCACTGGCCTGGGCTTCAA
CATTGTCGGTGGGGAAGATGGAGAAGGTATTTTTGTGTCCTTCATTCTGGCTGGTGGACCAGCAGACCTAAGTGGGGAGCTCCAGAGAGG
AGACCAGATCCTATCGGTGAATGGCATTGACCTCCGTGGTGCATCCCACGAGCAGGCAGCTGCTGCACTAAAGGGGGCTGGACAGACAGT
GACGATTATAGCACAATATCAACCTGAAGATTACGCTCGATTTGAGGCCAAAATCCATGACCTACGAGAGCAGATGATGAACCACAGCAT
GAGCTCCGGGTCCGGATCCCTGCGAACCAATCAGAAACGCTCCCTCTACGTCAGAGCCATGTTCGACTACGACAAGAGCAAGGACAGTGG
GCTGCCAAGTCAAGGACTTAGTTTTAAATATGGAGATATTCTCCACGTTATCAATGCCTCTGATGATGAGTGGTGGCAAGCCAGGAGAGT
CATGCTGGAGGGAGACAGTGAGGAGATGGGGGTCATCCCCAGCAAAAGGAGGGTGGAAAGAAAGGAACGTGCCCGATTGAAGACAGTGAA
GTTTAATGCCAAACCTGGAGTGATTGATTCGAAAGGGTCATTCAATGACAAGCGTAAAAAGAGCTTCATCTTTTCACGAAAATTCCCATT
CTACAAGAACAAGGAGCAGAGTGAGCAGGAAACCAGTGATCCTGAACGAGGACAAGAAGACCTCATTCTTTCCTATGAGCCTGTTACAAG
GCAGGAAATAAACTACACCCGGCCGGTGATTATCCTGGGGCCCATGAAGGATCGGATCAATGACGACTTGATATCTGAATTCCCTGATAA
ATTTGGCTCCTGTGTGCCTCATACTACGAGGCCAAAGCGAGACTACGAGGTGGATGGCAGAGACTATCACTTTGTCATTTCCAGAGAACA
AATGGAGAAAGATATCCAAGAGCACAAGTTTATAGAAGCCGGCCAGTACAATGACAATTTATATGGAACCAGTGTGCAGTCTGTGAGATT
TGTAGCAGAAAGAGGCAAACACTGTATACTTGATGTATCAGGAAATGCTATCAAGCGGTTACAAGTTGCCCAGCTCTATCCCATTGCCAT
CTTCATAAAACCCAGGTCTCTGGAACCTCTTATGGAGATGAATAAGCGTCTAACAGAGGAACAAGCCAAGAAAACCTATGATCGAGCAAT
TAAGCTAGAACAAGAATTTGGAGAATATTTTACAGCTATTGTCCAAGGAGATACTTTAGAAGATATATATAACCAATGCAAGCTTGTTAT
TGAAGAGCAATCTGGGCCTTTCATCTGGATTCCCTCAAAGGAAAAGTTATAAATTAGCTACTGCGCCTCTGACAACGACAGAAGAGCATT
TAGAAGAACAAAATATATATAACATACTACTTGGAGGCTTTTATGTTTTTGTTGCATTTATGTTTTTGCAGTCAATGTGAATTCTTACGA
ATGTACAACACAAACTGTATGAAGCCATGAAGGAAACAGAGGGGCCAAAGGGTGGGACAGAAAAGACATTGCAGTATGAAGGAAGGCTTT
GGTTTGCTCAAAGTGCCAGGTGTAGGGATGAACCTCTGACGGGCTTTCTGCCCAAGAGATGAGATGAGAGCCTCCTCACCCCAGCAGATG
TCCAGAGCTGATTTAGCTGCAGAGCTCTCTGTGTCTTTTGCTTTAAAGAAAAATTGCCAGCACTCGAACCTCATCAGCCTTCCCATTACC
CACATCTGTAATTGGTACACTTTGAATTTTATAACTATGCACATCTTTTGATTTCTTAACAAGCAAATGAAAGAAAGAAGGAAAAAAGAA
AGGAATCCCTTTGGAGATGACATACTATCAGGGAAGGATAAGTGTGTAGTTTTTTGACTGGCATCTGCAAAGACAAGAATTTCATAAAAT
TTGCAAGTGTATGGAGGACTAACCTCACTGACAGGAGGGGATTCCACCTGGGATTAGCTTTATGATTGTTGATTGCCTATTTTGCCATTT
ATAAACTGAAAGAAGGCACTAAAGATGAGAATAATTTATACAATAAAAATATATTAAATGTATAGAAACAAATTTCTATAGGTTAAAAAA
GTTTTGTGAAATATTTTGTAAAGACTAATATTGAAAGACTAAATGTATGCAACATCAGCAGATGATCAAATTCAAGACCTGAAAGTTGCA
CTCTCCCTTTTGTTGCCAATGATCTGTTAAGAGCATCTGAGTTCCTTTTAAGTCTGACAAAGACTTCTTCCTCACTTACCTCCCTTCCAC
ATTAGTGATACACTCTCATGCAGCACATCCCTTAATGAGTTGCCCTCATGGATATTTTTGGAAGACATTTGGTTAATGCATTTTTTTATG
CTGATGGCTTTTCAGAGACAAACTTATGCAAATGATCTAAAGGGAAGTTTTTGCTTTCCTCTAGTTAAATAACCTGAGCCTGCCATGCAA
ATAGTTGAATAACTTTGTTCCTAGTTACTGACATACAATTCTTAAAGGACCATTTAGCATTTTGGCCAACAATGAGTAATTAGGATTAGT
ACCTTTTTGTTTTACAGAGTAACTGAGAGTTTTGTAACATCCAGAGATGGTACTAGAGCCAATGAGAGATCTGTTCCTAGATGCACTATT
TCTTTGAGGAAGAGAGAGAAGAGAAGTGTCTGGTTGGGGGTGAGGGGGTGCAGACTTTTTTGTTTCTATGTACAGAGCAAAGAGATAGAG
TCACAAGGAAAGACAATTAATGACTTTGAGCTCAACCAACTGAACTGCCTTTCTTGGAGCTGCACCTGGACCAAGTTTATTTTTTAACAA
TTATAATAACGATGATTTAAAAAAAGAAACCTCCCAAAGCCTATAAACTGAACTAGAAGAGTTGGTTTCCCACTTTAGAGTGGATGGCGA
CATCAGCATTGCTTTTGCCCATGGTGTTTGGGGAGAGACTTTTCAGTGATAATAACCACTCTACTCTGGGTTCTGTGCATGCCCAGACTA
AGCCCCATCGCCTTATTTCTGGGGTACATCCAGACCTGGCAGGGATTCTGCCACACTGTGCAGCAAACCAGCATGTAGGCTGGGTAGGAG
AGCAAGAGATAGAGCCATCAGAGTGATGGGGCTTCTTCACAGTAAGAACATCGGAGCTTAGAATGAGAGTCTCTTTCCAAAAACAGGCAT
TGTTCATCTTACGCTAAACATCATTGTCTGCCTGGCTACAGTCACCAAAACAAAACAGAAATGCAAAATTATGCATCTTCCCATAGTCCT
GAGGCTTCCTTTGCCAATGGAAGGGCTAGCAATGCATTCTCCCTCTCATGAAAGTTAAATTTCCAGAGACTTCCTTAGATTGCTCAAAAT
GTTAAAGATATGTCCATGTCTGCAATTCGCCAGTTTCAGGTCAAGGCCTACTTTCATCAATATTGCTCCCAGAAGTTTTCTGACACCAGA
ATGCCATTCCTGATCCCAGCTCTATTTTTAGGCCACCACGATAACTTCTTTGGTTTCTCAACTGAGCATGCAACCATTTATTTAAAAGAC
TGTCATTAATGAGTAGATGTTTTCGCGGGTCGTGTGATGTGCTTTCCATTTACTAGTGTTGCTGTGGCTAAGTACAATCAAATTGAACCA
CCAACCCTTGGTTTTGTAGTAATATAACTATTTATTTTCCTAGTGTAGATGCTTTCAGATTAGAATTGGCATTTGCACTGATTTTTTTAT
GTAGATTTATATAAATATATAGATACATATATATTTGCTTGAAGAATCACCAAGCAAATTGGTGAGAGGGTCTTTTCCAATAGAATTTAC
ACCTCCATTTGTTGTGTTGTCTTGCACTTCCCAATGTTGATGTCTCTATGGCTCCAATGAACTGGTGTATTTTGCAGCAAATCTGATGAC
TTGTATGGAAATGGCATGAAAGTTACCCAGATTACATCTGGTGCAAATGCACTCGGAGCCTGGGGCCAGACTGGTGCTAACACTGCAAAC
TTTGTCCAGAGCTCTCTCCAACCTGAAGGCTTGCTGGGGGTGCAATGTCACCTTCACACATGCTGGGCCCTTTCAGAAAAGTGCCAGATC
GTGTAACTGGTGCTATTTTTCATGCTCTGGTACAATGTGTAGCACCACGGGGGTCTCAGCTTTACCAAAATCAAAATTCCATTTGTCAGC
TAAGTGCAGAGGCATTTGTTTTTTGCTCTCCTCCCACAGAATTGTCGGCCATTTATTTGCAGGCCTTTTGCGGGATTTCTTGGCTATTTA
TTTGCAGGCCTTTTTTCCCAGCCCCAAATTCTTGGGTTGGCTCTGTCTGCTTAAAGAGCCTGTCTTCACAAAGCTGCACTCGGGTGCCTC
TGTGCGCTGTCTTAGATCCTACTGCCGGCCCTTCAGGACTCCGAGCCAGGAAAGAACTCTCCAACCTCTGGCTCGAGACTCTACTTTTTT
TCTCATTCTTTTCCTTACTCTCCTCCTCCTTCTACTTCCGACTAATTCCATCTCTTTTTTTTTTTGTTCCTCTCCTTTTCCTATTCCTCC
TTCCCACCATCTCTGAGTTGTTGACTTTCTCCTATAATCCTTCTCTATTCCCTTTCTCTTTTTGTCCACCTCTCCTTTAGTCTCTGTTTC
TCTGCCCTTCTTATTCCTCTTCTGTCCTTTCTCCTCTCCTCAAATCTCTGATCATCTTCTCCCGTACATCCCTGTATTGATTTTTCTGTC
CTCTAAAGGGCTCATGGCTGATTCAGACAGCAAGTCCATGCACTGGACTAATGACACAAATACTTTAGGTCGCCGTTTCACCTACTCAGC
CCAGAAAGTAAAGCTGAGCGTGAGGCCCTGACCTGGAGCCTGCTCCAGCCCGCCTCCCGGAGCCAGCCTGCACCGTTGCCCTGGCAGCGA
TGATGCATGTGCTGTGGGCCCTGCCGGCGCCTGAGTGCCTCTGCCTGAACACTGCTCCTAAGCGAGCCCACTCCCAGCACTACCGCATGG
CTCTGAGGACATTTTCTTTCAATAAAGGCAGACTCTGGCCCCAATTATTCTGATAGCAAACCTCTTCCTCCTCATTGAAGCCATGCCATC
ACCTTGGTTTGGAGAGAGACATTTTTTTCCCATTCATAAGCTTTCTTTTTCCCATTTTTATGTGAAGCCCCCTCTGCTTTTCAGCTGGTG
ATTGCTCTGGTGAGACTGAATGGACTTGCTGGTGAAATGAAATCTCTTCTTTCCTGTCTTGGTCCTGCCTAAATTCCTACAAATATATTT
AAGCCAAGGACTCAGGCTAATTCCTAAGTTGATCACATTAATTTGTTACTCCTAGAGGGAAAAAGATCAATTCCCTTGAAGCATGTGGAG
TACCTCCTGTGACAGCTGACTTGCCAGGGGACTCCCTACAGAATTCTGTGATATACATTTTACTTCTGTGTATGTATGGTATATATGGTA
TGTATACCATGTACACACGTTACATTGAGTATGAATGACTGTGGTTGGAAACACACACACACACTCAAGTCTGTAAATATCCTTCCTCAC
TGAAACCTGTGCTTTGGAAATCATTTCTTGTACAGCTGTGCAGTTTCTTGTAACAGCTGAGGACAAAGCTAAGACAGGCGGACAATTTAG
ACAAAGATCATCTAAAGAGTATAGTATCTCCCTAGCAACTCATGAGGACAGACAACCAAGTGGCAAGGTTGACTCCCAATGGGATGGCAG
ACTTTTCTTCTCTCCTTTTTGAGTTTGTGTTTCCTAAGTGTTTCTTAACTTCTGAGTGCACCAGGCTGTACCCGTTAGATCCTTTCAATA
TGACAGTTTTGTGCTTCTCTCTGACAGGATGTTTCTCCACCGAGCTGTAGCACAGGATGGGAGGGAGGTGGGAATACTCCTTGCCTAGGC
TGGAGTTTACAGAGACACTGCACAGCTTACACTCCTGTTAAGTGTAAATATTCAACACTTCCATTCCATTTGTGTAAAAAATAAAGCACA
CACGATTATAAAATCAAGATGTATATTTCATACTCAGTGTGTCTGTGCATATTTATTGCGTTTCTAGTTGTCAGCGGTGGGTGGCCCCAT

>In-frame_LRP5_ENST00000294304_chr11_68157520_+_DLG2_ENST00000376104_chr11_83676511_-_5461nt
GCCCGAGGGGGGAGGCGGAGGCGCCGGGAGCCGCGCGAGGAGCCGCCGCCGCCGCGCCATGGAGCCCGAGTGAGCGCGGCGCGGGCCCGT
CCGGCCGCCGGACAACATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTG
CCCGGCCCCCGCCGCGGCCTCGCCGCTCCTGCTATTTGCCAACCGCCGGGACGTACGGCTGGTGGACGCCGGCGGAGTCAAGCTGGAGTC
CACCATCGTGGTCAGCGGCCTGGAGGATGCGGCCGCAGTGGACTTCCAGTTTTCCAAGGGAGCCGTGTACTGGACAGACGTGAGCGAGGA
GGCCATCAAGCAGACCTACCTGAACCAGACGGGGGCCGCCGTGCAGAACGTGGTCATCTCCGGCCTGGTCTCTCCCGACGGCCTCGCCTG
CGACTGGGTGGGCAAGAAGCTGTACTGGACGGACTCAGAGACCAACCGCATCGAGGTGGCCAACCTCAATGGCACATCCCGGAAGGTGCT
CTTCTGGCAGGACCTTGACCAGCCGAGGGCCATCGCCTTGGACCCCGCTCACGGGTACATGTACTGGACAGACTGGGGTGAGACGCCCCG
GATTGAGCGGGCAGGGATGGATGGCAGCACCCGGAAGATCATTGTGGACTCGGACATTTACTGGCCCAATGGACTGACCATCGACCTGGA
GGAGCAGAAGCTCTACTGGGCTGACGCCAAGCTCAGCTTCATCCACCGTGCCAACCTGGACGGCTCGTTCCGGCAGAAGGTGGTGGAGGG
CAGCCTGACGCACCCCTTCGCCCTGACGCTCTCCGGGGACACTCTGTACTGGACAGACTGGCAGACCCGCTCCATCCATGCCTGCAACAA
GCGCACTGGGGGGAAGAGGAAGGAGATCCTGAGTGCCCTCTACTCACCCATGGACATCCAGGTGCTGAGCCAGGAGCGGCAGCCTTTCTT
CCACACTCGCTGTGAGGAGGACAATGGCGGCTGCTCCCACCTGTGCCTGCTGTCCCCAAGCGAGCCTTTCTACACATGCGCCTGCCCCAC
GGGTGTGCAGCTGCAGGACAACGGCAGGACGTGTAAGGCAGGAGCCGAGGAGGTGCTGCTGCTGGCCCGGCGGACGGACCTACGGAGGAT
CTCGCTGGACACGCCGGACTTCACCGACATCGTGCTGCAGGTGGACGACATCCGGCACGCCATTGCCATCGACTACGACCCGCTAGAGGG
CTATGTCTACTGGACAGATGACGAGGTGCGGGCCATCCGCAGGGCGTACCTGGACGGGTCTGGGGCGCAGACGCTGGTCAACACCGAGAT
CAACGACCCCGATGGCATCGCGGTCGACTGGGTGGCCCGAAACCTCTACTGGACCGACACGGGCACGGACCGCATCGAGGTGACGCGCCT
CAACGGCACCTCCCGCAAGATCCTGGTGTCGGAGGACCTGGACGAGCCCCGAGCCATCGCACTGCACCCCGTGATGGGCCTCATGTACTG
GACAGACTGGGGAGAGAACCCTAAAATCGAGTGTGCCAACTTGGATGGGCAGGAGCGGCGTGTGCTGGTCAATGCCTCCCTCGGGTGGCC
CAACGGCCTGGCCCTGGACCTGCAGGAGGGGAAGCTCTACTGGGGAGACGCCAAGACAGACAAGATCGAGGTAAACAACTACAGTTTAGA
AGAAGTAACACACGAAGAGGCAGTAGCAATATTAAAGAACACATCAGAGGTAGTTTATTTAAAAGTTGGCAAACCCACTACCATTTATAT
GACTGATCCTTATGGTCCACCTGATATTACTCACTCTTATTCTCCACCAATGGAAAACCATCTACTCTCTGGCAACAATGGCACTTTAGA
ATATAAAACCTCCCTGCCACCCATCTCTCCAGGAAGGTACTCACCAATTCCAAAGCACATGCTTGTTGACGACGACTACACCAGGCCTCC
GGAACCTGTTTACAGCACTGTGAACAAACTATGTGATAAGCCTGCTTCTCCCAGGCACTATTCCCCTGTTGAGTGTGACAAAAGCTTCCT
CCTCTCAGCTCCCTATTCCCACTACCACCTAGGCCTGCTACCTGACTCTGAGATGACCAGTCATTCCCAACATAGCACCGCAACTCGTCA
GCCTTCAATGACTCTCCAACGGGCCGTCTCCCTGGAAGGAGAGCCTCGCAAGGTAGTCCTGCACAAAGGCTCCACTGGCCTGGGCTTCAA
CATTGTCGGTGGGGAAGATGGAGAAGGTATTTTTGTGTCCTTCATTCTGGCTGGTGGACCAGCAGACCTAAGTGGGGAGCTCCAGAGAGG
AGACCAGATCCTATCGGTGAATGGCATTGACCTCCGTGGTGCATCCCACGAGCAGGCAGCTGCTGCACTAAAGGGGGCTGGACAGACAGT
GACGATTATAGCACAATATCAACCTGAAGATTACGCTCGATTTGAGGCCAAAATCCATGACCTACGAGAGCAGATGATGAACCACAGCAT
GAGCTCCGGGTCCGGATCCCTGCGAACCAATCAGAAACGCTCCCTCTACGTCAGAGCCATGTTCGACTACGACAAGAGCAAGGACAGTGG
GCTGCCAAGTCAAGGACTTAGTTTTAAATATGGAGATATTCTCCACGTTATCAATGCCTCTGATGATGAGTGGTGGCAAGCCAGGAGAGT
CATGCTGGAGGGAGACAGTGAGGAGATGGGGGTCATCCCCAGCAAAAGGAGGGTGGAAAGAAAGGAACGTGCCCGATTGAAGACAGTGAA
GTTTAATGCCAAACCTGGAGTGATTGATTCGAAAGGGTCATTCAATGACAAGCGTAAAAAGAGCTTCATCTTTTCACGAAAATTCCCATT
CTACAAGAACAAGGAGCAGAGTGAGCAGGAAACCAGTGATCCTGAACGAGGACAAGAAGACCTCATTCTTTCCTATGAGCCTGTTACAAG
GCAGGAAATAAACTACACCCGGCCGGTGATTATCCTGGGGCCCATGAAGGATCGGATCAATGACGACTTGATATCTGAATTCCCTGATAA
ATTTGGCTCCTGTGTGCCTCATACTACGAGGCCAAAGCGAGACTACGAGGTGGATGGCAGAGACTATCACTTTGTCATTTCCAGAGAACA
AATGGAGAAAGATATCCAAGAGCACAAGTTTATAGAAGCCGGCCAGTACAATGACAATTTATATGGAACCAGTGTGCAGTCTGTGAGATT
TGTAGCAGAAAGAGGCAAACACTGTATACTTGATGTATCAGGAAATGCTATCAAGCGGTTACAAGTTGCCCAGCTCTATCCCATTGCCAT
CTTCATAAAACCCAGGTCTCTGGAACCTCTTATGGAGATGAATAAGCGTCTAACAGAGGAACAAGCCAAGAAAACCTATGATCGAGCAAT
TAAGCTAGAACAAGAATTTGGAGAATATTTTACAGCTATTGTCCAAGGAGATACTTTAGAAGATATATATAACCAATGCAAGCTTGTTAT
TGAAGAGCAATCTGGGCCTTTCATCTGGATTCCCTCAAAGGAAAAGTTATAAATTAGCTACTGCGCCTCTGACAACGACAGAAGAGCATT
TAGAAGAACAAAATATATATAACATACTACTTGGAGGCTTTTATGTTTTTGTTGCATTTATGTTTTTGCAGTCAATGTGAATTCTTACGA
ATGTACAACACAAACTGTATGAAGCCATGAAGGAAACAGAGGGGCCAAAGGGTGGGACAGAAAAGACATTGCAGTATGAAGGAAGGCTTT
GGTTTGCTCAAAGTGCCAGGTGTAGGGATGAACCTCTGACGGGCTTTCTGCCCAAGAGATGAGATGAGAGCCTCCTCACCCCAGCAGATG
TCCAGAGCTGATTTAGCTGCAGAGCTCTCTGTGTCTTTTGCTTTAAAGAAAAATTGCCAGCACTCGAACCTCATCAGCCTTCCCATTACC
CACATCTGTAATTGGTACACTTTGAATTTTATAACTATGCACATCTTTTGATTTCTTAACAAGCAAATGAAAGAAAGAAGGAAAAAAGAA
AGGAATCCCTTTGGAGATGACATACTATCAGGGAAGGATAAGTGTGTAGTTTTTTGACTGGCATCTGCAAAGACAAGAATTTCATAAAAT
TTGCAAGTGTATGGAGGACTAACCTCACTGACAGGAGGGGATTCCACCTGGGATTAGCTTTATGATTGTTGATTGCCTATTTTGCCATTT
ATAAACTGAAAGAAGGCACTAAAGATGAGAATAATTTATACAATAAAAATATATTAAATGTATAGAAACAAATTTCTATAGGTTAAAAAA
GTTTTGTGAAATATTTTGTAAAGACTAATATTGAAAGACTAAATGTATGCAACATCAGCAGATGATCAAATTCAAGACCTGAAAGTTGCA
CTCTCCCTTTTGTTGCCAATGATCTGTTAAGAGCATCTGAGTTCCTTTTAAGTCTGACAAAGACTTCTTCCTCACTTACCTCCCTTCCAC
ATTAGTGATACACTCTCATGCAGCACATCCCTTAATGAGTTGCCCTCATGGATATTTTTGGAAGACATTTGGTTAATGCATTTTTTTATG
CTGATGGCTTTTCAGAGACAAACTTATGCAAATGATCTAAAGGGAAGTTTTTGCTTTCCTCTAGTTAAATAACCTGAGCCTGCCATGCAA
ATAGTTGAATAACTTTGTTCCTAGTTACTGACATACAATTCTTAAAGGACCATTTAGCATTTTGGCCAACAATGAGTAATTAGGATTAGT
ACCTTTTTGTTTTACAGAGTAACTGAGAGTTTTGTAACATCCAGAGATGGTACTAGAGCCAATGAGAGATCTGTTCCTAGATGCACTATT
TCTTTGAGGAAGAGAGAGAAGAGAAGTGTCTGGTTGGGGGTGAGGGGGTGCAGACTTTTTTGTTTCTATGTACAGAGCAAAGAGATAGAG
TCACAAGGAAAGACAATTAATGACTTTGAGCTCAACCAACTGAACTGCCTTTCTTGGAGCTGCACCTGGACCAAGTTTATTTTTTAACAA
TTATAATAACGATGATTTAAAAAAAGAAACCTCCCAAAGCCTATAAACTGAACTAGAAGAGTTGGTTTCCCACTTTAGAGTGGATGGCGA
CATCAGCATTGCTTTTGCCCATGGTGTTTGGGGAGAGACTTTTCAGTGATAATAACCACTCTACTCTGGGTTCTGTGCATGCCCAGACTA
AGCCCCATCGCCTTATTTCTGGGGTACATCCAGACCTGGCAGGGATTCTGCCACACTGTGCAGCAAACCAGCATGTAGGCTGGGTAGGAG
AGCAAGAGATAGAGCCATCAGAGTGATGGGGCTTCTTCACAGTAAGAACATCGGAGCTTAGAATGAGAGTCTCTTTCCAAAAACAGGCAT

>In-frame_LRP5_ENST00000294304_chr11_68157520_+_DLG2_ENST00000418306_chr11_83676511_-_4104nt
GCCCGAGGGGGGAGGCGGAGGCGCCGGGAGCCGCGCGAGGAGCCGCCGCCGCCGCGCCATGGAGCCCGAGTGAGCGCGGCGCGGGCCCGT
CCGGCCGCCGGACAACATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTG
CCCGGCCCCCGCCGCGGCCTCGCCGCTCCTGCTATTTGCCAACCGCCGGGACGTACGGCTGGTGGACGCCGGCGGAGTCAAGCTGGAGTC
CACCATCGTGGTCAGCGGCCTGGAGGATGCGGCCGCAGTGGACTTCCAGTTTTCCAAGGGAGCCGTGTACTGGACAGACGTGAGCGAGGA
GGCCATCAAGCAGACCTACCTGAACCAGACGGGGGCCGCCGTGCAGAACGTGGTCATCTCCGGCCTGGTCTCTCCCGACGGCCTCGCCTG
CGACTGGGTGGGCAAGAAGCTGTACTGGACGGACTCAGAGACCAACCGCATCGAGGTGGCCAACCTCAATGGCACATCCCGGAAGGTGCT
CTTCTGGCAGGACCTTGACCAGCCGAGGGCCATCGCCTTGGACCCCGCTCACGGGTACATGTACTGGACAGACTGGGGTGAGACGCCCCG
GATTGAGCGGGCAGGGATGGATGGCAGCACCCGGAAGATCATTGTGGACTCGGACATTTACTGGCCCAATGGACTGACCATCGACCTGGA
GGAGCAGAAGCTCTACTGGGCTGACGCCAAGCTCAGCTTCATCCACCGTGCCAACCTGGACGGCTCGTTCCGGCAGAAGGTGGTGGAGGG
CAGCCTGACGCACCCCTTCGCCCTGACGCTCTCCGGGGACACTCTGTACTGGACAGACTGGCAGACCCGCTCCATCCATGCCTGCAACAA
GCGCACTGGGGGGAAGAGGAAGGAGATCCTGAGTGCCCTCTACTCACCCATGGACATCCAGGTGCTGAGCCAGGAGCGGCAGCCTTTCTT
CCACACTCGCTGTGAGGAGGACAATGGCGGCTGCTCCCACCTGTGCCTGCTGTCCCCAAGCGAGCCTTTCTACACATGCGCCTGCCCCAC
GGGTGTGCAGCTGCAGGACAACGGCAGGACGTGTAAGGCAGGAGCCGAGGAGGTGCTGCTGCTGGCCCGGCGGACGGACCTACGGAGGAT
CTCGCTGGACACGCCGGACTTCACCGACATCGTGCTGCAGGTGGACGACATCCGGCACGCCATTGCCATCGACTACGACCCGCTAGAGGG
CTATGTCTACTGGACAGATGACGAGGTGCGGGCCATCCGCAGGGCGTACCTGGACGGGTCTGGGGCGCAGACGCTGGTCAACACCGAGAT
CAACGACCCCGATGGCATCGCGGTCGACTGGGTGGCCCGAAACCTCTACTGGACCGACACGGGCACGGACCGCATCGAGGTGACGCGCCT
CAACGGCACCTCCCGCAAGATCCTGGTGTCGGAGGACCTGGACGAGCCCCGAGCCATCGCACTGCACCCCGTGATGGGCCTCATGTACTG
GACAGACTGGGGAGAGAACCCTAAAATCGAGTGTGCCAACTTGGATGGGCAGGAGCGGCGTGTGCTGGTCAATGCCTCCCTCGGGTGGCC
CAACGGCCTGGCCCTGGACCTGCAGGAGGGGAAGCTCTACTGGGGAGACGCCAAGACAGACAAGATCGAGGTAAACAACTACAGTTTAGA
AGAAGTAACACACGAAGAGGCAGTAGCAATATTAAAGAACACATCAGAGGTAGTTTATTTAAAAGTTGGCAAACCCACTACCATTTATAT
GACTGATCCTTATGGTCCACCTGATATTACTCACTCTTATTCTCCACCAATGGAAAACCATCTACTCTCTGGCAACAATGGCACTTTAGA
ATATAAAACCTCCCTGCCACCCATCTCTCCAGGAAGGTACTCACCAATTCCAAAGCACATGCTTGTTGACGACGACTACACCAGTCATTC
CCAACATAGCACCGCAACTCGTCAGCCTTCAATGACTCTCCAACGGGCCGTCTCCCTGGAAGGAGAGCCTCGCAAGGTAGTCCTGCACAA
AGGCTCCACTGGCCTGGGCTTCAACATTGTCGGTGGGGAAGATGGAGAAGGTATTTTTGTGTCCTTCATTCTGGCTGGTGGACCAGCAGA
CCTAAGTGGGGAGCTCCAGAGAGGAGACCAGATCCTATCGGTGAATGGCATTGACCTCCGTGGTGCATCCCACGAGCAGGCAGCTGCTGC
ACTAAAGGGGGCTGGACAGACAGTGACGATTATAGCACAATATCAACCTGAAGATTACGCTCGATTTGAGGCCAAAATCCATGACCTACG
AGAGCAGATGATGAACCACAGCATGAGCTCCGGGTCCGGATCCCTGCGAACCAATCAGAAACGCTCCCTCTACGTCAGAGCCATGTTCGA
CTACGACAAGAGCAAGGACAGTGGGCTGCCAAGTCAAGGACTTAGTTTTAAATATGGAGATATTCTCCACGTTATCAATGCCTCTGATGA
TGAGTGGTGGCAAGCCAGGAGAGTCATGCTGGAGGGAGACAGTGAGGAGATGGGGGTCATCCCCAGCAAAAGGAGGGTGGAAAGAAAGGA
ACGTGCCCGATTGAAGACAGTGAAGTTTAATGCCAAACCTGGAGTGATTGATTCGAAAGGGGACATCCCCGGATTAGGTGACGACGGTTA
TGGAACAAAGACTCTGAGAGGACAAGAAGACCTCATTCTTTCCTATGAGCCTGTTACAAGGCAGGAAATAAACTACACCCGGCCGGTGAT
TATCCTGGGGCCCATGAAGGATCGGATCAATGACGACTTGATATCTGAATTCCCTGATAAATTTGGCTCCTGTGTGCCTCATACTACGAG
GCCAAAGCGAGACTACGAGGTGGATGGCAGAGACTATCACTTTGTCATTTCCAGAGAACAAATGGAGAAAGATATCCAAGAGCACAAGTT
TATAGAAGCCGGCCAGTACAATGACAATTTATATGGAACCAGTGTGCAGTCTGTGAGATTTGTAGCAGAAAGAGGCAAACACTGTATACT
TGATGTATCAGGAAATGCTATCAAGCGGTTACAAGTTGCCCAGCTCTATCCCATTGCCATCTTCATAAAACCCAGGTCTCTGGAACCTCT
TATGGAGATGAATAAGCGTCTAACAGAGGAACAAGCCAAGAAAACCTATGATCGAGCAATTAAGCTAGAACAAGAATTTGGAGAATATTT
TACAGCTATTGTCCAAGGAGATACTTTAGAAGATATATATAACCAATGCAAGCTTGTTATTGAAGAGCAATCTGGGCCTTTCATCTGGAT
TCCCTCAAAGGAAAAGTTATAAATTAGCTACTGCGCCTCTGACAACGACAGAAGAGCATTTAGAAGAACAAAATATATATAACATACTAC
TTGGAGGCTTTTATGTTTTTGTTGCATTTATGTTTTTGCAGTCAATGTGAATTCTTACGAATGTACAACACAAACTGTATGAAGCCATGA
AGGAAACAGAGGGGCCAAAGGGTGGGACAGAAAAGACATTGCAGTATGAAGGAAGGCTTTGGTTTGCTCAAAGTGCCAGGTGTAGGGATG
AACCTCTGACGGGCTTTCTGCCCAAGAGATGAGATGAGAGCCTCCTCACCCCAGCAGATGTCCAGAGCTGATTTAGCTGCAGAGCTCTCT
GTGTCTTTTGCTTTAAAGAAAAATTGCCAGCACTCGAACCTCATCAGCCTTCCCATTACCCACATCTGTAATTGGTACACTTTGAATTTT
ATAACTATGCACATCTTTTGATTTCTTAACAAGCAAATGAAAGAAAGAAGGAAAAAAGAAAGGAATCCCTTTGGAGATGACATACTATCA
GGGAAGGATAAGTGTGTAGTTTTTTGACTGGCATCTGCAAAGACAAGAATTTCATAAAATTTGCAAGTGTATGGAGGACTAACCTCACTG
ACAGGAGGGGATTCCACCTGGGATTAGCTTTATGATTGTTGATTGCCTATTTTGCCATTTATAAACTGAAAGAAGGCACTAAAGATGAGA

>In-frame_LRP5_ENST00000294304_chr11_68157520_+_DLG2_ENST00000280241_chr11_83676511_-_4314nt
GCCCGAGGGGGGAGGCGGAGGCGCCGGGAGCCGCGCGAGGAGCCGCCGCCGCCGCGCCATGGAGCCCGAGTGAGCGCGGCGCGGGCCCGT
CCGGCCGCCGGACAACATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTG
CCCGGCCCCCGCCGCGGCCTCGCCGCTCCTGCTATTTGCCAACCGCCGGGACGTACGGCTGGTGGACGCCGGCGGAGTCAAGCTGGAGTC
CACCATCGTGGTCAGCGGCCTGGAGGATGCGGCCGCAGTGGACTTCCAGTTTTCCAAGGGAGCCGTGTACTGGACAGACGTGAGCGAGGA
GGCCATCAAGCAGACCTACCTGAACCAGACGGGGGCCGCCGTGCAGAACGTGGTCATCTCCGGCCTGGTCTCTCCCGACGGCCTCGCCTG
CGACTGGGTGGGCAAGAAGCTGTACTGGACGGACTCAGAGACCAACCGCATCGAGGTGGCCAACCTCAATGGCACATCCCGGAAGGTGCT
CTTCTGGCAGGACCTTGACCAGCCGAGGGCCATCGCCTTGGACCCCGCTCACGGGTACATGTACTGGACAGACTGGGGTGAGACGCCCCG
GATTGAGCGGGCAGGGATGGATGGCAGCACCCGGAAGATCATTGTGGACTCGGACATTTACTGGCCCAATGGACTGACCATCGACCTGGA
GGAGCAGAAGCTCTACTGGGCTGACGCCAAGCTCAGCTTCATCCACCGTGCCAACCTGGACGGCTCGTTCCGGCAGAAGGTGGTGGAGGG
CAGCCTGACGCACCCCTTCGCCCTGACGCTCTCCGGGGACACTCTGTACTGGACAGACTGGCAGACCCGCTCCATCCATGCCTGCAACAA
GCGCACTGGGGGGAAGAGGAAGGAGATCCTGAGTGCCCTCTACTCACCCATGGACATCCAGGTGCTGAGCCAGGAGCGGCAGCCTTTCTT
CCACACTCGCTGTGAGGAGGACAATGGCGGCTGCTCCCACCTGTGCCTGCTGTCCCCAAGCGAGCCTTTCTACACATGCGCCTGCCCCAC
GGGTGTGCAGCTGCAGGACAACGGCAGGACGTGTAAGGCAGGAGCCGAGGAGGTGCTGCTGCTGGCCCGGCGGACGGACCTACGGAGGAT
CTCGCTGGACACGCCGGACTTCACCGACATCGTGCTGCAGGTGGACGACATCCGGCACGCCATTGCCATCGACTACGACCCGCTAGAGGG
CTATGTCTACTGGACAGATGACGAGGTGCGGGCCATCCGCAGGGCGTACCTGGACGGGTCTGGGGCGCAGACGCTGGTCAACACCGAGAT
CAACGACCCCGATGGCATCGCGGTCGACTGGGTGGCCCGAAACCTCTACTGGACCGACACGGGCACGGACCGCATCGAGGTGACGCGCCT
CAACGGCACCTCCCGCAAGATCCTGGTGTCGGAGGACCTGGACGAGCCCCGAGCCATCGCACTGCACCCCGTGATGGGCCTCATGTACTG
GACAGACTGGGGAGAGAACCCTAAAATCGAGTGTGCCAACTTGGATGGGCAGGAGCGGCGTGTGCTGGTCAATGCCTCCCTCGGGTGGCC
CAACGGCCTGGCCCTGGACCTGCAGGAGGGGAAGCTCTACTGGGGAGACGCCAAGACAGACAAGATCGAGGTAAACAACTACAGTTTAGA
AGAAGTAACACACGAAGAGGCAGTAGCAATATTAAAGAACACATCAGAGGTAGTTTATTTAAAAGTTGGCAAACCCACTACCATTTATAT
GACTGATCCTTATGGTCCACCTGATATTACTCACTCTTATTCTCCACCAATGGAAAACCATCTACTCTCTGGCAACAATGGCACTTTAGA
ATATAAAACCTCCCTGCCACCCATCTCTCCAGGAAGGTACTCACCAATTCCAAAGCACATGCTTGTTGACGACGACTACACCAGGCCTCC
GGAACCTGTTTACAGCACTGTGAACAAACTATGTGATAAGCCTGCTTCTCCCAGGCACTATTCCCCTGTTGAGTGTGACAAAAGCTTCCT
CCTCTCAGCTCCCTATTCCCACTACCACCTAGGCCTGCTACCTGACTCTGAGATGACCAGTCATTCCCAACATAGCACCGCAACTCGTCA
GCCTTCAATGACTCTCCAACGGGCCGTCTCCCTGGAAGGAGAGCCTCGCAAGGTAGTCCTGCACAAAGGCTCCACTGGCCTGGGCTTCAA
CATTGTCGGTGGGGAAGATGGAGAAGGTATTTTTGTGTCCTTCATTCTGGCTGGTGGACCAGCAGACCTAAGTGGGGAGCTCCAGAGAGG
AGACCAGATCCTATCGGTGAATGGCATTGACCTCCGTGGTGCATCCCACGAGCAGGCAGCTGCTGCACTAAAGGGGGCTGGACAGACAGT
GACGATTATAGCACAATATCAACCTGAAGATTACGCTCGATTTGAGGCCAAAATCCATGACCTACGAGAGCAGATGATGAACCACAGCAT
GAGCTCCGGGTCCGGATCCCTGCGAACCAATCAGAAACGCTCCCTCTACGTCAGAGCCATGTTCGACTACGACAAGAGCAAGGACAGTGG
GCTGCCAAGTCAAGGACTTAGTTTTAAATATGGAGATATTCTCCACGTTATCAATGCCTCTGATGATGAGTGGTGGCAAGCCAGGAGAGT
CATGCTGGAGGGAGACAGTGAGGAGATGGGGGTCATCCCCAGCAAAAGGAGGGTGGAAAGAAAGGAACGTGCCCGATTGAAGACAGTGAA
GTTTAATGCCAAACCTGGAGTGATTGATTCGAAAGGGTCATTCAATGACAAGCGTAAAAAGAGCTTCATCTTTTCACGAAAATTCCCATT
CTACAAGAACAAGGAGCAGAGTGAGCAGGAAACCAGTGATCCTGAACGAGGACAAGAAGACCTCATTCTTTCCTATGAGCCTGTTACAAG
GCAGGAAATAAACTACACCCGGCCGGTGATTATCCTGGGGCCCATGAAGGATCGGATCAATGACGACTTGATATCTGAATTCCCTGATAA
ATTTGGCTCCTGTGTGCCTCATACTACGAGGCCAAAGCGAGACTACGAGGTGGATGGCAGAGACTATCACTTTGTCATTTCCAGAGAACA
AATGGAGAAAGATATCCAAGAGCACAAGTTTATAGAAGCCGGCCAGTACAATGACAATTTATATGGAACCAGTGTGCAGTCTGTGAGATT
TGTAGCAGAAAGAGGCAAACACTGTATACTTGATGTATCAGGAAATGCTATCAAGCGGTTACAAGTTGCCCAGCTCTATCCCATTGCCAT
CTTCATAAAACCCAGGTCTCTGGAACCTCTTATGGAGATGAATAAGCGTCTAACAGAGGAACAAGCCAAGAAAACCTATGATCGAGCAAT
TAAGCTAGAACAAGAATTTGGAGAATATTTTACAGCTATTGTCCAAGGAGATACTTTAGAAGATATATATAACCAATGCAAGCTTGTTAT
TGAAGAGCAATCTGGGCCTTTCATCTGGATTCCCTCAAAGGAAAAGTTATAAATTAGCTACTGCGCCTCTGACAACGACAGAAGAGCATT
TAGAAGAACAAAATATATATAACATACTACTTGGAGGCTTTTATGTTTTTGTTGCATTTATGTTTTTGCAGTCAATGTGAATTCTTACGA
ATGTACAACACAAACTGTATGAAGCCATGAAGGAAACAGAGGGGCCAAAGGGTGGGACAGAAAAGACATTGCAGTATGAAGGAAGGCTTT
GGTTTGCTCAAAGTGCCAGGTGTAGGGATGAACCTCTGACGGGCTTTCTGCCCAAGAGATGAGATGAGAGCCTCCTCACCCCAGCAGATG
TCCAGAGCTGATTTAGCTGCAGAGCTCTCTGTGTCTTTTGCTTTAAAGAAAAATTGCCAGCACTCGAACCTCATCAGCCTTCCCATTACC
CACATCTGTAATTGGTACACTTTGAATTTTATAACTATGCACATCTTTTGATTTCTTAACAAGCAAATGAAAGAAAGAAGGAAAAAAGAA
AGGAATCCCTTTGGAGATGACATACTATCAGGGAAGGATAAGTGTGTAGTTTTTTGACTGGCATCTGCAAAGACAAGAATTTCATAAAAT
TTGCAAGTGTATGGAGGACTAACCTCACTGACAGGAGGGGATTCCACCTGGGATTAGCTTTATGATTGTTGATTGCCTATTTTGCCATTT

>In-frame_LRP5_ENST00000294304_chr11_68157520_+_DLG2_ENST00000543673_chr11_83676511_-_4314nt
GCCCGAGGGGGGAGGCGGAGGCGCCGGGAGCCGCGCGAGGAGCCGCCGCCGCCGCGCCATGGAGCCCGAGTGAGCGCGGCGCGGGCCCGT
CCGGCCGCCGGACAACATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTG
CCCGGCCCCCGCCGCGGCCTCGCCGCTCCTGCTATTTGCCAACCGCCGGGACGTACGGCTGGTGGACGCCGGCGGAGTCAAGCTGGAGTC
CACCATCGTGGTCAGCGGCCTGGAGGATGCGGCCGCAGTGGACTTCCAGTTTTCCAAGGGAGCCGTGTACTGGACAGACGTGAGCGAGGA
GGCCATCAAGCAGACCTACCTGAACCAGACGGGGGCCGCCGTGCAGAACGTGGTCATCTCCGGCCTGGTCTCTCCCGACGGCCTCGCCTG
CGACTGGGTGGGCAAGAAGCTGTACTGGACGGACTCAGAGACCAACCGCATCGAGGTGGCCAACCTCAATGGCACATCCCGGAAGGTGCT
CTTCTGGCAGGACCTTGACCAGCCGAGGGCCATCGCCTTGGACCCCGCTCACGGGTACATGTACTGGACAGACTGGGGTGAGACGCCCCG
GATTGAGCGGGCAGGGATGGATGGCAGCACCCGGAAGATCATTGTGGACTCGGACATTTACTGGCCCAATGGACTGACCATCGACCTGGA
GGAGCAGAAGCTCTACTGGGCTGACGCCAAGCTCAGCTTCATCCACCGTGCCAACCTGGACGGCTCGTTCCGGCAGAAGGTGGTGGAGGG
CAGCCTGACGCACCCCTTCGCCCTGACGCTCTCCGGGGACACTCTGTACTGGACAGACTGGCAGACCCGCTCCATCCATGCCTGCAACAA
GCGCACTGGGGGGAAGAGGAAGGAGATCCTGAGTGCCCTCTACTCACCCATGGACATCCAGGTGCTGAGCCAGGAGCGGCAGCCTTTCTT
CCACACTCGCTGTGAGGAGGACAATGGCGGCTGCTCCCACCTGTGCCTGCTGTCCCCAAGCGAGCCTTTCTACACATGCGCCTGCCCCAC
GGGTGTGCAGCTGCAGGACAACGGCAGGACGTGTAAGGCAGGAGCCGAGGAGGTGCTGCTGCTGGCCCGGCGGACGGACCTACGGAGGAT
CTCGCTGGACACGCCGGACTTCACCGACATCGTGCTGCAGGTGGACGACATCCGGCACGCCATTGCCATCGACTACGACCCGCTAGAGGG
CTATGTCTACTGGACAGATGACGAGGTGCGGGCCATCCGCAGGGCGTACCTGGACGGGTCTGGGGCGCAGACGCTGGTCAACACCGAGAT
CAACGACCCCGATGGCATCGCGGTCGACTGGGTGGCCCGAAACCTCTACTGGACCGACACGGGCACGGACCGCATCGAGGTGACGCGCCT
CAACGGCACCTCCCGCAAGATCCTGGTGTCGGAGGACCTGGACGAGCCCCGAGCCATCGCACTGCACCCCGTGATGGGCCTCATGTACTG
GACAGACTGGGGAGAGAACCCTAAAATCGAGTGTGCCAACTTGGATGGGCAGGAGCGGCGTGTGCTGGTCAATGCCTCCCTCGGGTGGCC
CAACGGCCTGGCCCTGGACCTGCAGGAGGGGAAGCTCTACTGGGGAGACGCCAAGACAGACAAGATCGAGGTAAACAACTACAGTTTAGA
AGAAGTAACACACGAAGAGGCAGTAGCAATATTAAAGAACACATCAGAGGTAGTTTATTTAAAAGTTGGCAAACCCACTACCATTTATAT
GACTGATCCTTATGGTCCACCTGATATTACTCACTCTTATTCTCCACCAATGGAAAACCATCTACTCTCTGGCAACAATGGCACTTTAGA
ATATAAAACCTCCCTGCCACCCATCTCTCCAGGAAGGTACTCACCAATTCCAAAGCACATGCTTGTTGACGACGACTACACCAGGCCTCC
GGAACCTGTTTACAGCACTGTGAACAAACTATGTGATAAGCCTGCTTCTCCCAGGCACTATTCCCCTGTTGAGTGTGACAAAAGCTTCCT
CCTCTCAGCTCCCTATTCCCACTACCACCTAGGCCTGCTACCTGACTCTGAGATGACCAGTCATTCCCAACATAGCACCGCAACTCGTCA
GCCTTCAATGACTCTCCAACGGGCCGTCTCCCTGGAAGGAGAGCCTCGCAAGGTAGTCCTGCACAAAGGCTCCACTGGCCTGGGCTTCAA
CATTGTCGGTGGGGAAGATGGAGAAGGTATTTTTGTGTCCTTCATTCTGGCTGGTGGACCAGCAGACCTAAGTGGGGAGCTCCAGAGAGG
AGACCAGATCCTATCGGTGAATGGCATTGACCTCCGTGGTGCATCCCACGAGCAGGCAGCTGCTGCACTAAAGGGGGCTGGACAGACAGT
GACGATTATAGCACAATATCAACCTGAAGATTACGCTCGATTTGAGGCCAAAATCCATGACCTACGAGAGCAGATGATGAACCACAGCAT
GAGCTCCGGGTCCGGATCCCTGCGAACCAATCAGAAACGCTCCCTCTACGTCAGAGCCATGTTCGACTACGACAAGAGCAAGGACAGTGG
GCTGCCAAGTCAAGGACTTAGTTTTAAATATGGAGATATTCTCCACGTTATCAATGCCTCTGATGATGAGTGGTGGCAAGCCAGGAGAGT
CATGCTGGAGGGAGACAGTGAGGAGATGGGGGTCATCCCCAGCAAAAGGAGGGTGGAAAGAAAGGAACGTGCCCGATTGAAGACAGTGAA
GTTTAATGCCAAACCTGGAGTGATTGATTCGAAAGGGTCATTCAATGACAAGCGTAAAAAGAGCTTCATCTTTTCACGAAAATTCCCATT
CTACAAGAACAAGGAGCAGAGTGAGCAGGAAACCAGTGATCCTGAACGAGGACAAGAAGACCTCATTCTTTCCTATGAGCCTGTTACAAG
GCAGGAAATAAACTACACCCGGCCGGTGATTATCCTGGGGCCCATGAAGGATCGGATCAATGACGACTTGATATCTGAATTCCCTGATAA
ATTTGGCTCCTGTGTGCCTCATACTACGAGGCCAAAGCGAGACTACGAGGTGGATGGCAGAGACTATCACTTTGTCATTTCCAGAGAACA
AATGGAGAAAGATATCCAAGAGCACAAGTTTATAGAAGCCGGCCAGTACAATGACAATTTATATGGAACCAGTGTGCAGTCTGTGAGATT
TGTAGCAGAAAGAGGCAAACACTGTATACTTGATGTATCAGGAAATGCTATCAAGCGGTTACAAGTTGCCCAGCTCTATCCCATTGCCAT
CTTCATAAAACCCAGGTCTCTGGAACCTCTTATGGAGATGAATAAGCGTCTAACAGAGGAACAAGCCAAGAAAACCTATGATCGAGCAAT
TAAGCTAGAACAAGAATTTGGAGAATATTTTACAGCTATTGTCCAAGGAGATACTTTAGAAGATATATATAACCAATGCAAGCTTGTTAT
TGAAGAGCAATCTGGGCCTTTCATCTGGATTCCCTCAAAGGAAAAGTTATAAATTAGCTACTGCGCCTCTGACAACGACAGAAGAGCATT
TAGAAGAACAAAATATATATAACATACTACTTGGAGGCTTTTATGTTTTTGTTGCATTTATGTTTTTGCAGTCAATGTGAATTCTTACGA
ATGTACAACACAAACTGTATGAAGCCATGAAGGAAACAGAGGGGCCAAAGGGTGGGACAGAAAAGACATTGCAGTATGAAGGAAGGCTTT
GGTTTGCTCAAAGTGCCAGGTGTAGGGATGAACCTCTGACGGGCTTTCTGCCCAAGAGATGAGATGAGAGCCTCCTCACCCCAGCAGATG
TCCAGAGCTGATTTAGCTGCAGAGCTCTCTGTGTCTTTTGCTTTAAAGAAAAATTGCCAGCACTCGAACCTCATCAGCCTTCCCATTACC
CACATCTGTAATTGGTACACTTTGAATTTTATAACTATGCACATCTTTTGATTTCTTAACAAGCAAATGAAAGAAAGAAGGAAAAAAGAA
AGGAATCCCTTTGGAGATGACATACTATCAGGGAAGGATAAGTGTGTAGTTTTTTGACTGGCATCTGCAAAGACAAGAATTTCATAAAAT
TTGCAAGTGTATGGAGGACTAACCTCACTGACAGGAGGGGATTCCACCTGGGATTAGCTTTATGATTGTTGATTGCCTATTTTGCCATTT


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FusionGenePPI for LRP5_DLG2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LRP5AXIN1, SMAD9, CAPRIN2, SOST, DKK1, FZD8, TAZ, RASD2, SUSD4, PARP16, POMK, B3GALT2, ETV6, CHST9, LIPH, PRSS37, CSNK1A1, TGIF2LY, DKKL1, SERPINA12, ST8SIA4, SCGB1D1, DKK4, MGAT4C, F9, FAM3B, C4orf26, FCGRT, PODN, ADAM33, BRINP3, LRRC4C, CLPSL1, NXPH2, TRIM25DLG2LRP2, ERBB4, KCNJ12, KCNJ4, GRIN2B, KCNA4, DLGAP1, DYNLL1, DYNLL2, DLG4, NLGN2, NLGN1, NLGN3, GRIN2A, SEMA4C, NOS1, ATP2B2, ATP2B4, GUCY1A2, KHDRBS1, FASLG, MAP1A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LRP5_DLG2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LRP5_DLG2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLRP5C0432252Osteoporosis with pseudoglioma8CTD_human;ORPHANET;UNIPROT
HgeneLRP5C1866176EXUDATIVE VITREORETINOPATHY 4 (disorder)8CTD_human;UNIPROT
HgeneLRP5C1866079BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 15UNIPROT
HgeneLRP5C0242852Proliferative vitreoretinopathy1CTD_human
HgeneLRP5C0432273Worth disease1CTD_human;ORPHANET;UNIPROT
HgeneLRP5C1843330OSTEOPETROSIS, AUTOSOMAL DOMINANT 11CTD_human;ORPHANET;UNIPROT
HgeneLRP5C1851402Exudative vitreoretinopathy 11ORPHANET;UNIPROT
TgeneDLG2C0036341Schizophrenia4PSYGENET
TgeneDLG2C0005586Bipolar Disorder2PSYGENET
TgeneDLG2C0025202melanoma1CTD_human
TgeneDLG2C0041696Unipolar Depression1PSYGENET
TgeneDLG2C0809983Schizophrenia and related disorders1PSYGENET
TgeneDLG2C1269683Major Depressive Disorder1PSYGENET