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Fusion gene ID: 20155 |
FusionGeneSummary for LRP5_CHRM1 |
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Fusion gene information | Fusion gene name: LRP5_CHRM1 | Fusion gene ID: 20155 | Hgene | Tgene | Gene symbol | LRP5 | CHRM1 | Gene ID | 4041 | 1128 |
Gene name | LDL receptor related protein 5 | cholinergic receptor muscarinic 1 | |
Synonyms | BMND1|EVR1|EVR4|HBM|LR3|LRP-5|LRP7|OPPG|OPS|OPTA1|PCLD4|VBCH2 | HM1|M1|M1R | |
Cytomap | 11q13.2 | 11q12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | low-density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 7 | muscarinic acetylcholine receptor M1acetylcholine receptor, muscarinic 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O75197 | P11229 | |
Ensembl transtripts involved in fusion gene | ENST00000294304, ENST00000529481, | ENST00000306960, | |
Fusion gene scores | * DoF score | 21 X 16 X 9=3024 | 3 X 1 X 3=9 |
# samples | 22 | 3 | |
** MAII score | log2(22/3024*10)=-3.78088271069641 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: LRP5 [Title/Abstract] AND CHRM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LRP5 | GO:0008284 | positive regulation of cell proliferation | 9790987 |
Hgene | LRP5 | GO:0016055 | Wnt signaling pathway | 17955262 |
Hgene | LRP5 | GO:0044332 | Wnt signaling pathway involved in dorsal/ventral axis specification | 11029007 |
Hgene | LRP5 | GO:0045840 | positive regulation of mitotic nuclear division | 9790987 |
Hgene | LRP5 | GO:0045893 | positive regulation of transcription, DNA-templated | 15035989|17955262 |
Hgene | LRP5 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12857724 |
Hgene | LRP5 | GO:0060070 | canonical Wnt signaling pathway | 12121999|12857724|15035989 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | STAD | TCGA-HU-A4GH-01A | LRP5 | chr11 | 68181480 | + | CHRM1 | chr11 | 62678650 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000294304 | ENST00000306960 | LRP5 | chr11 | 68181480 | + | CHRM1 | chr11 | 62678650 | - |
intron-5UTR | ENST00000529481 | ENST00000306960 | LRP5 | chr11 | 68181480 | + | CHRM1 | chr11 | 62678650 | - |
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FusionProtFeatures for LRP5_CHRM1 |
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Hgene | Tgene |
LRP5 | CHRM1 |
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggersbeta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surfacecoreceptor of Wnt/beta-catenin signaling, which plays a pivotalrole in bone formation. Plays a role in norrin (NDP) signaltransduction (PubMed:27228167). The Wnt-induced Fzd/LRP6coreceptor complex recruits DVL1 polymers to the plasma membranewhich, in turn, recruits the AXIN1/GSK3B-complex to the cellsurface promoting the formation of signalsomes and inhibitingAXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascularregression in the eye (By similarity). Required for posteriorpatterning of the epiblast during gastrulation (By similarity).{ECO:0000250|UniProtKB:Q91VN0, ECO:0000269|PubMed:11336703,ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:14727154,ECO:0000269|PubMed:14731402, ECO:0000269|PubMed:15778503,ECO:0000269|PubMed:27228167}. | The muscarinic acetylcholine receptor mediates variouscellular responses, including inhibition of adenylate cyclase,breakdown of phosphoinositides and modulation of potassiumchannels through the action of G proteins. Primary transducingeffect is Pi turnover. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LRP5_CHRM1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LRP5_CHRM1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LRP5 | AXIN1, SMAD9, CAPRIN2, SOST, DKK1, FZD8, TAZ, RASD2, SUSD4, PARP16, POMK, B3GALT2, ETV6, CHST9, LIPH, PRSS37, CSNK1A1, TGIF2LY, DKKL1, SERPINA12, ST8SIA4, SCGB1D1, DKK4, MGAT4C, F9, FAM3B, C4orf26, FCGRT, PODN, ADAM33, BRINP3, LRRC4C, CLPSL1, NXPH2, TRIM25 | CHRM1 | GPRASP1, GPRASP2, CDC14A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LRP5_CHRM1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | CHRM1 | P11229 | DB00185 | Cevimeline | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00202 | Succinylcholine | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00209 | Trospium | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00215 | Citalopram | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00219 | Oxyphenonium | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00245 | Benzatropine | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00246 | Ziprasidone | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00280 | Disopyramide | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00321 | Amitriptyline | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00332 | Ipratropium bromide | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00340 | Metixene | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00354 | Buclizine | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00363 | Clozapine | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00376 | Trihexyphenidyl | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00383 | Oxyphencyclimine | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00387 | Procyclidine | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00392 | Ethopropazine | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00408 | Loxapine | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00411 | Carbachol | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00424 | Hyoscyamine | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00434 | Cyproheptadine | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00454 | Pethidine | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00458 | Imipramine | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00540 | Nortriptyline | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00543 | Amoxapine | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00543 | Amoxapine | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00670 | Pirenzepine | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00725 | Homatropine Methylbromide | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00726 | Trimipramine | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00771 | Clidinium | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00777 | Propiomazine | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00782 | Propantheline | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00804 | Dicyclomine | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00805 | Minaprine | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00835 | Brompheniramine | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00979 | Cyclopentolate | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB01019 | Bethanechol | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB01148 | Flavoxate | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB01224 | Quetiapine | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB01409 | Tiotropium | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB01591 | Solifenacin | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB01618 | Molindone | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB03128 | Acetylcholine | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB04843 | Mepenzolate | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB06702 | Fesoterodine | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB06787 | Hexocyclium | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB08897 | Aclidinium | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB09076 | Umeclidinium | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB09167 | Dosulepin | Muscarinic acetylcholine receptor M1 | small molecule | approved |
Tgene | CHRM1 | P11229 | DB00907 | Cocaine | Muscarinic acetylcholine receptor M1 | small molecule | approved|illicit |
Tgene | CHRM1 | P11229 | DB00334 | Olanzapine | Muscarinic acetylcholine receptor M1 | small molecule | approved|investigational |
Tgene | CHRM1 | P11229 | DB00496 | Darifenacin | Muscarinic acetylcholine receptor M1 | small molecule | approved|investigational |
Tgene | CHRM1 | P11229 | DB00555 | Lamotrigine | Muscarinic acetylcholine receptor M1 | small molecule | approved|investigational |
Tgene | CHRM1 | P11229 | DB00568 | Cinnarizine | Muscarinic acetylcholine receptor M1 | small molecule | approved|investigational |
Tgene | CHRM1 | P11229 | DB00622 | Nicardipine | Muscarinic acetylcholine receptor M1 | small molecule | approved|investigational |
Tgene | CHRM1 | P11229 | DB00715 | Paroxetine | Muscarinic acetylcholine receptor M1 | small molecule | approved|investigational |
Tgene | CHRM1 | P11229 | DB00747 | Scopolamine | Muscarinic acetylcholine receptor M1 | small molecule | approved|investigational |
Tgene | CHRM1 | P11229 | DB00809 | Tropicamide | Muscarinic acetylcholine receptor M1 | small molecule | approved|investigational |
Tgene | CHRM1 | P11229 | DB00810 | Biperiden | Muscarinic acetylcholine receptor M1 | small molecule | approved|investigational |
Tgene | CHRM1 | P11229 | DB00934 | Maprotiline | Muscarinic acetylcholine receptor M1 | small molecule | approved|investigational |
Tgene | CHRM1 | P11229 | DB00940 | Methantheline | Muscarinic acetylcholine receptor M1 | small molecule | approved|investigational |
Tgene | CHRM1 | P11229 | DB01036 | Tolterodine | Muscarinic acetylcholine receptor M1 | small molecule | approved|investigational |
Tgene | CHRM1 | P11229 | DB01062 | Oxybutynin | Muscarinic acetylcholine receptor M1 | small molecule | approved|investigational |
Tgene | CHRM1 | P11229 | DB01069 | Promethazine | Muscarinic acetylcholine receptor M1 | small molecule | approved|investigational |
Tgene | CHRM1 | P11229 | DB01085 | Pilocarpine | Muscarinic acetylcholine receptor M1 | small molecule | approved|investigational |
Tgene | CHRM1 | P11229 | DB01142 | Doxepin | Muscarinic acetylcholine receptor M1 | small molecule | approved|investigational |
Tgene | CHRM1 | P11229 | DB01151 | Desipramine | Muscarinic acetylcholine receptor M1 | small molecule | approved|investigational |
Tgene | CHRM1 | P11229 | DB01175 | Escitalopram | Muscarinic acetylcholine receptor M1 | small molecule | approved|investigational |
Tgene | CHRM1 | P11229 | DB01233 | Metoclopramide | Muscarinic acetylcholine receptor M1 | small molecule | approved|investigational |
Tgene | CHRM1 | P11229 | DB01238 | Aripiprazole | Muscarinic acetylcholine receptor M1 | small molecule | approved|investigational |
Tgene | CHRM1 | P11229 | DB01403 | Methotrimeprazine | Muscarinic acetylcholine receptor M1 | small molecule | approved|investigational |
Tgene | CHRM1 | P11229 | DB00477 | Chlorpromazine | Muscarinic acetylcholine receptor M1 | small molecule | approved|investigational|vet_approved |
Tgene | CHRM1 | P11229 | DB00986 | Glycopyrronium | Muscarinic acetylcholine receptor M1 | small molecule | approved|investigational|vet_approved |
Tgene | CHRM1 | P11229 | DB00875 | Flupentixol | Muscarinic acetylcholine receptor M1 | small molecule | approved|investigational|withdrawn |
Tgene | CHRM1 | P11229 | DB01239 | Chlorprothixene | Muscarinic acetylcholine receptor M1 | small molecule | approved|investigational|withdrawn |
Tgene | CHRM1 | P11229 | DB00366 | Doxylamine | Muscarinic acetylcholine receptor M1 | small molecule | approved|vet_approved |
Tgene | CHRM1 | P11229 | DB00420 | Promazine | Muscarinic acetylcholine receptor M1 | small molecule | approved|vet_approved |
Tgene | CHRM1 | P11229 | DB00508 | Triflupromazine | Muscarinic acetylcholine receptor M1 | small molecule | approved|vet_approved |
Tgene | CHRM1 | P11229 | DB00572 | Atropine | Muscarinic acetylcholine receptor M1 | small molecule | approved|vet_approved |
Tgene | CHRM1 | P11229 | DB01221 | Ketamine | Muscarinic acetylcholine receptor M1 | small molecule | approved|vet_approved |
Tgene | CHRM1 | P11229 | DB11156 | Pyrantel | Muscarinic acetylcholine receptor M1 | small molecule | approved|vet_approved |
Tgene | CHRM1 | P11229 | DB00342 | Terfenadine | Muscarinic acetylcholine receptor M1 | small molecule | approved|withdrawn |
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RelatedDiseases for LRP5_CHRM1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | LRP5 | C0432252 | Osteoporosis with pseudoglioma | 8 | CTD_human;ORPHANET;UNIPROT |
Hgene | LRP5 | C1866176 | EXUDATIVE VITREORETINOPATHY 4 (disorder) | 8 | CTD_human;UNIPROT |
Hgene | LRP5 | C1866079 | BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 1 | 5 | UNIPROT |
Hgene | LRP5 | C0242852 | Proliferative vitreoretinopathy | 1 | CTD_human |
Hgene | LRP5 | C0432273 | Worth disease | 1 | CTD_human;ORPHANET;UNIPROT |
Hgene | LRP5 | C1843330 | OSTEOPETROSIS, AUTOSOMAL DOMINANT 1 | 1 | CTD_human;ORPHANET;UNIPROT |
Hgene | LRP5 | C1851402 | Exudative vitreoretinopathy 1 | 1 | ORPHANET;UNIPROT |
Tgene | CHRM1 | C0036572 | Seizures | 5 | CTD_human |
Tgene | CHRM1 | C0036341 | Schizophrenia | 4 | PSYGENET |
Tgene | CHRM1 | C0007786 | Brain Ischemia | 1 | CTD_human |
Tgene | CHRM1 | C0014544 | Epilepsy | 1 | CTD_human |
Tgene | CHRM1 | C0025261 | Memory Disorders | 1 | CTD_human |
Tgene | CHRM1 | C0221765 | Chronic schizophrenia | 1 | PSYGENET |