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Fusion gene ID: 2015 |
FusionGeneSummary for AP1AR_NDST4 |
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Fusion gene information | Fusion gene name: AP1AR_NDST4 | Fusion gene ID: 2015 | Hgene | Tgene | Gene symbol | AP1AR | NDST4 | Gene ID | 55435 | 64579 |
Gene name | adaptor related protein complex 1 associated regulatory protein | N-deacetylase and N-sulfotransferase 4 | |
Synonyms | 2C18|C4orf16|GBAR|PRO0971|gamma-BAR | N-HSST|N-HSST 4|NDST-4|NHSST4 | |
Cytomap | 4q25 | 4q26 | |
Type of gene | protein-coding | protein-coding | |
Description | AP-1 complex-associated regulatory proteinadapter-related protein complex 1-associated regulatory proteingadkingamma-1-adaptin brefeldin A resistance proteingamma-A1-adaptin and kinesin interactorgamma1-adaptin brefeldin A resistance protein, gamma-B | bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4N-deacetylase/N-sulfotransferase 4N-heparan sulfate sulfotransferase 4glucosaminyl N-deacetylase/N-sulfotransferase 4 | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | Q63HQ0 | Q9H3R1 | |
Ensembl transtripts involved in fusion gene | ENST00000274000, ENST00000309703, | ENST00000264363, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
# samples | 2 | 1 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: AP1AR [Title/Abstract] AND NDST4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | AP1AR | GO:0048203 | vesicle targeting, trans-Golgi to endosome | 19706427 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-HC-7738-01A | AP1AR | chr4 | 113153330 | + | NDST4 | chr4 | 115792106 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000274000 | ENST00000264363 | AP1AR | chr4 | 113153330 | + | NDST4 | chr4 | 115792106 | - |
Frame-shift | ENST00000309703 | ENST00000264363 | AP1AR | chr4 | 113153330 | + | NDST4 | chr4 | 115792106 | - |
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FusionProtFeatures for AP1AR_NDST4 |
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Hgene | Tgene |
AP1AR | NDST4 |
Necessary for adaptor protein complex 1 (AP-1)-dependenttransport between the trans-Golgi network and endosomes. Regulatesthe membrane association of AP1G1/gamma1-adaptin, one of thesubunits of the AP-1 adaptor complex. The direct interaction withAP1G1/gamma1-adaptin attenuates the release of the AP-1 complexfrom membranes. Regulates endosomal membrane traffic viaassociation with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membranetraffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negativelyregulates cell spreading, size and motility via intracellularsequestration of the Arp2/3 complex. {ECO:0000269|PubMed:15775984,ECO:0000269|PubMed:19706427, ECO:0000269|PubMed:21525240,ECO:0000269|PubMed:22689987}. | Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of theglycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcAdisaccharide repeating sugar backbone to make N-sulfatedheparosan, a prerequisite substrate for later modifications inheparin biosynthesis. Has low deacetylase activity but highsulfotransferase activity (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AP1AR_NDST4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for AP1AR_NDST4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
AP1AR | ELAVL1, AP1S2, DUSP9 | NDST4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AP1AR_NDST4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AP1AR_NDST4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |