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Fusion gene ID: 20136 |
FusionGeneSummary for LRP1_TMEM194A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LRP1_TMEM194A | Fusion gene ID: 20136 | Hgene | Tgene | Gene symbol | LRP1 | TMEM194A | Gene ID | 10438 | 23306 |
| Gene name | C1D nuclear receptor corepressor | nuclear envelope integral membrane protein 1 | |
| Synonyms | LRP1|Rrp47|SUN-CoR|SUNCOR|hC1D | TMEM194|TMEM194A | |
| Cytomap | 2p14 | 12q13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear nucleic acid-binding protein C1DC1D DNA-binding proteinC1D nuclear receptor co-repressornuclear DNA-binding proteinsmall unique nuclear receptor co-repressorsmall unique nuclear receptor corepressor | nuclear envelope integral membrane protein 1transmembrane protein 194transmembrane protein 194A | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q07954 | ||
| Ensembl transtripts involved in fusion gene | ENST00000553277, ENST00000243077, ENST00000338962, ENST00000554174, ENST00000553446, | ENST00000379391, ENST00000300128, ENST00000553654, | |
| Fusion gene scores | * DoF score | 16 X 14 X 7=1568 | 1 X 1 X 1=1 |
| # samples | 17 | 1 | |
| ** MAII score | log2(17/1568*10)=-3.20531890797751 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: LRP1 [Title/Abstract] AND TMEM194A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-GF-A769-01A | LRP1 | chr12 | 57537581 | + | TMEM194A | chr12 | 57466695 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000553277 | ENST00000379391 | LRP1 | chr12 | 57537581 | + | TMEM194A | chr12 | 57466695 | - |
| In-frame | ENST00000553277 | ENST00000300128 | LRP1 | chr12 | 57537581 | + | TMEM194A | chr12 | 57466695 | - |
| 5CDS-5UTR | ENST00000553277 | ENST00000553654 | LRP1 | chr12 | 57537581 | + | TMEM194A | chr12 | 57466695 | - |
| In-frame | ENST00000243077 | ENST00000379391 | LRP1 | chr12 | 57537581 | + | TMEM194A | chr12 | 57466695 | - |
| In-frame | ENST00000243077 | ENST00000300128 | LRP1 | chr12 | 57537581 | + | TMEM194A | chr12 | 57466695 | - |
| 5CDS-5UTR | ENST00000243077 | ENST00000553654 | LRP1 | chr12 | 57537581 | + | TMEM194A | chr12 | 57466695 | - |
| In-frame | ENST00000338962 | ENST00000379391 | LRP1 | chr12 | 57537581 | + | TMEM194A | chr12 | 57466695 | - |
| In-frame | ENST00000338962 | ENST00000300128 | LRP1 | chr12 | 57537581 | + | TMEM194A | chr12 | 57466695 | - |
| 5CDS-5UTR | ENST00000338962 | ENST00000553654 | LRP1 | chr12 | 57537581 | + | TMEM194A | chr12 | 57466695 | - |
| In-frame | ENST00000554174 | ENST00000379391 | LRP1 | chr12 | 57537581 | + | TMEM194A | chr12 | 57466695 | - |
| In-frame | ENST00000554174 | ENST00000300128 | LRP1 | chr12 | 57537581 | + | TMEM194A | chr12 | 57466695 | - |
| 5CDS-5UTR | ENST00000554174 | ENST00000553654 | LRP1 | chr12 | 57537581 | + | TMEM194A | chr12 | 57466695 | - |
| intron-3CDS | ENST00000553446 | ENST00000379391 | LRP1 | chr12 | 57537581 | + | TMEM194A | chr12 | 57466695 | - |
| intron-3CDS | ENST00000553446 | ENST00000300128 | LRP1 | chr12 | 57537581 | + | TMEM194A | chr12 | 57466695 | - |
| intron-5UTR | ENST00000553446 | ENST00000553654 | LRP1 | chr12 | 57537581 | + | TMEM194A | chr12 | 57466695 | - |
Top |
FusionProtFeatures for LRP1_TMEM194A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LRP1 | TMEM194A |
| Endocytic receptor involved in endocytosis and inphagocytosis of apoptotic cells. Required for early embryonicdevelopment. Involved in cellular lipid homeostasis. Involved inthe plasma clearance of chylomicron remnants and activated LRPAP1(alpha 2-macroglobulin), as well as the local metabolism ofcomplexes between plasminogen activators and their endogenousinhibitors. May modulate cellular events, such as APP metabolism,kinase-dependent intracellular signaling, neuronal calciumsignaling as well as neurotransmission (PubMed:11907044,PubMed:12888553, PubMed:12713657). Acts as an alpha-2-macroglobulin receptor (PubMed:26142438).{ECO:0000269|PubMed:11907044, ECO:0000269|PubMed:12713657,ECO:0000269|PubMed:12888553, ECO:0000269|PubMed:26142438}. (Microbial infection) Functions as a receptor forPseudomonas aeruginosa exotoxin A. {ECO:0000269|PubMed:1618748}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 111_149 | 149 | 4545 | Domain | EGF-like 1 |
| Hgene | LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 25_66 | 149 | 4545 | Domain | LDL-receptor class A 1 |
| Hgene | LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 70_110 | 149 | 4545 | Domain | LDL-receptor class A 2 |
| Tgene | >TMEM194A | chr12:57537581 | chr12:57466695 | ENST00000300128 | - | 0 | 9 | 186_297 | 42 | 445 | Region | A%3B required for its colocalization with lamins at the nuclear envelope |
| Tgene | >TMEM194A | chr12:57537581 | chr12:57466695 | ENST00000300128 | - | 0 | 9 | 336_444 | 42 | 445 | Region | Required for nuclear localization |
| Tgene | >TMEM194A | chr12:57537581 | chr12:57466695 | ENST00000379391 | - | 0 | 8 | 186_297 | 42 | 372 | Region | A%3B required for its colocalization with lamins at the nuclear envelope |
| Tgene | >TMEM194A | chr12:57537581 | chr12:57466695 | ENST00000379391 | - | 0 | 8 | 336_444 | 42 | 372 | Region | Required for nuclear localization |
| Tgene | >TMEM194A | chr12:57537581 | chr12:57466695 | ENST00000300128 | - | 0 | 9 | 161_181 | 42 | 445 | Transmembrane | Helical |
| Tgene | >TMEM194A | chr12:57537581 | chr12:57466695 | ENST00000300128 | - | 0 | 9 | 186_206 | 42 | 445 | Transmembrane | Helical |
| Tgene | >TMEM194A | chr12:57537581 | chr12:57466695 | ENST00000300128 | - | 0 | 9 | 216_236 | 42 | 445 | Transmembrane | Helical |
| Tgene | >TMEM194A | chr12:57537581 | chr12:57466695 | ENST00000300128 | - | 0 | 9 | 245_265 | 42 | 445 | Transmembrane | Helical |
| Tgene | >TMEM194A | chr12:57537581 | chr12:57466695 | ENST00000300128 | - | 0 | 9 | 289_309 | 42 | 445 | Transmembrane | Helical |
| Tgene | >TMEM194A | chr12:57537581 | chr12:57466695 | ENST00000379391 | - | 0 | 8 | 161_181 | 42 | 372 | Transmembrane | Helical |
| Tgene | >TMEM194A | chr12:57537581 | chr12:57466695 | ENST00000379391 | - | 0 | 8 | 186_206 | 42 | 372 | Transmembrane | Helical |
| Tgene | >TMEM194A | chr12:57537581 | chr12:57466695 | ENST00000379391 | - | 0 | 8 | 216_236 | 42 | 372 | Transmembrane | Helical |
| Tgene | >TMEM194A | chr12:57537581 | chr12:57466695 | ENST00000379391 | - | 0 | 8 | 245_265 | 42 | 372 | Transmembrane | Helical |
| Tgene | >TMEM194A | chr12:57537581 | chr12:57466695 | ENST00000379391 | - | 0 | 8 | 289_309 | 42 | 372 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 1013_1053 | 149 | 4545 | Domain | LDL-receptor class A 7 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 1060_1099 | 149 | 4545 | Domain | LDL-receptor class A 8 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 1102_1142 | 149 | 4545 | Domain | LDL-receptor class A 9 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 1143_1182 | 149 | 4545 | Domain | LDL-receptor class A 10 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 1183_1222 | 149 | 4545 | Domain | EGF-like 5 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 1223_1262 | 149 | 4545 | Domain | EGF-like 6 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 150_189 | 149 | 4545 | Domain | EGF-like 2%3B calcium-binding |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 1536_1579 | 149 | 4545 | Domain | EGF-like 7 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 1846_1887 | 149 | 4545 | Domain | EGF-like 8 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 2155_2195 | 149 | 4545 | Domain | EGF-like 9 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 2478_2518 | 149 | 4545 | Domain | EGF-like 10 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 2522_2563 | 149 | 4545 | Domain | LDL-receptor class A 11 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 2564_2602 | 149 | 4545 | Domain | LDL-receptor class A 12 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 2603_2641 | 149 | 4545 | Domain | LDL-receptor class A 13 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 2642_2690 | 149 | 4545 | Domain | LDL-receptor class A 14 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 2694_2732 | 149 | 4545 | Domain | LDL-receptor class A 15 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 2732_2771 | 149 | 4545 | Domain | LDL-receptor class A 16 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 2772_2814 | 149 | 4545 | Domain | LDL-receptor class A 17 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 2816_2855 | 149 | 4545 | Domain | LDL-receptor class A 18 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 2856_2899 | 149 | 4545 | Domain | LDL-receptor class A 19 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 2902_2940 | 149 | 4545 | Domain | LDL-receptor class A 20 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 2941_2981 | 149 | 4545 | Domain | EGF-like 11 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 2982_3022 | 149 | 4545 | Domain | EGF-like 12%3B calcium-binding |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 3290_3331 | 149 | 4545 | Domain | EGF-like 13 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 3332_3371 | 149 | 4545 | Domain | LDL-receptor class A 21 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 3372_3410 | 149 | 4545 | Domain | LDL-receptor class A 22 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 3411_3450 | 149 | 4545 | Domain | LDL-receptor class A 23 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 3451_3491 | 149 | 4545 | Domain | LDL-receptor class A 24 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 3492_3533 | 149 | 4545 | Domain | LDL-receptor class A 25 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 3534_3572 | 149 | 4545 | Domain | LDL-receptor class A 26 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 3573_3611 | 149 | 4545 | Domain | LDL-receptor class A 27 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 3611_3649 | 149 | 4545 | Domain | LDL-receptor class A 28 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 3652_3692 | 149 | 4545 | Domain | LDL-receptor class A 29 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 3693_3733 | 149 | 4545 | Domain | LDL-receptor class A 30 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 3739_3778 | 149 | 4545 | Domain | LDL-receptor class A 31 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 3781_3823 | 149 | 4545 | Domain | EGF-like 14 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 3824_3861 | 149 | 4545 | Domain | EGF-like 15 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 4147_4183 | 149 | 4545 | Domain | EGF-like 16 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 4196_4232 | 149 | 4545 | Domain | EGF-like 17 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 4232_4268 | 149 | 4545 | Domain | EGF-like 18 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 4268_4304 | 149 | 4545 | Domain | EGF-like 19 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 4304_4340 | 149 | 4545 | Domain | EGF-like 20 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 4340_4375 | 149 | 4545 | Domain | EGF-like 21 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 4373_4409 | 149 | 4545 | Domain | EGF-like 22 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 474_520 | 149 | 4545 | Domain | EGF-like 3 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 803_843 | 149 | 4545 | Domain | EGF-like 4 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 852_892 | 149 | 4545 | Domain | LDL-receptor class A 3 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 893_933 | 149 | 4545 | Domain | LDL-receptor class A 4 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 934_973 | 149 | 4545 | Domain | LDL-receptor class A 5 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 974_1013 | 149 | 4545 | Domain | LDL-receptor class A 6 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 3940_3943 | 149 | 4545 | Motif | Recognition site for proteolytical processing |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 4502_4507 | 149 | 4545 | Motif | Note=NPXY motif |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 1309_1355 | 149 | 4545 | Repeat | Note=LDL-receptor class B 8 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 1356_1398 | 149 | 4545 | Repeat | Note=LDL-receptor class B 9 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 1399_1445 | 149 | 4545 | Repeat | Note=LDL-receptor class B 10 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 1446_1490 | 149 | 4545 | Repeat | Note=LDL-receptor class B 11 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 1491_1531 | 149 | 4545 | Repeat | Note=LDL-receptor class B 12 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 1627_1669 | 149 | 4545 | Repeat | Note=LDL-receptor class B 13 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 1670_1713 | 149 | 4545 | Repeat | Note=LDL-receptor class B 14 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 1714_1753 | 149 | 4545 | Repeat | Note=LDL-receptor class B 15 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 1754_1798 | 149 | 4545 | Repeat | Note=LDL-receptor class B 16 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 1934_1976 | 149 | 4545 | Repeat | Note=LDL-receptor class B 17 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 1977_2019 | 149 | 4545 | Repeat | Note=LDL-receptor class B 18 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 2020_2063 | 149 | 4545 | Repeat | Note=LDL-receptor class B 19 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 2064_2107 | 149 | 4545 | Repeat | Note=LDL-receptor class B 20 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 2253_2294 | 149 | 4545 | Repeat | Note=LDL-receptor class B 21 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 2295_2343 | 149 | 4545 | Repeat | Note=LDL-receptor class B 22 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 2344_2388 | 149 | 4545 | Repeat | Note=LDL-receptor class B 23 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 2389_2431 | 149 | 4545 | Repeat | Note=LDL-receptor class B 24 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 2432_2473 | 149 | 4545 | Repeat | Note=LDL-receptor class B 25 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 292_334 | 149 | 4545 | Repeat | Note=LDL-receptor class B 1 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 3069_3113 | 149 | 4545 | Repeat | Note=LDL-receptor class B 26 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 3114_3156 | 149 | 4545 | Repeat | Note=LDL-receptor class B 27 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 3157_3200 | 149 | 4545 | Repeat | Note=LDL-receptor class B 28 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 3201_3243 | 149 | 4545 | Repeat | Note=LDL-receptor class B 29 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 3244_3284 | 149 | 4545 | Repeat | Note=LDL-receptor class B 30 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 335_378 | 149 | 4545 | Repeat | Note=LDL-receptor class B 2 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 379_422 | 149 | 4545 | Repeat | Note=LDL-receptor class B 3 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 3912_3954 | 149 | 4545 | Repeat | Note=LDL-receptor class B 31 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 3970_4012 | 149 | 4545 | Repeat | Note=LDL-receptor class B 32 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 4013_4056 | 149 | 4545 | Repeat | Note=LDL-receptor class B 33 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 4057_4101 | 149 | 4545 | Repeat | Note=LDL-receptor class B 34 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 571_613 | 149 | 4545 | Repeat | Note=LDL-receptor class B 4 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 614_659 | 149 | 4545 | Repeat | Note=LDL-receptor class B 5 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 660_710 | 149 | 4545 | Repeat | Note=LDL-receptor class B 6 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 711_754 | 149 | 4545 | Repeat | Note=LDL-receptor class B 7 |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 20_4419 | 149 | 4545 | Topological domain | Extracellular |
| Hgene | >LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 4420_4444 | 149 | 4545 | Transmembrane | Helical |
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FusionGeneSequence for LRP1_TMEM194A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LRP1_TMEM194A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LRP1 | SERPINE1, CANX, CALR, PDIA2, MMP14, KAT5, CALCR, SHC1, THBS1, GIPC1, MAPK8IP1, DLG4, MAPK8IP2, SYNJ2BP, NOS1AP, SCN3A, APBA2, DAB1, ITGB1BP1, ANAPC10, A2M, PDGFB, SRC, DAB2, MDK, F8, GULP1, PLAUR, PLAT, F9, LRPAP1, LPL, LIPC, SNX17, APBB1, USP3, CACNA1A, APOE, RIC8B, CC2D1A, SNRNP70, ANKS1B, PID1, HNRNPDL, MAPRE1, FBXO6, CUBN, CHFR, SKIL, RANBP9, APP, COPS5, EGFR, ZFP41, DIAPH1, FOXB1, KCTD18, INTS6, TNKS2, TNKS, FOXF2, BCKDHB, TUBB8, SAMD1, TUBA4A, TUBB3, LOXL2, MTG2, SLC25A6, SLC25A30, GATB, SMOC1, C17orf80, GSG2, NME4, HARS2, TUBA1A, TUBB4A, SLC25A23, LCOR, CCRN4L, FAM115A, SLC25A25, MTO1, C1orf85, PC, PTGES2, SLC26A6, GFPT2, GFPT1, HSPA5, RPL23, TUBB2A, NPC2, MTPAP, TUBB4B, RPUSD3, GNB2, NPRL3, FAM132B, ERAL1, GCNT1, TUBB2B, PTCD2, SENP1, MAP2K7, RTEL1, LGALS9 | TMEM194A | ELAVL1, LYPD3, KPNB1, MBOAT1, FOXL1, RGPD2, RGPD8, ADCY9, RGPD5, RAN, DLGAP5, RANBP2, ACAD11, GLRB, RANGAP1, PIP4K2A, PIP4K2B, UBE2I, B2M, METAP2, NOP58, SDAD1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | LRP1 | chr12:57537581 | chr12:57466695 | ENST00000243077 | + | 4 | 89 | 4445_4544 | 149 | 4545 | MAFB |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LRP1_TMEM194A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | LRP1 | Q07954 | DB00031 | Tenecteplase | Prolow-density lipoprotein receptor-related protein 1 | biotech | approved |
| Hgene | LRP1 | Q07954 | DB00025 | Antihemophilic factor, human recombinant | Prolow-density lipoprotein receptor-related protein 1 | biotech | approved|investigational |
| Hgene | LRP1 | Q07954 | DB00100 | Coagulation Factor IX (Recombinant) | Prolow-density lipoprotein receptor-related protein 1 | biotech | approved|investigational |
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RelatedDiseases for LRP1_TMEM194A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | LRP1 | C0036341 | Schizophrenia | 1 | CTD_human |
| Hgene | LRP1 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Hgene | LRP1 | C0149931 | Migraine Disorders | 1 | CTD_human |
| Hgene | LRP1 | C0338480 | Common Migraine | 1 | CTD_human |
| Hgene | LRP1 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
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