FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 20127

FusionGeneSummary for LRP1_ETV6

check button Fusion gene summary
Fusion gene informationFusion gene name: LRP1_ETV6
Fusion gene ID: 20127
HgeneTgene
Gene symbol

LRP1

ETV6

Gene ID

10438

2120

Gene nameC1D nuclear receptor corepressorETS variant 6
SynonymsLRP1|Rrp47|SUN-CoR|SUNCOR|hC1DTEL|TEL/ABL|THC5
Cytomap

2p14

12p13.2

Type of geneprotein-codingprotein-coding
Descriptionnuclear nucleic acid-binding protein C1DC1D DNA-binding proteinC1D nuclear receptor co-repressornuclear DNA-binding proteinsmall unique nuclear receptor co-repressorsmall unique nuclear receptor corepressortranscription factor ETV6ETS translocation variant 6ETS-related protein Tel1TEL1 oncogeneets variant gene 6 (TEL oncogene)
Modification date2018051920180523
UniProtAcc

Q07954

P41212

Ensembl transtripts involved in fusion geneENST00000553277, ENST00000243077, 
ENST00000338962, ENST00000554174, 
ENST00000553446, 
ENST00000396373, 
ENST00000544715, 
Fusion gene scores* DoF score16 X 14 X 7=15689 X 9 X 4=324
# samples 1712
** MAII scorelog2(17/1568*10)=-3.20531890797751
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/324*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRP1 [Title/Abstract] AND ETV6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
Transcription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneETV6

GO:0000122

negative regulation of transcription by RNA polymerase II

10514502


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-PC-A5DN-01ALRP1chr12

57539273

+ETV6chr12

12037379

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000553277ENST00000396373LRP1chr12

57539273

+ETV6chr12

12037379

+
5CDS-intronENST00000553277ENST00000544715LRP1chr12

57539273

+ETV6chr12

12037379

+
In-frameENST00000243077ENST00000396373LRP1chr12

57539273

+ETV6chr12

12037379

+
5CDS-intronENST00000243077ENST00000544715LRP1chr12

57539273

+ETV6chr12

12037379

+
In-frameENST00000338962ENST00000396373LRP1chr12

57539273

+ETV6chr12

12037379

+
5CDS-intronENST00000338962ENST00000544715LRP1chr12

57539273

+ETV6chr12

12037379

+
In-frameENST00000554174ENST00000396373LRP1chr12

57539273

+ETV6chr12

12037379

+
5CDS-intronENST00000554174ENST00000544715LRP1chr12

57539273

+ETV6chr12

12037379

+
intron-3CDSENST00000553446ENST00000396373LRP1chr12

57539273

+ETV6chr12

12037379

+
intron-intronENST00000553446ENST00000544715LRP1chr12

57539273

+ETV6chr12

12037379

+

Top

FusionProtFeatures for LRP1_ETV6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRP1

Q07954

ETV6

P41212

Endocytic receptor involved in endocytosis and inphagocytosis of apoptotic cells. Required for early embryonicdevelopment. Involved in cellular lipid homeostasis. Involved inthe plasma clearance of chylomicron remnants and activated LRPAP1(alpha 2-macroglobulin), as well as the local metabolism ofcomplexes between plasminogen activators and their endogenousinhibitors. May modulate cellular events, such as APP metabolism,kinase-dependent intracellular signaling, neuronal calciumsignaling as well as neurotransmission (PubMed:11907044,PubMed:12888553, PubMed:12713657). Acts as an alpha-2-macroglobulin receptor (PubMed:26142438).{ECO:0000269|PubMed:11907044, ECO:0000269|PubMed:12713657,ECO:0000269|PubMed:12888553, ECO:0000269|PubMed:26142438}. (Microbial infection) Functions as a receptor forPseudomonas aeruginosa exotoxin A. {ECO:0000269|PubMed:1618748}. Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignanttransformation. {ECO:0000269|PubMed:25581430}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+689111_1492804545DomainEGF-like 1
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+689150_1892804545DomainEGF-like 2%3B calcium-binding
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+68925_662804545DomainLDL-receptor class A 1
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+68970_1102804545DomainLDL-receptor class A 2
TgeneETV6chr12:57539273chr12:12037379ENST00000396373+48339_420336453DNA bindingETS

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6891013_10532804545DomainLDL-receptor class A 7
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6891060_10992804545DomainLDL-receptor class A 8
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6891102_11422804545DomainLDL-receptor class A 9
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6891143_11822804545DomainLDL-receptor class A 10
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6891183_12222804545DomainEGF-like 5
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6891223_12622804545DomainEGF-like 6
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6891536_15792804545DomainEGF-like 7
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6891846_18872804545DomainEGF-like 8
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6892155_21952804545DomainEGF-like 9
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6892478_25182804545DomainEGF-like 10
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6892522_25632804545DomainLDL-receptor class A 11
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6892564_26022804545DomainLDL-receptor class A 12
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6892603_26412804545DomainLDL-receptor class A 13
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6892642_26902804545DomainLDL-receptor class A 14
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6892694_27322804545DomainLDL-receptor class A 15
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6892732_27712804545DomainLDL-receptor class A 16
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6892772_28142804545DomainLDL-receptor class A 17
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6892816_28552804545DomainLDL-receptor class A 18
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6892856_28992804545DomainLDL-receptor class A 19
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6892902_29402804545DomainLDL-receptor class A 20
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6892941_29812804545DomainEGF-like 11
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6892982_30222804545DomainEGF-like 12%3B calcium-binding
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6893290_33312804545DomainEGF-like 13
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6893332_33712804545DomainLDL-receptor class A 21
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6893372_34102804545DomainLDL-receptor class A 22
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6893411_34502804545DomainLDL-receptor class A 23
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6893451_34912804545DomainLDL-receptor class A 24
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6893492_35332804545DomainLDL-receptor class A 25
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6893534_35722804545DomainLDL-receptor class A 26
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6893573_36112804545DomainLDL-receptor class A 27
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6893611_36492804545DomainLDL-receptor class A 28
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6893652_36922804545DomainLDL-receptor class A 29
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6893693_37332804545DomainLDL-receptor class A 30
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6893739_37782804545DomainLDL-receptor class A 31
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6893781_38232804545DomainEGF-like 14
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6893824_38612804545DomainEGF-like 15
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6894147_41832804545DomainEGF-like 16
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6894196_42322804545DomainEGF-like 17
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6894232_42682804545DomainEGF-like 18
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6894268_43042804545DomainEGF-like 19
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6894304_43402804545DomainEGF-like 20
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6894340_43752804545DomainEGF-like 21
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6894373_44092804545DomainEGF-like 22
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+689474_5202804545DomainEGF-like 3
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+689803_8432804545DomainEGF-like 4
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+689852_8922804545DomainLDL-receptor class A 3
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+689893_9332804545DomainLDL-receptor class A 4
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+689934_9732804545DomainLDL-receptor class A 5
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+689974_10132804545DomainLDL-receptor class A 6
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6893940_39432804545MotifRecognition site for proteolytical processing
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6894502_45072804545MotifNote=NPXY motif
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6891309_13552804545RepeatNote=LDL-receptor class B 8
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6891356_13982804545RepeatNote=LDL-receptor class B 9
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6891399_14452804545RepeatNote=LDL-receptor class B 10
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6891446_14902804545RepeatNote=LDL-receptor class B 11
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6891491_15312804545RepeatNote=LDL-receptor class B 12
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6891627_16692804545RepeatNote=LDL-receptor class B 13
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6891670_17132804545RepeatNote=LDL-receptor class B 14
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6891714_17532804545RepeatNote=LDL-receptor class B 15
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6891754_17982804545RepeatNote=LDL-receptor class B 16
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6891934_19762804545RepeatNote=LDL-receptor class B 17
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6891977_20192804545RepeatNote=LDL-receptor class B 18
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6892020_20632804545RepeatNote=LDL-receptor class B 19
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6892064_21072804545RepeatNote=LDL-receptor class B 20
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6892253_22942804545RepeatNote=LDL-receptor class B 21
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6892295_23432804545RepeatNote=LDL-receptor class B 22
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6892344_23882804545RepeatNote=LDL-receptor class B 23
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6892389_24312804545RepeatNote=LDL-receptor class B 24
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6892432_24732804545RepeatNote=LDL-receptor class B 25
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+689292_3342804545RepeatNote=LDL-receptor class B 1
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6893069_31132804545RepeatNote=LDL-receptor class B 26
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6893114_31562804545RepeatNote=LDL-receptor class B 27
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6893157_32002804545RepeatNote=LDL-receptor class B 28
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6893201_32432804545RepeatNote=LDL-receptor class B 29
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6893244_32842804545RepeatNote=LDL-receptor class B 30
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+689335_3782804545RepeatNote=LDL-receptor class B 2
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+689379_4222804545RepeatNote=LDL-receptor class B 3
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6893912_39542804545RepeatNote=LDL-receptor class B 31
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6893970_40122804545RepeatNote=LDL-receptor class B 32
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6894013_40562804545RepeatNote=LDL-receptor class B 33
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6894057_41012804545RepeatNote=LDL-receptor class B 34
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+689571_6132804545RepeatNote=LDL-receptor class B 4
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+689614_6592804545RepeatNote=LDL-receptor class B 5
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+689660_7102804545RepeatNote=LDL-receptor class B 6
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+689711_7542804545RepeatNote=LDL-receptor class B 7
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+68920_44192804545Topological domainExtracellular
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6894420_44442804545TransmembraneHelical
TgeneETV6chr12:57539273chr12:12037379ENST00000396373+4840_124336453DomainPNT


Top

FusionGeneSequence for LRP1_ETV6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_LRP1_ENST00000553277_chr12_57539273_+_ETV6_ENST00000396373_chr12_12037379_+_397aa
MLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSR
LCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYL
LQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSTANETVCWVHVGDSAAQTQLKCARMPGLKGFVDE
HTINISLSLHHCRLLWDYVTQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTTEKMSRALRHYYKLNIIRKEPGQRLL

>In-frame_LRP1_ENST00000243077_chr12_57539273_+_ETV6_ENST00000396373_chr12_12037379_+_397aa
MLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSR
LCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYL
LQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSTANETVCWVHVGDSAAQTQLKCARMPGLKGFVDE
HTINISLSLHHCRLLWDYVTQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTTEKMSRALRHYYKLNIIRKEPGQRLL

>In-frame_LRP1_ENST00000338962_chr12_57539273_+_ETV6_ENST00000396373_chr12_12037379_+_397aa
MLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSR
LCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYL
LQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSTANETVCWVHVGDSAAQTQLKCARMPGLKGFVDE
HTINISLSLHHCRLLWDYVTQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTTEKMSRALRHYYKLNIIRKEPGQRLL

>In-frame_LRP1_ENST00000554174_chr12_57539273_+_ETV6_ENST00000396373_chr12_12037379_+_397aa
MLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSR
LCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYL
LQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSTANETVCWVHVGDSAAQTQLKCARMPGLKGFVDE
HTINISLSLHHCRLLWDYVTQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTTEKMSRALRHYYKLNIIRKEPGQRLL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_LRP1_ENST00000553277_chr12_57539273_+_ETV6_ENST00000396373_chr12_12037379_+_1191nt
ATGCTGACCCCGCCGTTGCTCCTGCTGCTGCCCCTGCTCTCAGCTCTGGTCGCGGCGGCTATCGACGCCCCTAAGACTTGCAGCCCCAAG
CAGTTTGCCTGCAGAGATCAAATAACCTGTATCTCAAAGGGCTGGCGGTGCGACGGTGAGAGGGACTGCCCAGACGGATCTGACGAGGCC
CCTGAGATTTGTCCACAGAGTAAGGCCCAGCGATGCCAGCCAAACGAGCATAACTGCCTGGGTACTGAGCTGTGTGTTCCCATGTCCCGC
CTCTGCAATGGGGTCCAGGACTGCATGGACGGCTCAGATGAGGGGCCCCACTGCCGAGAGCTCCAAGGCAACTGCTCTCGCCTGGGCTGC
CAGCACCATTGTGTCCCCACACTCGATGGGCCCACCTGCTACTGCAACAGCAGCTTTCAGCTTCAGGCAGATGGCAAGACCTGCAAAGAT
TTTGATGAGTGCTCAGTGTACGGCACCTGCAGCCAGCTATGCACCAACACAGACGGCTCCTTCATATGTGGCTGTGTTGAAGGATACCTC
CTGCAGCCGGATAACCGCTCCTGCAAGGCCAAGAACGAGCCAGTAGACCGGCCCCCTGTGCTGTTGATAGCCAACTCCCAGAACATCTTG
GCCACGTACCTGAGTGGGGCCCAGGTGTCTACCATCACACCTACGAGCACGCGGCAGACCACAGCCATGGACTTCAGCTATGCCAACGAG
ACCGTATGCTGGGTGCATGTTGGGGACAGTGCTGCTCAGACGCAGCTCAAGTGTGCCCGCATGCCTGGCCTAAAGGGCTTCGTGGATGAG
CACACCATCAACATCTCCCTCAGTCTGCACCACTGTAGACTGCTTTGGGATTACGTCTATCAGTTGCTTTCTGACAGCCGGTACGAAAAC
TTCATCCGATGGGAGGACAAAGAATCCAAAATATTCCGGATAGTGGATCCCAACGGACTGGCTCGACTGTGGGGAAACCATAAGAACAGA
ACAAACATGACCTATGAGAAAATGTCCAGAGCCCTGCGCCACTACTACAAACTAAACATTATCAGGAAGGAGCCAGGACAAAGGCTTTTG
TTCAGGTTTATGAAAACCCCAGATGAAATCATGAGTGGCCGAACAGACCGTCTGGAGCACCTAGAGTCCCAGGAGCTGGATGAACAAATA

>In-frame_LRP1_ENST00000243077_chr12_57539273_+_ETV6_ENST00000396373_chr12_12037379_+_1191nt
ATGCTGACCCCGCCGTTGCTCCTGCTGCTGCCCCTGCTCTCAGCTCTGGTCGCGGCGGCTATCGACGCCCCTAAGACTTGCAGCCCCAAG
CAGTTTGCCTGCAGAGATCAAATAACCTGTATCTCAAAGGGCTGGCGGTGCGACGGTGAGAGGGACTGCCCAGACGGATCTGACGAGGCC
CCTGAGATTTGTCCACAGAGTAAGGCCCAGCGATGCCAGCCAAACGAGCATAACTGCCTGGGTACTGAGCTGTGTGTTCCCATGTCCCGC
CTCTGCAATGGGGTCCAGGACTGCATGGACGGCTCAGATGAGGGGCCCCACTGCCGAGAGCTCCAAGGCAACTGCTCTCGCCTGGGCTGC
CAGCACCATTGTGTCCCCACACTCGATGGGCCCACCTGCTACTGCAACAGCAGCTTTCAGCTTCAGGCAGATGGCAAGACCTGCAAAGAT
TTTGATGAGTGCTCAGTGTACGGCACCTGCAGCCAGCTATGCACCAACACAGACGGCTCCTTCATATGTGGCTGTGTTGAAGGATACCTC
CTGCAGCCGGATAACCGCTCCTGCAAGGCCAAGAACGAGCCAGTAGACCGGCCCCCTGTGCTGTTGATAGCCAACTCCCAGAACATCTTG
GCCACGTACCTGAGTGGGGCCCAGGTGTCTACCATCACACCTACGAGCACGCGGCAGACCACAGCCATGGACTTCAGCTATGCCAACGAG
ACCGTATGCTGGGTGCATGTTGGGGACAGTGCTGCTCAGACGCAGCTCAAGTGTGCCCGCATGCCTGGCCTAAAGGGCTTCGTGGATGAG
CACACCATCAACATCTCCCTCAGTCTGCACCACTGTAGACTGCTTTGGGATTACGTCTATCAGTTGCTTTCTGACAGCCGGTACGAAAAC
TTCATCCGATGGGAGGACAAAGAATCCAAAATATTCCGGATAGTGGATCCCAACGGACTGGCTCGACTGTGGGGAAACCATAAGAACAGA
ACAAACATGACCTATGAGAAAATGTCCAGAGCCCTGCGCCACTACTACAAACTAAACATTATCAGGAAGGAGCCAGGACAAAGGCTTTTG
TTCAGGTTTATGAAAACCCCAGATGAAATCATGAGTGGCCGAACAGACCGTCTGGAGCACCTAGAGTCCCAGGAGCTGGATGAACAAATA

>In-frame_LRP1_ENST00000338962_chr12_57539273_+_ETV6_ENST00000396373_chr12_12037379_+_1191nt
ATGCTGACCCCGCCGTTGCTCCTGCTGCTGCCCCTGCTCTCAGCTCTGGTCGCGGCGGCTATCGACGCCCCTAAGACTTGCAGCCCCAAG
CAGTTTGCCTGCAGAGATCAAATAACCTGTATCTCAAAGGGCTGGCGGTGCGACGGTGAGAGGGACTGCCCAGACGGATCTGACGAGGCC
CCTGAGATTTGTCCACAGAGTAAGGCCCAGCGATGCCAGCCAAACGAGCATAACTGCCTGGGTACTGAGCTGTGTGTTCCCATGTCCCGC
CTCTGCAATGGGGTCCAGGACTGCATGGACGGCTCAGATGAGGGGCCCCACTGCCGAGAGCTCCAAGGCAACTGCTCTCGCCTGGGCTGC
CAGCACCATTGTGTCCCCACACTCGATGGGCCCACCTGCTACTGCAACAGCAGCTTTCAGCTTCAGGCAGATGGCAAGACCTGCAAAGAT
TTTGATGAGTGCTCAGTGTACGGCACCTGCAGCCAGCTATGCACCAACACAGACGGCTCCTTCATATGTGGCTGTGTTGAAGGATACCTC
CTGCAGCCGGATAACCGCTCCTGCAAGGCCAAGAACGAGCCAGTAGACCGGCCCCCTGTGCTGTTGATAGCCAACTCCCAGAACATCTTG
GCCACGTACCTGAGTGGGGCCCAGGTGTCTACCATCACACCTACGAGCACGCGGCAGACCACAGCCATGGACTTCAGCTATGCCAACGAG
ACCGTATGCTGGGTGCATGTTGGGGACAGTGCTGCTCAGACGCAGCTCAAGTGTGCCCGCATGCCTGGCCTAAAGGGCTTCGTGGATGAG
CACACCATCAACATCTCCCTCAGTCTGCACCACTGTAGACTGCTTTGGGATTACGTCTATCAGTTGCTTTCTGACAGCCGGTACGAAAAC
TTCATCCGATGGGAGGACAAAGAATCCAAAATATTCCGGATAGTGGATCCCAACGGACTGGCTCGACTGTGGGGAAACCATAAGAACAGA
ACAAACATGACCTATGAGAAAATGTCCAGAGCCCTGCGCCACTACTACAAACTAAACATTATCAGGAAGGAGCCAGGACAAAGGCTTTTG
TTCAGGTTTATGAAAACCCCAGATGAAATCATGAGTGGCCGAACAGACCGTCTGGAGCACCTAGAGTCCCAGGAGCTGGATGAACAAATA

>In-frame_LRP1_ENST00000554174_chr12_57539273_+_ETV6_ENST00000396373_chr12_12037379_+_1191nt
ATGCTGACCCCGCCGTTGCTCCTGCTGCTGCCCCTGCTCTCAGCTCTGGTCGCGGCGGCTATCGACGCCCCTAAGACTTGCAGCCCCAAG
CAGTTTGCCTGCAGAGATCAAATAACCTGTATCTCAAAGGGCTGGCGGTGCGACGGTGAGAGGGACTGCCCAGACGGATCTGACGAGGCC
CCTGAGATTTGTCCACAGAGTAAGGCCCAGCGATGCCAGCCAAACGAGCATAACTGCCTGGGTACTGAGCTGTGTGTTCCCATGTCCCGC
CTCTGCAATGGGGTCCAGGACTGCATGGACGGCTCAGATGAGGGGCCCCACTGCCGAGAGCTCCAAGGCAACTGCTCTCGCCTGGGCTGC
CAGCACCATTGTGTCCCCACACTCGATGGGCCCACCTGCTACTGCAACAGCAGCTTTCAGCTTCAGGCAGATGGCAAGACCTGCAAAGAT
TTTGATGAGTGCTCAGTGTACGGCACCTGCAGCCAGCTATGCACCAACACAGACGGCTCCTTCATATGTGGCTGTGTTGAAGGATACCTC
CTGCAGCCGGATAACCGCTCCTGCAAGGCCAAGAACGAGCCAGTAGACCGGCCCCCTGTGCTGTTGATAGCCAACTCCCAGAACATCTTG
GCCACGTACCTGAGTGGGGCCCAGGTGTCTACCATCACACCTACGAGCACGCGGCAGACCACAGCCATGGACTTCAGCTATGCCAACGAG
ACCGTATGCTGGGTGCATGTTGGGGACAGTGCTGCTCAGACGCAGCTCAAGTGTGCCCGCATGCCTGGCCTAAAGGGCTTCGTGGATGAG
CACACCATCAACATCTCCCTCAGTCTGCACCACTGTAGACTGCTTTGGGATTACGTCTATCAGTTGCTTTCTGACAGCCGGTACGAAAAC
TTCATCCGATGGGAGGACAAAGAATCCAAAATATTCCGGATAGTGGATCCCAACGGACTGGCTCGACTGTGGGGAAACCATAAGAACAGA
ACAAACATGACCTATGAGAAAATGTCCAGAGCCCTGCGCCACTACTACAAACTAAACATTATCAGGAAGGAGCCAGGACAAAGGCTTTTG
TTCAGGTTTATGAAAACCCCAGATGAAATCATGAGTGGCCGAACAGACCGTCTGGAGCACCTAGAGTCCCAGGAGCTGGATGAACAAATA


* Fusion transcript sequences (Full-length transcript).
>In-frame_LRP1_ENST00000553277_chr12_57539273_+_ETV6_ENST00000396373_chr12_12037379_+_6019nt
GGGGAACAGCGGTGCGAGCTCCAGGCCCATGCACTGAGGAGGCGGAAACAAGGGGAGCCCCCAGAGCTCCATCAAGCCCCCTCCAAAGGC
TCCCCTACCCGGTCCACGCCCCCCACCCCCCCTCCCCGCCTCCTCCCAATTGTGCATTTTTGCAGCCGGAGGCGGCTCCGAGATGGGGCT
GTGAGCTTCGCCCGGGGAGGGGGAAAGAGCAGCGAGGAGTGAAGCGGGGGGGTGGGGTGAAGGGTTTGGATTTCGGGGCAGGGGGCGCAC
CCCCGTCAGCAGGCCCTCCCCAAGGGGCTCGGAACTCTACCTCTTCACCCACGCCCCTGGTGCGCTTTGCCGAAGGAAAGAATAAGAACA
GAGAAGGAGGAGGGGGAAAGGAGGAAAAGGGGGACCCCCCAACTGGGGGGGGTGAAGGAGAGAAGTAGCAGGACCAGAGGGGAAGGGGCT
GCTGCTTGCATCAGCCCACACCATGCTGACCCCGCCGTTGCTCCTGCTGCTGCCCCTGCTCTCAGCTCTGGTCGCGGCGGCTATCGACGC
CCCTAAGACTTGCAGCCCCAAGCAGTTTGCCTGCAGAGATCAAATAACCTGTATCTCAAAGGGCTGGCGGTGCGACGGTGAGAGGGACTG
CCCAGACGGATCTGACGAGGCCCCTGAGATTTGTCCACAGAGTAAGGCCCAGCGATGCCAGCCAAACGAGCATAACTGCCTGGGTACTGA
GCTGTGTGTTCCCATGTCCCGCCTCTGCAATGGGGTCCAGGACTGCATGGACGGCTCAGATGAGGGGCCCCACTGCCGAGAGCTCCAAGG
CAACTGCTCTCGCCTGGGCTGCCAGCACCATTGTGTCCCCACACTCGATGGGCCCACCTGCTACTGCAACAGCAGCTTTCAGCTTCAGGC
AGATGGCAAGACCTGCAAAGATTTTGATGAGTGCTCAGTGTACGGCACCTGCAGCCAGCTATGCACCAACACAGACGGCTCCTTCATATG
TGGCTGTGTTGAAGGATACCTCCTGCAGCCGGATAACCGCTCCTGCAAGGCCAAGAACGAGCCAGTAGACCGGCCCCCTGTGCTGTTGAT
AGCCAACTCCCAGAACATCTTGGCCACGTACCTGAGTGGGGCCCAGGTGTCTACCATCACACCTACGAGCACGCGGCAGACCACAGCCAT
GGACTTCAGCTATGCCAACGAGACCGTATGCTGGGTGCATGTTGGGGACAGTGCTGCTCAGACGCAGCTCAAGTGTGCCCGCATGCCTGG
CCTAAAGGGCTTCGTGGATGAGCACACCATCAACATCTCCCTCAGTCTGCACCACTGTAGACTGCTTTGGGATTACGTCTATCAGTTGCT
TTCTGACAGCCGGTACGAAAACTTCATCCGATGGGAGGACAAAGAATCCAAAATATTCCGGATAGTGGATCCCAACGGACTGGCTCGACT
GTGGGGAAACCATAAGAACAGAACAAACATGACCTATGAGAAAATGTCCAGAGCCCTGCGCCACTACTACAAACTAAACATTATCAGGAA
GGAGCCAGGACAAAGGCTTTTGTTCAGGTTTATGAAAACCCCAGATGAAATCATGAGTGGCCGAACAGACCGTCTGGAGCACCTAGAGTC
CCAGGAGCTGGATGAACAAATATACCAAGAAGATGAATGCTGAAGGAACCAACAGTCCACCTCAGCGGGCCAGCAGCCCAGGGAACCCCT
GCCCACCAGGATTGCTGGAAGTGTGACGGAGCAGGCGGGCTGAGGAGAGTGGAAAAGGAAGCGACCCAGAAATGGCAGGGACACTTCTCT
TGCAGACCAAGAGGGACCCTGGAGCACCTTAGACAAACTACCCAGCACAGGCGGGGCTGGAATTCTGGCGGAGGGCATGAGCCTGGGACT
CCATGTCACGTTTCCTTCTGATTTGGAATCTCTCCATCTGTAATTCCTCACCCTCACCCTTCCACCGTTGTTAGTATCATGGTGTTTTTG
TTTTTGTTTTTGTTTTAAGAACCTGCAGTTTGACTCTTCATCGTTCATCTAGGGGAAGACATCTGATGTTGTTTTCCTATGGAAATATAT
ATCTATTATATATATATTTTTTGCAAATCTCACAAAGTGCGGCAAGCCCAGCTGGTCAGGAAAGAGAATACTTGCAGAGGGGTTCAGGTT
CCTCTTTTTCCTGCCACGTGGATCAGGTCTGTTCCTGTTACTGTTGGGTCTTGGCTGAAAAAAAAAAATGCTTTTAAAAAAGATAAAATG
AAAAGGAGAGCTCTCTTTTTCTCTCTCTTGCTCTGTTCTTCCCTTGGTCCCCTCTGTCCTCCCGCCCTGCCTGCAGTTGAGATTCAGATG
CCTTCTGACAGAGTTCAGCCTCTTGGAGAGTCTTGGGGATTGTTGGCACCTAAACAGAATCAGTGACCCGGGTGCTTTGTGGCCAGCAGC
ACAGAATCAAACCCGCATCCCAGCATTGGGCCACCCATCTGAGGGAGGCCAAAATCATCACAGATGCTGCTGTGCTGCAGACAGATACAT
GCTAGTCCAGAGAGCCGCCCCTGAGATGGCTGTGAGAACCATGTGTCTAAGGCGTAAGATAAGGATGGAAGGCTGTCCAAGTTATTTGGA
AGGCCTCGGCAGCTTGGGATTAGCTTGGGAGCGCAGCGCTGCAAAGTGGAAAATATGAAAAGACCACACAGGCCCAGCAGTCCAGAAACT
GGGCAAAAATATTCTGCAGTGGGGATTTATTTTTCCAAAGCAGGTAACAGAGGCTAGTGAGAAAGAAAAGCTCCTCTCTGCTCCATTCCA
AAGGCCATCTTGTGGTCAGTTTCATGCCCTCACCTGATTTTTTTTTTTTTTTTTTTTTTTCAATTCCTAACCTTTTTTAAAGTTTCCTGG
TCTCCACTGGACACAGAGCTTTGGAGACGGAGGATCCCAGAGGGCAGTCTCAGTTGCAATCAGTGTGTGCCCAGCCTGGGCAGACAGGAA
ATTCCTCGGATACATTATTTTTTCTTTCTTTCATAGCTGTGTCTCAGAAAGGACCCATTTGTGGCTCTTTTTCACCTCAAAATAAGATCG
ATGGTATCTTGTAAAATGAGGGTAGTGCCACTTCTTAGTATTTTTGAAAGCTGTTTTAGATTTTTTTTTTTTTTCCTTTTCTAGCCATCT
AAATTGACTCTTCCAATATAGGTCTCAGAAATCCAATATTTGGAGTACAATTTCTTTTAATCCAGATTACACCTGCCTTACAAAGCACCC
CCTCCTTGTTCCCCTCTGTTTCCTCTACTCAGTTGGGGGAGAAACTCACAGCTCCTCCGGGATACATATGTGCCCTCAGCAGCAGCTCCC
AGGTGAAGTTACCAGACCCCTGGGCTTCTCCCCAGCTTTTTCTGAGTTGAGTCAGACATGTAGAGTTTGGGTCACACAGGCAAGAGGAAT
TTTCCCTCGGCCTTACTGACAAGGACACCAACCTAGGGTGCAAACAGATGGACTATGGTTCAAGGACACTGGAATTGAGGAGCTGATCAA
GGCTCTCTTCAGCCTTGCTCTGTCCCTGCCTCTTATCAGAGCACAGGTAGACACACGGGCATAGCCAGCCCACTCCTACTGTCACAGGCG
CCCCACCATTCAACCTTCCGGGAGGTCAGGGACCTTCTATATGAGGCGAGTGGGTCTCAGTCTGCTTGAATGGTGATGAGATTCTGCTGG
ATCTCAGCACGCTGCAGGTGTCTTTTGAGAGCATTCAGTAGGACATGGTGATCCCTATTTCAGCCTCTAAGATGACTGGTATTCTATCTG
AAATGCAGAGATTAAGCCAAATACCTGATGTATTGTGAAAGCCACTGATTTTAAGAATGGAGAGAAAGGGATTTTTTACTGCATCCCTCT
GTATGAATATGAAATCAGAGACCAGGGCATGATGTTGCTAGGATTAGAGCCTCTCAGTCTGGCCTCTTCACCCAAGTGCAAGAACTCAGT
CTCTTACTGTTCAAAGAATCTTAACAGTTGAATTATGGAGGGAAATTCCCTTTTGCCCCAAGCATTTCTATATTTAAAGCAATATCCCAG
GAGAATATGTTAGACTTAGGATGATACCTTCAGCCACTTGAAGAAGAAATAGAAGGCGCTCATTCCAATATAGTCTTTATTTCCCATTCA
GATACAGGTTGAGCATCCCTAATCTGAACAGTTAAAACCCCCAAATGCCCCAAAATCCAAACCTTCCTGAACGCTATGACACCATGAGTG
GAAAATTCCACACCTAACAAACACATTTGCTTTCTTATGGTTCAATGTACACAAACTGTTTTATATAGAAAATGATTTCAAATATCATAA
AATTACCTTCAGGCTATGTGTATAAAGTATATATGAGCCATAAATGAATTTTGTGTTTAGACTTTGTGTCCATCCCCAAGATCTCTCATT
TTATATATATATATATATATATATATATATATATATATATATATATATACACACACACACACATACACAAATATTCCAGGATACAAAAAA
AAACATTTAAAAATCCGAGACCCAGAACACTTCTGGTCCCAAGCATTTCAGATAAGGGATATCAATCTGTACTACCAATAAGGATTTCGT
AATTCCCCTAACTGCAAATGTCCTCTTCATTTGTTCTTTATGAGAAAACCCGGGTAGTGCCAGCACCTGGATACAGTATTTACACCCTGC
AGACCCTAAAGATTTCAGATTCAGTTAGCAAACCTTGATGAAGCACCTGCTGGACACTGAGGGACCCAAAGCTCAATCAGCCATAATCCC
TGCTTTCAGAGTTTATATTGTACCTGCCTAATCCACCCGGCGTGACTCATTTCAACACTAAGTACTAGGGGTGTTGTCAGGAGACAAATC
TGAAGTCAGGAGAGGAAAATGCAAAGGAGCCCTGCCGTGTGATGGATGTGCATTCTCACTTGGGTCTTGAAGTTCTCATTCCTACATCTC
AAGCTAGCCAGGCAGTCTCCTCTCTATCAGAAGAAAGCACTGGTAATTGGCTAGACTGGCTATGTTGAAGGTAACATGAACTCTAAGATC
TTGACCCAGGGCGACTTGGTTTTGCTTAAGGTGGCATCACCAATGTTCCAAATCCTTTAGGGAGATGAGGGTATCCCCACAGAAAAAGAG
GAATAATAGACCAATGGATTTTCTCCTTTCACCAGTATGTTTGGAACCCTCTGATCCAATGTCTTTTGATACTGATCTCTTGTCCAAATG
AGAATGTCGCTTTAGCTGAAATTCAAATGGCTGTGACAATTTACCGAAATGATGAAGTAACCACCATTCCCACCTTTCACTGCCTAGGCT
CCAAGTCTGAATACATTTTTGAAATAGGAACTCCCTTTTGCAAAAAAGAAACCTGGGTGTCAGGGAGGTGAAGTGACTTGCCCTAGGAGC
AGACAGCATGCCAAGAATGGAATTAGGCTCAGGATCCAGCCTGGGCTCACCCTGTGTGGCTCATTCCCACCCAGGAAACTGAAGATAAAA
GATTTGGGAAAACACACCAAGAAAAAGGGGCAGTTTTCTTTGCCCAAGCATTTGGTGCTAGTTAGAGGCTGTTCACTCTCTCCTGCTCCT
CTTCGGAGTAGAAATAAAGGCTGTGACACAAGGAAGCCAGTGGGGTGGGAGGGAGGCACCATAATCCCTCCCTAAAACCCACAGAAGACT
AACCTGATACTCTTTTGACCCAACTGCATCAACACTAAACAGCTGCAGACCCCCTGAATCTTTCACACATGCCAAGTGAACATTCTTGAT
GATTTCTCTTTGTGACCGCAACCACCTGCAAACCAGAACGACTCTAGAATTTCCTTCCCCGCCCCCCTTTTTGTTTAGTTTCTAATCTCT
TGTTTATGAGGTGTGGGGTTTATAAGGGACTGAATCAAATGAATGTAACAAAAAAGAAAAAAAAAACAAAAAAAAATGCCTTTTCTCAGG

>In-frame_LRP1_ENST00000243077_chr12_57539273_+_ETV6_ENST00000396373_chr12_12037379_+_6013nt
CAGCGGTGCGAGCTCCAGGCCCATGCACTGAGGAGGCGGAAACAAGGGGAGCCCCCAGAGCTCCATCAAGCCCCCTCCAAAGGCTCCCCT
ACCCGGTCCACGCCCCCCACCCCCCCTCCCCGCCTCCTCCCAATTGTGCATTTTTGCAGCCGGAGGCGGCTCCGAGATGGGGCTGTGAGC
TTCGCCCGGGGAGGGGGAAAGAGCAGCGAGGAGTGAAGCGGGGGGGTGGGGTGAAGGGTTTGGATTTCGGGGCAGGGGGCGCACCCCCGT
CAGCAGGCCCTCCCCAAGGGGCTCGGAACTCTACCTCTTCACCCACGCCCCTGGTGCGCTTTGCCGAAGGAAAGAATAAGAACAGAGAAG
GAGGAGGGGGAAAGGAGGAAAAGGGGGACCCCCCAACTGGGGGGGGTGAAGGAGAGAAGTAGCAGGACCAGAGGGGAAGGGGCTGCTGCT
TGCATCAGCCCACACCATGCTGACCCCGCCGTTGCTCCTGCTGCTGCCCCTGCTCTCAGCTCTGGTCGCGGCGGCTATCGACGCCCCTAA
GACTTGCAGCCCCAAGCAGTTTGCCTGCAGAGATCAAATAACCTGTATCTCAAAGGGCTGGCGGTGCGACGGTGAGAGGGACTGCCCAGA
CGGATCTGACGAGGCCCCTGAGATTTGTCCACAGAGTAAGGCCCAGCGATGCCAGCCAAACGAGCATAACTGCCTGGGTACTGAGCTGTG
TGTTCCCATGTCCCGCCTCTGCAATGGGGTCCAGGACTGCATGGACGGCTCAGATGAGGGGCCCCACTGCCGAGAGCTCCAAGGCAACTG
CTCTCGCCTGGGCTGCCAGCACCATTGTGTCCCCACACTCGATGGGCCCACCTGCTACTGCAACAGCAGCTTTCAGCTTCAGGCAGATGG
CAAGACCTGCAAAGATTTTGATGAGTGCTCAGTGTACGGCACCTGCAGCCAGCTATGCACCAACACAGACGGCTCCTTCATATGTGGCTG
TGTTGAAGGATACCTCCTGCAGCCGGATAACCGCTCCTGCAAGGCCAAGAACGAGCCAGTAGACCGGCCCCCTGTGCTGTTGATAGCCAA
CTCCCAGAACATCTTGGCCACGTACCTGAGTGGGGCCCAGGTGTCTACCATCACACCTACGAGCACGCGGCAGACCACAGCCATGGACTT
CAGCTATGCCAACGAGACCGTATGCTGGGTGCATGTTGGGGACAGTGCTGCTCAGACGCAGCTCAAGTGTGCCCGCATGCCTGGCCTAAA
GGGCTTCGTGGATGAGCACACCATCAACATCTCCCTCAGTCTGCACCACTGTAGACTGCTTTGGGATTACGTCTATCAGTTGCTTTCTGA
CAGCCGGTACGAAAACTTCATCCGATGGGAGGACAAAGAATCCAAAATATTCCGGATAGTGGATCCCAACGGACTGGCTCGACTGTGGGG
AAACCATAAGAACAGAACAAACATGACCTATGAGAAAATGTCCAGAGCCCTGCGCCACTACTACAAACTAAACATTATCAGGAAGGAGCC
AGGACAAAGGCTTTTGTTCAGGTTTATGAAAACCCCAGATGAAATCATGAGTGGCCGAACAGACCGTCTGGAGCACCTAGAGTCCCAGGA
GCTGGATGAACAAATATACCAAGAAGATGAATGCTGAAGGAACCAACAGTCCACCTCAGCGGGCCAGCAGCCCAGGGAACCCCTGCCCAC
CAGGATTGCTGGAAGTGTGACGGAGCAGGCGGGCTGAGGAGAGTGGAAAAGGAAGCGACCCAGAAATGGCAGGGACACTTCTCTTGCAGA
CCAAGAGGGACCCTGGAGCACCTTAGACAAACTACCCAGCACAGGCGGGGCTGGAATTCTGGCGGAGGGCATGAGCCTGGGACTCCATGT
CACGTTTCCTTCTGATTTGGAATCTCTCCATCTGTAATTCCTCACCCTCACCCTTCCACCGTTGTTAGTATCATGGTGTTTTTGTTTTTG
TTTTTGTTTTAAGAACCTGCAGTTTGACTCTTCATCGTTCATCTAGGGGAAGACATCTGATGTTGTTTTCCTATGGAAATATATATCTAT
TATATATATATTTTTTGCAAATCTCACAAAGTGCGGCAAGCCCAGCTGGTCAGGAAAGAGAATACTTGCAGAGGGGTTCAGGTTCCTCTT
TTTCCTGCCACGTGGATCAGGTCTGTTCCTGTTACTGTTGGGTCTTGGCTGAAAAAAAAAAATGCTTTTAAAAAAGATAAAATGAAAAGG
AGAGCTCTCTTTTTCTCTCTCTTGCTCTGTTCTTCCCTTGGTCCCCTCTGTCCTCCCGCCCTGCCTGCAGTTGAGATTCAGATGCCTTCT
GACAGAGTTCAGCCTCTTGGAGAGTCTTGGGGATTGTTGGCACCTAAACAGAATCAGTGACCCGGGTGCTTTGTGGCCAGCAGCACAGAA
TCAAACCCGCATCCCAGCATTGGGCCACCCATCTGAGGGAGGCCAAAATCATCACAGATGCTGCTGTGCTGCAGACAGATACATGCTAGT
CCAGAGAGCCGCCCCTGAGATGGCTGTGAGAACCATGTGTCTAAGGCGTAAGATAAGGATGGAAGGCTGTCCAAGTTATTTGGAAGGCCT
CGGCAGCTTGGGATTAGCTTGGGAGCGCAGCGCTGCAAAGTGGAAAATATGAAAAGACCACACAGGCCCAGCAGTCCAGAAACTGGGCAA
AAATATTCTGCAGTGGGGATTTATTTTTCCAAAGCAGGTAACAGAGGCTAGTGAGAAAGAAAAGCTCCTCTCTGCTCCATTCCAAAGGCC
ATCTTGTGGTCAGTTTCATGCCCTCACCTGATTTTTTTTTTTTTTTTTTTTTTTCAATTCCTAACCTTTTTTAAAGTTTCCTGGTCTCCA
CTGGACACAGAGCTTTGGAGACGGAGGATCCCAGAGGGCAGTCTCAGTTGCAATCAGTGTGTGCCCAGCCTGGGCAGACAGGAAATTCCT
CGGATACATTATTTTTTCTTTCTTTCATAGCTGTGTCTCAGAAAGGACCCATTTGTGGCTCTTTTTCACCTCAAAATAAGATCGATGGTA
TCTTGTAAAATGAGGGTAGTGCCACTTCTTAGTATTTTTGAAAGCTGTTTTAGATTTTTTTTTTTTTTCCTTTTCTAGCCATCTAAATTG
ACTCTTCCAATATAGGTCTCAGAAATCCAATATTTGGAGTACAATTTCTTTTAATCCAGATTACACCTGCCTTACAAAGCACCCCCTCCT
TGTTCCCCTCTGTTTCCTCTACTCAGTTGGGGGAGAAACTCACAGCTCCTCCGGGATACATATGTGCCCTCAGCAGCAGCTCCCAGGTGA
AGTTACCAGACCCCTGGGCTTCTCCCCAGCTTTTTCTGAGTTGAGTCAGACATGTAGAGTTTGGGTCACACAGGCAAGAGGAATTTTCCC
TCGGCCTTACTGACAAGGACACCAACCTAGGGTGCAAACAGATGGACTATGGTTCAAGGACACTGGAATTGAGGAGCTGATCAAGGCTCT
CTTCAGCCTTGCTCTGTCCCTGCCTCTTATCAGAGCACAGGTAGACACACGGGCATAGCCAGCCCACTCCTACTGTCACAGGCGCCCCAC
CATTCAACCTTCCGGGAGGTCAGGGACCTTCTATATGAGGCGAGTGGGTCTCAGTCTGCTTGAATGGTGATGAGATTCTGCTGGATCTCA
GCACGCTGCAGGTGTCTTTTGAGAGCATTCAGTAGGACATGGTGATCCCTATTTCAGCCTCTAAGATGACTGGTATTCTATCTGAAATGC
AGAGATTAAGCCAAATACCTGATGTATTGTGAAAGCCACTGATTTTAAGAATGGAGAGAAAGGGATTTTTTACTGCATCCCTCTGTATGA
ATATGAAATCAGAGACCAGGGCATGATGTTGCTAGGATTAGAGCCTCTCAGTCTGGCCTCTTCACCCAAGTGCAAGAACTCAGTCTCTTA
CTGTTCAAAGAATCTTAACAGTTGAATTATGGAGGGAAATTCCCTTTTGCCCCAAGCATTTCTATATTTAAAGCAATATCCCAGGAGAAT
ATGTTAGACTTAGGATGATACCTTCAGCCACTTGAAGAAGAAATAGAAGGCGCTCATTCCAATATAGTCTTTATTTCCCATTCAGATACA
GGTTGAGCATCCCTAATCTGAACAGTTAAAACCCCCAAATGCCCCAAAATCCAAACCTTCCTGAACGCTATGACACCATGAGTGGAAAAT
TCCACACCTAACAAACACATTTGCTTTCTTATGGTTCAATGTACACAAACTGTTTTATATAGAAAATGATTTCAAATATCATAAAATTAC
CTTCAGGCTATGTGTATAAAGTATATATGAGCCATAAATGAATTTTGTGTTTAGACTTTGTGTCCATCCCCAAGATCTCTCATTTTATAT
ATATATATATATATATATATATATATATATATATATATATATACACACACACACACATACACAAATATTCCAGGATACAAAAAAAAACAT
TTAAAAATCCGAGACCCAGAACACTTCTGGTCCCAAGCATTTCAGATAAGGGATATCAATCTGTACTACCAATAAGGATTTCGTAATTCC
CCTAACTGCAAATGTCCTCTTCATTTGTTCTTTATGAGAAAACCCGGGTAGTGCCAGCACCTGGATACAGTATTTACACCCTGCAGACCC
TAAAGATTTCAGATTCAGTTAGCAAACCTTGATGAAGCACCTGCTGGACACTGAGGGACCCAAAGCTCAATCAGCCATAATCCCTGCTTT
CAGAGTTTATATTGTACCTGCCTAATCCACCCGGCGTGACTCATTTCAACACTAAGTACTAGGGGTGTTGTCAGGAGACAAATCTGAAGT
CAGGAGAGGAAAATGCAAAGGAGCCCTGCCGTGTGATGGATGTGCATTCTCACTTGGGTCTTGAAGTTCTCATTCCTACATCTCAAGCTA
GCCAGGCAGTCTCCTCTCTATCAGAAGAAAGCACTGGTAATTGGCTAGACTGGCTATGTTGAAGGTAACATGAACTCTAAGATCTTGACC
CAGGGCGACTTGGTTTTGCTTAAGGTGGCATCACCAATGTTCCAAATCCTTTAGGGAGATGAGGGTATCCCCACAGAAAAAGAGGAATAA
TAGACCAATGGATTTTCTCCTTTCACCAGTATGTTTGGAACCCTCTGATCCAATGTCTTTTGATACTGATCTCTTGTCCAAATGAGAATG
TCGCTTTAGCTGAAATTCAAATGGCTGTGACAATTTACCGAAATGATGAAGTAACCACCATTCCCACCTTTCACTGCCTAGGCTCCAAGT
CTGAATACATTTTTGAAATAGGAACTCCCTTTTGCAAAAAAGAAACCTGGGTGTCAGGGAGGTGAAGTGACTTGCCCTAGGAGCAGACAG
CATGCCAAGAATGGAATTAGGCTCAGGATCCAGCCTGGGCTCACCCTGTGTGGCTCATTCCCACCCAGGAAACTGAAGATAAAAGATTTG
GGAAAACACACCAAGAAAAAGGGGCAGTTTTCTTTGCCCAAGCATTTGGTGCTAGTTAGAGGCTGTTCACTCTCTCCTGCTCCTCTTCGG
AGTAGAAATAAAGGCTGTGACACAAGGAAGCCAGTGGGGTGGGAGGGAGGCACCATAATCCCTCCCTAAAACCCACAGAAGACTAACCTG
ATACTCTTTTGACCCAACTGCATCAACACTAAACAGCTGCAGACCCCCTGAATCTTTCACACATGCCAAGTGAACATTCTTGATGATTTC
TCTTTGTGACCGCAACCACCTGCAAACCAGAACGACTCTAGAATTTCCTTCCCCGCCCCCCTTTTTGTTTAGTTTCTAATCTCTTGTTTA
TGAGGTGTGGGGTTTATAAGGGACTGAATCAAATGAATGTAACAAAAAAGAAAAAAAAAACAAAAAAAAATGCCTTTTCTCAGGGCCAGT

>In-frame_LRP1_ENST00000338962_chr12_57539273_+_ETV6_ENST00000396373_chr12_12037379_+_5796nt
GCGGGGGGGTGGGGTGAAGGGTTTGGATTTCGGGGCAGGGGGCGCACCCCCGTCAGCAGGCCCTCCCCAAGGGGCTCGGAACTCTACCTC
TTCACCCACGCCCCTGGTGCGCTTTGCCGAAGGAAAGAATAAGAACAGAGAAGGAGGAGGGGGAAAGGAGGAAAAGGGGGACCCCCCAAC
TGGGGGGGGTGAAGGAGAGAAGTAGCAGGACCAGAGGGGAAGGGGCTGCTGCTTGCATCAGCCCACACCATGCTGACCCCGCCGTTGCTC
CTGCTGCTGCCCCTGCTCTCAGCTCTGGTCGCGGCGGCTATCGACGCCCCTAAGACTTGCAGCCCCAAGCAGTTTGCCTGCAGAGATCAA
ATAACCTGTATCTCAAAGGGCTGGCGGTGCGACGGTGAGAGGGACTGCCCAGACGGATCTGACGAGGCCCCTGAGATTTGTCCACAGAGT
AAGGCCCAGCGATGCCAGCCAAACGAGCATAACTGCCTGGGTACTGAGCTGTGTGTTCCCATGTCCCGCCTCTGCAATGGGGTCCAGGAC
TGCATGGACGGCTCAGATGAGGGGCCCCACTGCCGAGAGCTCCAAGGCAACTGCTCTCGCCTGGGCTGCCAGCACCATTGTGTCCCCACA
CTCGATGGGCCCACCTGCTACTGCAACAGCAGCTTTCAGCTTCAGGCAGATGGCAAGACCTGCAAAGATTTTGATGAGTGCTCAGTGTAC
GGCACCTGCAGCCAGCTATGCACCAACACAGACGGCTCCTTCATATGTGGCTGTGTTGAAGGATACCTCCTGCAGCCGGATAACCGCTCC
TGCAAGGCCAAGAACGAGCCAGTAGACCGGCCCCCTGTGCTGTTGATAGCCAACTCCCAGAACATCTTGGCCACGTACCTGAGTGGGGCC
CAGGTGTCTACCATCACACCTACGAGCACGCGGCAGACCACAGCCATGGACTTCAGCTATGCCAACGAGACCGTATGCTGGGTGCATGTT
GGGGACAGTGCTGCTCAGACGCAGCTCAAGTGTGCCCGCATGCCTGGCCTAAAGGGCTTCGTGGATGAGCACACCATCAACATCTCCCTC
AGTCTGCACCACTGTAGACTGCTTTGGGATTACGTCTATCAGTTGCTTTCTGACAGCCGGTACGAAAACTTCATCCGATGGGAGGACAAA
GAATCCAAAATATTCCGGATAGTGGATCCCAACGGACTGGCTCGACTGTGGGGAAACCATAAGAACAGAACAAACATGACCTATGAGAAA
ATGTCCAGAGCCCTGCGCCACTACTACAAACTAAACATTATCAGGAAGGAGCCAGGACAAAGGCTTTTGTTCAGGTTTATGAAAACCCCA
GATGAAATCATGAGTGGCCGAACAGACCGTCTGGAGCACCTAGAGTCCCAGGAGCTGGATGAACAAATATACCAAGAAGATGAATGCTGA
AGGAACCAACAGTCCACCTCAGCGGGCCAGCAGCCCAGGGAACCCCTGCCCACCAGGATTGCTGGAAGTGTGACGGAGCAGGCGGGCTGA
GGAGAGTGGAAAAGGAAGCGACCCAGAAATGGCAGGGACACTTCTCTTGCAGACCAAGAGGGACCCTGGAGCACCTTAGACAAACTACCC
AGCACAGGCGGGGCTGGAATTCTGGCGGAGGGCATGAGCCTGGGACTCCATGTCACGTTTCCTTCTGATTTGGAATCTCTCCATCTGTAA
TTCCTCACCCTCACCCTTCCACCGTTGTTAGTATCATGGTGTTTTTGTTTTTGTTTTTGTTTTAAGAACCTGCAGTTTGACTCTTCATCG
TTCATCTAGGGGAAGACATCTGATGTTGTTTTCCTATGGAAATATATATCTATTATATATATATTTTTTGCAAATCTCACAAAGTGCGGC
AAGCCCAGCTGGTCAGGAAAGAGAATACTTGCAGAGGGGTTCAGGTTCCTCTTTTTCCTGCCACGTGGATCAGGTCTGTTCCTGTTACTG
TTGGGTCTTGGCTGAAAAAAAAAAATGCTTTTAAAAAAGATAAAATGAAAAGGAGAGCTCTCTTTTTCTCTCTCTTGCTCTGTTCTTCCC
TTGGTCCCCTCTGTCCTCCCGCCCTGCCTGCAGTTGAGATTCAGATGCCTTCTGACAGAGTTCAGCCTCTTGGAGAGTCTTGGGGATTGT
TGGCACCTAAACAGAATCAGTGACCCGGGTGCTTTGTGGCCAGCAGCACAGAATCAAACCCGCATCCCAGCATTGGGCCACCCATCTGAG
GGAGGCCAAAATCATCACAGATGCTGCTGTGCTGCAGACAGATACATGCTAGTCCAGAGAGCCGCCCCTGAGATGGCTGTGAGAACCATG
TGTCTAAGGCGTAAGATAAGGATGGAAGGCTGTCCAAGTTATTTGGAAGGCCTCGGCAGCTTGGGATTAGCTTGGGAGCGCAGCGCTGCA
AAGTGGAAAATATGAAAAGACCACACAGGCCCAGCAGTCCAGAAACTGGGCAAAAATATTCTGCAGTGGGGATTTATTTTTCCAAAGCAG
GTAACAGAGGCTAGTGAGAAAGAAAAGCTCCTCTCTGCTCCATTCCAAAGGCCATCTTGTGGTCAGTTTCATGCCCTCACCTGATTTTTT
TTTTTTTTTTTTTTTTTCAATTCCTAACCTTTTTTAAAGTTTCCTGGTCTCCACTGGACACAGAGCTTTGGAGACGGAGGATCCCAGAGG
GCAGTCTCAGTTGCAATCAGTGTGTGCCCAGCCTGGGCAGACAGGAAATTCCTCGGATACATTATTTTTTCTTTCTTTCATAGCTGTGTC
TCAGAAAGGACCCATTTGTGGCTCTTTTTCACCTCAAAATAAGATCGATGGTATCTTGTAAAATGAGGGTAGTGCCACTTCTTAGTATTT
TTGAAAGCTGTTTTAGATTTTTTTTTTTTTTCCTTTTCTAGCCATCTAAATTGACTCTTCCAATATAGGTCTCAGAAATCCAATATTTGG
AGTACAATTTCTTTTAATCCAGATTACACCTGCCTTACAAAGCACCCCCTCCTTGTTCCCCTCTGTTTCCTCTACTCAGTTGGGGGAGAA
ACTCACAGCTCCTCCGGGATACATATGTGCCCTCAGCAGCAGCTCCCAGGTGAAGTTACCAGACCCCTGGGCTTCTCCCCAGCTTTTTCT
GAGTTGAGTCAGACATGTAGAGTTTGGGTCACACAGGCAAGAGGAATTTTCCCTCGGCCTTACTGACAAGGACACCAACCTAGGGTGCAA
ACAGATGGACTATGGTTCAAGGACACTGGAATTGAGGAGCTGATCAAGGCTCTCTTCAGCCTTGCTCTGTCCCTGCCTCTTATCAGAGCA
CAGGTAGACACACGGGCATAGCCAGCCCACTCCTACTGTCACAGGCGCCCCACCATTCAACCTTCCGGGAGGTCAGGGACCTTCTATATG
AGGCGAGTGGGTCTCAGTCTGCTTGAATGGTGATGAGATTCTGCTGGATCTCAGCACGCTGCAGGTGTCTTTTGAGAGCATTCAGTAGGA
CATGGTGATCCCTATTTCAGCCTCTAAGATGACTGGTATTCTATCTGAAATGCAGAGATTAAGCCAAATACCTGATGTATTGTGAAAGCC
ACTGATTTTAAGAATGGAGAGAAAGGGATTTTTTACTGCATCCCTCTGTATGAATATGAAATCAGAGACCAGGGCATGATGTTGCTAGGA
TTAGAGCCTCTCAGTCTGGCCTCTTCACCCAAGTGCAAGAACTCAGTCTCTTACTGTTCAAAGAATCTTAACAGTTGAATTATGGAGGGA
AATTCCCTTTTGCCCCAAGCATTTCTATATTTAAAGCAATATCCCAGGAGAATATGTTAGACTTAGGATGATACCTTCAGCCACTTGAAG
AAGAAATAGAAGGCGCTCATTCCAATATAGTCTTTATTTCCCATTCAGATACAGGTTGAGCATCCCTAATCTGAACAGTTAAAACCCCCA
AATGCCCCAAAATCCAAACCTTCCTGAACGCTATGACACCATGAGTGGAAAATTCCACACCTAACAAACACATTTGCTTTCTTATGGTTC
AATGTACACAAACTGTTTTATATAGAAAATGATTTCAAATATCATAAAATTACCTTCAGGCTATGTGTATAAAGTATATATGAGCCATAA
ATGAATTTTGTGTTTAGACTTTGTGTCCATCCCCAAGATCTCTCATTTTATATATATATATATATATATATATATATATATATATATATA
TATATACACACACACACACATACACAAATATTCCAGGATACAAAAAAAAACATTTAAAAATCCGAGACCCAGAACACTTCTGGTCCCAAG
CATTTCAGATAAGGGATATCAATCTGTACTACCAATAAGGATTTCGTAATTCCCCTAACTGCAAATGTCCTCTTCATTTGTTCTTTATGA
GAAAACCCGGGTAGTGCCAGCACCTGGATACAGTATTTACACCCTGCAGACCCTAAAGATTTCAGATTCAGTTAGCAAACCTTGATGAAG
CACCTGCTGGACACTGAGGGACCCAAAGCTCAATCAGCCATAATCCCTGCTTTCAGAGTTTATATTGTACCTGCCTAATCCACCCGGCGT
GACTCATTTCAACACTAAGTACTAGGGGTGTTGTCAGGAGACAAATCTGAAGTCAGGAGAGGAAAATGCAAAGGAGCCCTGCCGTGTGAT
GGATGTGCATTCTCACTTGGGTCTTGAAGTTCTCATTCCTACATCTCAAGCTAGCCAGGCAGTCTCCTCTCTATCAGAAGAAAGCACTGG
TAATTGGCTAGACTGGCTATGTTGAAGGTAACATGAACTCTAAGATCTTGACCCAGGGCGACTTGGTTTTGCTTAAGGTGGCATCACCAA
TGTTCCAAATCCTTTAGGGAGATGAGGGTATCCCCACAGAAAAAGAGGAATAATAGACCAATGGATTTTCTCCTTTCACCAGTATGTTTG
GAACCCTCTGATCCAATGTCTTTTGATACTGATCTCTTGTCCAAATGAGAATGTCGCTTTAGCTGAAATTCAAATGGCTGTGACAATTTA
CCGAAATGATGAAGTAACCACCATTCCCACCTTTCACTGCCTAGGCTCCAAGTCTGAATACATTTTTGAAATAGGAACTCCCTTTTGCAA
AAAAGAAACCTGGGTGTCAGGGAGGTGAAGTGACTTGCCCTAGGAGCAGACAGCATGCCAAGAATGGAATTAGGCTCAGGATCCAGCCTG
GGCTCACCCTGTGTGGCTCATTCCCACCCAGGAAACTGAAGATAAAAGATTTGGGAAAACACACCAAGAAAAAGGGGCAGTTTTCTTTGC
CCAAGCATTTGGTGCTAGTTAGAGGCTGTTCACTCTCTCCTGCTCCTCTTCGGAGTAGAAATAAAGGCTGTGACACAAGGAAGCCAGTGG
GGTGGGAGGGAGGCACCATAATCCCTCCCTAAAACCCACAGAAGACTAACCTGATACTCTTTTGACCCAACTGCATCAACACTAAACAGC
TGCAGACCCCCTGAATCTTTCACACATGCCAAGTGAACATTCTTGATGATTTCTCTTTGTGACCGCAACCACCTGCAAACCAGAACGACT
CTAGAATTTCCTTCCCCGCCCCCCTTTTTGTTTAGTTTCTAATCTCTTGTTTATGAGGTGTGGGGTTTATAAGGGACTGAATCAAATGAA
TGTAACAAAAAAGAAAAAAAAAACAAAAAAAAATGCCTTTTCTCAGGGCCAGTGAGTTGCAAATAATTTTTAAAGAAAAGCCTATAATTA

>In-frame_LRP1_ENST00000554174_chr12_57539273_+_ETV6_ENST00000396373_chr12_12037379_+_5603nt
GGAGAGAAGTAGCAGGACCAGAGGGGAAGGGGCTGCTGCTTGCATCAGCCCACACCATGCTGACCCCGCCGTTGCTCCTGCTGCTGCCCC
TGCTCTCAGCTCTGGTCGCGGCGGCTATCGACGCCCCTAAGACTTGCAGCCCCAAGCAGTTTGCCTGCAGAGATCAAATAACCTGTATCT
CAAAGGGCTGGCGGTGCGACGGTGAGAGGGACTGCCCAGACGGATCTGACGAGGCCCCTGAGATTTGTCCACAGAGTAAGGCCCAGCGAT
GCCAGCCAAACGAGCATAACTGCCTGGGTACTGAGCTGTGTGTTCCCATGTCCCGCCTCTGCAATGGGGTCCAGGACTGCATGGACGGCT
CAGATGAGGGGCCCCACTGCCGAGAGCTCCAAGGCAACTGCTCTCGCCTGGGCTGCCAGCACCATTGTGTCCCCACACTCGATGGGCCCA
CCTGCTACTGCAACAGCAGCTTTCAGCTTCAGGCAGATGGCAAGACCTGCAAAGATTTTGATGAGTGCTCAGTGTACGGCACCTGCAGCC
AGCTATGCACCAACACAGACGGCTCCTTCATATGTGGCTGTGTTGAAGGATACCTCCTGCAGCCGGATAACCGCTCCTGCAAGGCCAAGA
ACGAGCCAGTAGACCGGCCCCCTGTGCTGTTGATAGCCAACTCCCAGAACATCTTGGCCACGTACCTGAGTGGGGCCCAGGTGTCTACCA
TCACACCTACGAGCACGCGGCAGACCACAGCCATGGACTTCAGCTATGCCAACGAGACCGTATGCTGGGTGCATGTTGGGGACAGTGCTG
CTCAGACGCAGCTCAAGTGTGCCCGCATGCCTGGCCTAAAGGGCTTCGTGGATGAGCACACCATCAACATCTCCCTCAGTCTGCACCACT
GTAGACTGCTTTGGGATTACGTCTATCAGTTGCTTTCTGACAGCCGGTACGAAAACTTCATCCGATGGGAGGACAAAGAATCCAAAATAT
TCCGGATAGTGGATCCCAACGGACTGGCTCGACTGTGGGGAAACCATAAGAACAGAACAAACATGACCTATGAGAAAATGTCCAGAGCCC
TGCGCCACTACTACAAACTAAACATTATCAGGAAGGAGCCAGGACAAAGGCTTTTGTTCAGGTTTATGAAAACCCCAGATGAAATCATGA
GTGGCCGAACAGACCGTCTGGAGCACCTAGAGTCCCAGGAGCTGGATGAACAAATATACCAAGAAGATGAATGCTGAAGGAACCAACAGT
CCACCTCAGCGGGCCAGCAGCCCAGGGAACCCCTGCCCACCAGGATTGCTGGAAGTGTGACGGAGCAGGCGGGCTGAGGAGAGTGGAAAA
GGAAGCGACCCAGAAATGGCAGGGACACTTCTCTTGCAGACCAAGAGGGACCCTGGAGCACCTTAGACAAACTACCCAGCACAGGCGGGG
CTGGAATTCTGGCGGAGGGCATGAGCCTGGGACTCCATGTCACGTTTCCTTCTGATTTGGAATCTCTCCATCTGTAATTCCTCACCCTCA
CCCTTCCACCGTTGTTAGTATCATGGTGTTTTTGTTTTTGTTTTTGTTTTAAGAACCTGCAGTTTGACTCTTCATCGTTCATCTAGGGGA
AGACATCTGATGTTGTTTTCCTATGGAAATATATATCTATTATATATATATTTTTTGCAAATCTCACAAAGTGCGGCAAGCCCAGCTGGT
CAGGAAAGAGAATACTTGCAGAGGGGTTCAGGTTCCTCTTTTTCCTGCCACGTGGATCAGGTCTGTTCCTGTTACTGTTGGGTCTTGGCT
GAAAAAAAAAAATGCTTTTAAAAAAGATAAAATGAAAAGGAGAGCTCTCTTTTTCTCTCTCTTGCTCTGTTCTTCCCTTGGTCCCCTCTG
TCCTCCCGCCCTGCCTGCAGTTGAGATTCAGATGCCTTCTGACAGAGTTCAGCCTCTTGGAGAGTCTTGGGGATTGTTGGCACCTAAACA
GAATCAGTGACCCGGGTGCTTTGTGGCCAGCAGCACAGAATCAAACCCGCATCCCAGCATTGGGCCACCCATCTGAGGGAGGCCAAAATC
ATCACAGATGCTGCTGTGCTGCAGACAGATACATGCTAGTCCAGAGAGCCGCCCCTGAGATGGCTGTGAGAACCATGTGTCTAAGGCGTA
AGATAAGGATGGAAGGCTGTCCAAGTTATTTGGAAGGCCTCGGCAGCTTGGGATTAGCTTGGGAGCGCAGCGCTGCAAAGTGGAAAATAT
GAAAAGACCACACAGGCCCAGCAGTCCAGAAACTGGGCAAAAATATTCTGCAGTGGGGATTTATTTTTCCAAAGCAGGTAACAGAGGCTA
GTGAGAAAGAAAAGCTCCTCTCTGCTCCATTCCAAAGGCCATCTTGTGGTCAGTTTCATGCCCTCACCTGATTTTTTTTTTTTTTTTTTT
TTTTCAATTCCTAACCTTTTTTAAAGTTTCCTGGTCTCCACTGGACACAGAGCTTTGGAGACGGAGGATCCCAGAGGGCAGTCTCAGTTG
CAATCAGTGTGTGCCCAGCCTGGGCAGACAGGAAATTCCTCGGATACATTATTTTTTCTTTCTTTCATAGCTGTGTCTCAGAAAGGACCC
ATTTGTGGCTCTTTTTCACCTCAAAATAAGATCGATGGTATCTTGTAAAATGAGGGTAGTGCCACTTCTTAGTATTTTTGAAAGCTGTTT
TAGATTTTTTTTTTTTTTCCTTTTCTAGCCATCTAAATTGACTCTTCCAATATAGGTCTCAGAAATCCAATATTTGGAGTACAATTTCTT
TTAATCCAGATTACACCTGCCTTACAAAGCACCCCCTCCTTGTTCCCCTCTGTTTCCTCTACTCAGTTGGGGGAGAAACTCACAGCTCCT
CCGGGATACATATGTGCCCTCAGCAGCAGCTCCCAGGTGAAGTTACCAGACCCCTGGGCTTCTCCCCAGCTTTTTCTGAGTTGAGTCAGA
CATGTAGAGTTTGGGTCACACAGGCAAGAGGAATTTTCCCTCGGCCTTACTGACAAGGACACCAACCTAGGGTGCAAACAGATGGACTAT
GGTTCAAGGACACTGGAATTGAGGAGCTGATCAAGGCTCTCTTCAGCCTTGCTCTGTCCCTGCCTCTTATCAGAGCACAGGTAGACACAC
GGGCATAGCCAGCCCACTCCTACTGTCACAGGCGCCCCACCATTCAACCTTCCGGGAGGTCAGGGACCTTCTATATGAGGCGAGTGGGTC
TCAGTCTGCTTGAATGGTGATGAGATTCTGCTGGATCTCAGCACGCTGCAGGTGTCTTTTGAGAGCATTCAGTAGGACATGGTGATCCCT
ATTTCAGCCTCTAAGATGACTGGTATTCTATCTGAAATGCAGAGATTAAGCCAAATACCTGATGTATTGTGAAAGCCACTGATTTTAAGA
ATGGAGAGAAAGGGATTTTTTACTGCATCCCTCTGTATGAATATGAAATCAGAGACCAGGGCATGATGTTGCTAGGATTAGAGCCTCTCA
GTCTGGCCTCTTCACCCAAGTGCAAGAACTCAGTCTCTTACTGTTCAAAGAATCTTAACAGTTGAATTATGGAGGGAAATTCCCTTTTGC
CCCAAGCATTTCTATATTTAAAGCAATATCCCAGGAGAATATGTTAGACTTAGGATGATACCTTCAGCCACTTGAAGAAGAAATAGAAGG
CGCTCATTCCAATATAGTCTTTATTTCCCATTCAGATACAGGTTGAGCATCCCTAATCTGAACAGTTAAAACCCCCAAATGCCCCAAAAT
CCAAACCTTCCTGAACGCTATGACACCATGAGTGGAAAATTCCACACCTAACAAACACATTTGCTTTCTTATGGTTCAATGTACACAAAC
TGTTTTATATAGAAAATGATTTCAAATATCATAAAATTACCTTCAGGCTATGTGTATAAAGTATATATGAGCCATAAATGAATTTTGTGT
TTAGACTTTGTGTCCATCCCCAAGATCTCTCATTTTATATATATATATATATATATATATATATATATATATATATATATATACACACAC
ACACACATACACAAATATTCCAGGATACAAAAAAAAACATTTAAAAATCCGAGACCCAGAACACTTCTGGTCCCAAGCATTTCAGATAAG
GGATATCAATCTGTACTACCAATAAGGATTTCGTAATTCCCCTAACTGCAAATGTCCTCTTCATTTGTTCTTTATGAGAAAACCCGGGTA
GTGCCAGCACCTGGATACAGTATTTACACCCTGCAGACCCTAAAGATTTCAGATTCAGTTAGCAAACCTTGATGAAGCACCTGCTGGACA
CTGAGGGACCCAAAGCTCAATCAGCCATAATCCCTGCTTTCAGAGTTTATATTGTACCTGCCTAATCCACCCGGCGTGACTCATTTCAAC
ACTAAGTACTAGGGGTGTTGTCAGGAGACAAATCTGAAGTCAGGAGAGGAAAATGCAAAGGAGCCCTGCCGTGTGATGGATGTGCATTCT
CACTTGGGTCTTGAAGTTCTCATTCCTACATCTCAAGCTAGCCAGGCAGTCTCCTCTCTATCAGAAGAAAGCACTGGTAATTGGCTAGAC
TGGCTATGTTGAAGGTAACATGAACTCTAAGATCTTGACCCAGGGCGACTTGGTTTTGCTTAAGGTGGCATCACCAATGTTCCAAATCCT
TTAGGGAGATGAGGGTATCCCCACAGAAAAAGAGGAATAATAGACCAATGGATTTTCTCCTTTCACCAGTATGTTTGGAACCCTCTGATC
CAATGTCTTTTGATACTGATCTCTTGTCCAAATGAGAATGTCGCTTTAGCTGAAATTCAAATGGCTGTGACAATTTACCGAAATGATGAA
GTAACCACCATTCCCACCTTTCACTGCCTAGGCTCCAAGTCTGAATACATTTTTGAAATAGGAACTCCCTTTTGCAAAAAAGAAACCTGG
GTGTCAGGGAGGTGAAGTGACTTGCCCTAGGAGCAGACAGCATGCCAAGAATGGAATTAGGCTCAGGATCCAGCCTGGGCTCACCCTGTG
TGGCTCATTCCCACCCAGGAAACTGAAGATAAAAGATTTGGGAAAACACACCAAGAAAAAGGGGCAGTTTTCTTTGCCCAAGCATTTGGT
GCTAGTTAGAGGCTGTTCACTCTCTCCTGCTCCTCTTCGGAGTAGAAATAAAGGCTGTGACACAAGGAAGCCAGTGGGGTGGGAGGGAGG
CACCATAATCCCTCCCTAAAACCCACAGAAGACTAACCTGATACTCTTTTGACCCAACTGCATCAACACTAAACAGCTGCAGACCCCCTG
AATCTTTCACACATGCCAAGTGAACATTCTTGATGATTTCTCTTTGTGACCGCAACCACCTGCAAACCAGAACGACTCTAGAATTTCCTT
CCCCGCCCCCCTTTTTGTTTAGTTTCTAATCTCTTGTTTATGAGGTGTGGGGTTTATAAGGGACTGAATCAAATGAATGTAACAAAAAAG
AAAAAAAAAACAAAAAAAAATGCCTTTTCTCAGGGCCAGTGAGTTGCAAATAATTTTTAAAGAAAAGCCTATAATTACATCATCTCAATA


Top

FusionGenePPI for LRP1_ETV6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LRP1SERPINE1, CANX, CALR, PDIA2, MMP14, KAT5, CALCR, SHC1, THBS1, GIPC1, MAPK8IP1, DLG4, MAPK8IP2, SYNJ2BP, NOS1AP, SCN3A, APBA2, DAB1, ITGB1BP1, ANAPC10, A2M, PDGFB, SRC, DAB2, MDK, F8, GULP1, PLAUR, PLAT, F9, LRPAP1, LPL, LIPC, SNX17, APBB1, USP3, CACNA1A, APOE, RIC8B, CC2D1A, SNRNP70, ANKS1B, PID1, HNRNPDL, MAPRE1, FBXO6, CUBN, CHFR, SKIL, RANBP9, APP, COPS5, EGFR, ZFP41, DIAPH1, FOXB1, KCTD18, INTS6, TNKS2, TNKS, FOXF2, BCKDHB, TUBB8, SAMD1, TUBA4A, TUBB3, LOXL2, MTG2, SLC25A6, SLC25A30, GATB, SMOC1, C17orf80, GSG2, NME4, HARS2, TUBA1A, TUBB4A, SLC25A23, LCOR, CCRN4L, FAM115A, SLC25A25, MTO1, C1orf85, PC, PTGES2, SLC26A6, GFPT2, GFPT1, HSPA5, RPL23, TUBB2A, NPC2, MTPAP, TUBB4B, RPUSD3, GNB2, NPRL3, FAM132B, ERAL1, GCNT1, TUBB2B, PTCD2, SENP1, MAP2K7, RTEL1, LGALS9ETV6KAT5, GAB2, ETV6, GRB2, CRKL, ACTA1, HDAC9, FLI1, FBXL6, SKP1, L3MBTL1, IRF8, NCOR1, SIN3A, HDAC3, UBE2I, ELAVL1, PDGFRB, SUMO1, SOCS1, SOCS3, TRAF3, SOX2, HDAC6, PIN1, AP1M1, WDYHV1, LRP6, LRP5, NID2, ETV7, USP7, VPS26B, NFATC2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneLRP1chr12:57539273chr12:12037379ENST00000243077+6894445_45442804545MAFB


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for LRP1_ETV6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneLRP1Q07954DB00031TenecteplaseProlow-density lipoprotein receptor-related protein 1biotechapproved
HgeneLRP1Q07954DB00025Antihemophilic factor, human recombinantProlow-density lipoprotein receptor-related protein 1biotechapproved|investigational
HgeneLRP1Q07954DB00100Coagulation Factor IX (Recombinant)Prolow-density lipoprotein receptor-related protein 1biotechapproved|investigational

Top

RelatedDiseases for LRP1_ETV6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLRP1C0036341Schizophrenia1CTD_human
HgeneLRP1C0041696Unipolar Depression1PSYGENET
HgeneLRP1C0149931Migraine Disorders1CTD_human
HgeneLRP1C0338480Common Migraine1CTD_human
HgeneLRP1C1269683Major Depressive Disorder1PSYGENET
TgeneETV6C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma3CTD_human
TgeneETV6C0040034Thrombocytopenia2CTD_human;HPO
TgeneETV6C0236969Substance-Related Disorders1CTD_human
TgeneETV6C0376545Hematologic Neoplasms1CTD_human
TgeneETV6C1838656Macrocytosis, Familial1CTD_human
TgeneETV6C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneETV6C3495559Juvenile arthritis1CTD_human
TgeneETV6C4015537THROMBOCYTOPENIA 51UNIPROT