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Fusion gene ID: 20127 |
FusionGeneSummary for LRP1_ETV6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LRP1_ETV6 | Fusion gene ID: 20127 | Hgene | Tgene | Gene symbol | LRP1 | ETV6 | Gene ID | 10438 | 2120 |
| Gene name | C1D nuclear receptor corepressor | ETS variant 6 | |
| Synonyms | LRP1|Rrp47|SUN-CoR|SUNCOR|hC1D | TEL|TEL/ABL|THC5 | |
| Cytomap | 2p14 | 12p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear nucleic acid-binding protein C1DC1D DNA-binding proteinC1D nuclear receptor co-repressornuclear DNA-binding proteinsmall unique nuclear receptor co-repressorsmall unique nuclear receptor corepressor | transcription factor ETV6ETS translocation variant 6ETS-related protein Tel1TEL1 oncogeneets variant gene 6 (TEL oncogene) | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q07954 | P41212 | |
| Ensembl transtripts involved in fusion gene | ENST00000553277, ENST00000243077, ENST00000338962, ENST00000554174, ENST00000553446, | ENST00000396373, ENST00000544715, | |
| Fusion gene scores | * DoF score | 16 X 14 X 7=1568 | 9 X 9 X 4=324 |
| # samples | 17 | 12 | |
| ** MAII score | log2(17/1568*10)=-3.20531890797751 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/324*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LRP1 [Title/Abstract] AND ETV6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ETV6 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10514502 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-PC-A5DN-01A | LRP1 | chr12 | 57539273 | + | ETV6 | chr12 | 12037379 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000553277 | ENST00000396373 | LRP1 | chr12 | 57539273 | + | ETV6 | chr12 | 12037379 | + |
| 5CDS-intron | ENST00000553277 | ENST00000544715 | LRP1 | chr12 | 57539273 | + | ETV6 | chr12 | 12037379 | + |
| In-frame | ENST00000243077 | ENST00000396373 | LRP1 | chr12 | 57539273 | + | ETV6 | chr12 | 12037379 | + |
| 5CDS-intron | ENST00000243077 | ENST00000544715 | LRP1 | chr12 | 57539273 | + | ETV6 | chr12 | 12037379 | + |
| In-frame | ENST00000338962 | ENST00000396373 | LRP1 | chr12 | 57539273 | + | ETV6 | chr12 | 12037379 | + |
| 5CDS-intron | ENST00000338962 | ENST00000544715 | LRP1 | chr12 | 57539273 | + | ETV6 | chr12 | 12037379 | + |
| In-frame | ENST00000554174 | ENST00000396373 | LRP1 | chr12 | 57539273 | + | ETV6 | chr12 | 12037379 | + |
| 5CDS-intron | ENST00000554174 | ENST00000544715 | LRP1 | chr12 | 57539273 | + | ETV6 | chr12 | 12037379 | + |
| intron-3CDS | ENST00000553446 | ENST00000396373 | LRP1 | chr12 | 57539273 | + | ETV6 | chr12 | 12037379 | + |
| intron-intron | ENST00000553446 | ENST00000544715 | LRP1 | chr12 | 57539273 | + | ETV6 | chr12 | 12037379 | + |
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FusionProtFeatures for LRP1_ETV6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LRP1 | ETV6 |
| Endocytic receptor involved in endocytosis and inphagocytosis of apoptotic cells. Required for early embryonicdevelopment. Involved in cellular lipid homeostasis. Involved inthe plasma clearance of chylomicron remnants and activated LRPAP1(alpha 2-macroglobulin), as well as the local metabolism ofcomplexes between plasminogen activators and their endogenousinhibitors. May modulate cellular events, such as APP metabolism,kinase-dependent intracellular signaling, neuronal calciumsignaling as well as neurotransmission (PubMed:11907044,PubMed:12888553, PubMed:12713657). Acts as an alpha-2-macroglobulin receptor (PubMed:26142438).{ECO:0000269|PubMed:11907044, ECO:0000269|PubMed:12713657,ECO:0000269|PubMed:12888553, ECO:0000269|PubMed:26142438}. (Microbial infection) Functions as a receptor forPseudomonas aeruginosa exotoxin A. {ECO:0000269|PubMed:1618748}. | Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignanttransformation. {ECO:0000269|PubMed:25581430}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 111_149 | 280 | 4545 | Domain | EGF-like 1 |
| Hgene | LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 150_189 | 280 | 4545 | Domain | EGF-like 2%3B calcium-binding |
| Hgene | LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 25_66 | 280 | 4545 | Domain | LDL-receptor class A 1 |
| Hgene | LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 70_110 | 280 | 4545 | Domain | LDL-receptor class A 2 |
| Tgene | >ETV6 | chr12:57539273 | chr12:12037379 | ENST00000396373 | + | 4 | 8 | 339_420 | 336 | 453 | DNA binding | ETS |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 1013_1053 | 280 | 4545 | Domain | LDL-receptor class A 7 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 1060_1099 | 280 | 4545 | Domain | LDL-receptor class A 8 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 1102_1142 | 280 | 4545 | Domain | LDL-receptor class A 9 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 1143_1182 | 280 | 4545 | Domain | LDL-receptor class A 10 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 1183_1222 | 280 | 4545 | Domain | EGF-like 5 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 1223_1262 | 280 | 4545 | Domain | EGF-like 6 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 1536_1579 | 280 | 4545 | Domain | EGF-like 7 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 1846_1887 | 280 | 4545 | Domain | EGF-like 8 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 2155_2195 | 280 | 4545 | Domain | EGF-like 9 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 2478_2518 | 280 | 4545 | Domain | EGF-like 10 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 2522_2563 | 280 | 4545 | Domain | LDL-receptor class A 11 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 2564_2602 | 280 | 4545 | Domain | LDL-receptor class A 12 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 2603_2641 | 280 | 4545 | Domain | LDL-receptor class A 13 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 2642_2690 | 280 | 4545 | Domain | LDL-receptor class A 14 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 2694_2732 | 280 | 4545 | Domain | LDL-receptor class A 15 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 2732_2771 | 280 | 4545 | Domain | LDL-receptor class A 16 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 2772_2814 | 280 | 4545 | Domain | LDL-receptor class A 17 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 2816_2855 | 280 | 4545 | Domain | LDL-receptor class A 18 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 2856_2899 | 280 | 4545 | Domain | LDL-receptor class A 19 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 2902_2940 | 280 | 4545 | Domain | LDL-receptor class A 20 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 2941_2981 | 280 | 4545 | Domain | EGF-like 11 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 2982_3022 | 280 | 4545 | Domain | EGF-like 12%3B calcium-binding |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 3290_3331 | 280 | 4545 | Domain | EGF-like 13 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 3332_3371 | 280 | 4545 | Domain | LDL-receptor class A 21 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 3372_3410 | 280 | 4545 | Domain | LDL-receptor class A 22 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 3411_3450 | 280 | 4545 | Domain | LDL-receptor class A 23 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 3451_3491 | 280 | 4545 | Domain | LDL-receptor class A 24 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 3492_3533 | 280 | 4545 | Domain | LDL-receptor class A 25 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 3534_3572 | 280 | 4545 | Domain | LDL-receptor class A 26 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 3573_3611 | 280 | 4545 | Domain | LDL-receptor class A 27 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 3611_3649 | 280 | 4545 | Domain | LDL-receptor class A 28 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 3652_3692 | 280 | 4545 | Domain | LDL-receptor class A 29 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 3693_3733 | 280 | 4545 | Domain | LDL-receptor class A 30 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 3739_3778 | 280 | 4545 | Domain | LDL-receptor class A 31 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 3781_3823 | 280 | 4545 | Domain | EGF-like 14 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 3824_3861 | 280 | 4545 | Domain | EGF-like 15 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 4147_4183 | 280 | 4545 | Domain | EGF-like 16 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 4196_4232 | 280 | 4545 | Domain | EGF-like 17 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 4232_4268 | 280 | 4545 | Domain | EGF-like 18 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 4268_4304 | 280 | 4545 | Domain | EGF-like 19 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 4304_4340 | 280 | 4545 | Domain | EGF-like 20 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 4340_4375 | 280 | 4545 | Domain | EGF-like 21 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 4373_4409 | 280 | 4545 | Domain | EGF-like 22 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 474_520 | 280 | 4545 | Domain | EGF-like 3 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 803_843 | 280 | 4545 | Domain | EGF-like 4 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 852_892 | 280 | 4545 | Domain | LDL-receptor class A 3 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 893_933 | 280 | 4545 | Domain | LDL-receptor class A 4 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 934_973 | 280 | 4545 | Domain | LDL-receptor class A 5 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 974_1013 | 280 | 4545 | Domain | LDL-receptor class A 6 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 3940_3943 | 280 | 4545 | Motif | Recognition site for proteolytical processing |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 4502_4507 | 280 | 4545 | Motif | Note=NPXY motif |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 1309_1355 | 280 | 4545 | Repeat | Note=LDL-receptor class B 8 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 1356_1398 | 280 | 4545 | Repeat | Note=LDL-receptor class B 9 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 1399_1445 | 280 | 4545 | Repeat | Note=LDL-receptor class B 10 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 1446_1490 | 280 | 4545 | Repeat | Note=LDL-receptor class B 11 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 1491_1531 | 280 | 4545 | Repeat | Note=LDL-receptor class B 12 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 1627_1669 | 280 | 4545 | Repeat | Note=LDL-receptor class B 13 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 1670_1713 | 280 | 4545 | Repeat | Note=LDL-receptor class B 14 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 1714_1753 | 280 | 4545 | Repeat | Note=LDL-receptor class B 15 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 1754_1798 | 280 | 4545 | Repeat | Note=LDL-receptor class B 16 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 1934_1976 | 280 | 4545 | Repeat | Note=LDL-receptor class B 17 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 1977_2019 | 280 | 4545 | Repeat | Note=LDL-receptor class B 18 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 2020_2063 | 280 | 4545 | Repeat | Note=LDL-receptor class B 19 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 2064_2107 | 280 | 4545 | Repeat | Note=LDL-receptor class B 20 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 2253_2294 | 280 | 4545 | Repeat | Note=LDL-receptor class B 21 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 2295_2343 | 280 | 4545 | Repeat | Note=LDL-receptor class B 22 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 2344_2388 | 280 | 4545 | Repeat | Note=LDL-receptor class B 23 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 2389_2431 | 280 | 4545 | Repeat | Note=LDL-receptor class B 24 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 2432_2473 | 280 | 4545 | Repeat | Note=LDL-receptor class B 25 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 292_334 | 280 | 4545 | Repeat | Note=LDL-receptor class B 1 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 3069_3113 | 280 | 4545 | Repeat | Note=LDL-receptor class B 26 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 3114_3156 | 280 | 4545 | Repeat | Note=LDL-receptor class B 27 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 3157_3200 | 280 | 4545 | Repeat | Note=LDL-receptor class B 28 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 3201_3243 | 280 | 4545 | Repeat | Note=LDL-receptor class B 29 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 3244_3284 | 280 | 4545 | Repeat | Note=LDL-receptor class B 30 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 335_378 | 280 | 4545 | Repeat | Note=LDL-receptor class B 2 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 379_422 | 280 | 4545 | Repeat | Note=LDL-receptor class B 3 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 3912_3954 | 280 | 4545 | Repeat | Note=LDL-receptor class B 31 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 3970_4012 | 280 | 4545 | Repeat | Note=LDL-receptor class B 32 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 4013_4056 | 280 | 4545 | Repeat | Note=LDL-receptor class B 33 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 4057_4101 | 280 | 4545 | Repeat | Note=LDL-receptor class B 34 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 571_613 | 280 | 4545 | Repeat | Note=LDL-receptor class B 4 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 614_659 | 280 | 4545 | Repeat | Note=LDL-receptor class B 5 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 660_710 | 280 | 4545 | Repeat | Note=LDL-receptor class B 6 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 711_754 | 280 | 4545 | Repeat | Note=LDL-receptor class B 7 |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 20_4419 | 280 | 4545 | Topological domain | Extracellular |
| Hgene | >LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 4420_4444 | 280 | 4545 | Transmembrane | Helical |
| Tgene | ETV6 | chr12:57539273 | chr12:12037379 | ENST00000396373 | + | 4 | 8 | 40_124 | 336 | 453 | Domain | PNT |
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FusionGeneSequence for LRP1_ETV6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_LRP1_ENST00000553277_chr12_57539273_+_ETV6_ENST00000396373_chr12_12037379_+_397aa MLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSR LCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYL LQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSTANETVCWVHVGDSAAQTQLKCARMPGLKGFVDE HTINISLSLHHCRLLWDYVTQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTTEKMSRALRHYYKLNIIRKEPGQRLL >In-frame_LRP1_ENST00000243077_chr12_57539273_+_ETV6_ENST00000396373_chr12_12037379_+_397aa MLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSR LCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYL LQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSTANETVCWVHVGDSAAQTQLKCARMPGLKGFVDE HTINISLSLHHCRLLWDYVTQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTTEKMSRALRHYYKLNIIRKEPGQRLL >In-frame_LRP1_ENST00000338962_chr12_57539273_+_ETV6_ENST00000396373_chr12_12037379_+_397aa MLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSR LCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYL LQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSTANETVCWVHVGDSAAQTQLKCARMPGLKGFVDE HTINISLSLHHCRLLWDYVTQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTTEKMSRALRHYYKLNIIRKEPGQRLL >In-frame_LRP1_ENST00000554174_chr12_57539273_+_ETV6_ENST00000396373_chr12_12037379_+_397aa MLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSR LCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYL LQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSTANETVCWVHVGDSAAQTQLKCARMPGLKGFVDE HTINISLSLHHCRLLWDYVTQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTTEKMSRALRHYYKLNIIRKEPGQRLL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_LRP1_ENST00000553277_chr12_57539273_+_ETV6_ENST00000396373_chr12_12037379_+_1191nt ATGCTGACCCCGCCGTTGCTCCTGCTGCTGCCCCTGCTCTCAGCTCTGGTCGCGGCGGCTATCGACGCCCCTAAGACTTGCAGCCCCAAG CAGTTTGCCTGCAGAGATCAAATAACCTGTATCTCAAAGGGCTGGCGGTGCGACGGTGAGAGGGACTGCCCAGACGGATCTGACGAGGCC CCTGAGATTTGTCCACAGAGTAAGGCCCAGCGATGCCAGCCAAACGAGCATAACTGCCTGGGTACTGAGCTGTGTGTTCCCATGTCCCGC CTCTGCAATGGGGTCCAGGACTGCATGGACGGCTCAGATGAGGGGCCCCACTGCCGAGAGCTCCAAGGCAACTGCTCTCGCCTGGGCTGC CAGCACCATTGTGTCCCCACACTCGATGGGCCCACCTGCTACTGCAACAGCAGCTTTCAGCTTCAGGCAGATGGCAAGACCTGCAAAGAT TTTGATGAGTGCTCAGTGTACGGCACCTGCAGCCAGCTATGCACCAACACAGACGGCTCCTTCATATGTGGCTGTGTTGAAGGATACCTC CTGCAGCCGGATAACCGCTCCTGCAAGGCCAAGAACGAGCCAGTAGACCGGCCCCCTGTGCTGTTGATAGCCAACTCCCAGAACATCTTG GCCACGTACCTGAGTGGGGCCCAGGTGTCTACCATCACACCTACGAGCACGCGGCAGACCACAGCCATGGACTTCAGCTATGCCAACGAG ACCGTATGCTGGGTGCATGTTGGGGACAGTGCTGCTCAGACGCAGCTCAAGTGTGCCCGCATGCCTGGCCTAAAGGGCTTCGTGGATGAG CACACCATCAACATCTCCCTCAGTCTGCACCACTGTAGACTGCTTTGGGATTACGTCTATCAGTTGCTTTCTGACAGCCGGTACGAAAAC TTCATCCGATGGGAGGACAAAGAATCCAAAATATTCCGGATAGTGGATCCCAACGGACTGGCTCGACTGTGGGGAAACCATAAGAACAGA ACAAACATGACCTATGAGAAAATGTCCAGAGCCCTGCGCCACTACTACAAACTAAACATTATCAGGAAGGAGCCAGGACAAAGGCTTTTG TTCAGGTTTATGAAAACCCCAGATGAAATCATGAGTGGCCGAACAGACCGTCTGGAGCACCTAGAGTCCCAGGAGCTGGATGAACAAATA >In-frame_LRP1_ENST00000243077_chr12_57539273_+_ETV6_ENST00000396373_chr12_12037379_+_1191nt ATGCTGACCCCGCCGTTGCTCCTGCTGCTGCCCCTGCTCTCAGCTCTGGTCGCGGCGGCTATCGACGCCCCTAAGACTTGCAGCCCCAAG CAGTTTGCCTGCAGAGATCAAATAACCTGTATCTCAAAGGGCTGGCGGTGCGACGGTGAGAGGGACTGCCCAGACGGATCTGACGAGGCC CCTGAGATTTGTCCACAGAGTAAGGCCCAGCGATGCCAGCCAAACGAGCATAACTGCCTGGGTACTGAGCTGTGTGTTCCCATGTCCCGC CTCTGCAATGGGGTCCAGGACTGCATGGACGGCTCAGATGAGGGGCCCCACTGCCGAGAGCTCCAAGGCAACTGCTCTCGCCTGGGCTGC CAGCACCATTGTGTCCCCACACTCGATGGGCCCACCTGCTACTGCAACAGCAGCTTTCAGCTTCAGGCAGATGGCAAGACCTGCAAAGAT TTTGATGAGTGCTCAGTGTACGGCACCTGCAGCCAGCTATGCACCAACACAGACGGCTCCTTCATATGTGGCTGTGTTGAAGGATACCTC CTGCAGCCGGATAACCGCTCCTGCAAGGCCAAGAACGAGCCAGTAGACCGGCCCCCTGTGCTGTTGATAGCCAACTCCCAGAACATCTTG GCCACGTACCTGAGTGGGGCCCAGGTGTCTACCATCACACCTACGAGCACGCGGCAGACCACAGCCATGGACTTCAGCTATGCCAACGAG ACCGTATGCTGGGTGCATGTTGGGGACAGTGCTGCTCAGACGCAGCTCAAGTGTGCCCGCATGCCTGGCCTAAAGGGCTTCGTGGATGAG CACACCATCAACATCTCCCTCAGTCTGCACCACTGTAGACTGCTTTGGGATTACGTCTATCAGTTGCTTTCTGACAGCCGGTACGAAAAC TTCATCCGATGGGAGGACAAAGAATCCAAAATATTCCGGATAGTGGATCCCAACGGACTGGCTCGACTGTGGGGAAACCATAAGAACAGA ACAAACATGACCTATGAGAAAATGTCCAGAGCCCTGCGCCACTACTACAAACTAAACATTATCAGGAAGGAGCCAGGACAAAGGCTTTTG TTCAGGTTTATGAAAACCCCAGATGAAATCATGAGTGGCCGAACAGACCGTCTGGAGCACCTAGAGTCCCAGGAGCTGGATGAACAAATA >In-frame_LRP1_ENST00000338962_chr12_57539273_+_ETV6_ENST00000396373_chr12_12037379_+_1191nt ATGCTGACCCCGCCGTTGCTCCTGCTGCTGCCCCTGCTCTCAGCTCTGGTCGCGGCGGCTATCGACGCCCCTAAGACTTGCAGCCCCAAG CAGTTTGCCTGCAGAGATCAAATAACCTGTATCTCAAAGGGCTGGCGGTGCGACGGTGAGAGGGACTGCCCAGACGGATCTGACGAGGCC CCTGAGATTTGTCCACAGAGTAAGGCCCAGCGATGCCAGCCAAACGAGCATAACTGCCTGGGTACTGAGCTGTGTGTTCCCATGTCCCGC CTCTGCAATGGGGTCCAGGACTGCATGGACGGCTCAGATGAGGGGCCCCACTGCCGAGAGCTCCAAGGCAACTGCTCTCGCCTGGGCTGC CAGCACCATTGTGTCCCCACACTCGATGGGCCCACCTGCTACTGCAACAGCAGCTTTCAGCTTCAGGCAGATGGCAAGACCTGCAAAGAT TTTGATGAGTGCTCAGTGTACGGCACCTGCAGCCAGCTATGCACCAACACAGACGGCTCCTTCATATGTGGCTGTGTTGAAGGATACCTC CTGCAGCCGGATAACCGCTCCTGCAAGGCCAAGAACGAGCCAGTAGACCGGCCCCCTGTGCTGTTGATAGCCAACTCCCAGAACATCTTG GCCACGTACCTGAGTGGGGCCCAGGTGTCTACCATCACACCTACGAGCACGCGGCAGACCACAGCCATGGACTTCAGCTATGCCAACGAG ACCGTATGCTGGGTGCATGTTGGGGACAGTGCTGCTCAGACGCAGCTCAAGTGTGCCCGCATGCCTGGCCTAAAGGGCTTCGTGGATGAG CACACCATCAACATCTCCCTCAGTCTGCACCACTGTAGACTGCTTTGGGATTACGTCTATCAGTTGCTTTCTGACAGCCGGTACGAAAAC TTCATCCGATGGGAGGACAAAGAATCCAAAATATTCCGGATAGTGGATCCCAACGGACTGGCTCGACTGTGGGGAAACCATAAGAACAGA ACAAACATGACCTATGAGAAAATGTCCAGAGCCCTGCGCCACTACTACAAACTAAACATTATCAGGAAGGAGCCAGGACAAAGGCTTTTG TTCAGGTTTATGAAAACCCCAGATGAAATCATGAGTGGCCGAACAGACCGTCTGGAGCACCTAGAGTCCCAGGAGCTGGATGAACAAATA >In-frame_LRP1_ENST00000554174_chr12_57539273_+_ETV6_ENST00000396373_chr12_12037379_+_1191nt ATGCTGACCCCGCCGTTGCTCCTGCTGCTGCCCCTGCTCTCAGCTCTGGTCGCGGCGGCTATCGACGCCCCTAAGACTTGCAGCCCCAAG CAGTTTGCCTGCAGAGATCAAATAACCTGTATCTCAAAGGGCTGGCGGTGCGACGGTGAGAGGGACTGCCCAGACGGATCTGACGAGGCC CCTGAGATTTGTCCACAGAGTAAGGCCCAGCGATGCCAGCCAAACGAGCATAACTGCCTGGGTACTGAGCTGTGTGTTCCCATGTCCCGC CTCTGCAATGGGGTCCAGGACTGCATGGACGGCTCAGATGAGGGGCCCCACTGCCGAGAGCTCCAAGGCAACTGCTCTCGCCTGGGCTGC CAGCACCATTGTGTCCCCACACTCGATGGGCCCACCTGCTACTGCAACAGCAGCTTTCAGCTTCAGGCAGATGGCAAGACCTGCAAAGAT TTTGATGAGTGCTCAGTGTACGGCACCTGCAGCCAGCTATGCACCAACACAGACGGCTCCTTCATATGTGGCTGTGTTGAAGGATACCTC CTGCAGCCGGATAACCGCTCCTGCAAGGCCAAGAACGAGCCAGTAGACCGGCCCCCTGTGCTGTTGATAGCCAACTCCCAGAACATCTTG GCCACGTACCTGAGTGGGGCCCAGGTGTCTACCATCACACCTACGAGCACGCGGCAGACCACAGCCATGGACTTCAGCTATGCCAACGAG ACCGTATGCTGGGTGCATGTTGGGGACAGTGCTGCTCAGACGCAGCTCAAGTGTGCCCGCATGCCTGGCCTAAAGGGCTTCGTGGATGAG CACACCATCAACATCTCCCTCAGTCTGCACCACTGTAGACTGCTTTGGGATTACGTCTATCAGTTGCTTTCTGACAGCCGGTACGAAAAC TTCATCCGATGGGAGGACAAAGAATCCAAAATATTCCGGATAGTGGATCCCAACGGACTGGCTCGACTGTGGGGAAACCATAAGAACAGA ACAAACATGACCTATGAGAAAATGTCCAGAGCCCTGCGCCACTACTACAAACTAAACATTATCAGGAAGGAGCCAGGACAAAGGCTTTTG TTCAGGTTTATGAAAACCCCAGATGAAATCATGAGTGGCCGAACAGACCGTCTGGAGCACCTAGAGTCCCAGGAGCTGGATGAACAAATA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_LRP1_ENST00000553277_chr12_57539273_+_ETV6_ENST00000396373_chr12_12037379_+_6019nt GGGGAACAGCGGTGCGAGCTCCAGGCCCATGCACTGAGGAGGCGGAAACAAGGGGAGCCCCCAGAGCTCCATCAAGCCCCCTCCAAAGGC TCCCCTACCCGGTCCACGCCCCCCACCCCCCCTCCCCGCCTCCTCCCAATTGTGCATTTTTGCAGCCGGAGGCGGCTCCGAGATGGGGCT GTGAGCTTCGCCCGGGGAGGGGGAAAGAGCAGCGAGGAGTGAAGCGGGGGGGTGGGGTGAAGGGTTTGGATTTCGGGGCAGGGGGCGCAC CCCCGTCAGCAGGCCCTCCCCAAGGGGCTCGGAACTCTACCTCTTCACCCACGCCCCTGGTGCGCTTTGCCGAAGGAAAGAATAAGAACA GAGAAGGAGGAGGGGGAAAGGAGGAAAAGGGGGACCCCCCAACTGGGGGGGGTGAAGGAGAGAAGTAGCAGGACCAGAGGGGAAGGGGCT GCTGCTTGCATCAGCCCACACCATGCTGACCCCGCCGTTGCTCCTGCTGCTGCCCCTGCTCTCAGCTCTGGTCGCGGCGGCTATCGACGC CCCTAAGACTTGCAGCCCCAAGCAGTTTGCCTGCAGAGATCAAATAACCTGTATCTCAAAGGGCTGGCGGTGCGACGGTGAGAGGGACTG CCCAGACGGATCTGACGAGGCCCCTGAGATTTGTCCACAGAGTAAGGCCCAGCGATGCCAGCCAAACGAGCATAACTGCCTGGGTACTGA GCTGTGTGTTCCCATGTCCCGCCTCTGCAATGGGGTCCAGGACTGCATGGACGGCTCAGATGAGGGGCCCCACTGCCGAGAGCTCCAAGG CAACTGCTCTCGCCTGGGCTGCCAGCACCATTGTGTCCCCACACTCGATGGGCCCACCTGCTACTGCAACAGCAGCTTTCAGCTTCAGGC AGATGGCAAGACCTGCAAAGATTTTGATGAGTGCTCAGTGTACGGCACCTGCAGCCAGCTATGCACCAACACAGACGGCTCCTTCATATG TGGCTGTGTTGAAGGATACCTCCTGCAGCCGGATAACCGCTCCTGCAAGGCCAAGAACGAGCCAGTAGACCGGCCCCCTGTGCTGTTGAT AGCCAACTCCCAGAACATCTTGGCCACGTACCTGAGTGGGGCCCAGGTGTCTACCATCACACCTACGAGCACGCGGCAGACCACAGCCAT GGACTTCAGCTATGCCAACGAGACCGTATGCTGGGTGCATGTTGGGGACAGTGCTGCTCAGACGCAGCTCAAGTGTGCCCGCATGCCTGG CCTAAAGGGCTTCGTGGATGAGCACACCATCAACATCTCCCTCAGTCTGCACCACTGTAGACTGCTTTGGGATTACGTCTATCAGTTGCT TTCTGACAGCCGGTACGAAAACTTCATCCGATGGGAGGACAAAGAATCCAAAATATTCCGGATAGTGGATCCCAACGGACTGGCTCGACT GTGGGGAAACCATAAGAACAGAACAAACATGACCTATGAGAAAATGTCCAGAGCCCTGCGCCACTACTACAAACTAAACATTATCAGGAA GGAGCCAGGACAAAGGCTTTTGTTCAGGTTTATGAAAACCCCAGATGAAATCATGAGTGGCCGAACAGACCGTCTGGAGCACCTAGAGTC CCAGGAGCTGGATGAACAAATATACCAAGAAGATGAATGCTGAAGGAACCAACAGTCCACCTCAGCGGGCCAGCAGCCCAGGGAACCCCT GCCCACCAGGATTGCTGGAAGTGTGACGGAGCAGGCGGGCTGAGGAGAGTGGAAAAGGAAGCGACCCAGAAATGGCAGGGACACTTCTCT TGCAGACCAAGAGGGACCCTGGAGCACCTTAGACAAACTACCCAGCACAGGCGGGGCTGGAATTCTGGCGGAGGGCATGAGCCTGGGACT CCATGTCACGTTTCCTTCTGATTTGGAATCTCTCCATCTGTAATTCCTCACCCTCACCCTTCCACCGTTGTTAGTATCATGGTGTTTTTG TTTTTGTTTTTGTTTTAAGAACCTGCAGTTTGACTCTTCATCGTTCATCTAGGGGAAGACATCTGATGTTGTTTTCCTATGGAAATATAT ATCTATTATATATATATTTTTTGCAAATCTCACAAAGTGCGGCAAGCCCAGCTGGTCAGGAAAGAGAATACTTGCAGAGGGGTTCAGGTT CCTCTTTTTCCTGCCACGTGGATCAGGTCTGTTCCTGTTACTGTTGGGTCTTGGCTGAAAAAAAAAAATGCTTTTAAAAAAGATAAAATG AAAAGGAGAGCTCTCTTTTTCTCTCTCTTGCTCTGTTCTTCCCTTGGTCCCCTCTGTCCTCCCGCCCTGCCTGCAGTTGAGATTCAGATG CCTTCTGACAGAGTTCAGCCTCTTGGAGAGTCTTGGGGATTGTTGGCACCTAAACAGAATCAGTGACCCGGGTGCTTTGTGGCCAGCAGC ACAGAATCAAACCCGCATCCCAGCATTGGGCCACCCATCTGAGGGAGGCCAAAATCATCACAGATGCTGCTGTGCTGCAGACAGATACAT GCTAGTCCAGAGAGCCGCCCCTGAGATGGCTGTGAGAACCATGTGTCTAAGGCGTAAGATAAGGATGGAAGGCTGTCCAAGTTATTTGGA AGGCCTCGGCAGCTTGGGATTAGCTTGGGAGCGCAGCGCTGCAAAGTGGAAAATATGAAAAGACCACACAGGCCCAGCAGTCCAGAAACT GGGCAAAAATATTCTGCAGTGGGGATTTATTTTTCCAAAGCAGGTAACAGAGGCTAGTGAGAAAGAAAAGCTCCTCTCTGCTCCATTCCA AAGGCCATCTTGTGGTCAGTTTCATGCCCTCACCTGATTTTTTTTTTTTTTTTTTTTTTTCAATTCCTAACCTTTTTTAAAGTTTCCTGG TCTCCACTGGACACAGAGCTTTGGAGACGGAGGATCCCAGAGGGCAGTCTCAGTTGCAATCAGTGTGTGCCCAGCCTGGGCAGACAGGAA ATTCCTCGGATACATTATTTTTTCTTTCTTTCATAGCTGTGTCTCAGAAAGGACCCATTTGTGGCTCTTTTTCACCTCAAAATAAGATCG ATGGTATCTTGTAAAATGAGGGTAGTGCCACTTCTTAGTATTTTTGAAAGCTGTTTTAGATTTTTTTTTTTTTTCCTTTTCTAGCCATCT AAATTGACTCTTCCAATATAGGTCTCAGAAATCCAATATTTGGAGTACAATTTCTTTTAATCCAGATTACACCTGCCTTACAAAGCACCC CCTCCTTGTTCCCCTCTGTTTCCTCTACTCAGTTGGGGGAGAAACTCACAGCTCCTCCGGGATACATATGTGCCCTCAGCAGCAGCTCCC AGGTGAAGTTACCAGACCCCTGGGCTTCTCCCCAGCTTTTTCTGAGTTGAGTCAGACATGTAGAGTTTGGGTCACACAGGCAAGAGGAAT TTTCCCTCGGCCTTACTGACAAGGACACCAACCTAGGGTGCAAACAGATGGACTATGGTTCAAGGACACTGGAATTGAGGAGCTGATCAA GGCTCTCTTCAGCCTTGCTCTGTCCCTGCCTCTTATCAGAGCACAGGTAGACACACGGGCATAGCCAGCCCACTCCTACTGTCACAGGCG CCCCACCATTCAACCTTCCGGGAGGTCAGGGACCTTCTATATGAGGCGAGTGGGTCTCAGTCTGCTTGAATGGTGATGAGATTCTGCTGG ATCTCAGCACGCTGCAGGTGTCTTTTGAGAGCATTCAGTAGGACATGGTGATCCCTATTTCAGCCTCTAAGATGACTGGTATTCTATCTG AAATGCAGAGATTAAGCCAAATACCTGATGTATTGTGAAAGCCACTGATTTTAAGAATGGAGAGAAAGGGATTTTTTACTGCATCCCTCT GTATGAATATGAAATCAGAGACCAGGGCATGATGTTGCTAGGATTAGAGCCTCTCAGTCTGGCCTCTTCACCCAAGTGCAAGAACTCAGT CTCTTACTGTTCAAAGAATCTTAACAGTTGAATTATGGAGGGAAATTCCCTTTTGCCCCAAGCATTTCTATATTTAAAGCAATATCCCAG GAGAATATGTTAGACTTAGGATGATACCTTCAGCCACTTGAAGAAGAAATAGAAGGCGCTCATTCCAATATAGTCTTTATTTCCCATTCA GATACAGGTTGAGCATCCCTAATCTGAACAGTTAAAACCCCCAAATGCCCCAAAATCCAAACCTTCCTGAACGCTATGACACCATGAGTG GAAAATTCCACACCTAACAAACACATTTGCTTTCTTATGGTTCAATGTACACAAACTGTTTTATATAGAAAATGATTTCAAATATCATAA AATTACCTTCAGGCTATGTGTATAAAGTATATATGAGCCATAAATGAATTTTGTGTTTAGACTTTGTGTCCATCCCCAAGATCTCTCATT TTATATATATATATATATATATATATATATATATATATATATATATATACACACACACACACATACACAAATATTCCAGGATACAAAAAA AAACATTTAAAAATCCGAGACCCAGAACACTTCTGGTCCCAAGCATTTCAGATAAGGGATATCAATCTGTACTACCAATAAGGATTTCGT AATTCCCCTAACTGCAAATGTCCTCTTCATTTGTTCTTTATGAGAAAACCCGGGTAGTGCCAGCACCTGGATACAGTATTTACACCCTGC AGACCCTAAAGATTTCAGATTCAGTTAGCAAACCTTGATGAAGCACCTGCTGGACACTGAGGGACCCAAAGCTCAATCAGCCATAATCCC TGCTTTCAGAGTTTATATTGTACCTGCCTAATCCACCCGGCGTGACTCATTTCAACACTAAGTACTAGGGGTGTTGTCAGGAGACAAATC TGAAGTCAGGAGAGGAAAATGCAAAGGAGCCCTGCCGTGTGATGGATGTGCATTCTCACTTGGGTCTTGAAGTTCTCATTCCTACATCTC AAGCTAGCCAGGCAGTCTCCTCTCTATCAGAAGAAAGCACTGGTAATTGGCTAGACTGGCTATGTTGAAGGTAACATGAACTCTAAGATC TTGACCCAGGGCGACTTGGTTTTGCTTAAGGTGGCATCACCAATGTTCCAAATCCTTTAGGGAGATGAGGGTATCCCCACAGAAAAAGAG GAATAATAGACCAATGGATTTTCTCCTTTCACCAGTATGTTTGGAACCCTCTGATCCAATGTCTTTTGATACTGATCTCTTGTCCAAATG AGAATGTCGCTTTAGCTGAAATTCAAATGGCTGTGACAATTTACCGAAATGATGAAGTAACCACCATTCCCACCTTTCACTGCCTAGGCT CCAAGTCTGAATACATTTTTGAAATAGGAACTCCCTTTTGCAAAAAAGAAACCTGGGTGTCAGGGAGGTGAAGTGACTTGCCCTAGGAGC AGACAGCATGCCAAGAATGGAATTAGGCTCAGGATCCAGCCTGGGCTCACCCTGTGTGGCTCATTCCCACCCAGGAAACTGAAGATAAAA GATTTGGGAAAACACACCAAGAAAAAGGGGCAGTTTTCTTTGCCCAAGCATTTGGTGCTAGTTAGAGGCTGTTCACTCTCTCCTGCTCCT CTTCGGAGTAGAAATAAAGGCTGTGACACAAGGAAGCCAGTGGGGTGGGAGGGAGGCACCATAATCCCTCCCTAAAACCCACAGAAGACT AACCTGATACTCTTTTGACCCAACTGCATCAACACTAAACAGCTGCAGACCCCCTGAATCTTTCACACATGCCAAGTGAACATTCTTGAT GATTTCTCTTTGTGACCGCAACCACCTGCAAACCAGAACGACTCTAGAATTTCCTTCCCCGCCCCCCTTTTTGTTTAGTTTCTAATCTCT TGTTTATGAGGTGTGGGGTTTATAAGGGACTGAATCAAATGAATGTAACAAAAAAGAAAAAAAAAACAAAAAAAAATGCCTTTTCTCAGG >In-frame_LRP1_ENST00000243077_chr12_57539273_+_ETV6_ENST00000396373_chr12_12037379_+_6013nt CAGCGGTGCGAGCTCCAGGCCCATGCACTGAGGAGGCGGAAACAAGGGGAGCCCCCAGAGCTCCATCAAGCCCCCTCCAAAGGCTCCCCT ACCCGGTCCACGCCCCCCACCCCCCCTCCCCGCCTCCTCCCAATTGTGCATTTTTGCAGCCGGAGGCGGCTCCGAGATGGGGCTGTGAGC TTCGCCCGGGGAGGGGGAAAGAGCAGCGAGGAGTGAAGCGGGGGGGTGGGGTGAAGGGTTTGGATTTCGGGGCAGGGGGCGCACCCCCGT CAGCAGGCCCTCCCCAAGGGGCTCGGAACTCTACCTCTTCACCCACGCCCCTGGTGCGCTTTGCCGAAGGAAAGAATAAGAACAGAGAAG GAGGAGGGGGAAAGGAGGAAAAGGGGGACCCCCCAACTGGGGGGGGTGAAGGAGAGAAGTAGCAGGACCAGAGGGGAAGGGGCTGCTGCT TGCATCAGCCCACACCATGCTGACCCCGCCGTTGCTCCTGCTGCTGCCCCTGCTCTCAGCTCTGGTCGCGGCGGCTATCGACGCCCCTAA GACTTGCAGCCCCAAGCAGTTTGCCTGCAGAGATCAAATAACCTGTATCTCAAAGGGCTGGCGGTGCGACGGTGAGAGGGACTGCCCAGA CGGATCTGACGAGGCCCCTGAGATTTGTCCACAGAGTAAGGCCCAGCGATGCCAGCCAAACGAGCATAACTGCCTGGGTACTGAGCTGTG TGTTCCCATGTCCCGCCTCTGCAATGGGGTCCAGGACTGCATGGACGGCTCAGATGAGGGGCCCCACTGCCGAGAGCTCCAAGGCAACTG CTCTCGCCTGGGCTGCCAGCACCATTGTGTCCCCACACTCGATGGGCCCACCTGCTACTGCAACAGCAGCTTTCAGCTTCAGGCAGATGG CAAGACCTGCAAAGATTTTGATGAGTGCTCAGTGTACGGCACCTGCAGCCAGCTATGCACCAACACAGACGGCTCCTTCATATGTGGCTG TGTTGAAGGATACCTCCTGCAGCCGGATAACCGCTCCTGCAAGGCCAAGAACGAGCCAGTAGACCGGCCCCCTGTGCTGTTGATAGCCAA CTCCCAGAACATCTTGGCCACGTACCTGAGTGGGGCCCAGGTGTCTACCATCACACCTACGAGCACGCGGCAGACCACAGCCATGGACTT CAGCTATGCCAACGAGACCGTATGCTGGGTGCATGTTGGGGACAGTGCTGCTCAGACGCAGCTCAAGTGTGCCCGCATGCCTGGCCTAAA GGGCTTCGTGGATGAGCACACCATCAACATCTCCCTCAGTCTGCACCACTGTAGACTGCTTTGGGATTACGTCTATCAGTTGCTTTCTGA CAGCCGGTACGAAAACTTCATCCGATGGGAGGACAAAGAATCCAAAATATTCCGGATAGTGGATCCCAACGGACTGGCTCGACTGTGGGG AAACCATAAGAACAGAACAAACATGACCTATGAGAAAATGTCCAGAGCCCTGCGCCACTACTACAAACTAAACATTATCAGGAAGGAGCC AGGACAAAGGCTTTTGTTCAGGTTTATGAAAACCCCAGATGAAATCATGAGTGGCCGAACAGACCGTCTGGAGCACCTAGAGTCCCAGGA GCTGGATGAACAAATATACCAAGAAGATGAATGCTGAAGGAACCAACAGTCCACCTCAGCGGGCCAGCAGCCCAGGGAACCCCTGCCCAC CAGGATTGCTGGAAGTGTGACGGAGCAGGCGGGCTGAGGAGAGTGGAAAAGGAAGCGACCCAGAAATGGCAGGGACACTTCTCTTGCAGA CCAAGAGGGACCCTGGAGCACCTTAGACAAACTACCCAGCACAGGCGGGGCTGGAATTCTGGCGGAGGGCATGAGCCTGGGACTCCATGT CACGTTTCCTTCTGATTTGGAATCTCTCCATCTGTAATTCCTCACCCTCACCCTTCCACCGTTGTTAGTATCATGGTGTTTTTGTTTTTG TTTTTGTTTTAAGAACCTGCAGTTTGACTCTTCATCGTTCATCTAGGGGAAGACATCTGATGTTGTTTTCCTATGGAAATATATATCTAT TATATATATATTTTTTGCAAATCTCACAAAGTGCGGCAAGCCCAGCTGGTCAGGAAAGAGAATACTTGCAGAGGGGTTCAGGTTCCTCTT TTTCCTGCCACGTGGATCAGGTCTGTTCCTGTTACTGTTGGGTCTTGGCTGAAAAAAAAAAATGCTTTTAAAAAAGATAAAATGAAAAGG AGAGCTCTCTTTTTCTCTCTCTTGCTCTGTTCTTCCCTTGGTCCCCTCTGTCCTCCCGCCCTGCCTGCAGTTGAGATTCAGATGCCTTCT GACAGAGTTCAGCCTCTTGGAGAGTCTTGGGGATTGTTGGCACCTAAACAGAATCAGTGACCCGGGTGCTTTGTGGCCAGCAGCACAGAA TCAAACCCGCATCCCAGCATTGGGCCACCCATCTGAGGGAGGCCAAAATCATCACAGATGCTGCTGTGCTGCAGACAGATACATGCTAGT CCAGAGAGCCGCCCCTGAGATGGCTGTGAGAACCATGTGTCTAAGGCGTAAGATAAGGATGGAAGGCTGTCCAAGTTATTTGGAAGGCCT CGGCAGCTTGGGATTAGCTTGGGAGCGCAGCGCTGCAAAGTGGAAAATATGAAAAGACCACACAGGCCCAGCAGTCCAGAAACTGGGCAA AAATATTCTGCAGTGGGGATTTATTTTTCCAAAGCAGGTAACAGAGGCTAGTGAGAAAGAAAAGCTCCTCTCTGCTCCATTCCAAAGGCC ATCTTGTGGTCAGTTTCATGCCCTCACCTGATTTTTTTTTTTTTTTTTTTTTTTCAATTCCTAACCTTTTTTAAAGTTTCCTGGTCTCCA CTGGACACAGAGCTTTGGAGACGGAGGATCCCAGAGGGCAGTCTCAGTTGCAATCAGTGTGTGCCCAGCCTGGGCAGACAGGAAATTCCT CGGATACATTATTTTTTCTTTCTTTCATAGCTGTGTCTCAGAAAGGACCCATTTGTGGCTCTTTTTCACCTCAAAATAAGATCGATGGTA TCTTGTAAAATGAGGGTAGTGCCACTTCTTAGTATTTTTGAAAGCTGTTTTAGATTTTTTTTTTTTTTCCTTTTCTAGCCATCTAAATTG ACTCTTCCAATATAGGTCTCAGAAATCCAATATTTGGAGTACAATTTCTTTTAATCCAGATTACACCTGCCTTACAAAGCACCCCCTCCT TGTTCCCCTCTGTTTCCTCTACTCAGTTGGGGGAGAAACTCACAGCTCCTCCGGGATACATATGTGCCCTCAGCAGCAGCTCCCAGGTGA AGTTACCAGACCCCTGGGCTTCTCCCCAGCTTTTTCTGAGTTGAGTCAGACATGTAGAGTTTGGGTCACACAGGCAAGAGGAATTTTCCC TCGGCCTTACTGACAAGGACACCAACCTAGGGTGCAAACAGATGGACTATGGTTCAAGGACACTGGAATTGAGGAGCTGATCAAGGCTCT CTTCAGCCTTGCTCTGTCCCTGCCTCTTATCAGAGCACAGGTAGACACACGGGCATAGCCAGCCCACTCCTACTGTCACAGGCGCCCCAC CATTCAACCTTCCGGGAGGTCAGGGACCTTCTATATGAGGCGAGTGGGTCTCAGTCTGCTTGAATGGTGATGAGATTCTGCTGGATCTCA GCACGCTGCAGGTGTCTTTTGAGAGCATTCAGTAGGACATGGTGATCCCTATTTCAGCCTCTAAGATGACTGGTATTCTATCTGAAATGC AGAGATTAAGCCAAATACCTGATGTATTGTGAAAGCCACTGATTTTAAGAATGGAGAGAAAGGGATTTTTTACTGCATCCCTCTGTATGA ATATGAAATCAGAGACCAGGGCATGATGTTGCTAGGATTAGAGCCTCTCAGTCTGGCCTCTTCACCCAAGTGCAAGAACTCAGTCTCTTA CTGTTCAAAGAATCTTAACAGTTGAATTATGGAGGGAAATTCCCTTTTGCCCCAAGCATTTCTATATTTAAAGCAATATCCCAGGAGAAT ATGTTAGACTTAGGATGATACCTTCAGCCACTTGAAGAAGAAATAGAAGGCGCTCATTCCAATATAGTCTTTATTTCCCATTCAGATACA GGTTGAGCATCCCTAATCTGAACAGTTAAAACCCCCAAATGCCCCAAAATCCAAACCTTCCTGAACGCTATGACACCATGAGTGGAAAAT TCCACACCTAACAAACACATTTGCTTTCTTATGGTTCAATGTACACAAACTGTTTTATATAGAAAATGATTTCAAATATCATAAAATTAC CTTCAGGCTATGTGTATAAAGTATATATGAGCCATAAATGAATTTTGTGTTTAGACTTTGTGTCCATCCCCAAGATCTCTCATTTTATAT ATATATATATATATATATATATATATATATATATATATATATACACACACACACACATACACAAATATTCCAGGATACAAAAAAAAACAT TTAAAAATCCGAGACCCAGAACACTTCTGGTCCCAAGCATTTCAGATAAGGGATATCAATCTGTACTACCAATAAGGATTTCGTAATTCC CCTAACTGCAAATGTCCTCTTCATTTGTTCTTTATGAGAAAACCCGGGTAGTGCCAGCACCTGGATACAGTATTTACACCCTGCAGACCC TAAAGATTTCAGATTCAGTTAGCAAACCTTGATGAAGCACCTGCTGGACACTGAGGGACCCAAAGCTCAATCAGCCATAATCCCTGCTTT CAGAGTTTATATTGTACCTGCCTAATCCACCCGGCGTGACTCATTTCAACACTAAGTACTAGGGGTGTTGTCAGGAGACAAATCTGAAGT CAGGAGAGGAAAATGCAAAGGAGCCCTGCCGTGTGATGGATGTGCATTCTCACTTGGGTCTTGAAGTTCTCATTCCTACATCTCAAGCTA GCCAGGCAGTCTCCTCTCTATCAGAAGAAAGCACTGGTAATTGGCTAGACTGGCTATGTTGAAGGTAACATGAACTCTAAGATCTTGACC CAGGGCGACTTGGTTTTGCTTAAGGTGGCATCACCAATGTTCCAAATCCTTTAGGGAGATGAGGGTATCCCCACAGAAAAAGAGGAATAA TAGACCAATGGATTTTCTCCTTTCACCAGTATGTTTGGAACCCTCTGATCCAATGTCTTTTGATACTGATCTCTTGTCCAAATGAGAATG TCGCTTTAGCTGAAATTCAAATGGCTGTGACAATTTACCGAAATGATGAAGTAACCACCATTCCCACCTTTCACTGCCTAGGCTCCAAGT CTGAATACATTTTTGAAATAGGAACTCCCTTTTGCAAAAAAGAAACCTGGGTGTCAGGGAGGTGAAGTGACTTGCCCTAGGAGCAGACAG CATGCCAAGAATGGAATTAGGCTCAGGATCCAGCCTGGGCTCACCCTGTGTGGCTCATTCCCACCCAGGAAACTGAAGATAAAAGATTTG GGAAAACACACCAAGAAAAAGGGGCAGTTTTCTTTGCCCAAGCATTTGGTGCTAGTTAGAGGCTGTTCACTCTCTCCTGCTCCTCTTCGG AGTAGAAATAAAGGCTGTGACACAAGGAAGCCAGTGGGGTGGGAGGGAGGCACCATAATCCCTCCCTAAAACCCACAGAAGACTAACCTG ATACTCTTTTGACCCAACTGCATCAACACTAAACAGCTGCAGACCCCCTGAATCTTTCACACATGCCAAGTGAACATTCTTGATGATTTC TCTTTGTGACCGCAACCACCTGCAAACCAGAACGACTCTAGAATTTCCTTCCCCGCCCCCCTTTTTGTTTAGTTTCTAATCTCTTGTTTA TGAGGTGTGGGGTTTATAAGGGACTGAATCAAATGAATGTAACAAAAAAGAAAAAAAAAACAAAAAAAAATGCCTTTTCTCAGGGCCAGT >In-frame_LRP1_ENST00000338962_chr12_57539273_+_ETV6_ENST00000396373_chr12_12037379_+_5796nt GCGGGGGGGTGGGGTGAAGGGTTTGGATTTCGGGGCAGGGGGCGCACCCCCGTCAGCAGGCCCTCCCCAAGGGGCTCGGAACTCTACCTC TTCACCCACGCCCCTGGTGCGCTTTGCCGAAGGAAAGAATAAGAACAGAGAAGGAGGAGGGGGAAAGGAGGAAAAGGGGGACCCCCCAAC TGGGGGGGGTGAAGGAGAGAAGTAGCAGGACCAGAGGGGAAGGGGCTGCTGCTTGCATCAGCCCACACCATGCTGACCCCGCCGTTGCTC CTGCTGCTGCCCCTGCTCTCAGCTCTGGTCGCGGCGGCTATCGACGCCCCTAAGACTTGCAGCCCCAAGCAGTTTGCCTGCAGAGATCAA ATAACCTGTATCTCAAAGGGCTGGCGGTGCGACGGTGAGAGGGACTGCCCAGACGGATCTGACGAGGCCCCTGAGATTTGTCCACAGAGT AAGGCCCAGCGATGCCAGCCAAACGAGCATAACTGCCTGGGTACTGAGCTGTGTGTTCCCATGTCCCGCCTCTGCAATGGGGTCCAGGAC TGCATGGACGGCTCAGATGAGGGGCCCCACTGCCGAGAGCTCCAAGGCAACTGCTCTCGCCTGGGCTGCCAGCACCATTGTGTCCCCACA CTCGATGGGCCCACCTGCTACTGCAACAGCAGCTTTCAGCTTCAGGCAGATGGCAAGACCTGCAAAGATTTTGATGAGTGCTCAGTGTAC GGCACCTGCAGCCAGCTATGCACCAACACAGACGGCTCCTTCATATGTGGCTGTGTTGAAGGATACCTCCTGCAGCCGGATAACCGCTCC TGCAAGGCCAAGAACGAGCCAGTAGACCGGCCCCCTGTGCTGTTGATAGCCAACTCCCAGAACATCTTGGCCACGTACCTGAGTGGGGCC CAGGTGTCTACCATCACACCTACGAGCACGCGGCAGACCACAGCCATGGACTTCAGCTATGCCAACGAGACCGTATGCTGGGTGCATGTT GGGGACAGTGCTGCTCAGACGCAGCTCAAGTGTGCCCGCATGCCTGGCCTAAAGGGCTTCGTGGATGAGCACACCATCAACATCTCCCTC AGTCTGCACCACTGTAGACTGCTTTGGGATTACGTCTATCAGTTGCTTTCTGACAGCCGGTACGAAAACTTCATCCGATGGGAGGACAAA GAATCCAAAATATTCCGGATAGTGGATCCCAACGGACTGGCTCGACTGTGGGGAAACCATAAGAACAGAACAAACATGACCTATGAGAAA ATGTCCAGAGCCCTGCGCCACTACTACAAACTAAACATTATCAGGAAGGAGCCAGGACAAAGGCTTTTGTTCAGGTTTATGAAAACCCCA GATGAAATCATGAGTGGCCGAACAGACCGTCTGGAGCACCTAGAGTCCCAGGAGCTGGATGAACAAATATACCAAGAAGATGAATGCTGA AGGAACCAACAGTCCACCTCAGCGGGCCAGCAGCCCAGGGAACCCCTGCCCACCAGGATTGCTGGAAGTGTGACGGAGCAGGCGGGCTGA GGAGAGTGGAAAAGGAAGCGACCCAGAAATGGCAGGGACACTTCTCTTGCAGACCAAGAGGGACCCTGGAGCACCTTAGACAAACTACCC AGCACAGGCGGGGCTGGAATTCTGGCGGAGGGCATGAGCCTGGGACTCCATGTCACGTTTCCTTCTGATTTGGAATCTCTCCATCTGTAA TTCCTCACCCTCACCCTTCCACCGTTGTTAGTATCATGGTGTTTTTGTTTTTGTTTTTGTTTTAAGAACCTGCAGTTTGACTCTTCATCG TTCATCTAGGGGAAGACATCTGATGTTGTTTTCCTATGGAAATATATATCTATTATATATATATTTTTTGCAAATCTCACAAAGTGCGGC AAGCCCAGCTGGTCAGGAAAGAGAATACTTGCAGAGGGGTTCAGGTTCCTCTTTTTCCTGCCACGTGGATCAGGTCTGTTCCTGTTACTG TTGGGTCTTGGCTGAAAAAAAAAAATGCTTTTAAAAAAGATAAAATGAAAAGGAGAGCTCTCTTTTTCTCTCTCTTGCTCTGTTCTTCCC TTGGTCCCCTCTGTCCTCCCGCCCTGCCTGCAGTTGAGATTCAGATGCCTTCTGACAGAGTTCAGCCTCTTGGAGAGTCTTGGGGATTGT TGGCACCTAAACAGAATCAGTGACCCGGGTGCTTTGTGGCCAGCAGCACAGAATCAAACCCGCATCCCAGCATTGGGCCACCCATCTGAG GGAGGCCAAAATCATCACAGATGCTGCTGTGCTGCAGACAGATACATGCTAGTCCAGAGAGCCGCCCCTGAGATGGCTGTGAGAACCATG TGTCTAAGGCGTAAGATAAGGATGGAAGGCTGTCCAAGTTATTTGGAAGGCCTCGGCAGCTTGGGATTAGCTTGGGAGCGCAGCGCTGCA AAGTGGAAAATATGAAAAGACCACACAGGCCCAGCAGTCCAGAAACTGGGCAAAAATATTCTGCAGTGGGGATTTATTTTTCCAAAGCAG GTAACAGAGGCTAGTGAGAAAGAAAAGCTCCTCTCTGCTCCATTCCAAAGGCCATCTTGTGGTCAGTTTCATGCCCTCACCTGATTTTTT TTTTTTTTTTTTTTTTTCAATTCCTAACCTTTTTTAAAGTTTCCTGGTCTCCACTGGACACAGAGCTTTGGAGACGGAGGATCCCAGAGG GCAGTCTCAGTTGCAATCAGTGTGTGCCCAGCCTGGGCAGACAGGAAATTCCTCGGATACATTATTTTTTCTTTCTTTCATAGCTGTGTC TCAGAAAGGACCCATTTGTGGCTCTTTTTCACCTCAAAATAAGATCGATGGTATCTTGTAAAATGAGGGTAGTGCCACTTCTTAGTATTT TTGAAAGCTGTTTTAGATTTTTTTTTTTTTTCCTTTTCTAGCCATCTAAATTGACTCTTCCAATATAGGTCTCAGAAATCCAATATTTGG AGTACAATTTCTTTTAATCCAGATTACACCTGCCTTACAAAGCACCCCCTCCTTGTTCCCCTCTGTTTCCTCTACTCAGTTGGGGGAGAA ACTCACAGCTCCTCCGGGATACATATGTGCCCTCAGCAGCAGCTCCCAGGTGAAGTTACCAGACCCCTGGGCTTCTCCCCAGCTTTTTCT GAGTTGAGTCAGACATGTAGAGTTTGGGTCACACAGGCAAGAGGAATTTTCCCTCGGCCTTACTGACAAGGACACCAACCTAGGGTGCAA ACAGATGGACTATGGTTCAAGGACACTGGAATTGAGGAGCTGATCAAGGCTCTCTTCAGCCTTGCTCTGTCCCTGCCTCTTATCAGAGCA CAGGTAGACACACGGGCATAGCCAGCCCACTCCTACTGTCACAGGCGCCCCACCATTCAACCTTCCGGGAGGTCAGGGACCTTCTATATG AGGCGAGTGGGTCTCAGTCTGCTTGAATGGTGATGAGATTCTGCTGGATCTCAGCACGCTGCAGGTGTCTTTTGAGAGCATTCAGTAGGA CATGGTGATCCCTATTTCAGCCTCTAAGATGACTGGTATTCTATCTGAAATGCAGAGATTAAGCCAAATACCTGATGTATTGTGAAAGCC ACTGATTTTAAGAATGGAGAGAAAGGGATTTTTTACTGCATCCCTCTGTATGAATATGAAATCAGAGACCAGGGCATGATGTTGCTAGGA TTAGAGCCTCTCAGTCTGGCCTCTTCACCCAAGTGCAAGAACTCAGTCTCTTACTGTTCAAAGAATCTTAACAGTTGAATTATGGAGGGA AATTCCCTTTTGCCCCAAGCATTTCTATATTTAAAGCAATATCCCAGGAGAATATGTTAGACTTAGGATGATACCTTCAGCCACTTGAAG AAGAAATAGAAGGCGCTCATTCCAATATAGTCTTTATTTCCCATTCAGATACAGGTTGAGCATCCCTAATCTGAACAGTTAAAACCCCCA AATGCCCCAAAATCCAAACCTTCCTGAACGCTATGACACCATGAGTGGAAAATTCCACACCTAACAAACACATTTGCTTTCTTATGGTTC AATGTACACAAACTGTTTTATATAGAAAATGATTTCAAATATCATAAAATTACCTTCAGGCTATGTGTATAAAGTATATATGAGCCATAA ATGAATTTTGTGTTTAGACTTTGTGTCCATCCCCAAGATCTCTCATTTTATATATATATATATATATATATATATATATATATATATATA TATATACACACACACACACATACACAAATATTCCAGGATACAAAAAAAAACATTTAAAAATCCGAGACCCAGAACACTTCTGGTCCCAAG CATTTCAGATAAGGGATATCAATCTGTACTACCAATAAGGATTTCGTAATTCCCCTAACTGCAAATGTCCTCTTCATTTGTTCTTTATGA GAAAACCCGGGTAGTGCCAGCACCTGGATACAGTATTTACACCCTGCAGACCCTAAAGATTTCAGATTCAGTTAGCAAACCTTGATGAAG CACCTGCTGGACACTGAGGGACCCAAAGCTCAATCAGCCATAATCCCTGCTTTCAGAGTTTATATTGTACCTGCCTAATCCACCCGGCGT GACTCATTTCAACACTAAGTACTAGGGGTGTTGTCAGGAGACAAATCTGAAGTCAGGAGAGGAAAATGCAAAGGAGCCCTGCCGTGTGAT GGATGTGCATTCTCACTTGGGTCTTGAAGTTCTCATTCCTACATCTCAAGCTAGCCAGGCAGTCTCCTCTCTATCAGAAGAAAGCACTGG TAATTGGCTAGACTGGCTATGTTGAAGGTAACATGAACTCTAAGATCTTGACCCAGGGCGACTTGGTTTTGCTTAAGGTGGCATCACCAA TGTTCCAAATCCTTTAGGGAGATGAGGGTATCCCCACAGAAAAAGAGGAATAATAGACCAATGGATTTTCTCCTTTCACCAGTATGTTTG GAACCCTCTGATCCAATGTCTTTTGATACTGATCTCTTGTCCAAATGAGAATGTCGCTTTAGCTGAAATTCAAATGGCTGTGACAATTTA CCGAAATGATGAAGTAACCACCATTCCCACCTTTCACTGCCTAGGCTCCAAGTCTGAATACATTTTTGAAATAGGAACTCCCTTTTGCAA AAAAGAAACCTGGGTGTCAGGGAGGTGAAGTGACTTGCCCTAGGAGCAGACAGCATGCCAAGAATGGAATTAGGCTCAGGATCCAGCCTG GGCTCACCCTGTGTGGCTCATTCCCACCCAGGAAACTGAAGATAAAAGATTTGGGAAAACACACCAAGAAAAAGGGGCAGTTTTCTTTGC CCAAGCATTTGGTGCTAGTTAGAGGCTGTTCACTCTCTCCTGCTCCTCTTCGGAGTAGAAATAAAGGCTGTGACACAAGGAAGCCAGTGG GGTGGGAGGGAGGCACCATAATCCCTCCCTAAAACCCACAGAAGACTAACCTGATACTCTTTTGACCCAACTGCATCAACACTAAACAGC TGCAGACCCCCTGAATCTTTCACACATGCCAAGTGAACATTCTTGATGATTTCTCTTTGTGACCGCAACCACCTGCAAACCAGAACGACT CTAGAATTTCCTTCCCCGCCCCCCTTTTTGTTTAGTTTCTAATCTCTTGTTTATGAGGTGTGGGGTTTATAAGGGACTGAATCAAATGAA TGTAACAAAAAAGAAAAAAAAAACAAAAAAAAATGCCTTTTCTCAGGGCCAGTGAGTTGCAAATAATTTTTAAAGAAAAGCCTATAATTA >In-frame_LRP1_ENST00000554174_chr12_57539273_+_ETV6_ENST00000396373_chr12_12037379_+_5603nt GGAGAGAAGTAGCAGGACCAGAGGGGAAGGGGCTGCTGCTTGCATCAGCCCACACCATGCTGACCCCGCCGTTGCTCCTGCTGCTGCCCC TGCTCTCAGCTCTGGTCGCGGCGGCTATCGACGCCCCTAAGACTTGCAGCCCCAAGCAGTTTGCCTGCAGAGATCAAATAACCTGTATCT CAAAGGGCTGGCGGTGCGACGGTGAGAGGGACTGCCCAGACGGATCTGACGAGGCCCCTGAGATTTGTCCACAGAGTAAGGCCCAGCGAT GCCAGCCAAACGAGCATAACTGCCTGGGTACTGAGCTGTGTGTTCCCATGTCCCGCCTCTGCAATGGGGTCCAGGACTGCATGGACGGCT CAGATGAGGGGCCCCACTGCCGAGAGCTCCAAGGCAACTGCTCTCGCCTGGGCTGCCAGCACCATTGTGTCCCCACACTCGATGGGCCCA CCTGCTACTGCAACAGCAGCTTTCAGCTTCAGGCAGATGGCAAGACCTGCAAAGATTTTGATGAGTGCTCAGTGTACGGCACCTGCAGCC AGCTATGCACCAACACAGACGGCTCCTTCATATGTGGCTGTGTTGAAGGATACCTCCTGCAGCCGGATAACCGCTCCTGCAAGGCCAAGA ACGAGCCAGTAGACCGGCCCCCTGTGCTGTTGATAGCCAACTCCCAGAACATCTTGGCCACGTACCTGAGTGGGGCCCAGGTGTCTACCA TCACACCTACGAGCACGCGGCAGACCACAGCCATGGACTTCAGCTATGCCAACGAGACCGTATGCTGGGTGCATGTTGGGGACAGTGCTG CTCAGACGCAGCTCAAGTGTGCCCGCATGCCTGGCCTAAAGGGCTTCGTGGATGAGCACACCATCAACATCTCCCTCAGTCTGCACCACT GTAGACTGCTTTGGGATTACGTCTATCAGTTGCTTTCTGACAGCCGGTACGAAAACTTCATCCGATGGGAGGACAAAGAATCCAAAATAT TCCGGATAGTGGATCCCAACGGACTGGCTCGACTGTGGGGAAACCATAAGAACAGAACAAACATGACCTATGAGAAAATGTCCAGAGCCC TGCGCCACTACTACAAACTAAACATTATCAGGAAGGAGCCAGGACAAAGGCTTTTGTTCAGGTTTATGAAAACCCCAGATGAAATCATGA GTGGCCGAACAGACCGTCTGGAGCACCTAGAGTCCCAGGAGCTGGATGAACAAATATACCAAGAAGATGAATGCTGAAGGAACCAACAGT CCACCTCAGCGGGCCAGCAGCCCAGGGAACCCCTGCCCACCAGGATTGCTGGAAGTGTGACGGAGCAGGCGGGCTGAGGAGAGTGGAAAA GGAAGCGACCCAGAAATGGCAGGGACACTTCTCTTGCAGACCAAGAGGGACCCTGGAGCACCTTAGACAAACTACCCAGCACAGGCGGGG CTGGAATTCTGGCGGAGGGCATGAGCCTGGGACTCCATGTCACGTTTCCTTCTGATTTGGAATCTCTCCATCTGTAATTCCTCACCCTCA CCCTTCCACCGTTGTTAGTATCATGGTGTTTTTGTTTTTGTTTTTGTTTTAAGAACCTGCAGTTTGACTCTTCATCGTTCATCTAGGGGA AGACATCTGATGTTGTTTTCCTATGGAAATATATATCTATTATATATATATTTTTTGCAAATCTCACAAAGTGCGGCAAGCCCAGCTGGT CAGGAAAGAGAATACTTGCAGAGGGGTTCAGGTTCCTCTTTTTCCTGCCACGTGGATCAGGTCTGTTCCTGTTACTGTTGGGTCTTGGCT GAAAAAAAAAAATGCTTTTAAAAAAGATAAAATGAAAAGGAGAGCTCTCTTTTTCTCTCTCTTGCTCTGTTCTTCCCTTGGTCCCCTCTG TCCTCCCGCCCTGCCTGCAGTTGAGATTCAGATGCCTTCTGACAGAGTTCAGCCTCTTGGAGAGTCTTGGGGATTGTTGGCACCTAAACA GAATCAGTGACCCGGGTGCTTTGTGGCCAGCAGCACAGAATCAAACCCGCATCCCAGCATTGGGCCACCCATCTGAGGGAGGCCAAAATC ATCACAGATGCTGCTGTGCTGCAGACAGATACATGCTAGTCCAGAGAGCCGCCCCTGAGATGGCTGTGAGAACCATGTGTCTAAGGCGTA AGATAAGGATGGAAGGCTGTCCAAGTTATTTGGAAGGCCTCGGCAGCTTGGGATTAGCTTGGGAGCGCAGCGCTGCAAAGTGGAAAATAT GAAAAGACCACACAGGCCCAGCAGTCCAGAAACTGGGCAAAAATATTCTGCAGTGGGGATTTATTTTTCCAAAGCAGGTAACAGAGGCTA GTGAGAAAGAAAAGCTCCTCTCTGCTCCATTCCAAAGGCCATCTTGTGGTCAGTTTCATGCCCTCACCTGATTTTTTTTTTTTTTTTTTT TTTTCAATTCCTAACCTTTTTTAAAGTTTCCTGGTCTCCACTGGACACAGAGCTTTGGAGACGGAGGATCCCAGAGGGCAGTCTCAGTTG CAATCAGTGTGTGCCCAGCCTGGGCAGACAGGAAATTCCTCGGATACATTATTTTTTCTTTCTTTCATAGCTGTGTCTCAGAAAGGACCC ATTTGTGGCTCTTTTTCACCTCAAAATAAGATCGATGGTATCTTGTAAAATGAGGGTAGTGCCACTTCTTAGTATTTTTGAAAGCTGTTT TAGATTTTTTTTTTTTTTCCTTTTCTAGCCATCTAAATTGACTCTTCCAATATAGGTCTCAGAAATCCAATATTTGGAGTACAATTTCTT TTAATCCAGATTACACCTGCCTTACAAAGCACCCCCTCCTTGTTCCCCTCTGTTTCCTCTACTCAGTTGGGGGAGAAACTCACAGCTCCT CCGGGATACATATGTGCCCTCAGCAGCAGCTCCCAGGTGAAGTTACCAGACCCCTGGGCTTCTCCCCAGCTTTTTCTGAGTTGAGTCAGA CATGTAGAGTTTGGGTCACACAGGCAAGAGGAATTTTCCCTCGGCCTTACTGACAAGGACACCAACCTAGGGTGCAAACAGATGGACTAT GGTTCAAGGACACTGGAATTGAGGAGCTGATCAAGGCTCTCTTCAGCCTTGCTCTGTCCCTGCCTCTTATCAGAGCACAGGTAGACACAC GGGCATAGCCAGCCCACTCCTACTGTCACAGGCGCCCCACCATTCAACCTTCCGGGAGGTCAGGGACCTTCTATATGAGGCGAGTGGGTC TCAGTCTGCTTGAATGGTGATGAGATTCTGCTGGATCTCAGCACGCTGCAGGTGTCTTTTGAGAGCATTCAGTAGGACATGGTGATCCCT ATTTCAGCCTCTAAGATGACTGGTATTCTATCTGAAATGCAGAGATTAAGCCAAATACCTGATGTATTGTGAAAGCCACTGATTTTAAGA ATGGAGAGAAAGGGATTTTTTACTGCATCCCTCTGTATGAATATGAAATCAGAGACCAGGGCATGATGTTGCTAGGATTAGAGCCTCTCA GTCTGGCCTCTTCACCCAAGTGCAAGAACTCAGTCTCTTACTGTTCAAAGAATCTTAACAGTTGAATTATGGAGGGAAATTCCCTTTTGC CCCAAGCATTTCTATATTTAAAGCAATATCCCAGGAGAATATGTTAGACTTAGGATGATACCTTCAGCCACTTGAAGAAGAAATAGAAGG CGCTCATTCCAATATAGTCTTTATTTCCCATTCAGATACAGGTTGAGCATCCCTAATCTGAACAGTTAAAACCCCCAAATGCCCCAAAAT CCAAACCTTCCTGAACGCTATGACACCATGAGTGGAAAATTCCACACCTAACAAACACATTTGCTTTCTTATGGTTCAATGTACACAAAC TGTTTTATATAGAAAATGATTTCAAATATCATAAAATTACCTTCAGGCTATGTGTATAAAGTATATATGAGCCATAAATGAATTTTGTGT TTAGACTTTGTGTCCATCCCCAAGATCTCTCATTTTATATATATATATATATATATATATATATATATATATATATATATATACACACAC ACACACATACACAAATATTCCAGGATACAAAAAAAAACATTTAAAAATCCGAGACCCAGAACACTTCTGGTCCCAAGCATTTCAGATAAG GGATATCAATCTGTACTACCAATAAGGATTTCGTAATTCCCCTAACTGCAAATGTCCTCTTCATTTGTTCTTTATGAGAAAACCCGGGTA GTGCCAGCACCTGGATACAGTATTTACACCCTGCAGACCCTAAAGATTTCAGATTCAGTTAGCAAACCTTGATGAAGCACCTGCTGGACA CTGAGGGACCCAAAGCTCAATCAGCCATAATCCCTGCTTTCAGAGTTTATATTGTACCTGCCTAATCCACCCGGCGTGACTCATTTCAAC ACTAAGTACTAGGGGTGTTGTCAGGAGACAAATCTGAAGTCAGGAGAGGAAAATGCAAAGGAGCCCTGCCGTGTGATGGATGTGCATTCT CACTTGGGTCTTGAAGTTCTCATTCCTACATCTCAAGCTAGCCAGGCAGTCTCCTCTCTATCAGAAGAAAGCACTGGTAATTGGCTAGAC TGGCTATGTTGAAGGTAACATGAACTCTAAGATCTTGACCCAGGGCGACTTGGTTTTGCTTAAGGTGGCATCACCAATGTTCCAAATCCT TTAGGGAGATGAGGGTATCCCCACAGAAAAAGAGGAATAATAGACCAATGGATTTTCTCCTTTCACCAGTATGTTTGGAACCCTCTGATC CAATGTCTTTTGATACTGATCTCTTGTCCAAATGAGAATGTCGCTTTAGCTGAAATTCAAATGGCTGTGACAATTTACCGAAATGATGAA GTAACCACCATTCCCACCTTTCACTGCCTAGGCTCCAAGTCTGAATACATTTTTGAAATAGGAACTCCCTTTTGCAAAAAAGAAACCTGG GTGTCAGGGAGGTGAAGTGACTTGCCCTAGGAGCAGACAGCATGCCAAGAATGGAATTAGGCTCAGGATCCAGCCTGGGCTCACCCTGTG TGGCTCATTCCCACCCAGGAAACTGAAGATAAAAGATTTGGGAAAACACACCAAGAAAAAGGGGCAGTTTTCTTTGCCCAAGCATTTGGT GCTAGTTAGAGGCTGTTCACTCTCTCCTGCTCCTCTTCGGAGTAGAAATAAAGGCTGTGACACAAGGAAGCCAGTGGGGTGGGAGGGAGG CACCATAATCCCTCCCTAAAACCCACAGAAGACTAACCTGATACTCTTTTGACCCAACTGCATCAACACTAAACAGCTGCAGACCCCCTG AATCTTTCACACATGCCAAGTGAACATTCTTGATGATTTCTCTTTGTGACCGCAACCACCTGCAAACCAGAACGACTCTAGAATTTCCTT CCCCGCCCCCCTTTTTGTTTAGTTTCTAATCTCTTGTTTATGAGGTGTGGGGTTTATAAGGGACTGAATCAAATGAATGTAACAAAAAAG AAAAAAAAAACAAAAAAAAATGCCTTTTCTCAGGGCCAGTGAGTTGCAAATAATTTTTAAAGAAAAGCCTATAATTACATCATCTCAATA |
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FusionGenePPI for LRP1_ETV6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LRP1 | SERPINE1, CANX, CALR, PDIA2, MMP14, KAT5, CALCR, SHC1, THBS1, GIPC1, MAPK8IP1, DLG4, MAPK8IP2, SYNJ2BP, NOS1AP, SCN3A, APBA2, DAB1, ITGB1BP1, ANAPC10, A2M, PDGFB, SRC, DAB2, MDK, F8, GULP1, PLAUR, PLAT, F9, LRPAP1, LPL, LIPC, SNX17, APBB1, USP3, CACNA1A, APOE, RIC8B, CC2D1A, SNRNP70, ANKS1B, PID1, HNRNPDL, MAPRE1, FBXO6, CUBN, CHFR, SKIL, RANBP9, APP, COPS5, EGFR, ZFP41, DIAPH1, FOXB1, KCTD18, INTS6, TNKS2, TNKS, FOXF2, BCKDHB, TUBB8, SAMD1, TUBA4A, TUBB3, LOXL2, MTG2, SLC25A6, SLC25A30, GATB, SMOC1, C17orf80, GSG2, NME4, HARS2, TUBA1A, TUBB4A, SLC25A23, LCOR, CCRN4L, FAM115A, SLC25A25, MTO1, C1orf85, PC, PTGES2, SLC26A6, GFPT2, GFPT1, HSPA5, RPL23, TUBB2A, NPC2, MTPAP, TUBB4B, RPUSD3, GNB2, NPRL3, FAM132B, ERAL1, GCNT1, TUBB2B, PTCD2, SENP1, MAP2K7, RTEL1, LGALS9 | ETV6 | KAT5, GAB2, ETV6, GRB2, CRKL, ACTA1, HDAC9, FLI1, FBXL6, SKP1, L3MBTL1, IRF8, NCOR1, SIN3A, HDAC3, UBE2I, ELAVL1, PDGFRB, SUMO1, SOCS1, SOCS3, TRAF3, SOX2, HDAC6, PIN1, AP1M1, WDYHV1, LRP6, LRP5, NID2, ETV7, USP7, VPS26B, NFATC2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | LRP1 | chr12:57539273 | chr12:12037379 | ENST00000243077 | + | 6 | 89 | 4445_4544 | 280 | 4545 | MAFB |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LRP1_ETV6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | LRP1 | Q07954 | DB00031 | Tenecteplase | Prolow-density lipoprotein receptor-related protein 1 | biotech | approved |
| Hgene | LRP1 | Q07954 | DB00025 | Antihemophilic factor, human recombinant | Prolow-density lipoprotein receptor-related protein 1 | biotech | approved|investigational |
| Hgene | LRP1 | Q07954 | DB00100 | Coagulation Factor IX (Recombinant) | Prolow-density lipoprotein receptor-related protein 1 | biotech | approved|investigational |
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RelatedDiseases for LRP1_ETV6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | LRP1 | C0036341 | Schizophrenia | 1 | CTD_human |
| Hgene | LRP1 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Hgene | LRP1 | C0149931 | Migraine Disorders | 1 | CTD_human |
| Hgene | LRP1 | C0338480 | Common Migraine | 1 | CTD_human |
| Hgene | LRP1 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| Tgene | ETV6 | C0023485 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 3 | CTD_human |
| Tgene | ETV6 | C0040034 | Thrombocytopenia | 2 | CTD_human;HPO |
| Tgene | ETV6 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| Tgene | ETV6 | C0376545 | Hematologic Neoplasms | 1 | CTD_human |
| Tgene | ETV6 | C1838656 | Macrocytosis, Familial | 1 | CTD_human |
| Tgene | ETV6 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
| Tgene | ETV6 | C3495559 | Juvenile arthritis | 1 | CTD_human |
| Tgene | ETV6 | C4015537 | THROMBOCYTOPENIA 5 | 1 | UNIPROT |
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