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Fusion gene ID: 20121 |
FusionGeneSummary for LRP1B_KCNH8 |
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Fusion gene information | Fusion gene name: LRP1B_KCNH8 | Fusion gene ID: 20121 | Hgene | Tgene | Gene symbol | LRP1B | KCNH8 | Gene ID | 53353 | 131096 |
Gene name | LDL receptor related protein 1B | potassium voltage-gated channel subfamily H member 8 | |
Synonyms | LRP-1B|LRP-DIT|LRPDIT | ELK|ELK1|Kv12.1|elk3 | |
Cytomap | 2q22.1-q22.2 | 3p24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | low-density lipoprotein receptor-related protein 1BLRP-deleted in tumorslow density lipoprotein receptor related protein-deleted in tumorlow density lipoprotein receptor-related protein 1Blow density lipoprotein-related protein 1B (deleted in tumors) | potassium voltage-gated channel subfamily H member 8ELK channel 3ether-a-go-go-like potassium channel 1ether-a-go-go-like potassium channel 3hElk1potassium channel, voltage gated eag related subfamily H, member 8potassium voltage-gated channel, subf | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9NZR2 | Q96L42 | |
Ensembl transtripts involved in fusion gene | ENST00000389484, ENST00000486364, | ENST00000328405, ENST00000475063, ENST00000537696, | |
Fusion gene scores | * DoF score | 7 X 7 X 3=147 | 2 X 2 X 1=4 |
# samples | 7 | 2 | |
** MAII score | log2(7/147*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: LRP1B [Title/Abstract] AND KCNH8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF364794 | LRP1B | chr2 | 142611154 | + | KCNH8 | chr3 | 19362665 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000389484 | ENST00000328405 | LRP1B | chr2 | 142611154 | + | KCNH8 | chr3 | 19362665 | - |
intron-intron | ENST00000389484 | ENST00000475063 | LRP1B | chr2 | 142611154 | + | KCNH8 | chr3 | 19362665 | - |
intron-intron | ENST00000389484 | ENST00000537696 | LRP1B | chr2 | 142611154 | + | KCNH8 | chr3 | 19362665 | - |
intron-intron | ENST00000486364 | ENST00000328405 | LRP1B | chr2 | 142611154 | + | KCNH8 | chr3 | 19362665 | - |
intron-intron | ENST00000486364 | ENST00000475063 | LRP1B | chr2 | 142611154 | + | KCNH8 | chr3 | 19362665 | - |
intron-intron | ENST00000486364 | ENST00000537696 | LRP1B | chr2 | 142611154 | + | KCNH8 | chr3 | 19362665 | - |
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FusionProtFeatures for LRP1B_KCNH8 |
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Hgene | Tgene |
LRP1B | KCNH8 |
Potential cell surface proteins that bind andinternalize ligands in the process of receptor-mediatedendocytosis. | Pore-forming (alpha) subunit of voltage-gated potassiumchannel. Elicits a slowly activating, outward rectifying current.Channel properties may be modulated by cAMP and subunit assembly. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LRP1B_KCNH8 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LRP1B_KCNH8 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LRP1B_KCNH8 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LRP1B_KCNH8 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | LRP1B | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Hgene | LRP1B | C0025202 | melanoma | 1 | CTD_human |