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Fusion gene ID: 20116 |
FusionGeneSummary for LRP1B_ADAP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LRP1B_ADAP1 | Fusion gene ID: 20116 | Hgene | Tgene | Gene symbol | LRP1B | ADAP1 | Gene ID | 53353 | 11033 |
| Gene name | LDL receptor related protein 1B | ArfGAP with dual PH domains 1 | |
| Synonyms | LRP-1B|LRP-DIT|LRPDIT | CENTA1|GCS1L|p42IP4 | |
| Cytomap | 2q22.1-q22.2 | 7p22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | low-density lipoprotein receptor-related protein 1BLRP-deleted in tumorslow density lipoprotein receptor related protein-deleted in tumorlow density lipoprotein receptor-related protein 1Blow density lipoprotein-related protein 1B (deleted in tumors) | arf-GAP with dual PH domain-containing protein 1centaurin-alphacentaurin-alpha-1cnt-a1putative MAPK-activating protein PM25 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9NZR2 | O75689 | |
| Ensembl transtripts involved in fusion gene | ENST00000389484, ENST00000486364, | ENST00000265846, ENST00000449296, ENST00000539900, ENST00000463358, | |
| Fusion gene scores | * DoF score | 7 X 7 X 3=147 | 3 X 2 X 3=18 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/147*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: LRP1B [Title/Abstract] AND ADAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | CESC | TCGA-EK-A2GZ-01A | LRP1B | chr2 | 142237965 | - | ADAP1 | chr7 | 975141 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000389484 | ENST00000265846 | LRP1B | chr2 | 142237965 | - | ADAP1 | chr7 | 975141 | - |
| 5CDS-intron | ENST00000389484 | ENST00000449296 | LRP1B | chr2 | 142237965 | - | ADAP1 | chr7 | 975141 | - |
| 5CDS-intron | ENST00000389484 | ENST00000539900 | LRP1B | chr2 | 142237965 | - | ADAP1 | chr7 | 975141 | - |
| 5CDS-5UTR | ENST00000389484 | ENST00000463358 | LRP1B | chr2 | 142237965 | - | ADAP1 | chr7 | 975141 | - |
| intron-3CDS | ENST00000486364 | ENST00000265846 | LRP1B | chr2 | 142237965 | - | ADAP1 | chr7 | 975141 | - |
| intron-intron | ENST00000486364 | ENST00000449296 | LRP1B | chr2 | 142237965 | - | ADAP1 | chr7 | 975141 | - |
| intron-intron | ENST00000486364 | ENST00000539900 | LRP1B | chr2 | 142237965 | - | ADAP1 | chr7 | 975141 | - |
| intron-5UTR | ENST00000486364 | ENST00000463358 | LRP1B | chr2 | 142237965 | - | ADAP1 | chr7 | 975141 | - |
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FusionProtFeatures for LRP1B_ADAP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LRP1B | ADAP1 |
| Potential cell surface proteins that bind andinternalize ligands in the process of receptor-mediatedendocytosis. | GTPase-activating protein for the ADP ribosylationfactor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate(InsP4). {ECO:0000269|PubMed:10448098,ECO:0000303|PubMed:10333475, ECO:0000305}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 31_70 | 114 | 4600 | Domain | LDL-receptor class A 1 |
| Hgene | LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 76_114 | 114 | 4600 | Domain | LDL-receptor class A 2 |
| Tgene | >ADAP1 | chr2:142237965 | chr7:975141 | ENST00000265846 | - | 0 | 11 | 129_230 | 27 | 375 | Domain | PH 1 |
| Tgene | >ADAP1 | chr2:142237965 | chr7:975141 | ENST00000265846 | - | 0 | 11 | 252_356 | 27 | 375 | Domain | PH 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 1005_1043 | 114 | 4600 | Domain | LDL-receptor class A 7 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 1052_1089 | 114 | 4600 | Domain | LDL-receptor class A 8 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 1094_1132 | 114 | 4600 | Domain | LDL-receptor class A 9 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 1135_1174 | 114 | 4600 | Domain | LDL-receptor class A 10 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 116_154 | 114 | 4600 | Domain | EGF-like 1 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 1174_1213 | 114 | 4600 | Domain | EGF-like 5 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 1214_1253 | 114 | 4600 | Domain | EGF-like 6 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 1527_1570 | 114 | 4600 | Domain | EGF-like 7 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 155_194 | 114 | 4600 | Domain | EGF-like 2%3B calcium-binding |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 1834_1875 | 114 | 4600 | Domain | EGF-like 8 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 2143_2183 | 114 | 4600 | Domain | EGF-like 9 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 2464_2504 | 114 | 4600 | Domain | EGF-like 10 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 2509_2548 | 114 | 4600 | Domain | LDL-receptor class A 11 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 2551_2587 | 114 | 4600 | Domain | LDL-receptor class A 12 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 2590_2626 | 114 | 4600 | Domain | LDL-receptor class A 13 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 2629_2675 | 114 | 4600 | Domain | LDL-receptor class A 14 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 2681_2717 | 114 | 4600 | Domain | LDL-receptor class A 15 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 2719_2757 | 114 | 4600 | Domain | LDL-receptor class A 16 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 2760_2800 | 114 | 4600 | Domain | LDL-receptor class A 17 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 2804_2841 | 114 | 4600 | Domain | LDL-receptor class A 18 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 2844_2885 | 114 | 4600 | Domain | LDL-receptor class A 19 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 2890_2926 | 114 | 4600 | Domain | LDL-receptor class A 20 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 2927_2967 | 114 | 4600 | Domain | EGF-like 11 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 2968_3008 | 114 | 4600 | Domain | EGF-like 12%3B calcium-binding |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 3273_3314 | 114 | 4600 | Domain | EGF-like 13 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 3316_3353 | 114 | 4600 | Domain | LDL-receptor class A 21 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 3356_3392 | 114 | 4600 | Domain | LDL-receptor class A 22 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 3395_3432 | 114 | 4600 | Domain | LDL-receptor class A 23 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 3435_3472 | 114 | 4600 | Domain | LDL-receptor class A 24 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 3475_3511 | 114 | 4600 | Domain | LDL-receptor class A 25 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 3514_3550 | 114 | 4600 | Domain | LDL-receptor class A 26 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 3552_3588 | 114 | 4600 | Domain | LDL-receptor class A 27 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 3593_3629 | 114 | 4600 | Domain | LDL-receptor class A 28 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 3631_3668 | 114 | 4600 | Domain | LDL-receptor class A 29 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 3673_3711 | 114 | 4600 | Domain | LDL-receptor class A 30 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 3714_3752 | 114 | 4600 | Domain | LDL-receptor class A 31 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 3761_3797 | 114 | 4600 | Domain | LDL-receptor class A 32 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 3801_3843 | 114 | 4600 | Domain | EGF-like 14 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 3844_3881 | 114 | 4600 | Domain | EGF-like 15 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 4171_4208 | 114 | 4600 | Domain | EGF-like 16 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 4213_4249 | 114 | 4600 | Domain | EGF-like 17 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 4249_4285 | 114 | 4600 | Domain | EGF-like 18 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 4285_4321 | 114 | 4600 | Domain | EGF-like 19 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 4321_4357 | 114 | 4600 | Domain | EGF-like 20 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 4357_4392 | 114 | 4600 | Domain | EGF-like 21 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 4390_4427 | 114 | 4600 | Domain | EGF-like 22 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 471_517 | 114 | 4600 | Domain | EGF-like 3 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 794_834 | 114 | 4600 | Domain | EGF-like 4 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 844_882 | 114 | 4600 | Domain | LDL-receptor class A 3 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 885_923 | 114 | 4600 | Domain | LDL-receptor class A 4 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 926_963 | 114 | 4600 | Domain | LDL-receptor class A 5 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 966_1003 | 114 | 4600 | Domain | LDL-receptor class A 6 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 4492_4495 | 114 | 4600 | Motif | Endocytosis signal |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 4559_4562 | 114 | 4600 | Motif | Endocytosis signal |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 1300_1346 | 114 | 4600 | Repeat | Note=LDL-receptor class B 8 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 1347_1389 | 114 | 4600 | Repeat | Note=LDL-receptor class B 9 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 1390_1436 | 114 | 4600 | Repeat | Note=LDL-receptor class B 10 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 1437_1480 | 114 | 4600 | Repeat | Note=LDL-receptor class B 11 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 1481_1522 | 114 | 4600 | Repeat | Note=LDL-receptor class B 12 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 1618_1660 | 114 | 4600 | Repeat | Note=LDL-receptor class B 13 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 1661_1704 | 114 | 4600 | Repeat | Note=LDL-receptor class B 14 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 1705_1744 | 114 | 4600 | Repeat | Note=LDL-receptor class B 15 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 1745_1787 | 114 | 4600 | Repeat | Note=LDL-receptor class B 16 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 1922_1964 | 114 | 4600 | Repeat | Note=LDL-receptor class B 17 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 1965_2007 | 114 | 4600 | Repeat | Note=LDL-receptor class B 28 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 2008_2051 | 114 | 4600 | Repeat | Note=LDL-receptor class B 19 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 2052_2095 | 114 | 4600 | Repeat | Note=LDL-receptor class B 20 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 2239_2280 | 114 | 4600 | Repeat | Note=LDL-receptor class B 21 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 2281_2329 | 114 | 4600 | Repeat | Note=LDL-receptor class B 22 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 2330_2374 | 114 | 4600 | Repeat | Note=LDL-receptor class B 23 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 2375_2416 | 114 | 4600 | Repeat | Note=LDL-receptor class B 24 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 2417_2459 | 114 | 4600 | Repeat | Note=LDL-receptor class B 25 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 295_337 | 114 | 4600 | Repeat | Note=LDL-receptor class B 1 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 3055_3098 | 114 | 4600 | Repeat | Note=LDL-receptor class B 26 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 3099_3141 | 114 | 4600 | Repeat | Note=LDL-receptor class B 27 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 3142_3185 | 114 | 4600 | Repeat | Note=LDL-receptor class B 28 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 3186_3224 | 114 | 4600 | Repeat | Note=LDL-receptor class B 29 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 3225_3268 | 114 | 4600 | Repeat | Note=LDL-receptor class B 30 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 338_381 | 114 | 4600 | Repeat | Note=LDL-receptor class B 2 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 382_425 | 114 | 4600 | Repeat | Note=LDL-receptor class B 3 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 3933_3980 | 114 | 4600 | Repeat | Note=LDL-receptor class B 31 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 3981_4038 | 114 | 4600 | Repeat | Note=LDL-receptor class B 32 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 4039_4082 | 114 | 4600 | Repeat | Note=LDL-receptor class B 33 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 4083_4127 | 114 | 4600 | Repeat | Note=LDL-receptor class B 34 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 568_610 | 114 | 4600 | Repeat | Note=LDL-receptor class B 4 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 611_656 | 114 | 4600 | Repeat | Note=LDL-receptor class B 5 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 657_706 | 114 | 4600 | Repeat | Note=LDL-receptor class B 6 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 707_750 | 114 | 4600 | Repeat | Note=LDL-receptor class B 7 |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 25_4444 | 114 | 4600 | Topological domain | Extracellular |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 4468_4599 | 114 | 4600 | Topological domain | Cytoplasmic |
| Hgene | >LRP1B | chr2:142237965 | chr7:975141 | ENST00000389484 | - | 3 | 91 | 4445_4467 | 114 | 4600 | Transmembrane | Helical |
| Tgene | ADAP1 | chr2:142237965 | chr7:975141 | ENST00000265846 | - | 0 | 11 | 7_126 | 27 | 375 | Domain | Arf-GAP |
| Tgene | ADAP1 | chr2:142237965 | chr7:975141 | ENST00000265846 | - | 0 | 11 | 21_44 | 27 | 375 | Zinc finger | C4-type |
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FusionGeneSequence for LRP1B_ADAP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_LRP1B_ENST00000389484_chr2_142237965_-_ADAP1_ENST00000265846_chr7_975141_-_462aa MSEFLLALLTLSGLLPIARVLTVGADRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKC VHLSQLCNGVLDCPDGYDEGVHCQDPDWASYTLGVFICLSCSGIHRNIPQVSKVKSVRLDAWEEAQVEFMASHGNDAARARFESKVPSFY YRPTPSDCQLLREQWIRAKYERQEFIYPEKQEPYSAGYREGFLWKRGRDNGQFLSRKFVLTEREGALKYFNRNDAKEPKAVMKIEHLNAT FQPAKIGHPHGLQVTYLKDNSTRNIFIYHEDGKEIVDWFNALRAARFHYLQVAFPGAGDADLVPKLSRNYLKEGYMEKTGPKQTEGFRKR WFTMDDRRLMYFKDPLDAFARGEVFIGSKESGYTVLHGFPPSTQGHHWPHGITIVTPDRKFLFACETESDQREWVAAFQKAVDRPMLPQE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_LRP1B_ENST00000389484_chr2_142237965_-_ADAP1_ENST00000265846_chr7_975141_-_1386nt ATGTCCGAGTTTCTCCTCGCCTTACTCACTCTCTCGGGATTATTGCCGATTGCCAGGGTGCTGACCGTGGGAGCCGACCGAGATCAGCAG TTGTGTGATCCTGGTGAATTTCTTTGCCACGATCACGTGACTTGTGTCTCCCAGAGCTGGCTGTGTGATGGGGACCCTGACTGCCCTGAT GATTCAGACGAGTCTTTAGATACCTGTCCCGAGGAGGTAGAAATCAAGTGCCCCTTGAATCACATTGCTTGCCTTGGTACCAACAAATGT GTTCATTTATCCCAGCTGTGCAATGGTGTCTTGGACTGCCCAGATGGGTATGACGAAGGAGTACATTGTCAGGATCCCGACTGGGCCTCC TACACTCTGGGCGTCTTCATCTGCCTGAGCTGCTCGGGAATCCACCGGAATATCCCCCAGGTCAGCAAGGTGAAGTCCGTCCGCCTGGAC GCCTGGGAGGAGGCCCAAGTGGAGTTCATGGCCTCCCACGGGAACGACGCCGCGAGAGCCAGGTTTGAGTCCAAAGTACCCTCCTTCTAC TACCGGCCCACGCCCTCCGACTGCCAGCTCCTTCGAGAGCAGTGGATCCGGGCCAAGTACGAGCGACAGGAGTTCATCTACCCGGAGAAG CAGGAGCCCTACTCGGCAGGGTACCGTGAGGGTTTTCTCTGGAAGCGTGGCCGGGACAACGGGCAGTTTTTGAGCCGGAAGTTTGTGCTG ACAGAACGAGAGGGTGCTCTGAAGTATTTCAACAGAAATGATGCCAAGGAGCCCAAGGCCGTGATGAAGATCGAGCACCTGAACGCCACC TTCCAGCCGGCCAAGATCGGCCACCCCCACGGCCTGCAGGTCACCTACCTGAAGGACAACAGCACCCGTAACATCTTCATCTACCATGAG GACGGGAAGGAGATTGTGGACTGGTTCAATGCACTCCGAGCTGCTCGCTTCCACTACCTGCAGGTGGCATTCCCAGGGGCCGGCGACGCA GATCTGGTGCCAAAGCTCTCCAGGAACTACCTGAAGGAAGGCTACATGGAGAAGACGGGGCCCAAGCAAACGGAAGGCTTCCGGAAGCGC TGGTTCACCATGGATGACCGCAGGCTCATGTACTTCAAAGACCCCCTGGACGCCTTCGCCCGAGGGGAAGTCTTCATTGGCAGCAAGGAG AGTGGCTACACGGTGCTGCATGGGTTCCCGCCGTCCACCCAGGGCCACCACTGGCCACATGGCATCACCATCGTCACGCCCGACCGCAAG TTTCTGTTTGCCTGCGAGACGGAGTCCGACCAGAGGGAGTGGGTGGCGGCCTTCCAGAAGGCGGTGGACAGGCCCATGCTGCCCCAGGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_LRP1B_ENST00000389484_chr2_142237965_-_ADAP1_ENST00000265846_chr7_975141_-_3376nt AAAGACAGAACCCCAGAGAAAAACGCTGCCAATTCGTTGCTTTATTGTTCCCTGCCTGGGGACCTCAATAGCCTTTTCCATTAACCTTCC CTTCTTACGCAACGGTTAATGACTTTGGGGGTTGTTTTGCTTTCTGTTTCTGCTGAGTCACTAAATTTTGCCTCTTTGTCCCCAGGTGCT GCTCAGCATAAAAGTTAAAAGTGCAATTCAGGAAGTACTGGGATTCTGTGTAGAGCCGAGGAAACCATTTCCCTAAGAGAAGCTCTGTTC CTTGGCTTGTCCTTCCTTCCCGGGAAGGAAGCTTCCGAGGAACGAAGGGAGAAGCTTTGTTTTGCCTGCAGAAGCAGCCCTGTGCTCGGC TGAGGGTTCTCAGCTGGCTGTGAACTGCGGAGCATTGTAGGCGCCTGGCTGGCTCAGGCCAATGCAGAAGTCTCTCCCTTCTCCAAAGAC CCAAATCCCCACAGAACCAGCTTCGAGTTACTTTCCCTTCAAGGGGATTAAAATAATTGTGATTTGTGGCGCTCTCCGTTCGCGGTGGTA TTTTCCTGTTGTGTTAAATGCCTCTTATTAAGTAATAGATGTGATTTATGTGAACGACGAAGGGGTGTGTGGTGGATTCGGTGATTAATC AGTGAATTCCCATCCGCTGGCATCTCTCACTGCCCCTCTTGCGTGATGTAAGATCAGACGTACCCTGCATTGAAAAGTCAAGACACACGG GCGTCTCGCTCGCGCTCACACACGCTCTGCCTCCTCTCTCCCGCACGCGCGCATCCCTCCACCTTCCACATCCTGCTCCAGGCAGGAGAA GGCTGACTGGCTGGACTCATTGAGCTGAAGAATTTCCAGTGACATTTGTAAATGACGCCGCTCGATTCCAGGCTCCAAGCGGCCCCTGCC GCCGCCGCCGCCGCCGGGCCGAAGGTGCCGCCGAGCAGTCTCCAGCGCAGGCTTCCTTACCGGGCGACCACAATGTCCGAGTTTCTCCTC GCCTTACTCACTCTCTCGGGATTATTGCCGATTGCCAGGGTGCTGACCGTGGGAGCCGACCGAGATCAGCAGTTGTGTGATCCTGGTGAA TTTCTTTGCCACGATCACGTGACTTGTGTCTCCCAGAGCTGGCTGTGTGATGGGGACCCTGACTGCCCTGATGATTCAGACGAGTCTTTA GATACCTGTCCCGAGGAGGTAGAAATCAAGTGCCCCTTGAATCACATTGCTTGCCTTGGTACCAACAAATGTGTTCATTTATCCCAGCTG TGCAATGGTGTCTTGGACTGCCCAGATGGGTATGACGAAGGAGTACATTGTCAGGATCCCGACTGGGCCTCCTACACTCTGGGCGTCTTC ATCTGCCTGAGCTGCTCGGGAATCCACCGGAATATCCCCCAGGTCAGCAAGGTGAAGTCCGTCCGCCTGGACGCCTGGGAGGAGGCCCAA GTGGAGTTCATGGCCTCCCACGGGAACGACGCCGCGAGAGCCAGGTTTGAGTCCAAAGTACCCTCCTTCTACTACCGGCCCACGCCCTCC GACTGCCAGCTCCTTCGAGAGCAGTGGATCCGGGCCAAGTACGAGCGACAGGAGTTCATCTACCCGGAGAAGCAGGAGCCCTACTCGGCA GGGTACCGTGAGGGTTTTCTCTGGAAGCGTGGCCGGGACAACGGGCAGTTTTTGAGCCGGAAGTTTGTGCTGACAGAACGAGAGGGTGCT CTGAAGTATTTCAACAGAAATGATGCCAAGGAGCCCAAGGCCGTGATGAAGATCGAGCACCTGAACGCCACCTTCCAGCCGGCCAAGATC GGCCACCCCCACGGCCTGCAGGTCACCTACCTGAAGGACAACAGCACCCGTAACATCTTCATCTACCATGAGGACGGGAAGGAGATTGTG GACTGGTTCAATGCACTCCGAGCTGCTCGCTTCCACTACCTGCAGGTGGCATTCCCAGGGGCCGGCGACGCAGATCTGGTGCCAAAGCTC TCCAGGAACTACCTGAAGGAAGGCTACATGGAGAAGACGGGGCCCAAGCAAACGGAAGGCTTCCGGAAGCGCTGGTTCACCATGGATGAC CGCAGGCTCATGTACTTCAAAGACCCCCTGGACGCCTTCGCCCGAGGGGAAGTCTTCATTGGCAGCAAGGAGAGTGGCTACACGGTGCTG CATGGGTTCCCGCCGTCCACCCAGGGCCACCACTGGCCACATGGCATCACCATCGTCACGCCCGACCGCAAGTTTCTGTTTGCCTGCGAG ACGGAGTCCGACCAGAGGGAGTGGGTGGCGGCCTTCCAGAAGGCGGTGGACAGGCCCATGCTGCCCCAGGAGTACGCAGTGGAGGCGCAC TTCAAGCATAAACCTTAGCGAGTGCGGCTGGAGGACCACGGACATTGGACTCACTGTGGCTGGACGGAGGGGACCCGTGGATGGGGGGGC TCTGGCGTCCTGAGGCCACCTGGCCCCACCTGCTCCTCAGGGCAGCCCGGCGCGGCCAGGTAGGGCCCGAGCTTCAGCTTCCAGGATGCT TCTCTGGAACCTCAAGGCAGGCAGCCCAGGCCCTGGGCCTGATCTCTAACCCCGTCATGCTGCTGCTGACCACACCCAGCCAACCTGCCC CTCCCTGACCCGGGGCCCCCTTTCCTCCAGGGCCCAGTCTGGCTCCCGAGCTCAGACACAGCCCCCAGGAGCCGCCCACCACGGCTGTGG GAACTTCCAGGCCTCAGCGCAGAGCCCTGCTTGGGGCCAGCACGGTGGGCAGCTGCCGGCCGCTGGGGACTGGGCCCTGCTCGCATGCCG CCCCGCCCTCCCCCCACCTCCACGACTATTTATTGAGCGCCTGTTGTGTGTCACGGGGCTATGAGGGCCGTGGGGTGTTTGGGTGGATTA TCCACACAGGTCCCGGCCCCTGCCCGGGCTGGAGTTGCCACAGCCTGTGCTCCTGGTCCTCACCTGGAGGGGCCAGCAGGCTGCCGTCCC ACCACACGTGGCCTCTGCGCCCAGCACGGTGCTCGCCGACAGTGGTGTCTGAACCCTTGGGGACGAGGGCCTGGGCCGCGGTGAGGCCAC CAGAGGCAGGAGTGGCCCTGGGGGTCCCGGGCACTGTCGCGCTTGCTGCAGGCGGCCCAGCCGTGTATTTATTTTTCACCTATCTCCTTC CTGTCAAGGCAGGCCGGGCTCCAGGGCTCCCCTTGCGTGGGGCATGTAGGTGGGGGAGGCGTCTGCAGGTCACCTGGGGGGCCCAGCCCT CTCCCAGCCTTGCCTGGCTGAGCTGTGTTCCAGGGGAGCCCTGGACAAGCCCTCATAGGCAGGGAGGGGGTTTCCGAGGCCAGGCATCCG |
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FusionGenePPI for LRP1B_ADAP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LRP1B | ARRB1, CUL4B, TAZ, RSPO1, SFRP4, PTPRK, FOXD4L6, ZFP41, EWSR1, LRPAP1, ZNF408, ZNF224, ZNF331, FAM19A3, ZNF563, ZNF517, ZNF169, SCGB1D1, DNAJC10, CHRDL1, OLFM3, EGFL6, TRIM25 | ADAP1 | PRKCI, PRKCZ, PIK3CA, PRKD1, PRKCE, PSME3, CSNK1A1, NCL, ANP32A, GSK3B, GADD45A, RANBP9, DVL3, GOLGA2, SDCBP2, ARF6 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LRP1B_ADAP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LRP1B_ADAP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | LRP1B | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| Hgene | LRP1B | C0025202 | melanoma | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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