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Fusion gene ID: 20100 |
FusionGeneSummary for LRIG3_FRS2 |
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Fusion gene information | Fusion gene name: LRIG3_FRS2 | Fusion gene ID: 20100 | Hgene | Tgene | Gene symbol | LRIG3 | FRS2 | Gene ID | 121227 | 10818 |
Gene name | leucine rich repeats and immunoglobulin like domains 3 | fibroblast growth factor receptor substrate 2 | |
Synonyms | LIG3 | FRS1A|FRS2A|FRS2alpha|SNT|SNT-1|SNT1 | |
Cytomap | 12q14.1 | 12q15 | |
Type of gene | protein-coding | protein-coding | |
Description | leucine-rich repeats and immunoglobulin-like domains protein 3LIG-3 | fibroblast growth factor receptor substrate 2FGFR signalling adaptorFGFR substrate 2FGFR-signaling adaptor SNTsuc1-associated neurotrophic factor target 1 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q6UXM1 | Q8WU20 | |
Ensembl transtripts involved in fusion gene | ENST00000379141, ENST00000320743, | ENST00000299293, ENST00000549921, ENST00000550389, ENST00000397997, | |
Fusion gene scores | * DoF score | 7 X 3 X 4=84 | 15 X 6 X 4=360 |
# samples | 7 | 14 | |
** MAII score | log2(7/84*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(14/360*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LRIG3 [Title/Abstract] AND FRS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-DX-A6BF-01A | LRIG3 | chr12 | 59307763 | - | FRS2 | chr12 | 69924645 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000379141 | ENST00000299293 | LRIG3 | chr12 | 59307763 | - | FRS2 | chr12 | 69924645 | + |
5CDS-5UTR | ENST00000379141 | ENST00000549921 | LRIG3 | chr12 | 59307763 | - | FRS2 | chr12 | 69924645 | + |
5CDS-intron | ENST00000379141 | ENST00000550389 | LRIG3 | chr12 | 59307763 | - | FRS2 | chr12 | 69924645 | + |
5CDS-5UTR | ENST00000379141 | ENST00000397997 | LRIG3 | chr12 | 59307763 | - | FRS2 | chr12 | 69924645 | + |
5CDS-5UTR | ENST00000320743 | ENST00000299293 | LRIG3 | chr12 | 59307763 | - | FRS2 | chr12 | 69924645 | + |
5CDS-5UTR | ENST00000320743 | ENST00000549921 | LRIG3 | chr12 | 59307763 | - | FRS2 | chr12 | 69924645 | + |
5CDS-intron | ENST00000320743 | ENST00000550389 | LRIG3 | chr12 | 59307763 | - | FRS2 | chr12 | 69924645 | + |
5CDS-5UTR | ENST00000320743 | ENST00000397997 | LRIG3 | chr12 | 59307763 | - | FRS2 | chr12 | 69924645 | + |
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FusionProtFeatures for LRIG3_FRS2 |
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Hgene | Tgene |
LRIG3 | FRS2 |
May play a role in craniofacial and inner earmorphogenesis during embryonic development. May act within theotic vesicle epithelium to control formation of the lateralsemicircular canal in the inner ear, possibly by restricting theexpression of NTN1 (By similarity). {ECO:0000250}. | Adapter protein that links activated FGR and NGFreceptors to downstream signaling pathways. Plays an importantrole in the activation of MAP kinases and in the phosphorylationof PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1.Modulates signaling via SHC1 by competing for a common bindingsite on NTRK1. {ECO:0000269|PubMed:12974390,ECO:0000269|PubMed:21765395}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LRIG3_FRS2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LRIG3_FRS2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LRIG3 | CAND1, TAZ, TNFSF13B, PVRIG, GINM1, LPAR6, PTPRK, PTGER3, GAL3ST1, LRIG1, LRRN2, TMPRSS3 | FRS2 | PTPN11, INSR, SOS1, GRB2, CBL, FGFR1, CRK, NTRK1, NTRK2, NTRK3, RET, PRKCI, FGFR2, FLOT1, SORBS1, SPRY2, LYN, BECN1, RPS6, TMEM17, GAB1, GAB2, CDH1, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LRIG3_FRS2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LRIG3_FRS2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |