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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20100

FusionGeneSummary for LRIG3_FRS2

check button Fusion gene summary
Fusion gene informationFusion gene name: LRIG3_FRS2
Fusion gene ID: 20100
HgeneTgene
Gene symbol

LRIG3

FRS2

Gene ID

121227

10818

Gene nameleucine rich repeats and immunoglobulin like domains 3fibroblast growth factor receptor substrate 2
SynonymsLIG3FRS1A|FRS2A|FRS2alpha|SNT|SNT-1|SNT1
Cytomap

12q14.1

12q15

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeats and immunoglobulin-like domains protein 3LIG-3fibroblast growth factor receptor substrate 2FGFR signalling adaptorFGFR substrate 2FGFR-signaling adaptor SNTsuc1-associated neurotrophic factor target 1
Modification date2018052320180522
UniProtAcc

Q6UXM1

Q8WU20

Ensembl transtripts involved in fusion geneENST00000379141, ENST00000320743, 
ENST00000299293, ENST00000549921, 
ENST00000550389, ENST00000397997, 
Fusion gene scores* DoF score7 X 3 X 4=8415 X 6 X 4=360
# samples 714
** MAII scorelog2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/360*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRIG3 [Title/Abstract] AND FRS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A6BF-01ALRIG3chr12

59307763

-FRS2chr12

69924645

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000379141ENST00000299293LRIG3chr12

59307763

-FRS2chr12

69924645

+
5CDS-5UTRENST00000379141ENST00000549921LRIG3chr12

59307763

-FRS2chr12

69924645

+
5CDS-intronENST00000379141ENST00000550389LRIG3chr12

59307763

-FRS2chr12

69924645

+
5CDS-5UTRENST00000379141ENST00000397997LRIG3chr12

59307763

-FRS2chr12

69924645

+
5CDS-5UTRENST00000320743ENST00000299293LRIG3chr12

59307763

-FRS2chr12

69924645

+
5CDS-5UTRENST00000320743ENST00000549921LRIG3chr12

59307763

-FRS2chr12

69924645

+
5CDS-intronENST00000320743ENST00000550389LRIG3chr12

59307763

-FRS2chr12

69924645

+
5CDS-5UTRENST00000320743ENST00000397997LRIG3chr12

59307763

-FRS2chr12

69924645

+

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FusionProtFeatures for LRIG3_FRS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRIG3

Q6UXM1

FRS2

Q8WU20

May play a role in craniofacial and inner earmorphogenesis during embryonic development. May act within theotic vesicle epithelium to control formation of the lateralsemicircular canal in the inner ear, possibly by restricting theexpression of NTN1 (By similarity). {ECO:0000250}. Adapter protein that links activated FGR and NGFreceptors to downstream signaling pathways. Plays an importantrole in the activation of MAP kinases and in the phosphorylationof PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1.Modulates signaling via SHC1 by competing for a common bindingsite on NTRK1. {ECO:0000269|PubMed:12974390,ECO:0000269|PubMed:21765395}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LRIG3_FRS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LRIG3_FRS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LRIG3CAND1, TAZ, TNFSF13B, PVRIG, GINM1, LPAR6, PTPRK, PTGER3, GAL3ST1, LRIG1, LRRN2, TMPRSS3FRS2PTPN11, INSR, SOS1, GRB2, CBL, FGFR1, CRK, NTRK1, NTRK2, NTRK3, RET, PRKCI, FGFR2, FLOT1, SORBS1, SPRY2, LYN, BECN1, RPS6, TMEM17, GAB1, GAB2, CDH1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LRIG3_FRS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LRIG3_FRS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource