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Fusion gene ID: 2010 |
FusionGeneSummary for AOAH_GUSBP3 |
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Fusion gene information | Fusion gene name: AOAH_GUSBP3 | Fusion gene ID: 2010 | Hgene | Tgene | Gene symbol | AOAH | GUSBP3 | Gene ID | 313 | 653188 |
Gene name | acyloxyacyl hydrolase | glucuronidase, beta pseudogene 3 | |
Synonyms | - | GUSBP1|SMA3 | |
Cytomap | 7p14.2 | 5q13.2 | |
Type of gene | protein-coding | pseudo | |
Description | acyloxyacyl hydrolaseacyloxyacyl hydrolase (neutrophil) | Putative inactive beta-glucuronidase-like protein SMA3 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P28039 | ||
Ensembl transtripts involved in fusion gene | ENST00000535891, ENST00000258749, ENST00000431169, ENST00000538464, ENST00000491444, | ENST00000513408, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 1 X 1 X 1=1 |
# samples | 3 | 1 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: AOAH [Title/Abstract] AND GUSBP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | AOAH | GO:0006631 | fatty acid metabolic process | 1883828|29343645 |
Hgene | AOAH | GO:0009104 | lipopolysaccharide catabolic process | 1883828|29343645 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BI019996 | AOAH | chr7 | 36557833 | + | GUSBP3 | chr5 | 69414291 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000535891 | ENST00000513408 | AOAH | chr7 | 36557833 | + | GUSBP3 | chr5 | 69414291 | + |
intron-intron | ENST00000258749 | ENST00000513408 | AOAH | chr7 | 36557833 | + | GUSBP3 | chr5 | 69414291 | + |
intron-intron | ENST00000431169 | ENST00000513408 | AOAH | chr7 | 36557833 | + | GUSBP3 | chr5 | 69414291 | + |
intron-intron | ENST00000538464 | ENST00000513408 | AOAH | chr7 | 36557833 | + | GUSBP3 | chr5 | 69414291 | + |
intron-intron | ENST00000491444 | ENST00000513408 | AOAH | chr7 | 36557833 | + | GUSBP3 | chr5 | 69414291 | + |
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FusionProtFeatures for AOAH_GUSBP3 |
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Hgene | Tgene |
AOAH | GUSBP3 |
Removes the secondary (acyloxyacyl-linked) fatty acylchains from the lipid A region of bacterial lipopolysaccharides(PubMed:1883828, PubMed:8089145, PubMed:29343645). By breakingdown LPS, terminates the host response to bacterial infection andprevents prolonged and damaging inflammatory responses (Bysimilarity). In peritoneal macrophages, seems to be important forrecovery from a state of immune tolerance following infection byGram-negative bacteria (By similarity).{ECO:0000250|UniProtKB:O35298, ECO:0000269|PubMed:1883828,ECO:0000269|PubMed:29343645, ECO:0000269|PubMed:8089145}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AOAH_GUSBP3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for AOAH_GUSBP3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AOAH_GUSBP3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AOAH_GUSBP3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | AOAH | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |