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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20097

FusionGeneSummary for LRIG3_ATF7

check button Fusion gene summary
Fusion gene informationFusion gene name: LRIG3_ATF7
Fusion gene ID: 20097
HgeneTgene
Gene symbol

LRIG3

ATF7

Gene ID

121227

11016

Gene nameleucine rich repeats and immunoglobulin like domains 3activating transcription factor 7
SynonymsLIG3ATFA
Cytomap

12q14.1

12q13.13

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeats and immunoglobulin-like domains protein 3LIG-3cyclic AMP-dependent transcription factor ATF-7transcription factor ATF-A
Modification date2018052320180519
UniProtAcc

Q6UXM1

P17544

Ensembl transtripts involved in fusion geneENST00000379141, ENST00000320743, 
ENST00000548446, ENST00000420353, 
ENST00000415113, ENST00000456903, 
ENST00000548118, ENST00000591397, 
ENST00000328463, ENST00000546661, 
Fusion gene scores* DoF score7 X 3 X 4=848 X 6 X 5=240
# samples 710
** MAII scorelog2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/240*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRIG3 [Title/Abstract] AND ATF7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneATF7

GO:0006355

regulation of transcription, DNA-templated

8288576


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPAADTCGA-HZ-A49I-01ALRIG3chr12

59307763

-ATF7chr12

53994805

-
TCGALDPAADTCGA-HZ-A4BK-01ALRIG3chr12

59307763

-ATF7chr12

53994805

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000379141ENST00000548446LRIG3chr12

59307763

-ATF7chr12

53994805

-
5CDS-5UTRENST00000379141ENST00000420353LRIG3chr12

59307763

-ATF7chr12

53994805

-
5CDS-5UTRENST00000379141ENST00000415113LRIG3chr12

59307763

-ATF7chr12

53994805

-
5CDS-5UTRENST00000379141ENST00000456903LRIG3chr12

59307763

-ATF7chr12

53994805

-
5CDS-5UTRENST00000379141ENST00000548118LRIG3chr12

59307763

-ATF7chr12

53994805

-
5CDS-5UTRENST00000379141ENST00000591397LRIG3chr12

59307763

-ATF7chr12

53994805

-
5CDS-5UTRENST00000379141ENST00000328463LRIG3chr12

59307763

-ATF7chr12

53994805

-
5CDS-intronENST00000379141ENST00000546661LRIG3chr12

59307763

-ATF7chr12

53994805

-
5CDS-5UTRENST00000320743ENST00000548446LRIG3chr12

59307763

-ATF7chr12

53994805

-
5CDS-5UTRENST00000320743ENST00000420353LRIG3chr12

59307763

-ATF7chr12

53994805

-
5CDS-5UTRENST00000320743ENST00000415113LRIG3chr12

59307763

-ATF7chr12

53994805

-
5CDS-5UTRENST00000320743ENST00000456903LRIG3chr12

59307763

-ATF7chr12

53994805

-
5CDS-5UTRENST00000320743ENST00000548118LRIG3chr12

59307763

-ATF7chr12

53994805

-
5CDS-5UTRENST00000320743ENST00000591397LRIG3chr12

59307763

-ATF7chr12

53994805

-
5CDS-5UTRENST00000320743ENST00000328463LRIG3chr12

59307763

-ATF7chr12

53994805

-
5CDS-intronENST00000320743ENST00000546661LRIG3chr12

59307763

-ATF7chr12

53994805

-

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FusionProtFeatures for LRIG3_ATF7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRIG3

Q6UXM1

ATF7

P17544

May play a role in craniofacial and inner earmorphogenesis during embryonic development. May act within theotic vesicle epithelium to control formation of the lateralsemicircular canal in the inner ear, possibly by restricting theexpression of NTN1 (By similarity). {ECO:0000250}. Plays important functions in early cell signaling. Bindsthe cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters.Activator of the NF-ELAM1/delta-A site of the E-selectin promoter.Has no intrinsic transcriptional activity, but activatestranscription on formation of JUN or FOS heterodimers. Also canbind TRE promoter sequences when heterodimerized with members ofthe JUN family. Isoform 4 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5 acts as a negative regulator, inhibiting bothATF2 and ATF7 transcriptional activities. It may exert theseeffects by sequestrating in the cytoplasm the Thr-53phosphorylating kinase, preventing activation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LRIG3_ATF7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LRIG3_ATF7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LRIG3CAND1, TAZ, TNFSF13B, PVRIG, GINM1, LPAR6, PTPRK, PTGER3, GAL3ST1, LRIG1, LRRN2, TMPRSS3ATF7PTP4A1, JDP2, TAF12, TAF4, BCL6, YY1, CREB1, MAPK8, OCIAD1, URI1, TAOK3, MITD1, FCER2, CCDC155, FAM9B, TMEM239, SCGN, CREB5, FOSL2, FOS, PCF11, MBD3, JUN, MEF2A, NFATC1, NFATC2, JUNB, BATF3, ATF2, PSMC5, MLLT6, PPP2R2D, BACH1, ARIH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LRIG3_ATF7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LRIG3_ATF7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource