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Fusion gene ID: 20097 |
FusionGeneSummary for LRIG3_ATF7 |
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Fusion gene information | Fusion gene name: LRIG3_ATF7 | Fusion gene ID: 20097 | Hgene | Tgene | Gene symbol | LRIG3 | ATF7 | Gene ID | 121227 | 11016 |
Gene name | leucine rich repeats and immunoglobulin like domains 3 | activating transcription factor 7 | |
Synonyms | LIG3 | ATFA | |
Cytomap | 12q14.1 | 12q13.13 | |
Type of gene | protein-coding | protein-coding | |
Description | leucine-rich repeats and immunoglobulin-like domains protein 3LIG-3 | cyclic AMP-dependent transcription factor ATF-7transcription factor ATF-A | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q6UXM1 | P17544 | |
Ensembl transtripts involved in fusion gene | ENST00000379141, ENST00000320743, | ENST00000548446, ENST00000420353, ENST00000415113, ENST00000456903, ENST00000548118, ENST00000591397, ENST00000328463, ENST00000546661, | |
Fusion gene scores | * DoF score | 7 X 3 X 4=84 | 8 X 6 X 5=240 |
# samples | 7 | 10 | |
** MAII score | log2(7/84*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/240*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LRIG3 [Title/Abstract] AND ATF7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ATF7 | GO:0006355 | regulation of transcription, DNA-templated | 8288576 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PAAD | TCGA-HZ-A49I-01A | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
TCGA | LD | PAAD | TCGA-HZ-A4BK-01A | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000379141 | ENST00000548446 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
5CDS-5UTR | ENST00000379141 | ENST00000420353 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
5CDS-5UTR | ENST00000379141 | ENST00000415113 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
5CDS-5UTR | ENST00000379141 | ENST00000456903 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
5CDS-5UTR | ENST00000379141 | ENST00000548118 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
5CDS-5UTR | ENST00000379141 | ENST00000591397 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
5CDS-5UTR | ENST00000379141 | ENST00000328463 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
5CDS-intron | ENST00000379141 | ENST00000546661 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
5CDS-5UTR | ENST00000320743 | ENST00000548446 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
5CDS-5UTR | ENST00000320743 | ENST00000420353 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
5CDS-5UTR | ENST00000320743 | ENST00000415113 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
5CDS-5UTR | ENST00000320743 | ENST00000456903 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
5CDS-5UTR | ENST00000320743 | ENST00000548118 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
5CDS-5UTR | ENST00000320743 | ENST00000591397 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
5CDS-5UTR | ENST00000320743 | ENST00000328463 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
5CDS-intron | ENST00000320743 | ENST00000546661 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
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FusionProtFeatures for LRIG3_ATF7 |
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Hgene | Tgene |
LRIG3 | ATF7 |
May play a role in craniofacial and inner earmorphogenesis during embryonic development. May act within theotic vesicle epithelium to control formation of the lateralsemicircular canal in the inner ear, possibly by restricting theexpression of NTN1 (By similarity). {ECO:0000250}. | Plays important functions in early cell signaling. Bindsthe cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters.Activator of the NF-ELAM1/delta-A site of the E-selectin promoter.Has no intrinsic transcriptional activity, but activatestranscription on formation of JUN or FOS heterodimers. Also canbind TRE promoter sequences when heterodimerized with members ofthe JUN family. Isoform 4 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5 acts as a negative regulator, inhibiting bothATF2 and ATF7 transcriptional activities. It may exert theseeffects by sequestrating in the cytoplasm the Thr-53phosphorylating kinase, preventing activation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LRIG3_ATF7 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LRIG3_ATF7 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LRIG3 | CAND1, TAZ, TNFSF13B, PVRIG, GINM1, LPAR6, PTPRK, PTGER3, GAL3ST1, LRIG1, LRRN2, TMPRSS3 | ATF7 | PTP4A1, JDP2, TAF12, TAF4, BCL6, YY1, CREB1, MAPK8, OCIAD1, URI1, TAOK3, MITD1, FCER2, CCDC155, FAM9B, TMEM239, SCGN, CREB5, FOSL2, FOS, PCF11, MBD3, JUN, MEF2A, NFATC1, NFATC2, JUNB, BATF3, ATF2, PSMC5, MLLT6, PPP2R2D, BACH1, ARIH1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LRIG3_ATF7 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LRIG3_ATF7 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |