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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 20094

FusionGeneSummary for LRIG1_PPM1L

check button Fusion gene summary
Fusion gene informationFusion gene name: LRIG1_PPM1L
Fusion gene ID: 20094
HgeneTgene
Gene symbol

LRIG1

PPM1L

Gene ID

26018

151742

Gene nameleucine rich repeats and immunoglobulin like domains 1protein phosphatase, Mg2+/Mn2+ dependent 1L
SynonymsLIG-1|LIG1PP2C-epsilon|PP2CE|PPM1-LIKE
Cytomap

3p14.1

3q25.33-q26.1

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeats and immunoglobulin-like domains protein 1leucine-rich repeat protein LRIG1ortholog of mouse integral membrane glycoprotein LIG-1protein phosphatase 1LPP2C epsilonProtein phosphatase 2C epsilon isoformprotein phosphatase 2C isoform epsilon
Modification date2018052320180519
UniProtAcc

Q96JA1

Q5SGD2

Ensembl transtripts involved in fusion geneENST00000273261, ENST00000383703, 
ENST00000496559, 		ENST00000497343, 
ENST00000498165, ENST00000464260, 
ENST00000295839, ENST00000480117, 
Fusion gene scores* DoF score3 X 3 X 3=272 X 2 X 2=8
# samples 32
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context

PubMed: LRIG1 [Title/Abstract] AND PPM1L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-29-1695-01ALRIG1chr3

66550614

-PPM1Lchr3

160679524

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000273261ENST00000497343LRIG1chr3

66550614

-PPM1Lchr3

160679524

+
In-frameENST00000273261ENST00000498165LRIG1chr3

66550614

-PPM1Lchr3

160679524

+
5CDS-5UTRENST00000273261ENST00000464260LRIG1chr3

66550614

-PPM1Lchr3

160679524

+
5CDS-5UTRENST00000273261ENST00000295839LRIG1chr3

66550614

-PPM1Lchr3

160679524

+
5CDS-3UTRENST00000273261ENST00000480117LRIG1chr3

66550614

-PPM1Lchr3

160679524

+
In-frameENST00000383703ENST00000497343LRIG1chr3

66550614

-PPM1Lchr3

160679524

+
In-frameENST00000383703ENST00000498165LRIG1chr3

66550614

-PPM1Lchr3

160679524

+
5CDS-5UTRENST00000383703ENST00000464260LRIG1chr3

66550614

-PPM1Lchr3

160679524

+
5CDS-5UTRENST00000383703ENST00000295839LRIG1chr3

66550614

-PPM1Lchr3

160679524

+
5CDS-3UTRENST00000383703ENST00000480117LRIG1chr3

66550614

-PPM1Lchr3

160679524

+
intron-3CDSENST00000496559ENST00000497343LRIG1chr3

66550614

-PPM1Lchr3

160679524

+
intron-3CDSENST00000496559ENST00000498165LRIG1chr3

66550614

-PPM1Lchr3

160679524

+
intron-5UTRENST00000496559ENST00000464260LRIG1chr3

66550614

-PPM1Lchr3

160679524

+
intron-5UTRENST00000496559ENST00000295839LRIG1chr3

66550614

-PPM1Lchr3

160679524

+
intron-3UTRENST00000496559ENST00000480117LRIG1chr3

66550614

-PPM1Lchr3

160679524

+

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FusionProtFeatures for LRIG1_PPM1L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRIG1

Q96JA1

PPM1L

Q5SGD2

Acts as a feedback negative regulator of signaling byreceptor tyrosine kinases, through a mechanism that involvesenhancement of receptor ubiquitination and acceleratedintracellular degradation. {ECO:0000269|PubMed:15282549}. Acts as a suppressor of the SAPK signaling pathways byassociating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, andby attenuating the association between MAP3K7/TAK1 and MAP2K4 orMAP2K6. {ECO:0000269|PubMed:17456047}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRIG1chr3:66550614chr3:160679524ENST00000273261-11935_68721094DomainNote=LRRNT
HgeneLRIG1chr3:66550614chr3:160679524ENST00000383703-12035_68721071DomainNote=LRRNT
TgenePPM1Lchr3:66550614chr3:160679524ENST00000295839+0492_3516234DomainPPM-type phosphatase
TgenePPM1Lchr3:66550614chr3:160679524ENST00000464260+1592_351-46182DomainPPM-type phosphatase
TgenePPM1Lchr3:66550614chr3:160679524ENST00000295839+0443_3606234Topological domainCytoplasmic
TgenePPM1Lchr3:66550614chr3:160679524ENST00000464260+151_25-46182Topological domainExtracellular
TgenePPM1Lchr3:66550614chr3:160679524ENST00000464260+1543_360-46182Topological domainCytoplasmic
TgenePPM1Lchr3:66550614chr3:160679524ENST00000295839+0426_426234TransmembraneHelical
TgenePPM1Lchr3:66550614chr3:160679524ENST00000464260+1526_42-46182TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRIG1chr3:66550614chr3:160679524ENST00000273261-119520_524721094Compositional biasNote=Poly-Ser
HgeneLRIG1chr3:66550614chr3:160679524ENST00000383703-120520_524721071Compositional biasNote=Poly-Ser
HgeneLRIG1chr3:66550614chr3:160679524ENST00000273261-119440_491721094DomainNote=LRRCT
HgeneLRIG1chr3:66550614chr3:160679524ENST00000273261-119495_594721094DomainNote=Ig-like C2-type 1
HgeneLRIG1chr3:66550614chr3:160679524ENST00000273261-119599_688721094DomainNote=Ig-like C2-type 2
HgeneLRIG1chr3:66550614chr3:160679524ENST00000273261-119693_779721094DomainNote=Ig-like C2-type 3
HgeneLRIG1chr3:66550614chr3:160679524ENST00000383703-120440_491721071DomainNote=LRRCT
HgeneLRIG1chr3:66550614chr3:160679524ENST00000383703-120495_594721071DomainNote=Ig-like C2-type 1
HgeneLRIG1chr3:66550614chr3:160679524ENST00000383703-120599_688721071DomainNote=Ig-like C2-type 2
HgeneLRIG1chr3:66550614chr3:160679524ENST00000383703-120693_779721071DomainNote=Ig-like C2-type 3
HgeneLRIG1chr3:66550614chr3:160679524ENST00000273261-119116_137721094RepeatNote=LRR 3
HgeneLRIG1chr3:66550614chr3:160679524ENST00000273261-119140_161721094RepeatNote=LRR 4
HgeneLRIG1chr3:66550614chr3:160679524ENST00000273261-119164_185721094RepeatNote=LRR 5
HgeneLRIG1chr3:66550614chr3:160679524ENST00000273261-119189_210721094RepeatNote=LRR 6
HgeneLRIG1chr3:66550614chr3:160679524ENST00000273261-119212_233721094RepeatNote=LRR 7
HgeneLRIG1chr3:66550614chr3:160679524ENST00000273261-119236_257721094RepeatNote=LRR 8
HgeneLRIG1chr3:66550614chr3:160679524ENST00000273261-119260_281721094RepeatNote=LRR 9
HgeneLRIG1chr3:66550614chr3:160679524ENST00000273261-119284_305721094RepeatNote=LRR 10
HgeneLRIG1chr3:66550614chr3:160679524ENST00000273261-119308_329721094RepeatNote=LRR 11
HgeneLRIG1chr3:66550614chr3:160679524ENST00000273261-119332_353721094RepeatNote=LRR 12
HgeneLRIG1chr3:66550614chr3:160679524ENST00000273261-119356_378721094RepeatNote=LRR 13
HgeneLRIG1chr3:66550614chr3:160679524ENST00000273261-119383_404721094RepeatNote=LRR 14
HgeneLRIG1chr3:66550614chr3:160679524ENST00000273261-119407_428721094RepeatNote=LRR 15
HgeneLRIG1chr3:66550614chr3:160679524ENST00000273261-11969_90721094RepeatNote=LRR 1
HgeneLRIG1chr3:66550614chr3:160679524ENST00000273261-11993_114721094RepeatNote=LRR 2
HgeneLRIG1chr3:66550614chr3:160679524ENST00000383703-120116_137721071RepeatNote=LRR 3
HgeneLRIG1chr3:66550614chr3:160679524ENST00000383703-120140_161721071RepeatNote=LRR 4
HgeneLRIG1chr3:66550614chr3:160679524ENST00000383703-120164_185721071RepeatNote=LRR 5
HgeneLRIG1chr3:66550614chr3:160679524ENST00000383703-120189_210721071RepeatNote=LRR 6
HgeneLRIG1chr3:66550614chr3:160679524ENST00000383703-120212_233721071RepeatNote=LRR 7
HgeneLRIG1chr3:66550614chr3:160679524ENST00000383703-120236_257721071RepeatNote=LRR 8
HgeneLRIG1chr3:66550614chr3:160679524ENST00000383703-120260_281721071RepeatNote=LRR 9
HgeneLRIG1chr3:66550614chr3:160679524ENST00000383703-120284_305721071RepeatNote=LRR 10
HgeneLRIG1chr3:66550614chr3:160679524ENST00000383703-120308_329721071RepeatNote=LRR 11
HgeneLRIG1chr3:66550614chr3:160679524ENST00000383703-120332_353721071RepeatNote=LRR 12
HgeneLRIG1chr3:66550614chr3:160679524ENST00000383703-120356_378721071RepeatNote=LRR 13
HgeneLRIG1chr3:66550614chr3:160679524ENST00000383703-120383_404721071RepeatNote=LRR 14
HgeneLRIG1chr3:66550614chr3:160679524ENST00000383703-120407_428721071RepeatNote=LRR 15
HgeneLRIG1chr3:66550614chr3:160679524ENST00000383703-12069_90721071RepeatNote=LRR 1
HgeneLRIG1chr3:66550614chr3:160679524ENST00000383703-12093_114721071RepeatNote=LRR 2
HgeneLRIG1chr3:66550614chr3:160679524ENST00000273261-11935_794721094Topological domainExtracellular
HgeneLRIG1chr3:66550614chr3:160679524ENST00000273261-119816_1093721094Topological domainCytoplasmic
HgeneLRIG1chr3:66550614chr3:160679524ENST00000383703-12035_794721071Topological domainExtracellular
HgeneLRIG1chr3:66550614chr3:160679524ENST00000383703-120816_1093721071Topological domainCytoplasmic
HgeneLRIG1chr3:66550614chr3:160679524ENST00000273261-119795_815721094TransmembraneHelical
HgeneLRIG1chr3:66550614chr3:160679524ENST00000383703-120795_815721071TransmembraneHelical
TgenePPM1Lchr3:66550614chr3:160679524ENST00000497343+0392_351133195DomainPPM-type phosphatase
TgenePPM1Lchr3:66550614chr3:160679524ENST00000498165+0492_351133361DomainPPM-type phosphatase
TgenePPM1Lchr3:66550614chr3:160679524ENST00000295839+041_256234Topological domainExtracellular
TgenePPM1Lchr3:66550614chr3:160679524ENST00000497343+031_25133195Topological domainExtracellular
TgenePPM1Lchr3:66550614chr3:160679524ENST00000497343+0343_360133195Topological domainCytoplasmic
TgenePPM1Lchr3:66550614chr3:160679524ENST00000498165+041_25133361Topological domainExtracellular
TgenePPM1Lchr3:66550614chr3:160679524ENST00000498165+0443_360133361Topological domainCytoplasmic
TgenePPM1Lchr3:66550614chr3:160679524ENST00000497343+0326_42133195TransmembraneHelical
TgenePPM1Lchr3:66550614chr3:160679524ENST00000498165+0426_42133361TransmembraneHelical


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FusionGeneSequence for LRIG1_PPM1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_LRIG1_ENST00000273261_chr3_66550614_-_PPM1L_ENST00000497343_chr3_160679524_+_134aa
MARPVRGGLGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLLQLNMXNLDSQRPLNSI

>In-frame_LRIG1_ENST00000273261_chr3_66550614_-_PPM1L_ENST00000498165_chr3_160679524_+_300aa
MARPVRGGLGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLLQLNMXNLDSQRPLNSI
FRTTRKTKKIVYYLTRPSLNSRFCQLTEKCXKNXLYPMMKQAQRVXLLCYQIKTSLWPTWVTRAGSCVTKMGTLFLCLMITSLTSXRKER
GXREQVVSSVSMAPGGSRESWPCLGPWGIIRXKISTWSSQTQTSXPLTWTSFSLSSXSWHQMVSGMLSAMKKQFDSSRSAWMNLTLGPRA

>In-frame_LRIG1_ENST00000383703_chr3_66550614_-_PPM1L_ENST00000497343_chr3_160679524_+_134aa
MARPVRGGLGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLLQLNMXNLDSQRPLNSI

>In-frame_LRIG1_ENST00000383703_chr3_66550614_-_PPM1L_ENST00000498165_chr3_160679524_+_300aa
MARPVRGGLGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLLQLNMXNLDSQRPLNSI
FRTTRKTKKIVYYLTRPSLNSRFCQLTEKCXKNXLYPMMKQAQRVXLLCYQIKTSLWPTWVTRAGSCVTKMGTLFLCLMITSLTSXRKER
GXREQVVSSVSMAPGGSRESWPCLGPWGIIRXKISTWSSQTQTSXPLTWTSFSLSSXSWHQMVSGMLSAMKKQFDSSRSAWMNLTLGPRA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_LRIG1_ENST00000273261_chr3_66550614_-_PPM1L_ENST00000497343_chr3_160679524_+_404nt
ATGGCGCGGCCGGTCCGGGGAGGGCTCGGGGCCCCGCGCCGCTCGCCTTGCCTTCTCCTTCTCTGGCTGCTTTTGCTTCGGCTGGAGCCG
GTGACCGCCGCGGCCGGCCCGCGGGCGCCCTGCGCGGCCGCCTGCACTTGCGCTGGGGACTCGCTGGACTGCGGTGGGCGCGGGCTGGCT
GCGTTGCCCGGGGACCTGCCCTCCTGGACGCGGAGCCTACTGCAGCTGAATATGTAAAATCTCGACTCCCAGAGGCCCTTAAACAGCATC
TTCAGGACTACGAGAAAGACAAAGAAAATAGTGTATTATCTTACCAGACCATCCTTGAACAGCAGATTTTGTCAATTGACCGAGAAATGC

>In-frame_LRIG1_ENST00000273261_chr3_66550614_-_PPM1L_ENST00000498165_chr3_160679524_+_902nt
ATGGCGCGGCCGGTCCGGGGAGGGCTCGGGGCCCCGCGCCGCTCGCCTTGCCTTCTCCTTCTCTGGCTGCTTTTGCTTCGGCTGGAGCCG
GTGACCGCCGCGGCCGGCCCGCGGGCGCCCTGCGCGGCCGCCTGCACTTGCGCTGGGGACTCGCTGGACTGCGGTGGGCGCGGGCTGGCT
GCGTTGCCCGGGGACCTGCCCTCCTGGACGCGGAGCCTACTGCAGCTGAATATGTAAAATCTCGACTCCCAGAGGCCCTTAAACAGCATC
TTCAGGACTACGAGAAAGACAAAGAAAATAGTGTATTATCTTACCAGACCATCCTTGAACAGCAGATTTTGTCAATTGACCGAGAAATGC
TAGAAAAATTGACTGTATCCTATGATGAAGCAGGCACAACGTGTTTGATTGCTCTGCTATCAGATAAAGACCTCACTGTGGCCAACGTGG
GTGACTCGCGCGGGGTCCTGTGTGACAAAGATGGGAACGCTATTCCTTTGTCTCATGATCACAAGCCTTACCAGTTGAAGGAAAGAAAGA
GGATAAAGAGAGCAGGTGGTTTCATCAGTTTCAATGGCTCCTGGAGGGTCCAGGGAATCCTGGCCATGTCTCGGTCCCTGGGGGATTATC
CGCTGAAAAATCTCAACGTGGTCATCCCAGACCCAGACATCCTGACCTTTGACCTGGACAAGCTTCAGCCTGAGTTCATGATCTTGGCAT
CAGATGGTCTCTGGGATGCTTTCAGCAATGAAGAAGCAGTTCGATTCATCAAGGAGCGCTTGGATGAACCTCACTTTGGGGCCAAGAGCA
TAGTTTTACAGTCATTTTACAGAGGCTGCCCTGACAATATAACAGTCATGGTGGTGAAGTTCAGAAATAGCAGCAAAACAGAAGAGCAGT

>In-frame_LRIG1_ENST00000383703_chr3_66550614_-_PPM1L_ENST00000497343_chr3_160679524_+_404nt
ATGGCGCGGCCGGTCCGGGGAGGGCTCGGGGCCCCGCGCCGCTCGCCTTGCCTTCTCCTTCTCTGGCTGCTTTTGCTTCGGCTGGAGCCG
GTGACCGCCGCGGCCGGCCCGCGGGCGCCCTGCGCGGCCGCCTGCACTTGCGCTGGGGACTCGCTGGACTGCGGTGGGCGCGGGCTGGCT
GCGTTGCCCGGGGACCTGCCCTCCTGGACGCGGAGCCTACTGCAGCTGAATATGTAAAATCTCGACTCCCAGAGGCCCTTAAACAGCATC
TTCAGGACTACGAGAAAGACAAAGAAAATAGTGTATTATCTTACCAGACCATCCTTGAACAGCAGATTTTGTCAATTGACCGAGAAATGC

>In-frame_LRIG1_ENST00000383703_chr3_66550614_-_PPM1L_ENST00000498165_chr3_160679524_+_902nt
ATGGCGCGGCCGGTCCGGGGAGGGCTCGGGGCCCCGCGCCGCTCGCCTTGCCTTCTCCTTCTCTGGCTGCTTTTGCTTCGGCTGGAGCCG
GTGACCGCCGCGGCCGGCCCGCGGGCGCCCTGCGCGGCCGCCTGCACTTGCGCTGGGGACTCGCTGGACTGCGGTGGGCGCGGGCTGGCT
GCGTTGCCCGGGGACCTGCCCTCCTGGACGCGGAGCCTACTGCAGCTGAATATGTAAAATCTCGACTCCCAGAGGCCCTTAAACAGCATC
TTCAGGACTACGAGAAAGACAAAGAAAATAGTGTATTATCTTACCAGACCATCCTTGAACAGCAGATTTTGTCAATTGACCGAGAAATGC
TAGAAAAATTGACTGTATCCTATGATGAAGCAGGCACAACGTGTTTGATTGCTCTGCTATCAGATAAAGACCTCACTGTGGCCAACGTGG
GTGACTCGCGCGGGGTCCTGTGTGACAAAGATGGGAACGCTATTCCTTTGTCTCATGATCACAAGCCTTACCAGTTGAAGGAAAGAAAGA
GGATAAAGAGAGCAGGTGGTTTCATCAGTTTCAATGGCTCCTGGAGGGTCCAGGGAATCCTGGCCATGTCTCGGTCCCTGGGGGATTATC
CGCTGAAAAATCTCAACGTGGTCATCCCAGACCCAGACATCCTGACCTTTGACCTGGACAAGCTTCAGCCTGAGTTCATGATCTTGGCAT
CAGATGGTCTCTGGGATGCTTTCAGCAATGAAGAAGCAGTTCGATTCATCAAGGAGCGCTTGGATGAACCTCACTTTGGGGCCAAGAGCA
TAGTTTTACAGTCATTTTACAGAGGCTGCCCTGACAATATAACAGTCATGGTGGTGAAGTTCAGAAATAGCAGCAAAACAGAAGAGCAGT


* Fusion transcript sequences (Full-length transcript).
>In-frame_LRIG1_ENST00000273261_chr3_66550614_-_PPM1L_ENST00000497343_chr3_160679524_+_1226nt
GCTCTCTGGCCGCGGCGTGGGGACAGCGAGGCGCACTGGGGCCTCCCAGCGCGGGGCCGGCCGCGCCGTCCAGCCCGAGGTCTACGGCTT
TGCGCTCCGAGCCCAGAGGAAGATGCCTGCCGGCACCGAGCTCGGGCTGCGGGGCTGAACGCCTGTCTTCCAGGCGCAGCGGCAGCACTG
CCCTCGGCCGGTGTCGGTAGCGGCACTCGGCGTGCCCCGGGCGGACGAAGAGCGCAGGCTGGGTACACCTTGCCCGAATCGGCGGAGTTC
GCAGCTAGCGCGGGCGGGCCGGCCGGCCCGGATGGGCGCGGGGTTTGCGGCCCCCGCCGGGTGCTCCGGAGCGGCCCGGGCACCGGGGGC
ACGCTGAGTGCCGGAGCCGCGGCCGCAGAGAGAACTTGGGGCGGGGGCCATGCCCCGGTGCGGAGTCTAGAGCCGAGCGGAGCGCCCCGC
GGGCCCGCCCGCGTCTGCGGCCGTTCGGGTCCTCACAGTCCCCGCGCCCGGAGTTCGCAGCGCGCTCCAGACAAGATGGCGCGGCCGGTC
CGGGGAGGGCTCGGGGCCCCGCGCCGCTCGCCTTGCCTTCTCCTTCTCTGGCTGCTTTTGCTTCGGCTGGAGCCGGTGACCGCCGCGGCC
GGCCCGCGGGCGCCCTGCGCGGCCGCCTGCACTTGCGCTGGGGACTCGCTGGACTGCGGTGGGCGCGGGCTGGCTGCGTTGCCCGGGGAC
CTGCCCTCCTGGACGCGGAGCCTACTGCAGCTGAATATGTAAAATCTCGACTCCCAGAGGCCCTTAAACAGCATCTTCAGGACTACGAGA
AAGACAAAGAAAATAGTGTATTATCTTACCAGACCATCCTTGAACAGCAGATTTTGTCAATTGACCGAGAAATGCTAGAAAAATTGACTG
TATCCTATGATGAAGCAGTTACTTTTTGAATGACTGCTTGGAGACTGCAAGTAACACCTTAGCTTCAAAATATCTAGTTCATATTAATTC
TAAACTAATTTCGATTTTAAACAAAGACTTTGCTTTAATATACCACTATTCCCTCCCCATTCTCTGTGCTGTTGTCAACCAAATTATATG
CTTATACATTATAATGTCATCAATAATTTCATAATTATTTCTTTATGCATTTATTTTTTAAATTAGAAGAAAAAAGTTAACAAATAAGAT

>In-frame_LRIG1_ENST00000273261_chr3_66550614_-_PPM1L_ENST00000498165_chr3_160679524_+_11177nt
GCTCTCTGGCCGCGGCGTGGGGACAGCGAGGCGCACTGGGGCCTCCCAGCGCGGGGCCGGCCGCGCCGTCCAGCCCGAGGTCTACGGCTT
TGCGCTCCGAGCCCAGAGGAAGATGCCTGCCGGCACCGAGCTCGGGCTGCGGGGCTGAACGCCTGTCTTCCAGGCGCAGCGGCAGCACTG
CCCTCGGCCGGTGTCGGTAGCGGCACTCGGCGTGCCCCGGGCGGACGAAGAGCGCAGGCTGGGTACACCTTGCCCGAATCGGCGGAGTTC
GCAGCTAGCGCGGGCGGGCCGGCCGGCCCGGATGGGCGCGGGGTTTGCGGCCCCCGCCGGGTGCTCCGGAGCGGCCCGGGCACCGGGGGC
ACGCTGAGTGCCGGAGCCGCGGCCGCAGAGAGAACTTGGGGCGGGGGCCATGCCCCGGTGCGGAGTCTAGAGCCGAGCGGAGCGCCCCGC
GGGCCCGCCCGCGTCTGCGGCCGTTCGGGTCCTCACAGTCCCCGCGCCCGGAGTTCGCAGCGCGCTCCAGACAAGATGGCGCGGCCGGTC
CGGGGAGGGCTCGGGGCCCCGCGCCGCTCGCCTTGCCTTCTCCTTCTCTGGCTGCTTTTGCTTCGGCTGGAGCCGGTGACCGCCGCGGCC
GGCCCGCGGGCGCCCTGCGCGGCCGCCTGCACTTGCGCTGGGGACTCGCTGGACTGCGGTGGGCGCGGGCTGGCTGCGTTGCCCGGGGAC
CTGCCCTCCTGGACGCGGAGCCTACTGCAGCTGAATATGTAAAATCTCGACTCCCAGAGGCCCTTAAACAGCATCTTCAGGACTACGAGA
AAGACAAAGAAAATAGTGTATTATCTTACCAGACCATCCTTGAACAGCAGATTTTGTCAATTGACCGAGAAATGCTAGAAAAATTGACTG
TATCCTATGATGAAGCAGGCACAACGTGTTTGATTGCTCTGCTATCAGATAAAGACCTCACTGTGGCCAACGTGGGTGACTCGCGCGGGG
TCCTGTGTGACAAAGATGGGAACGCTATTCCTTTGTCTCATGATCACAAGCCTTACCAGTTGAAGGAAAGAAAGAGGATAAAGAGAGCAG
GTGGTTTCATCAGTTTCAATGGCTCCTGGAGGGTCCAGGGAATCCTGGCCATGTCTCGGTCCCTGGGGGATTATCCGCTGAAAAATCTCA
ACGTGGTCATCCCAGACCCAGACATCCTGACCTTTGACCTGGACAAGCTTCAGCCTGAGTTCATGATCTTGGCATCAGATGGTCTCTGGG
ATGCTTTCAGCAATGAAGAAGCAGTTCGATTCATCAAGGAGCGCTTGGATGAACCTCACTTTGGGGCCAAGAGCATAGTTTTACAGTCAT
TTTACAGAGGCTGCCCTGACAATATAACAGTCATGGTGGTGAAGTTCAGAAATAGCAGCAAAACAGAAGAGCAGTGAACCCTTCAGGGGT
CTCAGCTGCCTTAGACTAAAGGACTTTCAACACACTGGTCTCTTTTAATTTAGTGAAAAGTGTGGGAGTTGTAATTAGGATCATCCACCC
CAGACATGGAATCCCCCCTCCCTGGTGGTCTTAGGTCTATAATCAGTGACGAACAGAGGGTGCCCTTGGCCAATGTAGTTAAGAAACTGG
AAAATGGTTTCTTCATGTTTTCCCAACTCTTTCATCCAGTGTCCAAAATATATAAGTAAATAGCTGTAGAGTCACATATATGAAGTGAAT
AGCATATGTGTCATTTAGTCTCCCTGAAGATTCTTTTCAAGATCCTGTTCAGGGTCCTCCAGGCATCAGCTGTTGTGTCCTCTCTTTGTA
ACAGTGGACAGGACAGACCACCCAGTGCTGCAGGAGACAGGCCACTGCGTCACCTGTGAGTGGTCAGGGGCTGATGTGGCAACACCCTCT
GCCAAGAGACAGAGCTGTCCTGAGAATGCTTTGTCCTTCTGAGCCCATGTTTTCTGCTCAGTAGCAGCTTGGAAGCAGATTTGGAATGGT
TTACTATTTTGGCTGCTCTTGGGGACTGCGAGAAGCAGAGAGAATGAGAGACCAGTGGCAACTGCCTGCACAGCAGAGATAACCCTCTTC
CCTTGCTTCCTTTAATAGTTAAATAGACTTTGTATACCACCTGACCAGCCTTTGTGCATTTATCCTAATCATGCATGACCGTTAACCTTT
TGCTTAGTCCTTACCATATGTAATAGGCAGCTGTTAAATTCACCAACAGATACCCTGATTTTTCATCTTACGTGACCAAGAAACCACGTT
AGGGGAAATGAAAAAAGCAAGCCACAATACCATGATTCCTTCCATTTTCAACAGTAGATGAAGGAAATGATACTGAATGAGTCACAGTGT
TCCCTGGCAAGTAAGCTGTTTGCATTGAGAAAGGAGTGAGCTGGTGAGGTTACCACCCTGAATTGAGCTCCAGCTGCCAGTTTTTGTGTT
TTTCCTTGCCCCTTTCCAAGTGGTTTTCAAGTGTCAGGCAGTGTTCTGAGAAGCAGCAGCCTATAACTGTATGTGTGTTCCTTGAAGCCA
GGTGCAGAGTTCCCAGCTACTGCAGCTTGGGATTTGGTGGGAAACTACTGGGATAAGCTTCTCCTTGACAATGGAAAGGCAGCAGTCTTC
AACATTTGGTTGCAAATCTCCATCCACATCAGGGAGCTTTCCCCAGGCAAATACAAACCGCCCCGTGGCCTGCAGGCCTGCAGGGGAGGC
AGCAAAGGGACCTGGCAGTTGCAACACAGTAAGTCAGGAATTCAAGCGTGAACCCATATTGATAAGTGGGCCAGAATTATTTAGGGGCCT
GGCTTGCTGCTCTCCATTTCCTGTATCGCTAATTTATCATTTTTCCAACCTTGGTATTTTATATTATTTAGAGAAAATGCTGGGTCACTC
TCTTTGCCTAAGGTGACTCAAACAGCCAAACGAAACTTCCGTTGCCTCCCAGCCCTCTGTATCCACCTGGTTTTGTTCTTTCCCTGTGAG
CATTTGTGGTTATAGCTTCCCATATGCCACATTCACCGGCCACCTCCTCGCCGTGGAACCCTGCCCTCTCCCCTCCTGCTGCTGTAGAGT
TTTCCCAAAGCAGTGTCCAGGAGAGAATTTGAGAGAGTGAAGAAATTGCCTTGTAGATGTGGAGGGCTGCAATCTGTCTTGATTTCTCCA
AGCACTTAACTTTCTTTGACTGCACTGAGAATTGCTAATGATTTCCCATGAGATTTGCTTACTTTTGTATACTGTATTTTCCAGCATTAC
AGAACCTTGGTTATTGTTTTTTAGCCATAGAATCTTCTAGTAAAAAATATCTGCCACCATTTTAGATTTAAGCATTTGCCTATGGGGAGA
CACTGAATATGTGGATGTGTGTATTAATATTTGGGGTGGGGACAGGGAAGGGAATGTGGAAAACAAATGCTGGCTGTGAGCAGTGCTGAG
ATGGCCAGGCCAGGCGGCTGAGTTTGCTTGGAAATTCAGGACATTCTGACTCCTAAGAGTTGCCCCCACCCACCATCAAACTGAAATCAG
CACCAATGGTGTCAGCACTTTACAGCCCATAGCCAACTTTCTTTATTTTTAACGTAGCACAAAAATGTATAATAGCAAGGAAAAGACATT
TTTAAATTCCGGTTATTTTTATTGTCTAAAATGAAAGCAACAGTGTTTTGATAAAGATGAAAAAGAAAAGCTACTAAATTAGTAAATCAG
TGGTTACGTGCCCTGCAGAATTTCTTAACAGATGGTGCTGAGTGCACGAGTTACATAACTTTCTCTCTAATTGAGGTTCACAAGGCGTCT
TCTAAATTTTGCTTTGTACAATTAATTCATTTCTGATGTTAACCAAATAGAGTGTATATATCCTACTCCCATTACTGCCTCTTTCCCCCC
TACTATGGCTTGTAGATTTTCAAAAGATAGAAGTTCTAGGCAAAACTGTAGCAGTTTCATTAATAGTTGTTAGGATAGTTATATCTAAAA
TCAGAGTATTTTGTTCCCTTCCTTCTGGAGCTCTCTCTCCCTAGCCCTTTTCCAGCTGTTGGGGATGTGCAGACATCACTCCTGGGGGTG
CCCTATGGTACACTGGCTGCTCCCCAGGGACCTGGGAATGCTGAATCTAGCCATTAGGGAAATTGATTTGAGATGTTTGCATGTGAAGCT
TCCCTAAGCAGCACTGCCAAAGCTTTGGAATTGTCACCCAAGGCTTCCTAGACTCCCTAGCTAGCTCGAGTTCGAATTGCCAATAGTCCC
CATGGTGCCAAATTTTGGGATGGTTTTACAGTCTTTTAGAAATGAAGACAGGAATGGCCATGTGCTTCTGAGACCCCAGCACGATGCCAG
GCCCAGGTCTCCATTAATGCAGTGCTCTGCTGCTGCTCCACTGGCAATTTGTACTCTTAACATAGGTTGGGGGAGGGACAGCTAGGGAAA
TTTTTTTTAATTAATTGTATCTAAAATTCTTTCATCATAGGAATAAACAACACATATAGAAAGCTCCAAAGCTGTTCCCAAGACCTGTAT
TATTTATTTTATATGACCAACTTGCCCCAAGGCAATTAACTCTGAATTGCTGTTCTAATGTGACATATCTGTGTACATATGTACATAGTA
CTGGTAACCAGTGGCTGCATTTTATTCCTTGCTGTGGACTGAGGTATTGGCTTCTTGAATCTTGTATATGTCATAAGAATATTATACAGA
GAGTGTTATAGTGAAGGATGTAAGCTGGATAATTTAAAACAGACCTTATTTCATACAAGTGTAATTATTACATCATTTTGGGTAAATGGC
AAACAGGATTGCATGAGAGTGATGGCATCATCATTTCAATTGAATCTGAAGTGATTCTAGGAAATTGATTCCACTGTTGGATTCTAGGAA
ATTGAGTCCACTGTTTTCCTTTGCGTTTAATTTCCTTTGTGTTTAATTTGACCACAGAAACTTTTTTGAGTAGCACCTAGTAACATTGCA
AGGAACTTGTGTATCAAGGTGTATCTTGATTATCCTGATTTTTTTTGTTCTCTAAGTTGTTGCCAGATCTCTCTTGCAACTGTGTCAATG
AAAGGTCTGTGTTTAGAAAAGGCAGCATATCATTGTATATTTGAAACTATAGGAATATATACTTTGTATAAAACTTTTCCAATGATTTCA
GAAATTCTTTTTTCCTCCTTTTGACCCACAACTAGACTGTTCATACCCTAATAGTTCCCCAAAATTGCCTTAGCATGTCACACCAGCATT
TGTCATCCAGCTCTGGAGAAATGACATGACTGTTAGATACTATGCCTGTTTAATTGCCTCTGGATTAAGTCATTGATAGCTAGACTTTTG
AGCTAGTTAGCTGTAGAAATAATAGAATCCAGTGTTTCCCAAAGTGTGTTCCAAAGAACACAAGTTCCAAAGATGCTCTTCTAAATATAG
GATTCTAGGATGAAATAAGTTTGGAAAACACATACCATCTTAGAAAGTTAGTGAACATGAGCACATCAAAGGCTCTAATTTAAATGTCCT
GTGAGGAGAGAAAAACACAACAAATATCTACTGTCAGTTAGCCCAGTGTTTTCCAGATTAATTTGACCACAGAAACTTTTTTGAGTGGCA
CCTAGTAACACTGCAAGGAACTTGTGTTCTAAAGAACACCCTTTGGGAAATTCTGGTATATTGAAATATTGCTGTGTTTTCATTCACGAT
GACTCTTAGTAGCAGTACAATTTGCAACTTAGAAGCATGAGCCTTTCATATATGAAGCTGACTTGTTAATAAAAGCAGTGTTAAGAAGTA
GTATGACTTAATATGACCAACAGCAGCCTCATATTGATAGCAGAACAATCCTACTTAAAGCTCTAAACATCATCCCCCCCTTTTTTTTTT
TAACGGAATCTCGCTCTGTCACCCAGGCTGGAATGCCGTGGCGCAATGTCAGGTCACTGCAAGCTCCGCCTCCCAGGTTCACACCATTCT
CCTGCCTCAGCCTCCTGAGCAGCTGGGACTACAGGCGGCCTCCACCACACCTGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCA
CCATGTTAGCCAGGATGGTCTTGATATCCTGACCTTGTAATCCACCAGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACT
GCACCCGGCCATCCCTTTCTTTTATATGAATAATGAGCAAGAGCCCTGCCATAGCTAAATATGTCTCAAATTCATTCCAAGATCTTTCCA
TTGCTTTTTTGCAGTTACCTTTGCTTTTTGGGTTGAATCAAAATGAATATTTTTATATTTCATTACTATATGATATTTAAAAATATACAG
AAAATCACAGAAAAGGAAAAACAGAAATTTGATTTTAATTCACTTTTGAAATTTTAACGATTTTTAAAACTAATGATCTGTTATATAATA
ACTGAAATGTAAACTATTAACAGTTATTTACTTTCTTTCCTTTATTGTCCTCTCTGGATTCAGTGAAATAATTTGAAATCAATTAGAGCT
CATACCTTCTAAAACTCCTGTCCCATATCATCCCACCTTTCATGTTTTATGTACATAGTTAAGTTTGGCATGTTATCTCTTGCCTAAAAT
GTGAGGCCTTCCTGTAGTTCCACAGTAGTTACTCTTGGCTGCAGAAATAGGTTTGGGAAGCTATGAGAGATTACCCCAAAGTCATGGATG
AAACAAATCTAGTCGAAAACATGGTACAGAGTGAATTAAGGCAAAAGTCATTAACTTAAAATTACATCCAATATTTAGGAATAGCTCATC
CTCTGCACATTATCCAAAATATTTTAAAAAACTAAAAGTAAGATCTCTTAGGCTAGGTGGCGGATTGCAAAGGGCAGGGGGCAGTTGATA
CCATGAAGCTTCCAATAGATGCATTTCTAAACATTTTTTCTAATATGTAAATTTGCTGATCCTTAGTAATGTTAATGCTTTGTCTATTTG
TTATTTTTACCACTGTTGAACAGCAAACTGTTGAGGCTAGGGTTGATTATTGATAATTTTTATGTGTTTAGTAATAACCACAGCATCATA
CGTACAACTGCTTTAATAAATCCAAGTTAAGGACTTTGAGGAGAGCATGTAGCAAGTATTCATTTTAACAAATCATCACAGACAGTTTCC
CTGTTCAAAGCTCCACCAAAAAGCAAGCATGCAGCAAAGGCATAGACTGTATTTAGAGATGTGGTTTCATTTATTCTTGAAGTCCTATAA
CCTTGCATTATTTAAACACAAAATCCCACCTAACATTTGCCAAATCCAAGTTAATCTCAAAAACCTCCGAGGACATTGAGCACAAGCAGA
TTACTGTAAGGGCACTGGTGGCAGATTGTGGTGGAGAGAGGGCTGAGTGACCCAGAGCAAAGCCTGCCCGGGTTACTCGCTGCCACTTCA
GGAGAGGGATTGTATCAGCTCTCATTACCTTTTGTCATGAGGCAGTTCATAAATTAAATATGATATCATGCATTATCTCAAAATATTTCT
ATATTAATTAGATAATTCACGATGTAAAACGTGTTCATGCAGAAGCAAAGGCGGATGTAATAGTCAAGTATCAGGGAAAAACCCCTTTAG
GATACCCAGACATTAAAAATGTAAAAAGTAGCTTATAAGAAATGTGGATTATCAGATTTTTACTATATATAGGTTGTGTTTAATAGTAAT
TTCTGACACCTGCACATAGATGAAGAAAAGGCAGTTGTTACCACTTTTCACCATTCAAAAAATGGGCTTGTCTCTTAGAGTATTGGTTAA
TGCTTTGCTTATTTGTTAATGAAGACAGCATTTTAATTTTAAAGCTTCCTTTTGTAGGACTGATGGCACGGGCAGAATCACATTTAAGAA
AAATGGTTTGGAACACTTTTTAATAAAAAATTGTAAAATCAGTTTCCAGTGTGGTCAAAATTAGAATGTAAAGGAAAGCATTTTTAAGAA
AATACAGAAGCCCAAATCAAGGGAGAGTAATATAAAAGGAAATATTTTAAATTAAGAAAAGGAGGTGTTATAGTTTATTACATCATGAAT
TATGCTTTCTGTACTTACGCTCTTAGTGAAGGAGATAACATTGAAGTGAGAAAATGAACATTCTCAGTTATTTGCGAAGTTAGTAAAATT
GCAGTCCCTATTCCATTTTTTTCTGATGAAAATGGATACATGAGATCTCATTTATTGCTCTCCTCAACACCTTTACTGTCCCAGATTCCA
TTCACGTTCCAAATCGTGGACAGTAAAACTGAAGTCAGATAAACACAGTCACAGGTACAACTGGGAGCGAGTTTTAACATAGTGGTAATT
TTGCAAATGCCAACATGAATACTAGTGAGTACTCAATTTACGACAGACAATTTCACAAAAACCAACCACAGAGTGATTTGATATTCTTGC
TTCTTAGAGAGTTTTCTAATCCATATAATGCAATGGGTCAGGTTGCTCATATGATTAAAAAAATTAATCCTGTAGAAATGATGTATTAGA
CATCTCTAACCCAAGAAAAAGATGTCTTTTGTATAACTTTTAAATTCCCATTTGTCTATCTTAGGACAAATGATGACTTCTTCGTGTAGT
AATGAAAACGTCTAAATCCTGCTCTGTGGAGAAAAGCTAGAACCATGGGACATTAAGCAAGAATACTCCTCTGATTTAGGCTCCCAGACT
ACAACTAACAGTCTTTATGTATTTATCATCTTGGTTATTGTTTTATCTCAAGCATATACAGTGTGCAGAAAGTAGAATAATGAATAAAAT
ATGACCATGGAGAAAACCCATAACTTTTGCTTCTATTATAGAAAGCAGTGTTTGTTCTTTTTAATTTATTACATGTTCACATTGAAACAT
TAACATCTACAATATTGTCTTTCAGTTTACTCTTCAATTACTAAAGCAAATGATTTTGATTTATAGCACTTACACAACTGCAGTTCAGGT
CACAGAATTGAAATCTATTTGATAATGTCTCAGCATTCTCATGGGCAGCCAGGAAAAAAAAAAAGAGAGAGAAAGACAAATAGAAATTTT
AGTGGGTTCAGATAAATGATTATTCTGACAAACCTGGAAAATAGTAATTAAACAGTTCATTCCAAAAGACCCCAATGTAAACTCTGCTCA
CATACATAATTTGTATAAGGAAAATGTATGAGTTTTTTTCTTAAAAATAAATAGAAGCATCATTGCATTTATAACAGATTGATCAATCTT
ATGAACAGATTACATTGGGAAAGTCACTATTATTGCTGTGTGTTTGTATATTTTATTCTTTCCTTTTTTGTGTGAGCATCTACTATGTGC
CAGGCAGTGACTGTGTCTGAGTGAATGTATCCATGGTGAGCACTCAGGCGCCATCACTGCCTTCTTGGGGCTTACACCCTATTGGGGTGT
CAGAGATATTATAACACTCAATATTGACCCAATGGGATGAAAATTGTTATCTTCATGATTTCTTCCAATGGGCTTAGATTTGTTGGGACA
GGGCAGAATTAGAATAATTATTTCTCACATATAAGAGTAAGTGATATGAGATTGGGAATTTCTTGCCAACACTCAAGCAAACTGCAGAAG
ATAATTACTCCATTTTACTAGCTCACCTAGTTTCTGAAGGATGGGGTGGGGAGTGAGACATGGAGCCTCTGGGGACAAGGATAGGGGGGT
GGGACTGTCCCAGTGGAGGGTGCCACTGGAAGCCTCCACCCAAGTGGGCCAGCAGCTGTGCAAGGGTGCAGCAGTAGGCTGGTGAAAGCC
AGGTTGTCCAGATCTTTCTAGGGGAAGAGAAGGATTATAGAAAAGGAGAAAAGGGAGGAGCAAGAACATCTCTCCATGGCCTATTTTTAT
TTTTGTTCCCAAGAGACTAGTGTAATAACCTTATGCCCCCAAAGACAGCCCAGAACTGAGTATCTTCAGTGTTCCTGAGTGTAAATCAGT
GAATCTGTTATATAGAAAGTTAACATTTCAGGAGCACAATTATTTCCTGATTTCAAATATGAACAGAAGACTAAATGTCATTTTTTTAAA
TCATAAATTTGGTATCCATAGTTACTTTACACATTCCAGAGTCTAAGCATGGAATTTAAGTTTTGTATTTTGAACAAAAATAGCAACATC
TGTTTTCTGTATGGCAAAGAAAAACTAAATCCCAGACTTTTATTTTTAACCACAGAAACCATCACTTCTTTCTAAATTATTTGCTTGCCT
GCTCATTTCCCCTAAACATCTCTGTTTATGCCAATGGCTTTTTAAATCCAAATAATACTAGTTATTGCCAAATTGCATTAGAATCCTATT
GAATTAGAATAATTCATATACTTCATATACTAGGCAGTAAATGGTTAGAGACGGTAAAGATCTGATTGTGATCAAAAGTAGGGTTTTTGT
TTTGTTTTTAATCATGAGCACATATAAAAGGAAATTCAAATGAAACCAAGCCAATTTCTGATTTAGTAAGATTAAAACCATAGATGGAGC
TCAGTTATTAAGGATGGAAAGGAGGAAAGCACAGAGTGAGGAGAGAAAAAGGGGAAGGAAAAAAAGTAGTGTTTTTTTGGGGAACAGTAT
AATGTCTCAGAAGTTCTTCTCTCTTATCCTGCTGATGTTGAGACAGTGGCTTTGTATAAGCTTTTATTTATACCTATTTCAACATCATGA
AAATTTTTCCATCAGCATTTTCTTGCAACTTTAAAAATCACAAGGGATTATTTGTTTATAAAGAGATACAGGATCTATAATTTATTGGCA
ATACTTTATTTTAGGAATCTTCAAATTGTACTTAATAAATAAATCACAGGTCAAAATGACTGTAAAATCAATCAGGCTTTCTCGTAAGTT
ATTTCCTGAAAACCATCCATGATAAATACAACAAGGCTTGGCGAAACCTCATTACTCTTGGAAGTCTTCAGAGGTTATTATACCTACTGA
TCTGTATTTGTCTCTAAGAGACATTTGAAACACAGTTACAATGTCAATTTGGTGTAACATTACCTGTAGTAGAGCTCAGAGTATATGGCA
GTGCACGGTCACTCAAGATGCATGGCGTGTCATTTGGGTCGCTTTGATGGGTGCTCGGGTAGAATTAGCCTTGTAGAGACTAATGTGTTC
ATGCTATCTCTGATCCTGTGGTGTTGTATAAAAATGAACAGCTAAAAATTTACCCATGACAAGATTAAAGCAAAAATAAACACAAAGTTG

>In-frame_LRIG1_ENST00000383703_chr3_66550614_-_PPM1L_ENST00000497343_chr3_160679524_+_1305nt
GATTGTTCGGCTGCGAGGTCGGCGGGACTCTTGCTGCGCGGAGGAGCCGTGCGGAACCCGAGGCTGCGCGCGCGCGCGCGCTCTCTGGCC
GCGGCGTGGGGACAGCGAGGCGCACTGGGGCCTCCCAGCGCGGGGCCGGCCGCGCCGTCCAGCCCGAGGTCTACGGCTTTGCGCTCCGAG
CCCAGAGGAAGATGCCTGCCGGCACCGAGCTCGGGCTGCGGGGCTGAACGCCTGTCTTCCAGGCGCAGCGGCAGCACTGCCCTCGGCCGG
TGTCGGTAGCGGCACTCGGCGTGCCCCGGGCGGACGAAGAGCGCAGGCTGGGTACACCTTGCCCGAATCGGCGGAGTTCGCAGCTAGCGC
GGGCGGGCCGGCCGGCCCGGATGGGCGCGGGGTTTGCGGCCCCCGCCGGGTGCTCCGGAGCGGCCCGGGCACCGGGGGCACGCTGAGTGC
CGGAGCCGCGGCCGCAGAGAGAACTTGGGGCGGGGGCCATGCCCCGGTGCGGAGTCTAGAGCCGAGCGGAGCGCCCCGCGGGCCCGCCCG
CGTCTGCGGCCGTTCGGGTCCTCACAGTCCCCGCGCCCGGAGTTCGCAGCGCGCTCCAGACAAGATGGCGCGGCCGGTCCGGGGAGGGCT
CGGGGCCCCGCGCCGCTCGCCTTGCCTTCTCCTTCTCTGGCTGCTTTTGCTTCGGCTGGAGCCGGTGACCGCCGCGGCCGGCCCGCGGGC
GCCCTGCGCGGCCGCCTGCACTTGCGCTGGGGACTCGCTGGACTGCGGTGGGCGCGGGCTGGCTGCGTTGCCCGGGGACCTGCCCTCCTG
GACGCGGAGCCTACTGCAGCTGAATATGTAAAATCTCGACTCCCAGAGGCCCTTAAACAGCATCTTCAGGACTACGAGAAAGACAAAGAA
AATAGTGTATTATCTTACCAGACCATCCTTGAACAGCAGATTTTGTCAATTGACCGAGAAATGCTAGAAAAATTGACTGTATCCTATGAT
GAAGCAGTTACTTTTTGAATGACTGCTTGGAGACTGCAAGTAACACCTTAGCTTCAAAATATCTAGTTCATATTAATTCTAAACTAATTT
CGATTTTAAACAAAGACTTTGCTTTAATATACCACTATTCCCTCCCCATTCTCTGTGCTGTTGTCAACCAAATTATATGCTTATACATTA
TAATGTCATCAATAATTTCATAATTATTTCTTTATGCATTTATTTTTTAAATTAGAAGAAAAAAGTTAACAAATAAGATCAAATTAGAAC

>In-frame_LRIG1_ENST00000383703_chr3_66550614_-_PPM1L_ENST00000498165_chr3_160679524_+_11256nt
GATTGTTCGGCTGCGAGGTCGGCGGGACTCTTGCTGCGCGGAGGAGCCGTGCGGAACCCGAGGCTGCGCGCGCGCGCGCGCTCTCTGGCC
GCGGCGTGGGGACAGCGAGGCGCACTGGGGCCTCCCAGCGCGGGGCCGGCCGCGCCGTCCAGCCCGAGGTCTACGGCTTTGCGCTCCGAG
CCCAGAGGAAGATGCCTGCCGGCACCGAGCTCGGGCTGCGGGGCTGAACGCCTGTCTTCCAGGCGCAGCGGCAGCACTGCCCTCGGCCGG
TGTCGGTAGCGGCACTCGGCGTGCCCCGGGCGGACGAAGAGCGCAGGCTGGGTACACCTTGCCCGAATCGGCGGAGTTCGCAGCTAGCGC
GGGCGGGCCGGCCGGCCCGGATGGGCGCGGGGTTTGCGGCCCCCGCCGGGTGCTCCGGAGCGGCCCGGGCACCGGGGGCACGCTGAGTGC
CGGAGCCGCGGCCGCAGAGAGAACTTGGGGCGGGGGCCATGCCCCGGTGCGGAGTCTAGAGCCGAGCGGAGCGCCCCGCGGGCCCGCCCG
CGTCTGCGGCCGTTCGGGTCCTCACAGTCCCCGCGCCCGGAGTTCGCAGCGCGCTCCAGACAAGATGGCGCGGCCGGTCCGGGGAGGGCT
CGGGGCCCCGCGCCGCTCGCCTTGCCTTCTCCTTCTCTGGCTGCTTTTGCTTCGGCTGGAGCCGGTGACCGCCGCGGCCGGCCCGCGGGC
GCCCTGCGCGGCCGCCTGCACTTGCGCTGGGGACTCGCTGGACTGCGGTGGGCGCGGGCTGGCTGCGTTGCCCGGGGACCTGCCCTCCTG
GACGCGGAGCCTACTGCAGCTGAATATGTAAAATCTCGACTCCCAGAGGCCCTTAAACAGCATCTTCAGGACTACGAGAAAGACAAAGAA
AATAGTGTATTATCTTACCAGACCATCCTTGAACAGCAGATTTTGTCAATTGACCGAGAAATGCTAGAAAAATTGACTGTATCCTATGAT
GAAGCAGGCACAACGTGTTTGATTGCTCTGCTATCAGATAAAGACCTCACTGTGGCCAACGTGGGTGACTCGCGCGGGGTCCTGTGTGAC
AAAGATGGGAACGCTATTCCTTTGTCTCATGATCACAAGCCTTACCAGTTGAAGGAAAGAAAGAGGATAAAGAGAGCAGGTGGTTTCATC
AGTTTCAATGGCTCCTGGAGGGTCCAGGGAATCCTGGCCATGTCTCGGTCCCTGGGGGATTATCCGCTGAAAAATCTCAACGTGGTCATC
CCAGACCCAGACATCCTGACCTTTGACCTGGACAAGCTTCAGCCTGAGTTCATGATCTTGGCATCAGATGGTCTCTGGGATGCTTTCAGC
AATGAAGAAGCAGTTCGATTCATCAAGGAGCGCTTGGATGAACCTCACTTTGGGGCCAAGAGCATAGTTTTACAGTCATTTTACAGAGGC
TGCCCTGACAATATAACAGTCATGGTGGTGAAGTTCAGAAATAGCAGCAAAACAGAAGAGCAGTGAACCCTTCAGGGGTCTCAGCTGCCT
TAGACTAAAGGACTTTCAACACACTGGTCTCTTTTAATTTAGTGAAAAGTGTGGGAGTTGTAATTAGGATCATCCACCCCAGACATGGAA
TCCCCCCTCCCTGGTGGTCTTAGGTCTATAATCAGTGACGAACAGAGGGTGCCCTTGGCCAATGTAGTTAAGAAACTGGAAAATGGTTTC
TTCATGTTTTCCCAACTCTTTCATCCAGTGTCCAAAATATATAAGTAAATAGCTGTAGAGTCACATATATGAAGTGAATAGCATATGTGT
CATTTAGTCTCCCTGAAGATTCTTTTCAAGATCCTGTTCAGGGTCCTCCAGGCATCAGCTGTTGTGTCCTCTCTTTGTAACAGTGGACAG
GACAGACCACCCAGTGCTGCAGGAGACAGGCCACTGCGTCACCTGTGAGTGGTCAGGGGCTGATGTGGCAACACCCTCTGCCAAGAGACA
GAGCTGTCCTGAGAATGCTTTGTCCTTCTGAGCCCATGTTTTCTGCTCAGTAGCAGCTTGGAAGCAGATTTGGAATGGTTTACTATTTTG
GCTGCTCTTGGGGACTGCGAGAAGCAGAGAGAATGAGAGACCAGTGGCAACTGCCTGCACAGCAGAGATAACCCTCTTCCCTTGCTTCCT
TTAATAGTTAAATAGACTTTGTATACCACCTGACCAGCCTTTGTGCATTTATCCTAATCATGCATGACCGTTAACCTTTTGCTTAGTCCT
TACCATATGTAATAGGCAGCTGTTAAATTCACCAACAGATACCCTGATTTTTCATCTTACGTGACCAAGAAACCACGTTAGGGGAAATGA
AAAAAGCAAGCCACAATACCATGATTCCTTCCATTTTCAACAGTAGATGAAGGAAATGATACTGAATGAGTCACAGTGTTCCCTGGCAAG
TAAGCTGTTTGCATTGAGAAAGGAGTGAGCTGGTGAGGTTACCACCCTGAATTGAGCTCCAGCTGCCAGTTTTTGTGTTTTTCCTTGCCC
CTTTCCAAGTGGTTTTCAAGTGTCAGGCAGTGTTCTGAGAAGCAGCAGCCTATAACTGTATGTGTGTTCCTTGAAGCCAGGTGCAGAGTT
CCCAGCTACTGCAGCTTGGGATTTGGTGGGAAACTACTGGGATAAGCTTCTCCTTGACAATGGAAAGGCAGCAGTCTTCAACATTTGGTT
GCAAATCTCCATCCACATCAGGGAGCTTTCCCCAGGCAAATACAAACCGCCCCGTGGCCTGCAGGCCTGCAGGGGAGGCAGCAAAGGGAC
CTGGCAGTTGCAACACAGTAAGTCAGGAATTCAAGCGTGAACCCATATTGATAAGTGGGCCAGAATTATTTAGGGGCCTGGCTTGCTGCT
CTCCATTTCCTGTATCGCTAATTTATCATTTTTCCAACCTTGGTATTTTATATTATTTAGAGAAAATGCTGGGTCACTCTCTTTGCCTAA
GGTGACTCAAACAGCCAAACGAAACTTCCGTTGCCTCCCAGCCCTCTGTATCCACCTGGTTTTGTTCTTTCCCTGTGAGCATTTGTGGTT
ATAGCTTCCCATATGCCACATTCACCGGCCACCTCCTCGCCGTGGAACCCTGCCCTCTCCCCTCCTGCTGCTGTAGAGTTTTCCCAAAGC
AGTGTCCAGGAGAGAATTTGAGAGAGTGAAGAAATTGCCTTGTAGATGTGGAGGGCTGCAATCTGTCTTGATTTCTCCAAGCACTTAACT
TTCTTTGACTGCACTGAGAATTGCTAATGATTTCCCATGAGATTTGCTTACTTTTGTATACTGTATTTTCCAGCATTACAGAACCTTGGT
TATTGTTTTTTAGCCATAGAATCTTCTAGTAAAAAATATCTGCCACCATTTTAGATTTAAGCATTTGCCTATGGGGAGACACTGAATATG
TGGATGTGTGTATTAATATTTGGGGTGGGGACAGGGAAGGGAATGTGGAAAACAAATGCTGGCTGTGAGCAGTGCTGAGATGGCCAGGCC
AGGCGGCTGAGTTTGCTTGGAAATTCAGGACATTCTGACTCCTAAGAGTTGCCCCCACCCACCATCAAACTGAAATCAGCACCAATGGTG
TCAGCACTTTACAGCCCATAGCCAACTTTCTTTATTTTTAACGTAGCACAAAAATGTATAATAGCAAGGAAAAGACATTTTTAAATTCCG
GTTATTTTTATTGTCTAAAATGAAAGCAACAGTGTTTTGATAAAGATGAAAAAGAAAAGCTACTAAATTAGTAAATCAGTGGTTACGTGC
CCTGCAGAATTTCTTAACAGATGGTGCTGAGTGCACGAGTTACATAACTTTCTCTCTAATTGAGGTTCACAAGGCGTCTTCTAAATTTTG
CTTTGTACAATTAATTCATTTCTGATGTTAACCAAATAGAGTGTATATATCCTACTCCCATTACTGCCTCTTTCCCCCCTACTATGGCTT
GTAGATTTTCAAAAGATAGAAGTTCTAGGCAAAACTGTAGCAGTTTCATTAATAGTTGTTAGGATAGTTATATCTAAAATCAGAGTATTT
TGTTCCCTTCCTTCTGGAGCTCTCTCTCCCTAGCCCTTTTCCAGCTGTTGGGGATGTGCAGACATCACTCCTGGGGGTGCCCTATGGTAC
ACTGGCTGCTCCCCAGGGACCTGGGAATGCTGAATCTAGCCATTAGGGAAATTGATTTGAGATGTTTGCATGTGAAGCTTCCCTAAGCAG
CACTGCCAAAGCTTTGGAATTGTCACCCAAGGCTTCCTAGACTCCCTAGCTAGCTCGAGTTCGAATTGCCAATAGTCCCCATGGTGCCAA
ATTTTGGGATGGTTTTACAGTCTTTTAGAAATGAAGACAGGAATGGCCATGTGCTTCTGAGACCCCAGCACGATGCCAGGCCCAGGTCTC
CATTAATGCAGTGCTCTGCTGCTGCTCCACTGGCAATTTGTACTCTTAACATAGGTTGGGGGAGGGACAGCTAGGGAAATTTTTTTTAAT
TAATTGTATCTAAAATTCTTTCATCATAGGAATAAACAACACATATAGAAAGCTCCAAAGCTGTTCCCAAGACCTGTATTATTTATTTTA
TATGACCAACTTGCCCCAAGGCAATTAACTCTGAATTGCTGTTCTAATGTGACATATCTGTGTACATATGTACATAGTACTGGTAACCAG
TGGCTGCATTTTATTCCTTGCTGTGGACTGAGGTATTGGCTTCTTGAATCTTGTATATGTCATAAGAATATTATACAGAGAGTGTTATAG
TGAAGGATGTAAGCTGGATAATTTAAAACAGACCTTATTTCATACAAGTGTAATTATTACATCATTTTGGGTAAATGGCAAACAGGATTG
CATGAGAGTGATGGCATCATCATTTCAATTGAATCTGAAGTGATTCTAGGAAATTGATTCCACTGTTGGATTCTAGGAAATTGAGTCCAC
TGTTTTCCTTTGCGTTTAATTTCCTTTGTGTTTAATTTGACCACAGAAACTTTTTTGAGTAGCACCTAGTAACATTGCAAGGAACTTGTG
TATCAAGGTGTATCTTGATTATCCTGATTTTTTTTGTTCTCTAAGTTGTTGCCAGATCTCTCTTGCAACTGTGTCAATGAAAGGTCTGTG
TTTAGAAAAGGCAGCATATCATTGTATATTTGAAACTATAGGAATATATACTTTGTATAAAACTTTTCCAATGATTTCAGAAATTCTTTT
TTCCTCCTTTTGACCCACAACTAGACTGTTCATACCCTAATAGTTCCCCAAAATTGCCTTAGCATGTCACACCAGCATTTGTCATCCAGC
TCTGGAGAAATGACATGACTGTTAGATACTATGCCTGTTTAATTGCCTCTGGATTAAGTCATTGATAGCTAGACTTTTGAGCTAGTTAGC
TGTAGAAATAATAGAATCCAGTGTTTCCCAAAGTGTGTTCCAAAGAACACAAGTTCCAAAGATGCTCTTCTAAATATAGGATTCTAGGAT
GAAATAAGTTTGGAAAACACATACCATCTTAGAAAGTTAGTGAACATGAGCACATCAAAGGCTCTAATTTAAATGTCCTGTGAGGAGAGA
AAAACACAACAAATATCTACTGTCAGTTAGCCCAGTGTTTTCCAGATTAATTTGACCACAGAAACTTTTTTGAGTGGCACCTAGTAACAC
TGCAAGGAACTTGTGTTCTAAAGAACACCCTTTGGGAAATTCTGGTATATTGAAATATTGCTGTGTTTTCATTCACGATGACTCTTAGTA
GCAGTACAATTTGCAACTTAGAAGCATGAGCCTTTCATATATGAAGCTGACTTGTTAATAAAAGCAGTGTTAAGAAGTAGTATGACTTAA
TATGACCAACAGCAGCCTCATATTGATAGCAGAACAATCCTACTTAAAGCTCTAAACATCATCCCCCCCTTTTTTTTTTTAACGGAATCT
CGCTCTGTCACCCAGGCTGGAATGCCGTGGCGCAATGTCAGGTCACTGCAAGCTCCGCCTCCCAGGTTCACACCATTCTCCTGCCTCAGC
CTCCTGAGCAGCTGGGACTACAGGCGGCCTCCACCACACCTGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTAGCC
AGGATGGTCTTGATATCCTGACCTTGTAATCCACCAGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCACCCGGCCA
TCCCTTTCTTTTATATGAATAATGAGCAAGAGCCCTGCCATAGCTAAATATGTCTCAAATTCATTCCAAGATCTTTCCATTGCTTTTTTG
CAGTTACCTTTGCTTTTTGGGTTGAATCAAAATGAATATTTTTATATTTCATTACTATATGATATTTAAAAATATACAGAAAATCACAGA
AAAGGAAAAACAGAAATTTGATTTTAATTCACTTTTGAAATTTTAACGATTTTTAAAACTAATGATCTGTTATATAATAACTGAAATGTA
AACTATTAACAGTTATTTACTTTCTTTCCTTTATTGTCCTCTCTGGATTCAGTGAAATAATTTGAAATCAATTAGAGCTCATACCTTCTA
AAACTCCTGTCCCATATCATCCCACCTTTCATGTTTTATGTACATAGTTAAGTTTGGCATGTTATCTCTTGCCTAAAATGTGAGGCCTTC
CTGTAGTTCCACAGTAGTTACTCTTGGCTGCAGAAATAGGTTTGGGAAGCTATGAGAGATTACCCCAAAGTCATGGATGAAACAAATCTA
GTCGAAAACATGGTACAGAGTGAATTAAGGCAAAAGTCATTAACTTAAAATTACATCCAATATTTAGGAATAGCTCATCCTCTGCACATT
ATCCAAAATATTTTAAAAAACTAAAAGTAAGATCTCTTAGGCTAGGTGGCGGATTGCAAAGGGCAGGGGGCAGTTGATACCATGAAGCTT
CCAATAGATGCATTTCTAAACATTTTTTCTAATATGTAAATTTGCTGATCCTTAGTAATGTTAATGCTTTGTCTATTTGTTATTTTTACC
ACTGTTGAACAGCAAACTGTTGAGGCTAGGGTTGATTATTGATAATTTTTATGTGTTTAGTAATAACCACAGCATCATACGTACAACTGC
TTTAATAAATCCAAGTTAAGGACTTTGAGGAGAGCATGTAGCAAGTATTCATTTTAACAAATCATCACAGACAGTTTCCCTGTTCAAAGC
TCCACCAAAAAGCAAGCATGCAGCAAAGGCATAGACTGTATTTAGAGATGTGGTTTCATTTATTCTTGAAGTCCTATAACCTTGCATTAT
TTAAACACAAAATCCCACCTAACATTTGCCAAATCCAAGTTAATCTCAAAAACCTCCGAGGACATTGAGCACAAGCAGATTACTGTAAGG
GCACTGGTGGCAGATTGTGGTGGAGAGAGGGCTGAGTGACCCAGAGCAAAGCCTGCCCGGGTTACTCGCTGCCACTTCAGGAGAGGGATT
GTATCAGCTCTCATTACCTTTTGTCATGAGGCAGTTCATAAATTAAATATGATATCATGCATTATCTCAAAATATTTCTATATTAATTAG
ATAATTCACGATGTAAAACGTGTTCATGCAGAAGCAAAGGCGGATGTAATAGTCAAGTATCAGGGAAAAACCCCTTTAGGATACCCAGAC
ATTAAAAATGTAAAAAGTAGCTTATAAGAAATGTGGATTATCAGATTTTTACTATATATAGGTTGTGTTTAATAGTAATTTCTGACACCT
GCACATAGATGAAGAAAAGGCAGTTGTTACCACTTTTCACCATTCAAAAAATGGGCTTGTCTCTTAGAGTATTGGTTAATGCTTTGCTTA
TTTGTTAATGAAGACAGCATTTTAATTTTAAAGCTTCCTTTTGTAGGACTGATGGCACGGGCAGAATCACATTTAAGAAAAATGGTTTGG
AACACTTTTTAATAAAAAATTGTAAAATCAGTTTCCAGTGTGGTCAAAATTAGAATGTAAAGGAAAGCATTTTTAAGAAAATACAGAAGC
CCAAATCAAGGGAGAGTAATATAAAAGGAAATATTTTAAATTAAGAAAAGGAGGTGTTATAGTTTATTACATCATGAATTATGCTTTCTG
TACTTACGCTCTTAGTGAAGGAGATAACATTGAAGTGAGAAAATGAACATTCTCAGTTATTTGCGAAGTTAGTAAAATTGCAGTCCCTAT
TCCATTTTTTTCTGATGAAAATGGATACATGAGATCTCATTTATTGCTCTCCTCAACACCTTTACTGTCCCAGATTCCATTCACGTTCCA
AATCGTGGACAGTAAAACTGAAGTCAGATAAACACAGTCACAGGTACAACTGGGAGCGAGTTTTAACATAGTGGTAATTTTGCAAATGCC
AACATGAATACTAGTGAGTACTCAATTTACGACAGACAATTTCACAAAAACCAACCACAGAGTGATTTGATATTCTTGCTTCTTAGAGAG
TTTTCTAATCCATATAATGCAATGGGTCAGGTTGCTCATATGATTAAAAAAATTAATCCTGTAGAAATGATGTATTAGACATCTCTAACC
CAAGAAAAAGATGTCTTTTGTATAACTTTTAAATTCCCATTTGTCTATCTTAGGACAAATGATGACTTCTTCGTGTAGTAATGAAAACGT
CTAAATCCTGCTCTGTGGAGAAAAGCTAGAACCATGGGACATTAAGCAAGAATACTCCTCTGATTTAGGCTCCCAGACTACAACTAACAG
TCTTTATGTATTTATCATCTTGGTTATTGTTTTATCTCAAGCATATACAGTGTGCAGAAAGTAGAATAATGAATAAAATATGACCATGGA
GAAAACCCATAACTTTTGCTTCTATTATAGAAAGCAGTGTTTGTTCTTTTTAATTTATTACATGTTCACATTGAAACATTAACATCTACA
ATATTGTCTTTCAGTTTACTCTTCAATTACTAAAGCAAATGATTTTGATTTATAGCACTTACACAACTGCAGTTCAGGTCACAGAATTGA
AATCTATTTGATAATGTCTCAGCATTCTCATGGGCAGCCAGGAAAAAAAAAAAGAGAGAGAAAGACAAATAGAAATTTTAGTGGGTTCAG
ATAAATGATTATTCTGACAAACCTGGAAAATAGTAATTAAACAGTTCATTCCAAAAGACCCCAATGTAAACTCTGCTCACATACATAATT
TGTATAAGGAAAATGTATGAGTTTTTTTCTTAAAAATAAATAGAAGCATCATTGCATTTATAACAGATTGATCAATCTTATGAACAGATT
ACATTGGGAAAGTCACTATTATTGCTGTGTGTTTGTATATTTTATTCTTTCCTTTTTTGTGTGAGCATCTACTATGTGCCAGGCAGTGAC
TGTGTCTGAGTGAATGTATCCATGGTGAGCACTCAGGCGCCATCACTGCCTTCTTGGGGCTTACACCCTATTGGGGTGTCAGAGATATTA
TAACACTCAATATTGACCCAATGGGATGAAAATTGTTATCTTCATGATTTCTTCCAATGGGCTTAGATTTGTTGGGACAGGGCAGAATTA
GAATAATTATTTCTCACATATAAGAGTAAGTGATATGAGATTGGGAATTTCTTGCCAACACTCAAGCAAACTGCAGAAGATAATTACTCC
ATTTTACTAGCTCACCTAGTTTCTGAAGGATGGGGTGGGGAGTGAGACATGGAGCCTCTGGGGACAAGGATAGGGGGGTGGGACTGTCCC
AGTGGAGGGTGCCACTGGAAGCCTCCACCCAAGTGGGCCAGCAGCTGTGCAAGGGTGCAGCAGTAGGCTGGTGAAAGCCAGGTTGTCCAG
ATCTTTCTAGGGGAAGAGAAGGATTATAGAAAAGGAGAAAAGGGAGGAGCAAGAACATCTCTCCATGGCCTATTTTTATTTTTGTTCCCA
AGAGACTAGTGTAATAACCTTATGCCCCCAAAGACAGCCCAGAACTGAGTATCTTCAGTGTTCCTGAGTGTAAATCAGTGAATCTGTTAT
ATAGAAAGTTAACATTTCAGGAGCACAATTATTTCCTGATTTCAAATATGAACAGAAGACTAAATGTCATTTTTTTAAATCATAAATTTG
GTATCCATAGTTACTTTACACATTCCAGAGTCTAAGCATGGAATTTAAGTTTTGTATTTTGAACAAAAATAGCAACATCTGTTTTCTGTA
TGGCAAAGAAAAACTAAATCCCAGACTTTTATTTTTAACCACAGAAACCATCACTTCTTTCTAAATTATTTGCTTGCCTGCTCATTTCCC
CTAAACATCTCTGTTTATGCCAATGGCTTTTTAAATCCAAATAATACTAGTTATTGCCAAATTGCATTAGAATCCTATTGAATTAGAATA
ATTCATATACTTCATATACTAGGCAGTAAATGGTTAGAGACGGTAAAGATCTGATTGTGATCAAAAGTAGGGTTTTTGTTTTGTTTTTAA
TCATGAGCACATATAAAAGGAAATTCAAATGAAACCAAGCCAATTTCTGATTTAGTAAGATTAAAACCATAGATGGAGCTCAGTTATTAA
GGATGGAAAGGAGGAAAGCACAGAGTGAGGAGAGAAAAAGGGGAAGGAAAAAAAGTAGTGTTTTTTTGGGGAACAGTATAATGTCTCAGA
AGTTCTTCTCTCTTATCCTGCTGATGTTGAGACAGTGGCTTTGTATAAGCTTTTATTTATACCTATTTCAACATCATGAAAATTTTTCCA
TCAGCATTTTCTTGCAACTTTAAAAATCACAAGGGATTATTTGTTTATAAAGAGATACAGGATCTATAATTTATTGGCAATACTTTATTT
TAGGAATCTTCAAATTGTACTTAATAAATAAATCACAGGTCAAAATGACTGTAAAATCAATCAGGCTTTCTCGTAAGTTATTTCCTGAAA
ACCATCCATGATAAATACAACAAGGCTTGGCGAAACCTCATTACTCTTGGAAGTCTTCAGAGGTTATTATACCTACTGATCTGTATTTGT
CTCTAAGAGACATTTGAAACACAGTTACAATGTCAATTTGGTGTAACATTACCTGTAGTAGAGCTCAGAGTATATGGCAGTGCACGGTCA
CTCAAGATGCATGGCGTGTCATTTGGGTCGCTTTGATGGGTGCTCGGGTAGAATTAGCCTTGTAGAGACTAATGTGTTCATGCTATCTCT
GATCCTGTGGTGTTGTATAAAAATGAACAGCTAAAAATTTACCCATGACAAGATTAAAGCAAAAATAAACACAAAGTTGTTAGACTTTAA


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FusionGenePPI for LRIG1_PPM1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LRIG1MET, EGFR, ERBB4, ERBB2, ERBB3, CBL, VCP, HGS, USP8, HLA-DRA, CANT1, PTPRK, GAL3ST1, SCARA3, PON2, LRIG3, LRRC40, RAB4A, CNPY4, CNPY3, SCRIB, MTFR1L, LRIG2, GML, SCGB2A2, TUBB8, HLA-EPPM1LMAP3K7, B4GAT1, PDGFRB, EPHA2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LRIG1_PPM1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LRIG1_PPM1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePPM1LC0028754Obesity1CTD_human