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Fusion gene ID: 20077 |
FusionGeneSummary for LRCH3_EIF2AK4 |
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Fusion gene information | Fusion gene name: LRCH3_EIF2AK4 | Fusion gene ID: 20077 | Hgene | Tgene | Gene symbol | LRCH3 | EIF2AK4 | Gene ID | 84859 | 440275 |
Gene name | leucine rich repeats and calponin homology domain containing 3 | eukaryotic translation initiation factor 2 alpha kinase 4 | |
Synonyms | - | GCN2|PVOD2 | |
Cytomap | 3q29 | 15q15.1 | |
Type of gene | protein-coding | protein-coding | |
Description | leucine-rich repeat and calponin homology domain-containing protein 3leucine-rich repeats and calponin homology (CH) domain containing 3 | eIF-2-alpha kinase GCN2GCN2 eIF2alpha kinaseGCN2-like proteingeneral control nonderepressible 2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q96II8 | Q9P2K8 | |
Ensembl transtripts involved in fusion gene | ENST00000438796, ENST00000414675, ENST00000441090, ENST00000334859, ENST00000425562, ENST00000493726, ENST00000536618, | ENST00000559624, ENST00000382727, ENST00000263791, ENST00000560648, ENST00000559311, | |
Fusion gene scores | * DoF score | 7 X 8 X 5=280 | 4 X 6 X 4=96 |
# samples | 10 | 7 | |
** MAII score | log2(10/280*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/96*10)=-0.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LRCH3 [Title/Abstract] AND EIF2AK4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW389992 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + | ||
ChiTaRS3.1 | AW390019 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000438796 | ENST00000559624 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000438796 | ENST00000382727 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000438796 | ENST00000263791 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000438796 | ENST00000560648 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000438796 | ENST00000559311 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000414675 | ENST00000559624 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000414675 | ENST00000382727 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000414675 | ENST00000263791 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000414675 | ENST00000560648 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000414675 | ENST00000559311 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000441090 | ENST00000559624 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000441090 | ENST00000382727 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000441090 | ENST00000263791 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000441090 | ENST00000560648 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000441090 | ENST00000559311 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000334859 | ENST00000559624 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000334859 | ENST00000382727 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000334859 | ENST00000263791 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000334859 | ENST00000560648 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000334859 | ENST00000559311 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000425562 | ENST00000559624 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000425562 | ENST00000382727 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000425562 | ENST00000263791 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000425562 | ENST00000560648 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000425562 | ENST00000559311 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000493726 | ENST00000559624 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000493726 | ENST00000382727 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000493726 | ENST00000263791 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000493726 | ENST00000560648 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000493726 | ENST00000559311 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000536618 | ENST00000559624 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000536618 | ENST00000382727 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000536618 | ENST00000263791 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000536618 | ENST00000560648 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
intron-intron | ENST00000536618 | ENST00000559311 | LRCH3 | chr3 | 197605525 | - | EIF2AK4 | chr15 | 40325451 | + |
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FusionProtFeatures for LRCH3_EIF2AK4 |
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Hgene | Tgene |
LRCH3 | EIF2AK4 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LRCH3_EIF2AK4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LRCH3_EIF2AK4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LRCH3_EIF2AK4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LRCH3_EIF2AK4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | EIF2AK4 | C0002514 | Amino Acid Metabolism, Inborn Errors | 1 | CTD_human |
Tgene | EIF2AK4 | C0018500 | Hair Diseases | 1 | CTD_human |
Tgene | EIF2AK4 | C0020542 | Pulmonary Hypertension | 1 | CTD_human |
Tgene | EIF2AK4 | C0021053 | Immune System Diseases | 1 | CTD_human |
Tgene | EIF2AK4 | C0026848 | Myopathy | 1 | CTD_human |
Tgene | EIF2AK4 | C0034091 | Pulmonary Veno-Occlusive Disease (disorder) | 1 | CTD_human;ORPHANET |
Tgene | EIF2AK4 | C0340848 | PULMONARY VENOOCCLUSIVE DISEASE 2, AUTOSOMAL RECESSIVE | 1 | UNIPROT |