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Fusion gene ID: 20063 |
FusionGeneSummary for LRBA_HTR1E |
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Fusion gene information | Fusion gene name: LRBA_HTR1E | Fusion gene ID: 20063 | Hgene | Tgene | Gene symbol | LRBA | HTR1E | Gene ID | 987 | 3354 |
Gene name | LPS responsive beige-like anchor protein | 5-hydroxytryptamine receptor 1E | |
Synonyms | BGL|CDC4L|CVID8|LAB300|LBA | 5-HT1E | |
Cytomap | 4q31.3 | 6q14.3 | |
Type of gene | protein-coding | protein-coding | |
Description | lipopolysaccharide-responsive and beige-like anchor proteinCDC4-like proteinLPS-responsive vesicle trafficking, beach and anchor containingvesicle trafficking, beach and anchor containing | 5-hydroxytryptamine receptor 1E5-HT-1E5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupledS31serotonin receptor 1E | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P50851 | P28566 | |
Ensembl transtripts involved in fusion gene | ENST00000535741, ENST00000510413, ENST00000503716, ENST00000357115, ENST00000507224, | ENST00000305344, | |
Fusion gene scores | * DoF score | 16 X 15 X 12=2880 | 2 X 2 X 2=8 |
# samples | 22 | 2 | |
** MAII score | log2(22/2880*10)=-3.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: LRBA [Title/Abstract] AND HTR1E [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BI042740 | LRBA | chr4 | 151185997 | - | HTR1E | chr6 | 87656965 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000535741 | ENST00000305344 | LRBA | chr4 | 151185997 | - | HTR1E | chr6 | 87656965 | + |
intron-intron | ENST00000510413 | ENST00000305344 | LRBA | chr4 | 151185997 | - | HTR1E | chr6 | 87656965 | + |
intron-intron | ENST00000503716 | ENST00000305344 | LRBA | chr4 | 151185997 | - | HTR1E | chr6 | 87656965 | + |
intron-intron | ENST00000357115 | ENST00000305344 | LRBA | chr4 | 151185997 | - | HTR1E | chr6 | 87656965 | + |
intron-intron | ENST00000507224 | ENST00000305344 | LRBA | chr4 | 151185997 | - | HTR1E | chr6 | 87656965 | + |
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FusionProtFeatures for LRBA_HTR1E |
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Hgene | Tgene |
LRBA | HTR1E |
May be involved in coupling signal transduction andvesicle trafficking to enable polarized secretion and/or membranedeposition of immune effector molecules. {ECO:0000250}. | G-protein coupled receptor for 5-hydroxytryptamine(serotonin). Also functions as a receptor for various alkaloidsand psychoactive substances. Ligand binding causes a conformationchange that triggers signaling via guanine nucleotide-bindingproteins (G proteins) and modulates the activity of down-streameffectors, such as adenylate cyclase. Signaling inhibits adenylatecyclase activity. {ECO:0000269|PubMed:14744596,ECO:0000269|PubMed:1513320, ECO:0000269|PubMed:1608964,ECO:0000269|PubMed:1733778, ECO:0000269|PubMed:21422162}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LRBA_HTR1E |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LRBA_HTR1E |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LRBA_HTR1E |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | HTR1E | P28566 | DB00246 | Ziprasidone | 5-hydroxytryptamine receptor 1E | small molecule | approved |
Tgene | HTR1E | P28566 | DB00247 | Methysergide | 5-hydroxytryptamine receptor 1E | small molecule | approved |
Tgene | HTR1E | P28566 | DB00363 | Clozapine | 5-hydroxytryptamine receptor 1E | small molecule | approved |
Tgene | HTR1E | P28566 | DB00408 | Loxapine | 5-hydroxytryptamine receptor 1E | small molecule | approved |
Tgene | HTR1E | P28566 | DB01224 | Quetiapine | 5-hydroxytryptamine receptor 1E | small molecule | approved |
Tgene | HTR1E | P28566 | DB00216 | Eletriptan | 5-hydroxytryptamine receptor 1E | small molecule | approved|investigational |
Tgene | HTR1E | P28566 | DB00334 | Olanzapine | 5-hydroxytryptamine receptor 1E | small molecule | approved|investigational |
Tgene | HTR1E | P28566 | DB01238 | Aripiprazole | 5-hydroxytryptamine receptor 1E | small molecule | approved|investigational |
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RelatedDiseases for LRBA_HTR1E |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | LRBA | C3553512 | IMMUNODEFICIENCY, COMMON VARIABLE, 8, WITH AUTOIMMUNITY | 1 | ORPHANET;UNIPROT |