![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 20054 |
FusionGeneSummary for LRAT_VTI1A |
![]() |
Fusion gene information | Fusion gene name: LRAT_VTI1A | Fusion gene ID: 20054 | Hgene | Tgene | Gene symbol | LRAT | VTI1A | Gene ID | 9227 | 143187 |
Gene name | lecithin retinol acyltransferase | vesicle transport through interaction with t-SNAREs 1A | |
Synonyms | LCA14 | MMDS3|MVti1|VTI1RP2|Vti1-rp2 | |
Cytomap | 4q32.1 | 10q25.2 | |
Type of gene | protein-coding | protein-coding | |
Description | lecithin retinol acyltransferaselecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) | vesicle transport through interaction with t-SNAREs homolog 1ASNARE Vti1a-beta proteinvesicle transport v-SNARE protein Vti1-like 2 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | O95237 | Q96AJ9 | |
Ensembl transtripts involved in fusion gene | ENST00000500890, ENST00000507827, ENST00000336356, | ENST00000432306, ENST00000393077, ENST00000483122, | |
Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 8 X 5 X 8=320 |
# samples | 2 | 13 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(13/320*10)=-1.29956028185891 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LRAT [Title/Abstract] AND VTI1A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LRAT | GO:0042572 | retinol metabolic process | 10819989 |
Tgene | VTI1A | GO:0042147 | retrograde transport, endosome to Golgi | 15215310|18195106 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LIHC | TCGA-GJ-A6C0-01A | LRAT | chr4 | 155557548 | + | VTI1A | chr10 | 114575049 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000500890 | ENST00000432306 | LRAT | chr4 | 155557548 | + | VTI1A | chr10 | 114575049 | + |
3UTR-intron | ENST00000500890 | ENST00000393077 | LRAT | chr4 | 155557548 | + | VTI1A | chr10 | 114575049 | + |
3UTR-intron | ENST00000500890 | ENST00000483122 | LRAT | chr4 | 155557548 | + | VTI1A | chr10 | 114575049 | + |
intron-intron | ENST00000507827 | ENST00000432306 | LRAT | chr4 | 155557548 | + | VTI1A | chr10 | 114575049 | + |
intron-intron | ENST00000507827 | ENST00000393077 | LRAT | chr4 | 155557548 | + | VTI1A | chr10 | 114575049 | + |
intron-intron | ENST00000507827 | ENST00000483122 | LRAT | chr4 | 155557548 | + | VTI1A | chr10 | 114575049 | + |
intron-intron | ENST00000336356 | ENST00000432306 | LRAT | chr4 | 155557548 | + | VTI1A | chr10 | 114575049 | + |
intron-intron | ENST00000336356 | ENST00000393077 | LRAT | chr4 | 155557548 | + | VTI1A | chr10 | 114575049 | + |
intron-intron | ENST00000336356 | ENST00000483122 | LRAT | chr4 | 155557548 | + | VTI1A | chr10 | 114575049 | + |
Top |
FusionProtFeatures for LRAT_VTI1A |
![]() |
Hgene | Tgene |
LRAT | VTI1A |
Transfers the acyl group from the sn-1 position ofphosphatidylcholine to all-trans retinol, producing all-transretinyl esters. Retinyl esters are storage forms of vitamin A.LRAT plays a critical role in vision. It provides the all-transretinyl ester substrates for the isomerohydrolase which processesthe esters into 11-cis-retinol in the retinal pigment epithelium;due to a membrane-associated alcohol dehydrogenase, 11 cis-retinolis oxidized and converted into 11-cis-retinaldehyde which is thechromophore for rhodopsin and the cone photopigments.{ECO:0000269|PubMed:9920938}. | V-SNARE that mediates vesicle transport pathways throughinteractions with t-SNAREs on the target membrane. Theseinteractions are proposed to mediate aspects of the specificity ofvesicle trafficking and to promote fusion of the lipid bilayers.Involved in vesicular transport from the late endosomes to thetrans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface usedby KCNIP1 and KCND2. May be involved in increased cytokinesecretion associated with cellular senescence.{ECO:0000269|PubMed:18195106, ECO:0000269|PubMed:19138172}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for LRAT_VTI1A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for LRAT_VTI1A |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LRAT | LRAT, NME2P1 | VTI1A | VAMP4, VAMP3, STX7, STX8, VAMP8, TMBIM6, STX6, STX12, CLEC12A, HAUS1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for LRAT_VTI1A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | LRAT | O95237 | DB00162 | Vitamin A | Lecithin retinol acyltransferase | small molecule | approved|nutraceutical|vet_approved |
Top |
RelatedDiseases for LRAT_VTI1A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | LRAT | C0917796 | Optic Atrophy, Hereditary, Leber | 2 | CTD_human |
Hgene | LRAT | C0015398 | Eye Diseases, Hereditary | 1 | CTD_human |
Hgene | LRAT | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | LRAT | C0042842 | Vitamin A Deficiency | 1 | CTD_human |
Hgene | LRAT | C0339527 | Leber Congenital Amaurosis | 1 | CTD_human;ORPHANET |
Hgene | LRAT | C2750063 | Leber Congenital Amaurosis 14 | 1 | CTD_human;UNIPROT |
Hgene | LRAT | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Tgene | VTI1A | C0001418 | Adenocarcinoma | 1 | CTD_human |
Tgene | VTI1A | C0009404 | Colorectal Neoplasms | 1 | CTD_human |