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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20050

FusionGeneSummary for LPP_ZNRF1

check button Fusion gene summary
Fusion gene informationFusion gene name: LPP_ZNRF1
Fusion gene ID: 20050
HgeneTgene
Gene symbol

LPP

ZNRF1

Gene ID

4026

84937

Gene nameLIM domain containing preferred translocation partner in lipomazinc and ring finger 1
Synonyms-NIN283
Cytomap

3q27.3-q28

16q23.1

Type of geneprotein-codingprotein-coding
Descriptionlipoma-preferred partnerLIM proteinlipoma preferred partnerE3 ubiquitin-protein ligase ZNRF1RING-type E3 ubiquitin transferase ZNRF1nerve injury gene 283nerve injury-induced gene 283 proteinzinc and ring finger 1, E3 ubiquitin protein ligasezinc and ring finger protein 1zinc/RING finger protein 1
Modification date2018051920180522
UniProtAcc

Q93052

Q8ND25

Ensembl transtripts involved in fusion geneENST00000448637, ENST00000312675, 
ENST00000543006, ENST00000471917, 
ENST00000335325, ENST00000320619, 
ENST00000566250, ENST00000567962, 
ENST00000564320, 
Fusion gene scores* DoF score29 X 22 X 11=70183 X 2 X 3=18
# samples 373
** MAII scorelog2(37/7018*10)=-4.24546277188585
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LPP [Title/Abstract] AND ZNRF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCSTCGA-N5-A4RF-01ALPPchr3

187943315

+ZNRF1chr16

75127470

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000448637ENST00000335325LPPchr3

187943315

+ZNRF1chr16

75127470

+
intron-3CDSENST00000448637ENST00000320619LPPchr3

187943315

+ZNRF1chr16

75127470

+
intron-3CDSENST00000448637ENST00000566250LPPchr3

187943315

+ZNRF1chr16

75127470

+
intron-3CDSENST00000448637ENST00000567962LPPchr3

187943315

+ZNRF1chr16

75127470

+
intron-3UTRENST00000448637ENST00000564320LPPchr3

187943315

+ZNRF1chr16

75127470

+
5UTR-3CDSENST00000312675ENST00000335325LPPchr3

187943315

+ZNRF1chr16

75127470

+
5UTR-3CDSENST00000312675ENST00000320619LPPchr3

187943315

+ZNRF1chr16

75127470

+
5UTR-3CDSENST00000312675ENST00000566250LPPchr3

187943315

+ZNRF1chr16

75127470

+
5UTR-3CDSENST00000312675ENST00000567962LPPchr3

187943315

+ZNRF1chr16

75127470

+
5UTR-3UTRENST00000312675ENST00000564320LPPchr3

187943315

+ZNRF1chr16

75127470

+
5UTR-3CDSENST00000543006ENST00000335325LPPchr3

187943315

+ZNRF1chr16

75127470

+
5UTR-3CDSENST00000543006ENST00000320619LPPchr3

187943315

+ZNRF1chr16

75127470

+
5UTR-3CDSENST00000543006ENST00000566250LPPchr3

187943315

+ZNRF1chr16

75127470

+
5UTR-3CDSENST00000543006ENST00000567962LPPchr3

187943315

+ZNRF1chr16

75127470

+
5UTR-3UTRENST00000543006ENST00000564320LPPchr3

187943315

+ZNRF1chr16

75127470

+
intron-3CDSENST00000471917ENST00000335325LPPchr3

187943315

+ZNRF1chr16

75127470

+
intron-3CDSENST00000471917ENST00000320619LPPchr3

187943315

+ZNRF1chr16

75127470

+
intron-3CDSENST00000471917ENST00000566250LPPchr3

187943315

+ZNRF1chr16

75127470

+
intron-3CDSENST00000471917ENST00000567962LPPchr3

187943315

+ZNRF1chr16

75127470

+
intron-3UTRENST00000471917ENST00000564320LPPchr3

187943315

+ZNRF1chr16

75127470

+

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FusionProtFeatures for LPP_ZNRF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LPP

Q93052

ZNRF1

Q8ND25

May play a structural role at sites of cell adhesion inmaintaining cell shape and motility. In addition to thesestructural functions, it may also be implicated in signalingevents and activation of gene transcription. May be involved insignal transduction from cell adhesion sites to the nucleusallowing successful integration of signals arising from solublefactors and cell-cell adhesion sites. Also suggested to serve as ascaffold protein upon which distinct protein complexes areassembled in the cytoplasm and in the nucleus.{ECO:0000269|PubMed:10637295, ECO:0000269|Ref.2}. E3 ubiquitin-protein ligase that mediates theubiquitination of AKT1 and GLUL, thereby playing a role in neuroncells differentiation. Plays a role in the establishment andmaintenance of neuronal transmission and plasticity. RegulatesSchwann cells differentiation by mediating ubiquitination of GLUL.Promotes neurodegeneration by mediating 'Lys-48'-linkedpolyubiquitination and subsequent degradation of AKT1 in axons:degradation of AKT1 prevents AKT1-mediated phosphorylation ofGSK3B, leading to GSK3B activation and phosphorylation ofDPYSL2/CRMP2 followed by destabilization of microtubule assemblyin axons (Probable). {ECO:0000305|PubMed:14561866}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LPP_ZNRF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LPP_ZNRF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LPPATP5J2, PPP2R1A, ELAVL1, EGLN2, VHL, CLNS1A, PNPO, HNRNPL, CPT1A, HSPA5, AGFG1, ALAD, ARPC3, ARPC4, CALR, DBNL, HSPBP1, IPO11, P3H1, DPP9, EFTUD1, FEN1, FKBP10, RPRD1B, SAE1, SURF2, UFM1, NIF3L1, NPLOC4, OGT, PPME1, PPP2R5D, RANGAP1, RDX, SH3GLB1, TPRKB, UBE3A, ZPR1, SUZ12, RNF2, COPS5, GMPPA, PICALM, NINL, XPO1, CDH1, PTPN21, PPP2R3A, WDYHV1, SERPINB2, PDLIM7, LPXN, CBLC, MRPL38, WASF3, MTNR1A, G3BP1, TESZNRF1UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2N, UBE2E3, UBE2V1, UBE2W, UBE2E2, UBE2V2, ZNRF2, YWHAQ, ATP1A2, ZNRF1, CDC34, ATP1A1, UBC, NMT1, NMT2, TSEN2, BHMT, TSEN54, FBXW5, NCEH1, AARS2, GLUL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LPP_ZNRF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LPP_ZNRF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLPPC3495559Juvenile arthritis1CTD_human