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Fusion gene ID: 20049 |
FusionGeneSummary for LPP_WWTR1 |
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Fusion gene information | Fusion gene name: LPP_WWTR1 | Fusion gene ID: 20049 | Hgene | Tgene | Gene symbol | LPP | WWTR1 | Gene ID | 4026 | 25937 |
Gene name | LIM domain containing preferred translocation partner in lipoma | WW domain containing transcription regulator 1 | |
Synonyms | - | TAZ | |
Cytomap | 3q27.3-q28 | 3q25.1 | |
Type of gene | protein-coding | protein-coding | |
Description | lipoma-preferred partnerLIM proteinlipoma preferred partner | WW domain-containing transcription regulator protein 1transcriptional co-activator with PDZ-binding motif | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q93052 | Q9GZV5 | |
Ensembl transtripts involved in fusion gene | ENST00000448637, ENST00000312675, ENST00000543006, ENST00000471917, | ENST00000465804, ENST00000360632, ENST00000467467, ENST00000474080, | |
Fusion gene scores | * DoF score | 29 X 22 X 11=7018 | 6 X 4 X 6=144 |
# samples | 37 | 7 | |
** MAII score | log2(37/7018*10)=-4.24546277188585 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LPP [Title/Abstract] AND WWTR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | WWTR1 | GO:0008284 | positive regulation of cell proliferation | 18227151 |
Tgene | WWTR1 | GO:0010718 | positive regulation of epithelial to mesenchymal transition | 18227151 |
Tgene | WWTR1 | GO:0017145 | stem cell division | 18568018 |
Tgene | WWTR1 | GO:0035329 | hippo signaling | 18227151|20412773 |
Tgene | WWTR1 | GO:0060390 | regulation of SMAD protein signal transduction | 18568018 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | UCEC | TCGA-AJ-A3EM-01A | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000448637 | ENST00000465804 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
intron-intron | ENST00000448637 | ENST00000360632 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
intron-intron | ENST00000448637 | ENST00000467467 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
intron-intron | ENST00000448637 | ENST00000474080 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
5UTR-5UTR | ENST00000312675 | ENST00000465804 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
5UTR-intron | ENST00000312675 | ENST00000360632 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
5UTR-intron | ENST00000312675 | ENST00000467467 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
5UTR-intron | ENST00000312675 | ENST00000474080 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
5UTR-5UTR | ENST00000543006 | ENST00000465804 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
5UTR-intron | ENST00000543006 | ENST00000360632 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
5UTR-intron | ENST00000543006 | ENST00000467467 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
5UTR-intron | ENST00000543006 | ENST00000474080 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
intron-5UTR | ENST00000471917 | ENST00000465804 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
intron-intron | ENST00000471917 | ENST00000360632 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
intron-intron | ENST00000471917 | ENST00000467467 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
intron-intron | ENST00000471917 | ENST00000474080 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
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FusionProtFeatures for LPP_WWTR1 |
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Hgene | Tgene |
LPP | WWTR1 |
May play a structural role at sites of cell adhesion inmaintaining cell shape and motility. In addition to thesestructural functions, it may also be implicated in signalingevents and activation of gene transcription. May be involved insignal transduction from cell adhesion sites to the nucleusallowing successful integration of signals arising from solublefactors and cell-cell adhesion sites. Also suggested to serve as ascaffold protein upon which distinct protein complexes areassembled in the cytoplasm and in the nucleus.{ECO:0000269|PubMed:10637295, ECO:0000269|Ref.2}. | Transcriptional coactivator which acts as a downstreamregulatory target in the Hippo signaling pathway that plays apivotal role in organ size control and tumor suppression byrestricting proliferation and promoting apoptosis. The core ofthis pathway is composed of a kinase cascade wherein STK3/MST2 andSTK4/MST1, in complex with its regulatory protein SAV1,phosphorylates and activates LATS1/2 in complex with itsregulatory protein MOB1, which in turn phosphorylates andinactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8and NKX2-1/TTF1-dependent gene activation. Regulates the nuclearaccumulation of SMADS and has a key role in coupling them to thetranscriptional machinery such as the mediator complex. Regulatesembryonic stem-cell self-renewal, promotes cell proliferation andepithelial-mesenchymal transition. {ECO:0000269|PubMed:11118213,ECO:0000269|PubMed:18227151, ECO:0000269|PubMed:18568018,ECO:0000269|PubMed:19010321}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LPP_WWTR1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LPP_WWTR1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LPP | ATP5J2, PPP2R1A, ELAVL1, EGLN2, VHL, CLNS1A, PNPO, HNRNPL, CPT1A, HSPA5, AGFG1, ALAD, ARPC3, ARPC4, CALR, DBNL, HSPBP1, IPO11, P3H1, DPP9, EFTUD1, FEN1, FKBP10, RPRD1B, SAE1, SURF2, UFM1, NIF3L1, NPLOC4, OGT, PPME1, PPP2R5D, RANGAP1, RDX, SH3GLB1, TPRKB, UBE3A, ZPR1, SUZ12, RNF2, COPS5, GMPPA, PICALM, NINL, XPO1, CDH1, PTPN21, PPP2R3A, WDYHV1, SERPINB2, PDLIM7, LPXN, CBLC, MRPL38, WASF3, MTNR1A, G3BP1, TES | WWTR1 | TEAD4, TEAD3, SLC9A3R2, YWHAE, YWHAZ, YWHAG, KLF5, PPP1CA, TP53BP2, BTRC, YWHAQ, LATS1, NOTCH1, MED28, DVL1, DVL2, DVL3, HIF1A, AMOTL1, AMOT, TEAD1, FBXW11, TEAD2, LATS2, WBP2, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LPP_WWTR1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LPP_WWTR1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | LPP | C3495559 | Juvenile arthritis | 1 | CTD_human |
Tgene | WWTR1 | C0026846 | Muscular Atrophy | 1 | CTD_human |