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Fusion gene ID: 20036 |
FusionGeneSummary for LPP_KCNIP4 |
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Fusion gene information | Fusion gene name: LPP_KCNIP4 | Fusion gene ID: 20036 | Hgene | Tgene | Gene symbol | LPP | KCNIP4 | Gene ID | 4026 | 80333 |
Gene name | LIM domain containing preferred translocation partner in lipoma | potassium voltage-gated channel interacting protein 4 | |
Synonyms | - | CALP|KCHIP4 | |
Cytomap | 3q27.3-q28 | 4p15.31-p15.2 | |
Type of gene | protein-coding | protein-coding | |
Description | lipoma-preferred partnerLIM proteinlipoma preferred partner | Kv channel-interacting protein 4Kv channel interacting protein 4a-type potassium channel modulatory protein 4calsenilin-like protein | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q93052 | Q6PIL6 | |
Ensembl transtripts involved in fusion gene | ENST00000448637, ENST00000312675, ENST00000543006, ENST00000471917, | ENST00000382148, ENST00000447367, ENST00000382150, ENST00000382152, ENST00000509207, ENST00000382149, ENST00000359001, | |
Fusion gene scores | * DoF score | 29 X 22 X 11=7018 | 12 X 7 X 9=756 |
# samples | 37 | 13 | |
** MAII score | log2(37/7018*10)=-4.24546277188585 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/756*10)=-2.53987461119262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LPP [Title/Abstract] AND KCNIP4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-DX-AB2Z-01A | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000448637 | ENST00000382148 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
intron-3CDS | ENST00000448637 | ENST00000447367 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
intron-3CDS | ENST00000448637 | ENST00000382150 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
intron-3CDS | ENST00000448637 | ENST00000382152 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
intron-5UTR | ENST00000448637 | ENST00000509207 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
intron-5UTR | ENST00000448637 | ENST00000382149 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
intron-5UTR | ENST00000448637 | ENST00000359001 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
5UTR-3CDS | ENST00000312675 | ENST00000382148 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
5UTR-3CDS | ENST00000312675 | ENST00000447367 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
5UTR-3CDS | ENST00000312675 | ENST00000382150 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
5UTR-3CDS | ENST00000312675 | ENST00000382152 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
5UTR-5UTR | ENST00000312675 | ENST00000509207 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
5UTR-5UTR | ENST00000312675 | ENST00000382149 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
5UTR-5UTR | ENST00000312675 | ENST00000359001 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
5UTR-3CDS | ENST00000543006 | ENST00000382148 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
5UTR-3CDS | ENST00000543006 | ENST00000447367 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
5UTR-3CDS | ENST00000543006 | ENST00000382150 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
5UTR-3CDS | ENST00000543006 | ENST00000382152 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
5UTR-5UTR | ENST00000543006 | ENST00000509207 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
5UTR-5UTR | ENST00000543006 | ENST00000382149 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
5UTR-5UTR | ENST00000543006 | ENST00000359001 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
intron-3CDS | ENST00000471917 | ENST00000382148 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
intron-3CDS | ENST00000471917 | ENST00000447367 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
intron-3CDS | ENST00000471917 | ENST00000382150 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
intron-3CDS | ENST00000471917 | ENST00000382152 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
intron-5UTR | ENST00000471917 | ENST00000509207 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
intron-5UTR | ENST00000471917 | ENST00000382149 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
intron-5UTR | ENST00000471917 | ENST00000359001 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
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FusionProtFeatures for LPP_KCNIP4 |
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Hgene | Tgene |
LPP | KCNIP4 |
May play a structural role at sites of cell adhesion inmaintaining cell shape and motility. In addition to thesestructural functions, it may also be implicated in signalingevents and activation of gene transcription. May be involved insignal transduction from cell adhesion sites to the nucleusallowing successful integration of signals arising from solublefactors and cell-cell adhesion sites. Also suggested to serve as ascaffold protein upon which distinct protein complexes areassembled in the cytoplasm and in the nucleus.{ECO:0000269|PubMed:10637295, ECO:0000269|Ref.2}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LPP_KCNIP4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LPP_KCNIP4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LPP | ATP5J2, PPP2R1A, ELAVL1, EGLN2, VHL, CLNS1A, PNPO, HNRNPL, CPT1A, HSPA5, AGFG1, ALAD, ARPC3, ARPC4, CALR, DBNL, HSPBP1, IPO11, P3H1, DPP9, EFTUD1, FEN1, FKBP10, RPRD1B, SAE1, SURF2, UFM1, NIF3L1, NPLOC4, OGT, PPME1, PPP2R5D, RANGAP1, RDX, SH3GLB1, TPRKB, UBE3A, ZPR1, SUZ12, RNF2, COPS5, GMPPA, PICALM, NINL, XPO1, CDH1, PTPN21, PPP2R3A, WDYHV1, SERPINB2, PDLIM7, LPXN, CBLC, MRPL38, WASF3, MTNR1A, G3BP1, TES | KCNIP4 | KCNIP2, PSEN2, PSEN1, APP, KCNIP1, SCGB1D1, MTX1, LACRT, ZG16B, PRR4, HLA-DRA, KLK4, TFPI, ECE2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LPP_KCNIP4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LPP_KCNIP4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | LPP | C3495559 | Juvenile arthritis | 1 | CTD_human |