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Fusion gene ID: 20008 |
FusionGeneSummary for LPHN3_ST3GAL5 |
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Fusion gene information | Fusion gene name: LPHN3_ST3GAL5 | Fusion gene ID: 20008 | Hgene | Tgene | Gene symbol | LPHN3 | ST3GAL5 | Gene ID | 23284 | 8869 |
Gene name | adhesion G protein-coupled receptor L3 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | |
Synonyms | CIRL3|CL3|LEC3|LPHN3 | SATI|SIAT9|SIATGM3S|SPDRS|ST3Gal V|ST3GalV | |
Cytomap | 4q13.1 | 2p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | adhesion G protein-coupled receptor L3CIRL-3calcium-independent alpha-latrotoxin receptor 3latrophilin homolog 3 (cow)latrophilin-3lectomedin 3 | lactosylceramide alpha-2,3-sialyltransferaseCMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferaseST3 beta-galactoside alpha-23-sialyltransferase 5alpha 2,3-sialyltransferase Vganglioside GM3 synthasesialyltransferase 9 (CMP-NeuAc:lactosylceramide al | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9UNP4 | ||
Ensembl transtripts involved in fusion gene | ENST00000512091, ENST00000514591, ENST00000511324, ENST00000506700, ENST00000509896, ENST00000545650, ENST00000508693, ENST00000507164, ENST00000507625, ENST00000514157, ENST00000504896, ENST00000514996, ENST00000506720, ENST00000506746, ENST00000508946, ENST00000508078, | ENST00000393805, ENST00000377332, ENST00000525834, ENST00000484728, ENST00000393808, | |
Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 2 X 2 X 2=8 |
# samples | 5 | 3 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/8*10)=1.90689059560852 | |
Context | PubMed: LPHN3 [Title/Abstract] AND ST3GAL5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LPHN3 | GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 26235030 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LGG | TCGA-HT-7477-01B | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000512091 | ENST00000393805 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000512091 | ENST00000377332 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000512091 | ENST00000525834 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000512091 | ENST00000484728 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000512091 | ENST00000393808 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000514591 | ENST00000393805 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000514591 | ENST00000377332 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000514591 | ENST00000525834 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000514591 | ENST00000484728 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000514591 | ENST00000393808 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000511324 | ENST00000393805 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000511324 | ENST00000377332 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000511324 | ENST00000525834 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000511324 | ENST00000484728 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000511324 | ENST00000393808 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000506700 | ENST00000393805 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000506700 | ENST00000377332 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000506700 | ENST00000525834 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000506700 | ENST00000484728 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000506700 | ENST00000393808 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000509896 | ENST00000393805 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000509896 | ENST00000377332 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000509896 | ENST00000525834 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000509896 | ENST00000484728 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000509896 | ENST00000393808 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000545650 | ENST00000393805 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000545650 | ENST00000377332 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000545650 | ENST00000525834 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000545650 | ENST00000484728 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000545650 | ENST00000393808 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000508693 | ENST00000393805 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000508693 | ENST00000377332 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000508693 | ENST00000525834 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000508693 | ENST00000484728 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000508693 | ENST00000393808 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000507164 | ENST00000393805 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000507164 | ENST00000377332 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000507164 | ENST00000525834 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000507164 | ENST00000484728 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000507164 | ENST00000393808 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000507625 | ENST00000393805 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000507625 | ENST00000377332 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000507625 | ENST00000525834 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000507625 | ENST00000484728 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000507625 | ENST00000393808 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000514157 | ENST00000393805 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000514157 | ENST00000377332 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000514157 | ENST00000525834 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000514157 | ENST00000484728 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000514157 | ENST00000393808 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000504896 | ENST00000393805 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000504896 | ENST00000377332 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000504896 | ENST00000525834 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000504896 | ENST00000484728 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000504896 | ENST00000393808 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000514996 | ENST00000393805 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000514996 | ENST00000377332 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000514996 | ENST00000525834 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000514996 | ENST00000484728 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000514996 | ENST00000393808 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000506720 | ENST00000393805 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000506720 | ENST00000377332 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000506720 | ENST00000525834 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000506720 | ENST00000484728 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000506720 | ENST00000393808 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000506746 | ENST00000393805 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000506746 | ENST00000377332 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000506746 | ENST00000525834 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000506746 | ENST00000484728 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000506746 | ENST00000393808 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000508946 | ENST00000393805 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000508946 | ENST00000377332 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000508946 | ENST00000525834 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000508946 | ENST00000484728 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
5CDS-5UTR | ENST00000508946 | ENST00000393808 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
intron-5UTR | ENST00000508078 | ENST00000393805 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
intron-5UTR | ENST00000508078 | ENST00000377332 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
intron-5UTR | ENST00000508078 | ENST00000525834 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
intron-5UTR | ENST00000508078 | ENST00000484728 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
intron-5UTR | ENST00000508078 | ENST00000393808 | LPHN3 | chr4 | 62453158 | + | ST3GAL5 | chr2 | 86090608 | - |
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FusionProtFeatures for LPHN3_ST3GAL5 |
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Hgene | Tgene |
LPHN3 | ST3GAL5 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Catalyzes the formation of ganglioside GM3 (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide). {ECO:0000269|PubMed:16934889}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LPHN3_ST3GAL5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LPHN3_ST3GAL5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LPHN3 | ASGR2, FLRT1, LPAR1, C3AR1, MMP26, CLEC2D, IPPK | ST3GAL5 | TMEM259, NDUFAF7, HLA-DPB1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LPHN3_ST3GAL5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LPHN3_ST3GAL5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |