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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20006

FusionGeneSummary for LPHN3_DBX2

check button Fusion gene summary
Fusion gene informationFusion gene name: LPHN3_DBX2
Fusion gene ID: 20006
HgeneTgene
Gene symbol

LPHN3

DBX2

Gene ID

23284

440097

Gene nameadhesion G protein-coupled receptor L3developing brain homeobox 2
SynonymsCIRL3|CL3|LEC3|LPHN3-
Cytomap

4q13.1

12q12

Type of geneprotein-codingprotein-coding
Descriptionadhesion G protein-coupled receptor L3CIRL-3calcium-independent alpha-latrotoxin receptor 3latrophilin homolog 3 (cow)latrophilin-3lectomedin 3homeobox protein DBX2developing brain homeobox protein 2
Modification date2018052320180403
UniProtAcc

Q6ZNG2

Ensembl transtripts involved in fusion geneENST00000512091, ENST00000514591, 
ENST00000511324, ENST00000506700, 
ENST00000509896, ENST00000545650, 
ENST00000508693, ENST00000507164, 
ENST00000507625, ENST00000514157, 
ENST00000504896, ENST00000514996, 
ENST00000506720, ENST00000506746, 
ENST00000508946, ENST00000508078, 
ENST00000332700, 
Fusion gene scores* DoF score5 X 3 X 4=601 X 1 X 1=1
# samples 51
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: LPHN3 [Title/Abstract] AND DBX2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLPHN3

GO:0098742

cell-cell adhesion via plasma-membrane adhesion molecules

26235030


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-DB-A64X-01ALPHN3chr4

62453158

+DBX2chr12

45429897

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000512091ENST00000332700LPHN3chr4

62453158

+DBX2chr12

45429897

-
Frame-shiftENST00000514591ENST00000332700LPHN3chr4

62453158

+DBX2chr12

45429897

-
Frame-shiftENST00000511324ENST00000332700LPHN3chr4

62453158

+DBX2chr12

45429897

-
Frame-shiftENST00000506700ENST00000332700LPHN3chr4

62453158

+DBX2chr12

45429897

-
Frame-shiftENST00000509896ENST00000332700LPHN3chr4

62453158

+DBX2chr12

45429897

-
Frame-shiftENST00000545650ENST00000332700LPHN3chr4

62453158

+DBX2chr12

45429897

-
Frame-shiftENST00000508693ENST00000332700LPHN3chr4

62453158

+DBX2chr12

45429897

-
Frame-shiftENST00000507164ENST00000332700LPHN3chr4

62453158

+DBX2chr12

45429897

-
Frame-shiftENST00000507625ENST00000332700LPHN3chr4

62453158

+DBX2chr12

45429897

-
Frame-shiftENST00000514157ENST00000332700LPHN3chr4

62453158

+DBX2chr12

45429897

-
Frame-shiftENST00000504896ENST00000332700LPHN3chr4

62453158

+DBX2chr12

45429897

-
Frame-shiftENST00000514996ENST00000332700LPHN3chr4

62453158

+DBX2chr12

45429897

-
Frame-shiftENST00000506720ENST00000332700LPHN3chr4

62453158

+DBX2chr12

45429897

-
Frame-shiftENST00000506746ENST00000332700LPHN3chr4

62453158

+DBX2chr12

45429897

-
Frame-shiftENST00000508946ENST00000332700LPHN3chr4

62453158

+DBX2chr12

45429897

-
intron-3CDSENST00000508078ENST00000332700LPHN3chr4

62453158

+DBX2chr12

45429897

-

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FusionProtFeatures for LPHN3_DBX2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LPHN3

DBX2

Q6ZNG2

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LPHN3_DBX2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LPHN3_DBX2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LPHN3ASGR2, FLRT1, LPAR1, C3AR1, MMP26, CLEC2D, IPPKDBX2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LPHN3_DBX2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LPHN3_DBX2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource