|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 19999 |
FusionGeneSummary for LPCAT4_SPRED1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LPCAT4_SPRED1 | Fusion gene ID: 19999 | Hgene | Tgene | Gene symbol | LPCAT4 | SPRED1 | Gene ID | 254531 | 161742 |
| Gene name | lysophosphatidylcholine acyltransferase 4 | sprouty related EVH1 domain containing 1 | |
| Synonyms | AGPAT7|AYTL3|LPAAT-eta|LPEAT2 | NFLS|PPP1R147|hSpred1|spred-1 | |
| Cytomap | 15q14 | 15q14 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lysophospholipid acyltransferase LPCAT41-AGP acyltransferase 71-AGPAT 71-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta)1-acylglycerophosphocholine O-acyltransferase1-acylglycerophosphoserine O-acyltransferas | sprouty-related, EVH1 domain-containing protein 1protein phosphatase 1, regulatory subunit 147suppressor of Ras/MAPK activation | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q643R3 | Q7Z699 | |
| Ensembl transtripts involved in fusion gene | ENST00000314891, ENST00000562431, | ENST00000299084, ENST00000561205, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 5 X 5 X 2=50 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/50*10)=0.263034405833794 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: LPCAT4 [Title/Abstract] AND SPRED1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LPCAT4 | GO:0006644 | phospholipid metabolic process | 18458083 |
| Tgene | SPRED1 | GO:0006469 | negative regulation of protein kinase activity | 18216281 |
| Tgene | SPRED1 | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ESCA | TCGA-2H-A9GN-01A | LPCAT4 | chr15 | 34654397 | - | SPRED1 | chr15 | 38591574 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000314891 | ENST00000299084 | LPCAT4 | chr15 | 34654397 | - | SPRED1 | chr15 | 38591574 | + |
| 5CDS-3UTR | ENST00000314891 | ENST00000561205 | LPCAT4 | chr15 | 34654397 | - | SPRED1 | chr15 | 38591574 | + |
| intron-3CDS | ENST00000562431 | ENST00000299084 | LPCAT4 | chr15 | 34654397 | - | SPRED1 | chr15 | 38591574 | + |
| intron-3UTR | ENST00000562431 | ENST00000561205 | LPCAT4 | chr15 | 34654397 | - | SPRED1 | chr15 | 38591574 | + |
Top |
FusionProtFeatures for LPCAT4_SPRED1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LPCAT4 | SPRED1 |
| Displays acyl-CoA-dependent lysophospholipidacyltransferase activity with a subset of lysophospholipids assubstrates; converts lysophosphatidylethanolamine tophosphatidylethanolamine, lysophosphatidylcholine tophosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol andalkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl-phosphatidylcholine, respectively. In contrast, has nolysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol orlysophosphatidic acid acyltransferase activity. Prefers long chainacyl-CoAs (C16, C18) as acyl donors.{ECO:0000269|PubMed:18458083}. | Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulateshematopoiesis of bone marrow (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LPCAT4 | chr15:34654397 | chr15:38591574 | ENST00000314891 | - | 10 | 14 | 129_134 | 336 | 525 | Motif | Note=HXXXXD motif |
| Hgene | LPCAT4 | chr15:34654397 | chr15:38591574 | ENST00000314891 | - | 10 | 14 | 40_62 | 336 | 525 | Transmembrane | Helical |
| Hgene | LPCAT4 | chr15:34654397 | chr15:38591574 | ENST00000314891 | - | 10 | 14 | 87_107 | 336 | 525 | Transmembrane | Helical |
| Tgene | >SPRED1 | chr15:34654397 | chr15:38591574 | ENST00000299084 | + | 0 | 7 | 147_150 | 10 | 445 | Compositional bias | Note=Poly-Ser |
| Tgene | >SPRED1 | chr15:34654397 | chr15:38591574 | ENST00000299084 | + | 0 | 7 | 233_285 | 10 | 445 | Domain | KBD |
| Tgene | >SPRED1 | chr15:34654397 | chr15:38591574 | ENST00000299084 | + | 0 | 7 | 334_442 | 10 | 445 | Domain | SPR |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | SPRED1 | chr15:34654397 | chr15:38591574 | ENST00000299084 | + | 0 | 7 | 6_123 | 10 | 445 | Domain | WH1 |
Top |
FusionGeneSequence for LPCAT4_SPRED1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_LPCAT4_ENST00000314891_chr15_34654397_-_SPRED1_ENST00000299084_chr15_38591574_+_771aa MSQGSPGDWAPLDPTPGPPASPNPFVHELHLSRLQRVKFCLLGALLAPIRVLLAFIVLFLLWPFAWLQVAGLSEEQLQEPITGWRKTVCH NGVLGLSRLLFFLLGFLRIRVRGQRASRLQAPVLVAAPHSTFFDPIVLLPCDLPKVVSRAENLSVPVIGALLRFNQAILVSRHDPASRRR VVEEVRRRATSGGKWPQVLFFPEGTCSNKKALLKFKPGAFIAGVPVQPVLIRYPNSLDTTSWAWRGPGVLKVLWLTASQPCSIVDVEFLP VYHPSPEESRDPTLYANNVQRVMAQALGIPATECEFVGSLPVIVVGRLKVALEPQLWELGKVLRKAGNSYARVRAVVMTRDDSSGGWLPL GGSGLSSVTVFKVPHQEENGCADFFIRGERLRDKMVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRAIEDIS QGCPESKNEAEGADDLQANEEDSSSSLVKDHLFQQETVVTSEPYRSSNIRPSPFEDLNARRVYMQSQANQITFGQPGLDIQSRSMEYVQR QISKECGSLKSQNRVPLKSIRHVSFQDEDEIVRINPRDILIRRYADYRHPDMWKNDLERDDADSSIQFSKPDSKKSDYLYSCGDETKLSS PKDSVVFKTQPSSLKIKKSKRRKEDGERSRCVYCQERFNHEENVRGKCQDAPDPIKRCIYQVSCMLCAESMLYHCMSDSEGDFSDPCSCD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_LPCAT4_ENST00000314891_chr15_34654397_-_SPRED1_ENST00000299084_chr15_38591574_+_2313nt ATGAGCCAGGGAAGTCCGGGGGACTGGGCCCCCCTAGATCCCACCCCCGGACCCCCAGCATCCCCCAACCCCTTCGTGCATGAGTTACAT CTCTCTCGCCTCCAGAGGGTTAAGTTCTGCCTCCTGGGGGCATTGCTGGCCCCCATCCGAGTGCTTCTGGCCTTTATCGTCCTCTTTCTC CTCTGGCCCTTTGCCTGGCTTCAAGTGGCCGGTCTTAGTGAGGAGCAGCTTCAGGAGCCAATTACAGGATGGAGGAAGACTGTGTGCCAC AACGGGGTGCTAGGCCTGAGCCGCCTGCTGTTTTTCCTGCTGGGCTTCCTCCGGATTCGCGTTCGTGGCCAGCGAGCCTCTCGCCTTCAA GCCCCTGTCCTTGTTGCTGCCCCACACTCCACTTTCTTTGACCCCATTGTTCTGCTGCCCTGTGACCTGCCCAAAGTTGTGTCCCGAGCT GAGAACCTTTCCGTTCCTGTCATTGGAGCCCTTCTTCGATTCAACCAAGCCATCCTGGTATCCCGGCATGACCCGGCTTCTCGACGCAGA GTGGTGGAGGAGGTCCGAAGGCGGGCCACCTCAGGAGGCAAGTGGCCGCAGGTGCTATTCTTTCCTGAGGGCACCTGTTCCAACAAGAAG GCTTTGCTTAAGTTCAAACCAGGAGCCTTCATCGCAGGGGTGCCTGTGCAGCCTGTCCTCATCCGCTACCCCAACAGTCTGGACACCACC AGCTGGGCATGGAGGGGTCCTGGAGTACTCAAAGTCCTCTGGCTCACAGCCTCTCAGCCCTGCAGCATTGTGGATGTGGAGTTCCTTCCT GTGTATCACCCCAGCCCTGAGGAGAGCAGGGACCCCACCCTCTATGCCAACAATGTTCAGAGGGTCATGGCACAGGCTCTGGGCATTCCA GCCACCGAATGTGAGTTTGTAGGGAGCTTACCTGTGATTGTGGTGGGCCGGCTGAAGGTGGCGTTGGAACCACAGCTCTGGGAACTGGGA AAAGTGCTTCGGAAGGCTGGTAATAGTTATGCACGAGTGCGAGCTGTGGTGATGACCCGAGATGACTCAAGTGGTGGATGGTTACCACTT GGAGGGAGTGGACTAAGCAGCGTCACTGTCTTCAAAGTCCCTCATCAGGAAGAGAATGGCTGTGCTGACTTTTTTATCCGTGGAGAGCGA CTCAGGGACAAAATGGTGGTTTTGGAATGTATGCTTAAAAAAGACCTCATTTATAATAAGGTCACTCCAACATTTCACCACTGGAAGATT GATGACAAGAAGTTTGGTCTTACGTTTCAAAGTCCTGCTGATGCTAGGGCTTTTGATAGAGGTATCCGAAGAGCTATAGAGGATATTTCT CAAGGATGCCCCGAATCAAAAAATGAAGCTGAAGGGGCAGATGACTTACAAGCAAATGAAGAGGATTCTTCCAGTTCTCTAGTGAAGGAT CACCTTTTTCAGCAAGAGACAGTTGTTACCAGTGAGCCTTATAGAAGCTCAAATATAAGACCTTCTCCCTTTGAAGATCTGAATGCCAGA AGAGTCTACATGCAAAGCCAAGCCAATCAGATAACATTTGGTCAGCCAGGCTTGGACATTCAGAGCAGAAGTATGGAATACGTACAGCGG CAAATATCCAAGGAATGTGGAAGCCTAAAGTCCCAAAATAGGGTCCCTTTGAAATCAATCAGACATGTCAGCTTTCAAGATGAGGATGAG ATTGTCAGAATAAACCCTCGAGATATCTTAATACGTCGCTATGCAGACTACAGACATCCTGACATGTGGAAAAATGACTTGGAAAGAGAT GATGCTGATTCCAGTATTCAGTTTTCTAAACCAGACAGTAAAAAATCAGACTATCTGTACTCTTGTGGGGATGAGACTAAGTTAAGTTCA CCCAAAGACTCTGTGGTATTTAAGACGCAGCCTTCCTCATTAAAAATTAAGAAGTCAAAACGAAGAAAAGAGGATGGTGAACGTTCTCGC TGCGTATACTGCCAGGAAAGGTTTAATCATGAAGAAAATGTTAGGGGAAAATGTCAGGATGCTCCAGACCCTATTAAAAGATGCATATAT CAAGTTAGTTGCATGCTCTGTGCAGAGAGCATGTTGTATCATTGTATGTCAGACTCAGAGGGAGATTTTTCTGATCCCTGTTCGTGTGAC ACTAGCGACGACAAGTTCTGCTTGCGATGGTTAGCCCTGGTAGCTTTGTCTTTCATTGTACCATGTATGTGCTGCTACGTCCCTTTGAGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_LPCAT4_ENST00000314891_chr15_34654397_-_SPRED1_ENST00000299084_chr15_38591574_+_8076nt GGCGCCCTGACAACGCGGGCGGGCTGGGCTGCGCCGCCTGCTCCCCGCCCCTCGGCCGCCTGCACCGGGCGGGGCCCGGGCCAGAGCGCC GCCGCCGCCGCTGCTGCAGCAGCAGCTGCTCTGCAGAGTGGTGGCCGGGGCCAGGGCCGGGGTGCCCTCCCTCCCACCTTCTCCCGCCAT GAGCCAGGGAAGTCCGGGGGACTGGGCCCCCCTAGATCCCACCCCCGGACCCCCAGCATCCCCCAACCCCTTCGTGCATGAGTTACATCT CTCTCGCCTCCAGAGGGTTAAGTTCTGCCTCCTGGGGGCATTGCTGGCCCCCATCCGAGTGCTTCTGGCCTTTATCGTCCTCTTTCTCCT CTGGCCCTTTGCCTGGCTTCAAGTGGCCGGTCTTAGTGAGGAGCAGCTTCAGGAGCCAATTACAGGATGGAGGAAGACTGTGTGCCACAA CGGGGTGCTAGGCCTGAGCCGCCTGCTGTTTTTCCTGCTGGGCTTCCTCCGGATTCGCGTTCGTGGCCAGCGAGCCTCTCGCCTTCAAGC CCCTGTCCTTGTTGCTGCCCCACACTCCACTTTCTTTGACCCCATTGTTCTGCTGCCCTGTGACCTGCCCAAAGTTGTGTCCCGAGCTGA GAACCTTTCCGTTCCTGTCATTGGAGCCCTTCTTCGATTCAACCAAGCCATCCTGGTATCCCGGCATGACCCGGCTTCTCGACGCAGAGT GGTGGAGGAGGTCCGAAGGCGGGCCACCTCAGGAGGCAAGTGGCCGCAGGTGCTATTCTTTCCTGAGGGCACCTGTTCCAACAAGAAGGC TTTGCTTAAGTTCAAACCAGGAGCCTTCATCGCAGGGGTGCCTGTGCAGCCTGTCCTCATCCGCTACCCCAACAGTCTGGACACCACCAG CTGGGCATGGAGGGGTCCTGGAGTACTCAAAGTCCTCTGGCTCACAGCCTCTCAGCCCTGCAGCATTGTGGATGTGGAGTTCCTTCCTGT GTATCACCCCAGCCCTGAGGAGAGCAGGGACCCCACCCTCTATGCCAACAATGTTCAGAGGGTCATGGCACAGGCTCTGGGCATTCCAGC CACCGAATGTGAGTTTGTAGGGAGCTTACCTGTGATTGTGGTGGGCCGGCTGAAGGTGGCGTTGGAACCACAGCTCTGGGAACTGGGAAA AGTGCTTCGGAAGGCTGGTAATAGTTATGCACGAGTGCGAGCTGTGGTGATGACCCGAGATGACTCAAGTGGTGGATGGTTACCACTTGG AGGGAGTGGACTAAGCAGCGTCACTGTCTTCAAAGTCCCTCATCAGGAAGAGAATGGCTGTGCTGACTTTTTTATCCGTGGAGAGCGACT CAGGGACAAAATGGTGGTTTTGGAATGTATGCTTAAAAAAGACCTCATTTATAATAAGGTCACTCCAACATTTCACCACTGGAAGATTGA TGACAAGAAGTTTGGTCTTACGTTTCAAAGTCCTGCTGATGCTAGGGCTTTTGATAGAGGTATCCGAAGAGCTATAGAGGATATTTCTCA AGGATGCCCCGAATCAAAAAATGAAGCTGAAGGGGCAGATGACTTACAAGCAAATGAAGAGGATTCTTCCAGTTCTCTAGTGAAGGATCA CCTTTTTCAGCAAGAGACAGTTGTTACCAGTGAGCCTTATAGAAGCTCAAATATAAGACCTTCTCCCTTTGAAGATCTGAATGCCAGAAG AGTCTACATGCAAAGCCAAGCCAATCAGATAACATTTGGTCAGCCAGGCTTGGACATTCAGAGCAGAAGTATGGAATACGTACAGCGGCA AATATCCAAGGAATGTGGAAGCCTAAAGTCCCAAAATAGGGTCCCTTTGAAATCAATCAGACATGTCAGCTTTCAAGATGAGGATGAGAT TGTCAGAATAAACCCTCGAGATATCTTAATACGTCGCTATGCAGACTACAGACATCCTGACATGTGGAAAAATGACTTGGAAAGAGATGA TGCTGATTCCAGTATTCAGTTTTCTAAACCAGACAGTAAAAAATCAGACTATCTGTACTCTTGTGGGGATGAGACTAAGTTAAGTTCACC CAAAGACTCTGTGGTATTTAAGACGCAGCCTTCCTCATTAAAAATTAAGAAGTCAAAACGAAGAAAAGAGGATGGTGAACGTTCTCGCTG CGTATACTGCCAGGAAAGGTTTAATCATGAAGAAAATGTTAGGGGAAAATGTCAGGATGCTCCAGACCCTATTAAAAGATGCATATATCA AGTTAGTTGCATGCTCTGTGCAGAGAGCATGTTGTATCATTGTATGTCAGACTCAGAGGGAGATTTTTCTGATCCCTGTTCGTGTGACAC TAGCGACGACAAGTTCTGCTTGCGATGGTTAGCCCTGGTAGCTTTGTCTTTCATTGTACCATGTATGTGCTGCTACGTCCCTTTGAGAAT GTGCCATCGCTGTGGTGAGGCATGTGGTTGCTGTGGTGGGAAACATAAAGCTGCTGGATGAAATGGTCCAGTGCCAAAATGAGCTTAAAA TCTTTGTTTCCAGGAATTAGCTAACTTGGATTTGTGGAAGCTTTTGGCAAGCAATATGGAATCTTGCCTGGTATCATTGAGCCCACACAT GGAGGAAGCAGAACTCATCAGTTCTTGGCGTTTCACGCCATGCCTAACTTTTCCCTTGAGTGCATGGCATGTTTTGTTACAGGTTGTAGA GTATTTGCAGAAGGAAACCATTTCTGGTTATTTGGCTATAAAAAGTCAGCATAAAATATGATCCAACTAAAAGGGATTAATTTTTGGCAT TTTTGTATATTTATGCATTAGGTGATGGGACTTTTAAAGGTTTGAATTTATTAGGACACGAACTAAAAATAAAAGTGCACTAGGGGACAG TTGATTTCAATCTAAGAAAAGTTAACACTTGGGAATTACAAGAAGTAAAACAAGTGCAACTAAATCATTTATTAGTTGTTTTTTGAAAGC AGTTTTATGTATAAATAACAAATGTTTATATTTAACTAAATGTAAGGTACGAATTATTACATATTAAACTTTTCTTCCCCTTCCTAGTTC TGAAGTAGATATATATATATATATATCTACTGTCACATTCCATATATTTTGAATATTTAACTCATCTAGTTAATAATGTTTTTATTCCAT GCGAATGATTTGATATTTTCATCCTTATTTCTCTTTGGCTACAATTTATATTGAGTTATATCTGTACATTCTGGTAATCTAAAATCCTTA AAAATACTCTAATAGCCTTGAGTGACCAACTTTTTTTTTAAAGCACAGATGTAATTGTCTAATGTTCTGATGGGAACGTAACACTTATTT TTATATAAAAAGAGACTGAGTAAACAAACATTATAGAAAAAAAGTGAAGTTTTTTAGTTGTTTTTTGTGGTATTCAACCAGCAAGTTGTT TTCTTTCAGAGTTTCCTCCTTCAAAAAGTTATATTGCATTTACAAATGTTTTACAAGGCAGAAAGTTTGACTGGATAGTTAGTGTAAAAG CTTCATGTTGAGATCTTCACGTATCATTCTGCTAAACCAGAATATGTTCAGCTGTGTTACTAATTTTTCAGCTTAATCCTCAGTGCTTAT TATTTACATAACAATAACTTTTTATCAGTTACATTTTATTTTTATTTAAACTGGCCAAAAGCAAAATTATTTTATGTTAAAATGTGTGCT AAACTATCCCAGGAAAGTATTTAATCCAACATTGTAAATGAAGTATCTTGTACATATAAATTTATTTCTTTTGCAGAGCATTATATTACT GGATGTTTAATTTACAAAATAGTTGGGTAAATGTTCCAACAAACTTTAAAGTACCTTGAAGTCAAATTGTCTGTTTTTGTTTTGTTGTTG TTGTTGTTGTTTTCTTAAGTGTTACATTAAAACTCTAACCAAGGAAAGGGTTCTTTAAGAACATTCCCTTAGAGGGATAAAGTTGAGAAG TGTGCCTTTTTTTTAATGGCTTGAAGTTTCAGAGGTGATAAAAATTAAAATCACACTACTATTTGAAGCTCATTTTCTATGCAGGTTTTT AAACGTCATTTATGTATCATTCTTTTTATATATCACACTTAAGCTTGTGTTAGCTTTTTTCTTTTGCCCCAGATCAAACTGAACAATGTA TATAACACTATCTGTCTGTAAAATACTTTTTTTAAGAAAGCATTTATATTTATATGACAGCTTGAACTGACAACATTGTGTATATAGATC ATCTTGAAGTATTATTTCACATTGAAAAGAAGAAAATATATTGATAACTATAGATGTTATGAAGAAGAGGGTATTTCTAGTTTTGTACTA AAAATCAATTGGATGAACTAAATCCAAAACATGACACTGTAGGCAGCAGTTTTAAGTCTTATTTTTACTGTTTATATATTTGAATGCTGC TACAACAGATGATCTTCATCCCTGAAGTTTTCAGCTAAACTTGGTTTCCTAGAATAGACTGTTAACTTTCAAAATTTTTATTGGTGAAAT GGAAATACTGTTTTTCCTTGTGAATGAATTTTCATATTTGTAAGTGCTAAGTTTATAATTCAGGTTTGATCAAGGTGTGAATAACTGAAG AAAATAACTTGCTGGCTATATAGGAAAATGCTGTGGAAATGAACTGTGTATATACTTCTGGGAGGAACAAATTTAATCATTTCTTCTGTT AAGCACTAATCAGTATAGTGCAACTCCTGGTTCTGTACTGTATTTTATATGCAACATATATGCTTTAATATTTTAATGTTTGTGCATTAA TATTTTCAATTTGTTTAACCACTTTGCTGCTAAGATTTTGCCGTCCCATTCCCATTTTTTCCTTTACAATTTTAAACAAGTTTCTTCATT AAAAACTATGGTGATGAAATGGTTTTTATTTTACCTTGGATCTTTATAGTTAACATACCCAGTTTCTTAATCAGTCTACAAGACTAACTG ATGATATAATGTTCTCTGAATCCCTATATGGAAATTTTCTTTTGAGTAAATGAGAATTCCTTTGTGAAAGCAAATGGGTAGTTTAAATCA CTGATTCTTAAACATGTGTATAGGCACCTTCAGGAACATTTTCTCATTCTCTGTACAGATTCGGCACTGCCAATTGGCTTTTCCTCTAAA ACTTTTCTTTGTTTTTATCTGATATAAGCAGATGGCTCAAGACAACTGCTTGAGTAATAGTATTGAAAATGGAATCATCTAGACGGCATG ACAAGCAAGACTGGTCTGATGAACTTGTTCAGAATTGATAATTCTTAAATATTTCTCTTGGCTTCAAAAGGGACATCATTTGATTTCTGA AGAAGTATGTCGTGTGGAGCTTCAGCACCACCTACTGGATGATTTCCAGGCCAGAGACATGAGATGGCAATAGGGATCTGACAGGGTTCA TCACTACTACCATTAAAGGGCTATTTATGTGGTGACCACCTCTACCAGGGAAACCAGGAATAAGAACTGTCTCAAAGGAATTGTAAAATG GTTATTTACCTAATGTGTCTTGTTGGCTTGCTGAAAGATTTTAAGCACTTTTTTCTTACATATCCTGTTTTAAAATATTTGTTGATATTT GGGACTGGCAATCAAACTTAATGGATGTACTGAGGCATTTATAGAACCAGTTGCTTTAACTCTCAAAAGCCATTACCAAAATGGTATTTT TTTCCTCCTTCCGCCAGTCAGGGAGAATTTTTAAAAATAATAATCAAAACATGAAAAAACATAATCACACCTGTATTTTATCATGACAGC TTCAGAGAGTGTGTGTGTACGTTTTTCTCTCTTTTATTTGAGACGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGTGCGATCT CAGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCCACCACCATG CCCAGCTAAGTTTTGGTATTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTTAGGTGATCCACCCA CCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCTACTGCGCCCAGCCGTGTGTATGTTTCTGAAATGATGATGGGGTGGGGTTAA AATCTAAAGGGAAAAACTTGAAACTACCTATTTTCATTGGTTATTCAGCAGTGCCTAAAATGAGCTTTTGAAGTAATGTAAATGCACTTT CAATTCATGTGTATAGTGCCATCTGATATCTTGGGTAAGTCTTGCTTTTTCTTTTCTTTTTCCTCTCCCCTGCCCCCTTAATTAAATGGC ACGGAAATGTTTCTTAATATGCACGTGAGTCTCCAGAGTACAGGAAATGTGCTTTCCTCTAAATGGTCAATGTAAAGAATCTTAAGGATA TTTCTTGTGTTGAAATTTACATTCGATTTTGTGATTACACTTGGAAGTATGTGTTAAATTGGGTTTTTAATTGTAGCCCAAAGGTGCATT AAGCAAGTGTAACATTTTTTCCACATAAAACTTAGAAAACTTTAGTTACCTGAAAAGCAAGGATTCTTTACTAATTATTATGCTCATTCT TGATTTGACTTCCATGTTCACACTTCAAAGTGTAAGAGGAAGCACTAGAAACTGGCATTATTGTTGCACTAAAAAAGTCTATAAATCATA ATAGCACCATGAGGTGTTTTGCAATGAGACAAACATGAAGAATGAATTTCTTTAAGAGAGAAACACAACCGGAGGTGATTTATATAAACC AAAAGAAAAAAAAAGGCTTTAAGGTATTAGGTACTGTTTGCCTAGCAGCCAGGTGGTTATAAAAGATTCATATGCTTTGGTACACTGATA AATGTTAGCCATTATTCCTGAAAGCTTCTTAAATTGCATCAGTTGTTTTGAAATTTTTTCAAGAATAAACTAGTTGAAAAGTCTTTGTAT TAAAAATACACATAGATTTTTGTGAACATTTCCAGTGTGTAGTGTCGTTTGCTTTCTATTTCTGACCTCAAAAGTGCCTCACTTGTATAT TATTTCCATTAAAAGCTTGACTGCATTCTTTCTAATGAACAATGAAAAACTGTTTAACTCATGTCATAATGTGTCTCCTCAGATATAGTT AACTAGCTTGATAGTTTTGAGTATATAATGTAAATAATACATTATAAGTTTGTAACCATTTCTGTTACTTCATACCCGTGTAATTGGACA TAGCAGATGATTATCATAAGAATTTGTTTTAATGGTTTTTTTCCCTCCTGGAATTACCTGATTAAACCTGTCATGAATTATAAAAGGACT TTTTCTTATTCTCCTAGAGCTTATCAAATTATCACATAAGAGATAATTACTGGAGGAGAAAGTAAAAATGGAAGCTTTTGATAATTAGCT CTGTTCTTTAAAAGTATACTTTTAAACTGAAAGTTCACATATAGTTCATCTTAATAACATATTTATTCATCCTTAATTGTATTCAGATTT TTTTTTAAGTCTCTAAGCTAATAATGTTATATTTATTGGTTTGGTAACATGTTGCAGCTAAGCTAATGACCTTAAGTGGCAATTGTTTAA CCCAGGACTACTGATTTTTTTATATTCAAGTCAGTTTCATCGTTTTACTTAACTCGCCATATAACCAAAAATAACGAATAATCTAAAGGA AAGGTTATTAGGACAGTAATAAAAAATTATAGTGTATCTCAACACTAGAATAAGTTGGATTACTATATTATAGTTTATTTGAAAAATCAA GGAGTAACTGTATCTTTACCATTAATTATGAAATGTAGTCTCATGTGCTTATTTACAGGTTTTTCAGAATTTGCTTTACATTCTTCACAT CAAGTTAATACCCACAAGTAAGTAGAATAGCTTTTATAACAAGGAAATTGAAACTAGGGTTCTAGCTTGGCTATCAATATAAGTGTCATG CACATAGTGCTCCTTAAAGAAAAAGACATCGACATCAATGGTATGAAAGCTGTAGTCACTCTTTAAATTGAACTGCTCTAAGATTTGCAG |
Top |
FusionGenePPI for LPCAT4_SPRED1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LPCAT4 | ELAVL1, TMEM25, ISLR, SPG7, CHRM4, SCGB2A2, DUSP14, DSG4, USP33, HAVCR2 | SPRED1 | TESK1, OSGEP, FAM118B, TTC19, DNAJB11, CDKN1A, NAGK, RCC1, TSC22D1, PPP1CA, ELAVL1, SUV39H1, ZDHHC17, FBXW7, CDH1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for LPCAT4_SPRED1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for LPCAT4_SPRED1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SPRED1 | C1969623 | NEUROFIBROMATOSIS, TYPE 1-LIKE SYNDROME | 2 | CTD_human;ORPHANET;UNIPROT |
| Tgene | SPRED1 | C0027831 | Neurofibromatosis 1 | 1 | CTD_human |
| Tgene | SPRED1 | C0221263 | Cafe-au-Lait Spots | 1 | CTD_human |
| Tgene | SPRED1 | C0497552 | Congenital neurologic anomalies | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|