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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19992

FusionGeneSummary for LPCAT2_TXNDC5

check button Fusion gene summary
Fusion gene informationFusion gene name: LPCAT2_TXNDC5
Fusion gene ID: 19992
HgeneTgene
Gene symbol

LPCAT2

TXNDC5

Gene ID

54947

81567

Gene namelysophosphatidylcholine acyltransferase 2thioredoxin domain containing 5
SynonymsAGPAT11|AYTL1|LysoPAFATENDOPDI|ERP46|HCC-2|HCC2|PDIA15|STRF8|UNQ364
Cytomap

16q12.2

6p24.3

Type of geneprotein-codingprotein-coding
Descriptionlysophosphatidylcholine acyltransferase 21-AGP acyltransferase 111-AGPAT 111-acylglycerol-3-phosphate O-acyltransferase 111-acylglycerophosphocholine O-acyltransferase1-alkylglycerophosphocholine O-acetyltransferaseLPAAT-alphaLPC acyltransferase 2thioredoxin domain-containing protein 5ER protein 46endoplasmic reticulum protein ERp46endoplasmic reticulum resident protein 46endothelial protein disulphide isomeraseprotein disulfide isomerase family A, member 15thioredoxin domain containing 5 (e
Modification date2018051920180523
UniProtAcc

Q7L5N7

Q8NBS9

Ensembl transtripts involved in fusion geneENST00000262134, ENST00000565056, 
ENST00000539054, ENST00000379757, 
ENST00000473453, 
Fusion gene scores* DoF score4 X 5 X 3=607 X 7 X 2=98
# samples 57
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/98*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LPCAT2 [Title/Abstract] AND TXNDC5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLPCAT2

GO:0036151

phosphatidylcholine acyl-chain remodeling

21498505


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AJ420584LPCAT2chr16

55617581

+TXNDC5chr6

8014530

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000262134ENST00000539054LPCAT2chr16

55617581

+TXNDC5chr6

8014530

-
3UTR-intronENST00000262134ENST00000379757LPCAT2chr16

55617581

+TXNDC5chr6

8014530

-
3UTR-intronENST00000262134ENST00000473453LPCAT2chr16

55617581

+TXNDC5chr6

8014530

-
intron-intronENST00000565056ENST00000539054LPCAT2chr16

55617581

+TXNDC5chr6

8014530

-
intron-intronENST00000565056ENST00000379757LPCAT2chr16

55617581

+TXNDC5chr6

8014530

-
intron-intronENST00000565056ENST00000473453LPCAT2chr16

55617581

+TXNDC5chr6

8014530

-

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FusionProtFeatures for LPCAT2_TXNDC5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LPCAT2

Q7L5N7

TXNDC5

Q8NBS9

Possesses both acyltransferase and acetyltransferaseactivities. Activity is calcium-dependent. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversionof the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF).Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAFprecursor. Under resting conditions, acyltransferase activity ispreferred. Upon acute inflammatory stimulus, acetyltransferaseactivity is enhanced and PAF synthesis increases. Also catalyzesthe conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine. {ECO:0000269|PubMed:20363836,ECO:0000269|PubMed:21498505}. Possesses thioredoxin activity. Has been shown to reduceinsulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LPCAT2_TXNDC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LPCAT2_TXNDC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LPCAT2_TXNDC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LPCAT2_TXNDC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLPCAT2C0032460Polycystic Ovary Syndrome1CTD_human
TgeneTXNDC5C0003873Rheumatoid Arthritis1CTD_human
TgeneTXNDC5C0027627Neoplasm Metastasis1CTD_human
TgeneTXNDC5C0033578Prostatic Neoplasms1CTD_human
TgeneTXNDC5C0036341Schizophrenia1PSYGENET
TgeneTXNDC5C0993582Arthritis, Experimental1CTD_human