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Fusion gene ID: 19992 |
FusionGeneSummary for LPCAT2_TXNDC5 |
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Fusion gene information | Fusion gene name: LPCAT2_TXNDC5 | Fusion gene ID: 19992 | Hgene | Tgene | Gene symbol | LPCAT2 | TXNDC5 | Gene ID | 54947 | 81567 |
Gene name | lysophosphatidylcholine acyltransferase 2 | thioredoxin domain containing 5 | |
Synonyms | AGPAT11|AYTL1|LysoPAFAT | ENDOPDI|ERP46|HCC-2|HCC2|PDIA15|STRF8|UNQ364 | |
Cytomap | 16q12.2 | 6p24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | lysophosphatidylcholine acyltransferase 21-AGP acyltransferase 111-AGPAT 111-acylglycerol-3-phosphate O-acyltransferase 111-acylglycerophosphocholine O-acyltransferase1-alkylglycerophosphocholine O-acetyltransferaseLPAAT-alphaLPC acyltransferase 2 | thioredoxin domain-containing protein 5ER protein 46endoplasmic reticulum protein ERp46endoplasmic reticulum resident protein 46endothelial protein disulphide isomeraseprotein disulfide isomerase family A, member 15thioredoxin domain containing 5 (e | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q7L5N7 | Q8NBS9 | |
Ensembl transtripts involved in fusion gene | ENST00000262134, ENST00000565056, | ENST00000539054, ENST00000379757, ENST00000473453, | |
Fusion gene scores | * DoF score | 4 X 5 X 3=60 | 7 X 7 X 2=98 |
# samples | 5 | 7 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/98*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LPCAT2 [Title/Abstract] AND TXNDC5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LPCAT2 | GO:0036151 | phosphatidylcholine acyl-chain remodeling | 21498505 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AJ420584 | LPCAT2 | chr16 | 55617581 | + | TXNDC5 | chr6 | 8014530 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000262134 | ENST00000539054 | LPCAT2 | chr16 | 55617581 | + | TXNDC5 | chr6 | 8014530 | - |
3UTR-intron | ENST00000262134 | ENST00000379757 | LPCAT2 | chr16 | 55617581 | + | TXNDC5 | chr6 | 8014530 | - |
3UTR-intron | ENST00000262134 | ENST00000473453 | LPCAT2 | chr16 | 55617581 | + | TXNDC5 | chr6 | 8014530 | - |
intron-intron | ENST00000565056 | ENST00000539054 | LPCAT2 | chr16 | 55617581 | + | TXNDC5 | chr6 | 8014530 | - |
intron-intron | ENST00000565056 | ENST00000379757 | LPCAT2 | chr16 | 55617581 | + | TXNDC5 | chr6 | 8014530 | - |
intron-intron | ENST00000565056 | ENST00000473453 | LPCAT2 | chr16 | 55617581 | + | TXNDC5 | chr6 | 8014530 | - |
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FusionProtFeatures for LPCAT2_TXNDC5 |
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Hgene | Tgene |
LPCAT2 | TXNDC5 |
Possesses both acyltransferase and acetyltransferaseactivities. Activity is calcium-dependent. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversionof the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF).Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAFprecursor. Under resting conditions, acyltransferase activity ispreferred. Upon acute inflammatory stimulus, acetyltransferaseactivity is enhanced and PAF synthesis increases. Also catalyzesthe conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine. {ECO:0000269|PubMed:20363836,ECO:0000269|PubMed:21498505}. | Possesses thioredoxin activity. Has been shown to reduceinsulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LPCAT2_TXNDC5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LPCAT2_TXNDC5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LPCAT2_TXNDC5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LPCAT2_TXNDC5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | LPCAT2 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
Tgene | TXNDC5 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
Tgene | TXNDC5 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Tgene | TXNDC5 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | TXNDC5 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | TXNDC5 | C0993582 | Arthritis, Experimental | 1 | CTD_human |