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Fusion gene ID: 19978 |
FusionGeneSummary for LPAR3_ST6GALNAC3 |
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Fusion gene information | Fusion gene name: LPAR3_ST6GALNAC3 | Fusion gene ID: 19978 | Hgene | Tgene | Gene symbol | LPAR3 | ST6GALNAC3 | Gene ID | 23566 | 256435 |
Gene name | lysophosphatidic acid receptor 3 | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 | |
Synonyms | EDG7|Edg-7|GPCR|HOFNH30|LP-A3|LPA3|RP4-678I3 | PRO7177|SIAT7C|ST6GALNACIII|STY | |
Cytomap | 1p22.3 | 1p31.1 | |
Type of gene | protein-coding | protein-coding | |
Description | lysophosphatidic acid receptor 3LPA receptor 3LPA receptor EDG7LPA-3calcium-mobilizing lysophosphatidic acid receptor LP-A3endothelial cell differentiation gene 7endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7lysoph | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3GalNAc alpha-2,6-sialyltransferase IIIST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltranST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3) | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9UBY5 | Q8NDV1 | |
Ensembl transtripts involved in fusion gene | ENST00000440886, ENST00000370611, ENST00000491034, | ENST00000328299, ENST00000464140, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 5 X 3=75 |
# samples | 1 | 5 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LPAR3 [Title/Abstract] AND ST6GALNAC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ST6GALNAC3 | GO:0006677 | glycosylceramide metabolic process | 17123352 |
Tgene | ST6GALNAC3 | GO:0006687 | glycosphingolipid metabolic process | 17123352 |
Tgene | ST6GALNAC3 | GO:0009100 | glycoprotein metabolic process | 17123352 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A2-A0D0-01A | LPAR3 | chr1 | 85331068 | - | ST6GALNAC3 | chr1 | 77093137 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000440886 | ENST00000328299 | LPAR3 | chr1 | 85331068 | - | ST6GALNAC3 | chr1 | 77093137 | + |
5CDS-intron | ENST00000440886 | ENST00000464140 | LPAR3 | chr1 | 85331068 | - | ST6GALNAC3 | chr1 | 77093137 | + |
Frame-shift | ENST00000370611 | ENST00000328299 | LPAR3 | chr1 | 85331068 | - | ST6GALNAC3 | chr1 | 77093137 | + |
5CDS-intron | ENST00000370611 | ENST00000464140 | LPAR3 | chr1 | 85331068 | - | ST6GALNAC3 | chr1 | 77093137 | + |
5UTR-3CDS | ENST00000491034 | ENST00000328299 | LPAR3 | chr1 | 85331068 | - | ST6GALNAC3 | chr1 | 77093137 | + |
5UTR-intron | ENST00000491034 | ENST00000464140 | LPAR3 | chr1 | 85331068 | - | ST6GALNAC3 | chr1 | 77093137 | + |
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FusionProtFeatures for LPAR3_ST6GALNAC3 |
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Hgene | Tgene |
LPAR3 | ST6GALNAC3 |
Receptor for lysophosphatidic acid (LPA), a mediator ofdiverse cellular activities. May play a role in the development ofovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q)families of heteromeric G proteins. | Involved in the biosynthesis of ganglioside GD1A fromGM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAcresidue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteinsand glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins(By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LPAR3_ST6GALNAC3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LPAR3_ST6GALNAC3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LPAR3 | APP, LMNA | ST6GALNAC3 | CAMK1, SAAL1, SELENBP1, PON2, DSG4, PKP3, PTCH1, SCN3B, GGT7, CLEC2D, KLRG2, TMED6, DUSP14, NCEH1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LPAR3_ST6GALNAC3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LPAR3_ST6GALNAC3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |