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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19978

FusionGeneSummary for LPAR3_ST6GALNAC3

check button Fusion gene summary
Fusion gene informationFusion gene name: LPAR3_ST6GALNAC3
Fusion gene ID: 19978
HgeneTgene
Gene symbol

LPAR3

ST6GALNAC3

Gene ID

23566

256435

Gene namelysophosphatidic acid receptor 3ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
SynonymsEDG7|Edg-7|GPCR|HOFNH30|LP-A3|LPA3|RP4-678I3PRO7177|SIAT7C|ST6GALNACIII|STY
Cytomap

1p22.3

1p31.1

Type of geneprotein-codingprotein-coding
Descriptionlysophosphatidic acid receptor 3LPA receptor 3LPA receptor EDG7LPA-3calcium-mobilizing lysophosphatidic acid receptor LP-A3endothelial cell differentiation gene 7endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7lysophalpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3GalNAc alpha-2,6-sialyltransferase IIIST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltranST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)
Modification date2018051920180523
UniProtAcc

Q9UBY5

Q8NDV1

Ensembl transtripts involved in fusion geneENST00000440886, ENST00000370611, 
ENST00000491034, 
ENST00000328299, 
ENST00000464140, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 5 X 3=75
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LPAR3 [Title/Abstract] AND ST6GALNAC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneST6GALNAC3

GO:0006677

glycosylceramide metabolic process

17123352

TgeneST6GALNAC3

GO:0006687

glycosphingolipid metabolic process

17123352

TgeneST6GALNAC3

GO:0009100

glycoprotein metabolic process

17123352


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A2-A0D0-01ALPAR3chr1

85331068

-ST6GALNAC3chr1

77093137

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000440886ENST00000328299LPAR3chr1

85331068

-ST6GALNAC3chr1

77093137

+
5CDS-intronENST00000440886ENST00000464140LPAR3chr1

85331068

-ST6GALNAC3chr1

77093137

+
Frame-shiftENST00000370611ENST00000328299LPAR3chr1

85331068

-ST6GALNAC3chr1

77093137

+
5CDS-intronENST00000370611ENST00000464140LPAR3chr1

85331068

-ST6GALNAC3chr1

77093137

+
5UTR-3CDSENST00000491034ENST00000328299LPAR3chr1

85331068

-ST6GALNAC3chr1

77093137

+
5UTR-intronENST00000491034ENST00000464140LPAR3chr1

85331068

-ST6GALNAC3chr1

77093137

+

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FusionProtFeatures for LPAR3_ST6GALNAC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LPAR3

Q9UBY5

ST6GALNAC3

Q8NDV1

Receptor for lysophosphatidic acid (LPA), a mediator ofdiverse cellular activities. May play a role in the development ofovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q)families of heteromeric G proteins. Involved in the biosynthesis of ganglioside GD1A fromGM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAcresidue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteinsand glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins(By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LPAR3_ST6GALNAC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LPAR3_ST6GALNAC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LPAR3APP, LMNAST6GALNAC3CAMK1, SAAL1, SELENBP1, PON2, DSG4, PKP3, PTCH1, SCN3B, GGT7, CLEC2D, KLRG2, TMED6, DUSP14, NCEH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LPAR3_ST6GALNAC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LPAR3_ST6GALNAC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource