FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 19975

FusionGeneSummary for LOXL4_MPO

check button Fusion gene summary
Fusion gene informationFusion gene name: LOXL4_MPO
Fusion gene ID: 19975
HgeneTgene
Gene symbol

LOXL4

MPO

Gene ID

84171

4353

Gene namelysyl oxidase like 4myeloperoxidase
SynonymsLOXC-
Cytomap

10q24.2

17q22

Type of geneprotein-codingprotein-coding
Descriptionlysyl oxidase homolog 4lysyl oxidase related Clysyl oxidase-like 4 pseudogenelysyl oxidase-like protein 4lysyl oxidase-related protein Cmyeloperoxidase
Modification date2018052320180523
UniProtAcc

Q96JB6

P05164

Ensembl transtripts involved in fusion geneENST00000260702, ENST00000340482, 
ENST00000225275, ENST00000578493, 
Fusion gene scores* DoF score2 X 2 X 1=410 X 12 X 2=240
# samples 211
** MAII scorelog2(2/4*10)=2.32192809488736log2(11/240*10)=-1.12553088208386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LOXL4 [Title/Abstract] AND MPO [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMPO

GO:0034374

low-density lipoprotein particle remodeling

10772654

TgeneMPO

GO:0042744

hydrogen peroxide catabolic process

10772654|11907569

TgeneMPO

GO:0055114

oxidation-reduction process

10772654


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI018469LOXL4chr10

100008717

+MPOchr17

56350354

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000260702ENST00000340482LOXL4chr10

100008717

+MPOchr17

56350354

+
intron-intronENST00000260702ENST00000225275LOXL4chr10

100008717

+MPOchr17

56350354

+
intron-intronENST00000260702ENST00000578493LOXL4chr10

100008717

+MPOchr17

56350354

+

Top

FusionProtFeatures for LOXL4_MPO


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LOXL4

Q96JB6

MPO

P05164

May modulate the formation of a collagenousextracellular matrix. Part of the host defense system of polymorphonuclearleukocytes. It is responsible for microbicidal activity against awide range of organisms. In the stimulated PMN, MPO catalyzes theproduction of hypohalous acids, primarily hypochlorous acid inphysiologic situations, and other toxic intermediates that greatlyenhance PMN microbicidal activity. {ECO:0000269|PubMed:9922160}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for LOXL4_MPO


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for LOXL4_MPO


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for LOXL4_MPO


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMPOP05164DB00244MesalazineMyeloperoxidasesmall moleculeapproved
TgeneMPOP05164DB00535CefdinirMyeloperoxidasesmall moleculeapproved
TgeneMPOP05164DB00583L-CarnitineMyeloperoxidasesmall moleculeapproved|investigational
TgeneMPOP05164DB01065MelatoninMyeloperoxidasesmall moleculeapproved|nutraceutical|vet_approved

Top

RelatedDiseases for LOXL4_MPO


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLOXL4C0005695Bladder Neoplasm1CTD_human
TgeneMPOC0035126Reperfusion Injury6CTD_human
TgeneMPOC0021368Inflammation5CTD_human
TgeneMPOC0009324Ulcerative Colitis3CTD_human
TgeneMPOC0398595Myeloperoxidase Deficiency3CTD_human;ORPHANET;UNIPROT
TgeneMPOC0003873Rheumatoid Arthritis2CTD_human
TgeneMPOC0023891Liver Cirrhosis, Alcoholic2CTD_human
TgeneMPOC0001969Alcoholic Intoxication1PSYGENET
TgeneMPOC0002395Alzheimer's Disease1CTD_human
TgeneMPOC0005695Bladder Neoplasm1CTD_human
TgeneMPOC0006111Brain Diseases1CTD_human
TgeneMPOC0007222Cardiovascular Diseases1CTD_human
TgeneMPOC0007786Brain Ischemia1CTD_human
TgeneMPOC0009319Colitis1CTD_human
TgeneMPOC0011609Drug Eruptions1CTD_human
TgeneMPOC0011853Diabetes Mellitus, Experimental1CTD_human
TgeneMPOC0022593Keratosis1CTD_human
TgeneMPOC0022658Kidney Diseases1CTD_human
TgeneMPOC0024115Lung diseases1CTD_human
TgeneMPOC0024121Lung Neoplasms1CTD_human
TgeneMPOC0028797Occupational Diseases1CTD_human
TgeneMPOC0030305Pancreatitis1CTD_human
TgeneMPOC0032927Precancerous Conditions1CTD_human
TgeneMPOC0033578Prostatic Neoplasms1CTD_human
TgeneMPOC0036982Shock, Hemorrhagic1CTD_human
TgeneMPOC0040954Infection by Trichuris trichiura1CTD_human
TgeneMPOC0042109Urticaria1CTD_human
TgeneMPOC0242184Hypoxia1CTD_human
TgeneMPOC0993582Arthritis, Experimental1CTD_human
TgeneMPOC1269683Major Depressive Disorder1CTD_human
TgeneMPOC2239176Liver carcinoma1CTD_human
TgeneMPOC2609414Acute kidney injury1CTD_human