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Fusion gene ID: 19974 |
FusionGeneSummary for LOXL4_FAM222B |
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Fusion gene information | Fusion gene name: LOXL4_FAM222B | Fusion gene ID: 19974 | Hgene | Tgene | Gene symbol | LOXL4 | FAM222B | Gene ID | 84171 | 55731 |
Gene name | lysyl oxidase like 4 | family with sequence similarity 222 member B | |
Synonyms | LOXC | C17orf63 | |
Cytomap | 10q24.2 | 17q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | lysyl oxidase homolog 4lysyl oxidase related Clysyl oxidase-like 4 pseudogenelysyl oxidase-like protein 4lysyl oxidase-related protein C | protein FAM222Buncharacterized protein C17orf63 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q96JB6 | Q8WU58 | |
Ensembl transtripts involved in fusion gene | ENST00000260702, | ENST00000341217, ENST00000581407, ENST00000582266, ENST00000452648, ENST00000582059, ENST00000583953, ENST00000577682, ENST00000583522, ENST00000581381, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 11 X 8 X 4=352 |
# samples | 2 | 12 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(12/352*10)=-1.55254102302878 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LOXL4 [Title/Abstract] AND FAM222B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF376500 | LOXL4 | chr10 | 100025588 | + | FAM222B | chr17 | 27148674 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000260702 | ENST00000341217 | LOXL4 | chr10 | 100025588 | + | FAM222B | chr17 | 27148674 | - |
intron-intron | ENST00000260702 | ENST00000581407 | LOXL4 | chr10 | 100025588 | + | FAM222B | chr17 | 27148674 | - |
intron-intron | ENST00000260702 | ENST00000582266 | LOXL4 | chr10 | 100025588 | + | FAM222B | chr17 | 27148674 | - |
intron-intron | ENST00000260702 | ENST00000452648 | LOXL4 | chr10 | 100025588 | + | FAM222B | chr17 | 27148674 | - |
intron-intron | ENST00000260702 | ENST00000582059 | LOXL4 | chr10 | 100025588 | + | FAM222B | chr17 | 27148674 | - |
intron-intron | ENST00000260702 | ENST00000583953 | LOXL4 | chr10 | 100025588 | + | FAM222B | chr17 | 27148674 | - |
intron-intron | ENST00000260702 | ENST00000577682 | LOXL4 | chr10 | 100025588 | + | FAM222B | chr17 | 27148674 | - |
intron-intron | ENST00000260702 | ENST00000583522 | LOXL4 | chr10 | 100025588 | + | FAM222B | chr17 | 27148674 | - |
intron-intron | ENST00000260702 | ENST00000581381 | LOXL4 | chr10 | 100025588 | + | FAM222B | chr17 | 27148674 | - |
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FusionProtFeatures for LOXL4_FAM222B |
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Hgene | Tgene |
LOXL4 | FAM222B |
May modulate the formation of a collagenousextracellular matrix. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LOXL4_FAM222B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LOXL4_FAM222B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LOXL4_FAM222B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LOXL4_FAM222B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | LOXL4 | C0005695 | Bladder Neoplasm | 1 | CTD_human |