FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 19974

FusionGeneSummary for LOXL4_FAM222B

check button Fusion gene summary
Fusion gene informationFusion gene name: LOXL4_FAM222B
Fusion gene ID: 19974
HgeneTgene
Gene symbol

LOXL4

FAM222B

Gene ID

84171

55731

Gene namelysyl oxidase like 4family with sequence similarity 222 member B
SynonymsLOXCC17orf63
Cytomap

10q24.2

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionlysyl oxidase homolog 4lysyl oxidase related Clysyl oxidase-like 4 pseudogenelysyl oxidase-like protein 4lysyl oxidase-related protein Cprotein FAM222Buncharacterized protein C17orf63
Modification date2018052320180519
UniProtAcc

Q96JB6

Q8WU58

Ensembl transtripts involved in fusion geneENST00000260702, ENST00000341217, 
ENST00000581407, ENST00000582266, 
ENST00000452648, ENST00000582059, 
ENST00000583953, ENST00000577682, 
ENST00000583522, ENST00000581381, 
Fusion gene scores* DoF score2 X 2 X 1=411 X 8 X 4=352
# samples 212
** MAII scorelog2(2/4*10)=2.32192809488736log2(12/352*10)=-1.55254102302878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LOXL4 [Title/Abstract] AND FAM222B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF376500LOXL4chr10

100025588

+FAM222Bchr17

27148674

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000260702ENST00000341217LOXL4chr10

100025588

+FAM222Bchr17

27148674

-
intron-intronENST00000260702ENST00000581407LOXL4chr10

100025588

+FAM222Bchr17

27148674

-
intron-intronENST00000260702ENST00000582266LOXL4chr10

100025588

+FAM222Bchr17

27148674

-
intron-intronENST00000260702ENST00000452648LOXL4chr10

100025588

+FAM222Bchr17

27148674

-
intron-intronENST00000260702ENST00000582059LOXL4chr10

100025588

+FAM222Bchr17

27148674

-
intron-intronENST00000260702ENST00000583953LOXL4chr10

100025588

+FAM222Bchr17

27148674

-
intron-intronENST00000260702ENST00000577682LOXL4chr10

100025588

+FAM222Bchr17

27148674

-
intron-intronENST00000260702ENST00000583522LOXL4chr10

100025588

+FAM222Bchr17

27148674

-
intron-intronENST00000260702ENST00000581381LOXL4chr10

100025588

+FAM222Bchr17

27148674

-

Top

FusionProtFeatures for LOXL4_FAM222B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LOXL4

Q96JB6

FAM222B

Q8WU58

May modulate the formation of a collagenousextracellular matrix.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for LOXL4_FAM222B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for LOXL4_FAM222B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for LOXL4_FAM222B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for LOXL4_FAM222B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLOXL4C0005695Bladder Neoplasm1CTD_human