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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1996

FusionGeneSummary for ANXA5_CLASP2

check button Fusion gene summary
Fusion gene informationFusion gene name: ANXA5_CLASP2
Fusion gene ID: 1996
HgeneTgene
Gene symbol

ANXA5

CLASP2

Gene ID

308

23122

Gene nameannexin A5cytoplasmic linker associated protein 2
SynonymsANX5|ENX2|HEL-S-7|PP4|RPRGL3-
Cytomap

4q27

3p22.3

Type of geneprotein-codingprotein-coding
Descriptionannexin A5CBP-IPAP-IVAC-alphaanchorin CIIannexin Vannexin-5calphobindin Iendonexin IIepididymis secretory protein Li 7lipocortin Vplacental anticoagulant protein 4placental anticoagulant protein Ithromboplastin inhibitorvascular anticoagulanCLIP-associating protein 2CLIP-associating protein CLASP2multiple asters (Mast)-like homolog 2protein Orbit homolog 2
Modification date2018052020180522
UniProtAcc

P08758

O75122

Ensembl transtripts involved in fusion geneENST00000296511, ENST00000501272, 
ENST00000515017, ENST00000509016, 
ENST00000468888, ENST00000399362, 
ENST00000539981, ENST00000359576, 
ENST00000307312, ENST00000480013, 
ENST00000461133, ENST00000313350, 
ENST00000487200, ENST00000333778, 
ENST00000482896, 
Fusion gene scores* DoF score4 X 5 X 2=409 X 5 X 6=270
# samples 59
** MAII scorelog2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(9/270*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANXA5 [Title/Abstract] AND CLASP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG958254ANXA5chr4

122595172

+CLASP2chr3

33753812

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000296511ENST00000468888ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000296511ENST00000399362ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000296511ENST00000539981ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000296511ENST00000359576ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000296511ENST00000307312ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000296511ENST00000480013ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000296511ENST00000461133ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000296511ENST00000313350ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000296511ENST00000487200ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000296511ENST00000333778ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000296511ENST00000482896ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000501272ENST00000468888ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000501272ENST00000399362ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000501272ENST00000539981ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000501272ENST00000359576ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000501272ENST00000307312ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000501272ENST00000480013ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000501272ENST00000461133ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000501272ENST00000313350ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000501272ENST00000487200ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000501272ENST00000333778ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000501272ENST00000482896ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000515017ENST00000468888ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000515017ENST00000399362ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000515017ENST00000539981ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000515017ENST00000359576ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000515017ENST00000307312ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000515017ENST00000480013ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000515017ENST00000461133ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000515017ENST00000313350ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000515017ENST00000487200ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000515017ENST00000333778ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000515017ENST00000482896ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000509016ENST00000468888ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000509016ENST00000399362ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000509016ENST00000539981ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000509016ENST00000359576ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000509016ENST00000307312ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000509016ENST00000480013ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000509016ENST00000461133ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000509016ENST00000313350ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000509016ENST00000487200ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000509016ENST00000333778ANXA5chr4

122595172

+CLASP2chr3

33753812

-
intron-intronENST00000509016ENST00000482896ANXA5chr4

122595172

+CLASP2chr3

33753812

-

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FusionProtFeatures for ANXA5_CLASP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANXA5

P08758

CLASP2

O75122

This protein is an anticoagulant protein that acts as anindirect inhibitor of the thromboplastin-specific complex, whichis involved in the blood coagulation cascade.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ANXA5_CLASP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANXA5_CLASP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANXA5_CLASP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANXA5_CLASP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANXA5C0007137Squamous cell carcinoma1CTD_human
HgeneANXA5C0019202Hepatolenticular Degeneration1CTD_human
HgeneANXA5C0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneANXA5C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneANXA5C0026640Mouth Neoplasms1CTD_human
HgeneANXA5C0032914Pre-Eclampsia1CTD_human
HgeneANXA5C0038356Stomach Neoplasms1CTD_human
HgeneANXA5C0043094Weight Gain1CTD_human
HgeneANXA5C0152013Adenocarcinoma of lung (disorder)1CTD_human