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Fusion gene ID: 19956 |
FusionGeneSummary for LONP1_SAFB2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LONP1_SAFB2 | Fusion gene ID: 19956 | Hgene | Tgene | Gene symbol | LONP1 | SAFB2 | Gene ID | 9361 | 9667 |
| Gene name | lon peptidase 1, mitochondrial | scaffold attachment factor B2 | |
| Synonyms | CODASS|LON|LONP|LonHS|PIM1|PRSS15|hLON | - | |
| Cytomap | 19p13.3 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lon protease homolog, mitochondrialhLON ATP-dependent proteaselon protease-like proteinmitochondrial ATP-dependent protease Lonmitochondrial lon protease-like proteinserine protease 15 | scaffold attachment factor B2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P36776 | Q14151 | |
| Ensembl transtripts involved in fusion gene | ENST00000360614, ENST00000585374, ENST00000593119, ENST00000540670, ENST00000590729, ENST00000590511, | ENST00000252542, ENST00000591310, | |
| Fusion gene scores | * DoF score | 14 X 10 X 11=1540 | 3 X 3 X 3=27 |
| # samples | 15 | 3 | |
| ** MAII score | log2(15/1540*10)=-3.35989594508638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: LONP1 [Title/Abstract] AND SAFB2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LONP1 | GO:0034599 | cellular response to oxidative stress | 17420247 |
| Hgene | LONP1 | GO:0051260 | protein homooligomerization | 14739292 |
| Hgene | LONP1 | GO:0051603 | proteolysis involved in cellular protein catabolic process | 8248235|17420247 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AR-A251-01A | LONP1 | chr19 | 5705783 | - | SAFB2 | chr19 | 5600271 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000360614 | ENST00000252542 | LONP1 | chr19 | 5705783 | - | SAFB2 | chr19 | 5600271 | - |
| 5CDS-5UTR | ENST00000360614 | ENST00000591310 | LONP1 | chr19 | 5705783 | - | SAFB2 | chr19 | 5600271 | - |
| Frame-shift | ENST00000585374 | ENST00000252542 | LONP1 | chr19 | 5705783 | - | SAFB2 | chr19 | 5600271 | - |
| 5CDS-5UTR | ENST00000585374 | ENST00000591310 | LONP1 | chr19 | 5705783 | - | SAFB2 | chr19 | 5600271 | - |
| In-frame | ENST00000593119 | ENST00000252542 | LONP1 | chr19 | 5705783 | - | SAFB2 | chr19 | 5600271 | - |
| 5CDS-5UTR | ENST00000593119 | ENST00000591310 | LONP1 | chr19 | 5705783 | - | SAFB2 | chr19 | 5600271 | - |
| In-frame | ENST00000540670 | ENST00000252542 | LONP1 | chr19 | 5705783 | - | SAFB2 | chr19 | 5600271 | - |
| 5CDS-5UTR | ENST00000540670 | ENST00000591310 | LONP1 | chr19 | 5705783 | - | SAFB2 | chr19 | 5600271 | - |
| In-frame | ENST00000590729 | ENST00000252542 | LONP1 | chr19 | 5705783 | - | SAFB2 | chr19 | 5600271 | - |
| 5CDS-5UTR | ENST00000590729 | ENST00000591310 | LONP1 | chr19 | 5705783 | - | SAFB2 | chr19 | 5600271 | - |
| intron-3CDS | ENST00000590511 | ENST00000252542 | LONP1 | chr19 | 5705783 | - | SAFB2 | chr19 | 5600271 | - |
| intron-5UTR | ENST00000590511 | ENST00000591310 | LONP1 | chr19 | 5705783 | - | SAFB2 | chr19 | 5600271 | - |
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FusionProtFeatures for LONP1_SAFB2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LONP1 | SAFB2 |
| ATP-dependent serine protease that mediates theselective degradation of misfolded, unassembled or oxidativelydamaged polypeptides as well as certain short-lived regulatoryproteins in the mitochondrial matrix. May also have a chaperonefunction in the assembly of inner membrane protein complexes.Participates in the regulation of mitochondrial gene expressionand in the maintenance of the integrity of the mitochondrialgenome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulatemitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation ofregulatory proteins binding to adjacent sites in mitochondrialpromoters (PubMed:12198491, PubMed:15870080, PubMed:17420247,PubMed:8248235). Endogenous substrates include mitochondrialsteroidogenic acute regulatory (StAR) protein, helicase Twinkle(TWNK) and the large ribosomal subunit protein bL32m. bL32m isprotected from degradation by LONP1 when it is bound to a nucleicacid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575).{ECO:0000255|HAMAP-Rule:MF_03120, ECO:0000269|PubMed:12198491,ECO:0000269|PubMed:15870080, ECO:0000269|PubMed:17420247,ECO:0000269|PubMed:17579211, ECO:0000269|PubMed:28377575,ECO:0000269|PubMed:8248235}. | Binds to scaffold/matrix attachment region (S/MAR) DNA.Can function as an estrogen receptor corepressor and can alsoinhibit cell proliferation. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LONP1 | chr19:5705783 | chr19:5600271 | ENST00000360614 | - | 8 | 18 | 124_368 | 455 | 960 | Domain | Lon N-terminal |
| Tgene | >SAFB2 | chr19:5705783 | chr19:5600271 | ENST00000252542 | - | 10 | 21 | 619_724 | 519 | 954 | Compositional bias | Note=Glu-rich |
| Tgene | >SAFB2 | chr19:5705783 | chr19:5600271 | ENST00000252542 | - | 10 | 21 | 621_788 | 519 | 954 | Compositional bias | Note=Arg-rich |
| Tgene | >SAFB2 | chr19:5705783 | chr19:5600271 | ENST00000252542 | - | 10 | 21 | 792_926 | 519 | 954 | Compositional bias | Note=Gly-rich |
| Tgene | >SAFB2 | chr19:5705783 | chr19:5600271 | ENST00000252542 | - | 10 | 21 | 713_730 | 519 | 954 | Motif | Nuclear localization signal |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >LONP1 | chr19:5705783 | chr19:5600271 | ENST00000360614 | - | 8 | 18 | 759_949 | 455 | 960 | Domain | Lon proteolytic |
| Hgene | >LONP1 | chr19:5705783 | chr19:5600271 | ENST00000360614 | - | 8 | 18 | 523_530 | 455 | 960 | Nucleotide binding | ATP |
| Tgene | SAFB2 | chr19:5705783 | chr19:5600271 | ENST00000252542 | - | 10 | 21 | 482_545 | 519 | 954 | Compositional bias | Note=Lys-rich |
| Tgene | SAFB2 | chr19:5705783 | chr19:5600271 | ENST00000252542 | - | 10 | 21 | 30_64 | 519 | 954 | Domain | SAP |
| Tgene | SAFB2 | chr19:5705783 | chr19:5600271 | ENST00000252542 | - | 10 | 21 | 407_485 | 519 | 954 | Domain | RRM |
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FusionGeneSequence for LONP1_SAFB2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_LONP1_ENST00000360614_chr19_5705783_-_SAFB2_ENST00000252542_chr19_5600271_-_890aa MAASTGYVRLWGAARCWVLRRPMLAAAGGRVPTAAGAWLLRGQRTCDASPPWALWGRGPAIGGQWRGFWEASSRGGGAFSGGEDASEGGA EEGAGGAGGSAGAGEGPVITALTPMTIPDVFPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVE SLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSKRGKKEAEDELSARHPAELAMEPTPELPAEV LMVEVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLY KALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDN HSSEFKTVIKKEEKIEKKEEKKPEDIKKEEKDQDELKPGPTNRSRVTKSGSRGMERTVVMDKSKGEPVISVKTTSRSKERSSKSQDRKSE SKEKRDILSFDKIKEQRERERQRQREREIRETERRREREQREREQRLEAFHERKEKARLQRERLQLECQRQRLERERMERERLERERMRV ERERRKEQERIHREREELRRQQEQLRYEQERRPGRRPYDLDRRDDAYWPEGKRVAMEDRYRADFPRPDHRFHDFDHRDRGQYQDHAIDRR EGSRPMMGDHRDGQHYGDDRHGHGGPPERHGRDSRDGWGGYGSDKRLSEGRGLPPPPRGGRDWGEHNQRLEEHQARAWQGAMDAGAASRE >In-frame_LONP1_ENST00000593119_chr19_5705783_-_SAFB2_ENST00000252542_chr19_5600271_-_826aa MAASTGYVRLWGAARCWVLRRPMLAAAGGRVPTAAGAWLLRGPVITALTPMTIPDVFPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLR RKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSKRGKK EAEDELSARHPAELAMEPTPELPAEVLMVEVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDM GAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFRER LKELVVPKHVMDVVDEELSKLGLLDNHSSEFKTVIKKEEKIEKKEEKKPEDIKKEEKDQDELKPGPTNRSRVTKSGSRGMERTVVMDKSK GEPVISVKTTSRSKERSSKSQDRKSESKEKRDILSFDKIKEQRERERQRQREREIRETERRREREQREREQRLEAFHERKEKARLQRERL QLECQRQRLERERMERERLERERMRVERERRKEQERIHREREELRRQQEQLRYEQERRPGRRPYDLDRRDDAYWPEGKRVAMEDRYRADF PRPDHRFHDFDHRDRGQYQDHAIDRREGSRPMMGDHRDGQHYGDDRHGHGGPPERHGRDSRDGWGGYGSDKRLSEGRGLPPPPRGGRDWG EHNQRLEEHQARAWQGAMDAGAASREHARWQGGERGLSGPSGPGHMASRGGVAGRGGFAQGGHSQGHVVPGGGLEGGGVASQDRGSRVPH >In-frame_LONP1_ENST00000540670_chr19_5705783_-_SAFB2_ENST00000252542_chr19_5600271_-_694aa MQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSKRGKKEAEDELSARHPAELAMEPTPELPAEVLMVEVENVVHEDFQVT EEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQ QRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFKTVIKKEEKIE KKEEKKPEDIKKEEKDQDELKPGPTNRSRVTKSGSRGMERTVVMDKSKGEPVISVKTTSRSKERSSKSQDRKSESKEKRDILSFDKIKEQ RERERQRQREREIRETERRREREQREREQRLEAFHERKEKARLQRERLQLECQRQRLERERMERERLERERMRVERERRKEQERIHRERE ELRRQQEQLRYEQERRPGRRPYDLDRRDDAYWPEGKRVAMEDRYRADFPRPDHRFHDFDHRDRGQYQDHAIDRREGSRPMMGDHRDGQHY GDDRHGHGGPPERHGRDSRDGWGGYGSDKRLSEGRGLPPPPRGGRDWGEHNQRLEEHQARAWQGAMDAGAASREHARWQGGERGLSGPSG >In-frame_LONP1_ENST00000590729_chr19_5705783_-_SAFB2_ENST00000252542_chr19_5600271_-_760aa MTIPDVFPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKL RMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSKRGKKEAEDELSARHPAELAMEPTPELPAEVLMVEALTAEIVKTIRDIIALNPLY RESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQL KIIKKELGLEKDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFKTVIKKEEKIEKKEEKKPEDIKKEEKDQDELKPGP TNRSRVTKSGSRGMERTVVMDKSKGEPVISVKTTSRSKERSSKSQDRKSESKEKRDILSFDKIKEQRERERQRQREREIRETERRREREQ REREQRLEAFHERKEKARLQRERLQLECQRQRLERERMERERLERERMRVERERRKEQERIHREREELRRQQEQLRYEQERRPGRRPYDL DRRDDAYWPEGKRVAMEDRYRADFPRPDHRFHDFDHRDRGQYQDHAIDRREGSRPMMGDHRDGQHYGDDRHGHGGPPERHGRDSRDGWGG YGSDKRLSEGRGLPPPPRGGRDWGEHNQRLEEHQARAWQGAMDAGAASREHARWQGGERGLSGPSGPGHMASRGGVAGRGGFAQGGHSQG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_LONP1_ENST00000360614_chr19_5705783_-_SAFB2_ENST00000252542_chr19_5600271_-_2670nt ATGGCGGCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCGATGCTGGCCGCCGCCGGGGGGCGG GTTCCCACTGCAGCAGGAGCGTGGTTGCTCCGAGGCCAGCGGACCTGCGACGCCTCTCCTCCTTGGGCACTGTGGGGCCGAGGCCCGGCA ATTGGGGGCCAATGGCGGGGGTTTTGGGAAGCGAGCAGCCGCGGCGGAGGCGCATTCTCGGGGGGCGAGGACGCCTCCGAGGGCGGCGCG GAGGAAGGAGCCGGCGGCGCGGGGGGCAGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTG TTTCCGCACCTGCCGCTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGGTTAAAAATAAGAAGTTGGTT GAGCTGCTGAGAAGGAAAGTTCGTCTCGCCCAGCCTTATGTCGGCGTCTTTCTAAAGAGAGATGACAGCAATGAGTCGGATGTGGTCGAG AGCCTGGATGAAATCTACCACACGGGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGACAAGCTGCGCATGATCGTCATGGGA CACAGAAGAGTCCATATCAGCAGACAGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCACAAGCCCCGCAGGAAGTCAAAG CGGGGCAAGAAGGAGGCGGAGGACGAGCTGAGCGCCAGGCACCCGGCGGAGCTGGCGATGGAGCCCACCCCTGAGCTCCCGGCTGAGGTG CTCATGGTGGAGGTAGAGAACGTTGTCCACGAGGACTTCCAGGTCACGGAGGAGGTGAAAGCCCTGACTGCAGAGATCGTGAAGACCATC CGGGACATCATTGCCTTGAACCCTCTCTACAGGGAGTCAGTGCTGCAGATGATGCAGGCTGGCCAGCGGGTGGTGGACAACCCCATCTAC CTGAGCGACATGGGCGCCGCGCTCACCGGGGCCGAGTCCCATGAGCTGCAGGACGTCCTGGAAGAGACCAATATTCCTAAGCGGCTGTAC AAGGCCCTCTCCCTGCTGAAGAAGGAATTTGAACTGAGCAAGCTGCAGCAGCGCCTGGGGCGGGAGGTGGAGGAGAAGATCAAGCAGACC CACCGTAAGTACCTGCTGCAGGAGCAGCTAAAGATCATCAAGAAGGAGCTGGGCCTGGAGAAGGACGACAAGGATGCCATCGAGGAGAAG TTCCGGGAGCGCCTGAAGGAGCTCGTGGTCCCCAAGCACGTCATGGATGTTGTGGACGAGGAGCTGAGCAAGCTGGGCCTGCTGGACAAC CACTCCTCGGAGTTCAAAACTGTAATTAAGAAGGAAGAGAAGATTGAGAAGAAGGAGGAAAAAAAGCCTGAAGACATTAAGAAGGAAGAA AAAGACCAGGATGAGCTGAAACCCGGACCTACAAATCGGTCTAGAGTCACCAAATCAGGAAGCAGAGGAATGGAGCGGACGGTCGTGATG GATAAATCGAAAGGAGAGCCCGTCATTAGCGTGAAAACCACAAGCAGGTCCAAAGAGAGAAGCTCCAAGAGTCAGGATCGCAAGTCAGAA AGCAAAGAAAAGAGAGACATCTTGTCGTTTGATAAAATCAAAGAACAAAGGGAGAGAGAGCGCCAGAGGCAGCGGGAACGGGAGATCCGC GAAACGGAGAGGCGGCGGGAGCGCGAGCAGCGGGAGCGGGAGCAACGCCTCGAGGCCTTCCATGAGCGGAAGGAGAAGGCCCGGCTACAG CGGGAACGCCTGCAGCTCGAGTGCCAGCGCCAGCGGCTGGAGCGGGAGCGCATGGAGCGGGAGCGGCTGGAGCGCGAGCGCATGCGCGTG GAGCGTGAGCGCAGGAAGGAGCAGGAGCGCATCCACCGCGAGCGCGAGGAGCTGCGGCGCCAGCAGGAGCAGCTGCGTTACGAGCAGGAG CGGCGGCCCGGGCGGAGGCCCTACGACCTGGACCGACGAGATGATGCCTATTGGCCAGAAGGAAAGCGTGTGGCAATGGAGGACCGATAT CGTGCAGACTTTCCCCGGCCAGACCACCGCTTTCACGACTTCGATCATCGAGACCGGGGCCAGTACCAGGACCACGCCATCGACAGGCGG GAGGGTTCGAGGCCAATGATGGGAGACCACCGGGATGGGCAGCACTATGGAGATGACCGCCATGGCCACGGAGGACCCCCAGAGCGCCAC GGCCGGGACTCCCGTGATGGCTGGGGGGGCTACGGCTCCGACAAGAGGCTGAGTGAAGGCCGGGGGCTGCCCCCTCCCCCCAGGGGTGGC CGTGACTGGGGAGAGCACAACCAGCGGCTAGAGGAGCACCAGGCACGCGCCTGGCAGGGTGCCATGGACGCAGGCGCGGCTAGCCGGGAG CACGCCAGGTGGCAAGGTGGCGAGAGGGGCCTGTCTGGGCCCTCGGGGCCGGGGCACATGGCAAGCCGCGGTGGAGTGGCGGGGCGAGGC GGCTTTGCACAAGGTGGACATTCCCAGGGCCACGTGGTGCCAGGTGGCGGACTGGAAGGTGGCGGAGTGGCCAGCCAGGACCGGGGCAGC >In-frame_LONP1_ENST00000593119_chr19_5705783_-_SAFB2_ENST00000252542_chr19_5600271_-_2478nt ATGGCGGCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCGATGCTGGCCGCCGCCGGGGGGCGG GTTCCCACTGCAGCAGGAGCGTGGTTGCTCCGAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCGCACCTG CCGCTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGGTTAAAAATAAGAAGTTGGTTGAGCTGCTGAGA AGGAAAGTTCGTCTCGCCCAGCCTTATGTCGGCGTCTTTCTAAAGAGAGATGACAGCAATGAGTCGGATGTGGTCGAGAGCCTGGATGAA ATCTACCACACGGGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGACAAGCTGCGCATGATCGTCATGGGACACAGAAGAGTC CATATCAGCAGACAGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCACAAGCCCCGCAGGAAGTCAAAGCGGGGCAAGAAG GAGGCGGAGGACGAGCTGAGCGCCAGGCACCCGGCGGAGCTGGCGATGGAGCCCACCCCTGAGCTCCCGGCTGAGGTGCTCATGGTGGAG GTAGAGAACGTTGTCCACGAGGACTTCCAGGTCACGGAGGAGGTGAAAGCCCTGACTGCAGAGATCGTGAAGACCATCCGGGACATCATT GCCTTGAACCCTCTCTACAGGGAGTCAGTGCTGCAGATGATGCAGGCTGGCCAGCGGGTGGTGGACAACCCCATCTACCTGAGCGACATG GGCGCCGCGCTCACCGGGGCCGAGTCCCATGAGCTGCAGGACGTCCTGGAAGAGACCAATATTCCTAAGCGGCTGTACAAGGCCCTCTCC CTGCTGAAGAAGGAATTTGAACTGAGCAAGCTGCAGCAGCGCCTGGGGCGGGAGGTGGAGGAGAAGATCAAGCAGACCCACCGTAAGTAC CTGCTGCAGGAGCAGCTAAAGATCATCAAGAAGGAGCTGGGCCTGGAGAAGGACGACAAGGATGCCATCGAGGAGAAGTTCCGGGAGCGC CTGAAGGAGCTCGTGGTCCCCAAGCACGTCATGGATGTTGTGGACGAGGAGCTGAGCAAGCTGGGCCTGCTGGACAACCACTCCTCGGAG TTCAAAACTGTAATTAAGAAGGAAGAGAAGATTGAGAAGAAGGAGGAAAAAAAGCCTGAAGACATTAAGAAGGAAGAAAAAGACCAGGAT GAGCTGAAACCCGGACCTACAAATCGGTCTAGAGTCACCAAATCAGGAAGCAGAGGAATGGAGCGGACGGTCGTGATGGATAAATCGAAA GGAGAGCCCGTCATTAGCGTGAAAACCACAAGCAGGTCCAAAGAGAGAAGCTCCAAGAGTCAGGATCGCAAGTCAGAAAGCAAAGAAAAG AGAGACATCTTGTCGTTTGATAAAATCAAAGAACAAAGGGAGAGAGAGCGCCAGAGGCAGCGGGAACGGGAGATCCGCGAAACGGAGAGG CGGCGGGAGCGCGAGCAGCGGGAGCGGGAGCAACGCCTCGAGGCCTTCCATGAGCGGAAGGAGAAGGCCCGGCTACAGCGGGAACGCCTG CAGCTCGAGTGCCAGCGCCAGCGGCTGGAGCGGGAGCGCATGGAGCGGGAGCGGCTGGAGCGCGAGCGCATGCGCGTGGAGCGTGAGCGC AGGAAGGAGCAGGAGCGCATCCACCGCGAGCGCGAGGAGCTGCGGCGCCAGCAGGAGCAGCTGCGTTACGAGCAGGAGCGGCGGCCCGGG CGGAGGCCCTACGACCTGGACCGACGAGATGATGCCTATTGGCCAGAAGGAAAGCGTGTGGCAATGGAGGACCGATATCGTGCAGACTTT CCCCGGCCAGACCACCGCTTTCACGACTTCGATCATCGAGACCGGGGCCAGTACCAGGACCACGCCATCGACAGGCGGGAGGGTTCGAGG CCAATGATGGGAGACCACCGGGATGGGCAGCACTATGGAGATGACCGCCATGGCCACGGAGGACCCCCAGAGCGCCACGGCCGGGACTCC CGTGATGGCTGGGGGGGCTACGGCTCCGACAAGAGGCTGAGTGAAGGCCGGGGGCTGCCCCCTCCCCCCAGGGGTGGCCGTGACTGGGGA GAGCACAACCAGCGGCTAGAGGAGCACCAGGCACGCGCCTGGCAGGGTGCCATGGACGCAGGCGCGGCTAGCCGGGAGCACGCCAGGTGG CAAGGTGGCGAGAGGGGCCTGTCTGGGCCCTCGGGGCCGGGGCACATGGCAAGCCGCGGTGGAGTGGCGGGGCGAGGCGGCTTTGCACAA GGTGGACATTCCCAGGGCCACGTGGTGCCAGGTGGCGGACTGGAAGGTGGCGGAGTGGCCAGCCAGGACCGGGGCAGCAGAGTCCCTCAC >In-frame_LONP1_ENST00000540670_chr19_5705783_-_SAFB2_ENST00000252542_chr19_5600271_-_2082nt ATGCAGGACCTTGGGGACAAGCTGCGCATGATCGTCATGGGACACAGAAGAGTCCATATCAGCAGACAGCTGGAGGTGGAGCCCGAGGAG CCGGAGGCGGAGAACAAGCACAAGCCCCGCAGGAAGTCAAAGCGGGGCAAGAAGGAGGCGGAGGACGAGCTGAGCGCCAGGCACCCGGCG GAGCTGGCGATGGAGCCCACCCCTGAGCTCCCGGCTGAGGTGCTCATGGTGGAGGTAGAGAACGTTGTCCACGAGGACTTCCAGGTCACG GAGGAGGTGAAAGCCCTGACTGCAGAGATCGTGAAGACCATCCGGGACATCATTGCCTTGAACCCTCTCTACAGGGAGTCAGTGCTGCAG ATGATGCAGGCTGGCCAGCGGGTGGTGGACAACCCCATCTACCTGAGCGACATGGGCGCCGCGCTCACCGGGGCCGAGTCCCATGAGCTG CAGGACGTCCTGGAAGAGACCAATATTCCTAAGCGGCTGTACAAGGCCCTCTCCCTGCTGAAGAAGGAATTTGAACTGAGCAAGCTGCAG CAGCGCCTGGGGCGGGAGGTGGAGGAGAAGATCAAGCAGACCCACCGTAAGTACCTGCTGCAGGAGCAGCTAAAGATCATCAAGAAGGAG CTGGGCCTGGAGAAGGACGACAAGGATGCCATCGAGGAGAAGTTCCGGGAGCGCCTGAAGGAGCTCGTGGTCCCCAAGCACGTCATGGAT GTTGTGGACGAGGAGCTGAGCAAGCTGGGCCTGCTGGACAACCACTCCTCGGAGTTCAAAACTGTAATTAAGAAGGAAGAGAAGATTGAG AAGAAGGAGGAAAAAAAGCCTGAAGACATTAAGAAGGAAGAAAAAGACCAGGATGAGCTGAAACCCGGACCTACAAATCGGTCTAGAGTC ACCAAATCAGGAAGCAGAGGAATGGAGCGGACGGTCGTGATGGATAAATCGAAAGGAGAGCCCGTCATTAGCGTGAAAACCACAAGCAGG TCCAAAGAGAGAAGCTCCAAGAGTCAGGATCGCAAGTCAGAAAGCAAAGAAAAGAGAGACATCTTGTCGTTTGATAAAATCAAAGAACAA AGGGAGAGAGAGCGCCAGAGGCAGCGGGAACGGGAGATCCGCGAAACGGAGAGGCGGCGGGAGCGCGAGCAGCGGGAGCGGGAGCAACGC CTCGAGGCCTTCCATGAGCGGAAGGAGAAGGCCCGGCTACAGCGGGAACGCCTGCAGCTCGAGTGCCAGCGCCAGCGGCTGGAGCGGGAG CGCATGGAGCGGGAGCGGCTGGAGCGCGAGCGCATGCGCGTGGAGCGTGAGCGCAGGAAGGAGCAGGAGCGCATCCACCGCGAGCGCGAG GAGCTGCGGCGCCAGCAGGAGCAGCTGCGTTACGAGCAGGAGCGGCGGCCCGGGCGGAGGCCCTACGACCTGGACCGACGAGATGATGCC TATTGGCCAGAAGGAAAGCGTGTGGCAATGGAGGACCGATATCGTGCAGACTTTCCCCGGCCAGACCACCGCTTTCACGACTTCGATCAT CGAGACCGGGGCCAGTACCAGGACCACGCCATCGACAGGCGGGAGGGTTCGAGGCCAATGATGGGAGACCACCGGGATGGGCAGCACTAT GGAGATGACCGCCATGGCCACGGAGGACCCCCAGAGCGCCACGGCCGGGACTCCCGTGATGGCTGGGGGGGCTACGGCTCCGACAAGAGG CTGAGTGAAGGCCGGGGGCTGCCCCCTCCCCCCAGGGGTGGCCGTGACTGGGGAGAGCACAACCAGCGGCTAGAGGAGCACCAGGCACGC GCCTGGCAGGGTGCCATGGACGCAGGCGCGGCTAGCCGGGAGCACGCCAGGTGGCAAGGTGGCGAGAGGGGCCTGTCTGGGCCCTCGGGG CCGGGGCACATGGCAAGCCGCGGTGGAGTGGCGGGGCGAGGCGGCTTTGCACAAGGTGGACATTCCCAGGGCCACGTGGTGCCAGGTGGC GGACTGGAAGGTGGCGGAGTGGCCAGCCAGGACCGGGGCAGCAGAGTCCCTCACCCACACCCTCATCCCCCCCCGTACCCCCACTTCACC >In-frame_LONP1_ENST00000590729_chr19_5705783_-_SAFB2_ENST00000252542_chr19_5600271_-_2280nt ATGACGATCCCCGATGTGTTTCCGCACCTGCCGCTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGGTT AAAAATAAGAAGTTGGTTGAGCTGCTGAGAAGGAAAGTTCGTCTCGCCCAGCCTTATGTCGGCGTCTTTCTAAAGAGAGATGACAGCAAT GAGTCGGATGTGGTCGAGAGCCTGGATGAAATCTACCACACGGGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGACAAGCTG CGCATGATCGTCATGGGACACAGAAGAGTCCATATCAGCAGACAGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCACAAG CCCCGCAGGAAGTCAAAGCGGGGCAAGAAGGAGGCGGAGGACGAGCTGAGCGCCAGGCACCCGGCGGAGCTGGCGATGGAGCCCACCCCT GAGCTCCCGGCTGAGGTGCTCATGGTGGAGGCCCTGACTGCAGAGATCGTGAAGACCATCCGGGACATCATTGCCTTGAACCCTCTCTAC AGGGAGTCAGTGCTGCAGATGATGCAGGCTGGCCAGCGGGTGGTGGACAACCCCATCTACCTGAGCGACATGGGCGCCGCGCTCACCGGG GCCGAGTCCCATGAGCTGCAGGACGTCCTGGAAGAGACCAATATTCCTAAGCGGCTGTACAAGGCCCTCTCCCTGCTGAAGAAGGAATTT GAACTGAGCAAGCTGCAGCAGCGCCTGGGGCGGGAGGTGGAGGAGAAGATCAAGCAGACCCACCGTAAGTACCTGCTGCAGGAGCAGCTA AAGATCATCAAGAAGGAGCTGGGCCTGGAGAAGGACGACAAGGATGCCATCGAGGAGAAGTTCCGGGAGCGCCTGAAGGAGCTCGTGGTC CCCAAGCACGTCATGGATGTTGTGGACGAGGAGCTGAGCAAGCTGGGCCTGCTGGACAACCACTCCTCGGAGTTCAAAACTGTAATTAAG AAGGAAGAGAAGATTGAGAAGAAGGAGGAAAAAAAGCCTGAAGACATTAAGAAGGAAGAAAAAGACCAGGATGAGCTGAAACCCGGACCT ACAAATCGGTCTAGAGTCACCAAATCAGGAAGCAGAGGAATGGAGCGGACGGTCGTGATGGATAAATCGAAAGGAGAGCCCGTCATTAGC GTGAAAACCACAAGCAGGTCCAAAGAGAGAAGCTCCAAGAGTCAGGATCGCAAGTCAGAAAGCAAAGAAAAGAGAGACATCTTGTCGTTT GATAAAATCAAAGAACAAAGGGAGAGAGAGCGCCAGAGGCAGCGGGAACGGGAGATCCGCGAAACGGAGAGGCGGCGGGAGCGCGAGCAG CGGGAGCGGGAGCAACGCCTCGAGGCCTTCCATGAGCGGAAGGAGAAGGCCCGGCTACAGCGGGAACGCCTGCAGCTCGAGTGCCAGCGC CAGCGGCTGGAGCGGGAGCGCATGGAGCGGGAGCGGCTGGAGCGCGAGCGCATGCGCGTGGAGCGTGAGCGCAGGAAGGAGCAGGAGCGC ATCCACCGCGAGCGCGAGGAGCTGCGGCGCCAGCAGGAGCAGCTGCGTTACGAGCAGGAGCGGCGGCCCGGGCGGAGGCCCTACGACCTG GACCGACGAGATGATGCCTATTGGCCAGAAGGAAAGCGTGTGGCAATGGAGGACCGATATCGTGCAGACTTTCCCCGGCCAGACCACCGC TTTCACGACTTCGATCATCGAGACCGGGGCCAGTACCAGGACCACGCCATCGACAGGCGGGAGGGTTCGAGGCCAATGATGGGAGACCAC CGGGATGGGCAGCACTATGGAGATGACCGCCATGGCCACGGAGGACCCCCAGAGCGCCACGGCCGGGACTCCCGTGATGGCTGGGGGGGC TACGGCTCCGACAAGAGGCTGAGTGAAGGCCGGGGGCTGCCCCCTCCCCCCAGGGGTGGCCGTGACTGGGGAGAGCACAACCAGCGGCTA GAGGAGCACCAGGCACGCGCCTGGCAGGGTGCCATGGACGCAGGCGCGGCTAGCCGGGAGCACGCCAGGTGGCAAGGTGGCGAGAGGGGC CTGTCTGGGCCCTCGGGGCCGGGGCACATGGCAAGCCGCGGTGGAGTGGCGGGGCGAGGCGGCTTTGCACAAGGTGGACATTCCCAGGGC CACGTGGTGCCAGGTGGCGGACTGGAAGGTGGCGGAGTGGCCAGCCAGGACCGGGGCAGCAGAGTCCCTCACCCACACCCTCATCCCCCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_LONP1_ENST00000360614_chr19_5705783_-_SAFB2_ENST00000252542_chr19_5600271_-_3072nt CGAACTCCGCCCCCTCTTCTCCGCGTAGGCCCAGCTCCCTGAAGCGGCTGTTTCGAGCCACGCGCCCATCGGGTACCGAGGCACGCGCCG GGCGTCACGTGCGTTTCGCGGCGAGCGGAAATGACGCGAGTTGTGTGAGCCGCCAGTATGGCCGGGCTATGGCGGCGAGCACTGGCTACG TGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCGATGCTGGCCGCCGCCGGGGGGCGGGTTCCCACTGCAGCAGGAGCGT GGTTGCTCCGAGGCCAGCGGACCTGCGACGCCTCTCCTCCTTGGGCACTGTGGGGCCGAGGCCCGGCAATTGGGGGCCAATGGCGGGGGT TTTGGGAAGCGAGCAGCCGCGGCGGAGGCGCATTCTCGGGGGGCGAGGACGCCTCCGAGGGCGGCGCGGAGGAAGGAGCCGGCGGCGCGG GGGGCAGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCGCACCTGCCGCTCATCG CCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGGTTAAAAATAAGAAGTTGGTTGAGCTGCTGAGAAGGAAAGTTC GTCTCGCCCAGCCTTATGTCGGCGTCTTTCTAAAGAGAGATGACAGCAATGAGTCGGATGTGGTCGAGAGCCTGGATGAAATCTACCACA CGGGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGACAAGCTGCGCATGATCGTCATGGGACACAGAAGAGTCCATATCAGCA GACAGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCACAAGCCCCGCAGGAAGTCAAAGCGGGGCAAGAAGGAGGCGGAGG ACGAGCTGAGCGCCAGGCACCCGGCGGAGCTGGCGATGGAGCCCACCCCTGAGCTCCCGGCTGAGGTGCTCATGGTGGAGGTAGAGAACG TTGTCCACGAGGACTTCCAGGTCACGGAGGAGGTGAAAGCCCTGACTGCAGAGATCGTGAAGACCATCCGGGACATCATTGCCTTGAACC CTCTCTACAGGGAGTCAGTGCTGCAGATGATGCAGGCTGGCCAGCGGGTGGTGGACAACCCCATCTACCTGAGCGACATGGGCGCCGCGC TCACCGGGGCCGAGTCCCATGAGCTGCAGGACGTCCTGGAAGAGACCAATATTCCTAAGCGGCTGTACAAGGCCCTCTCCCTGCTGAAGA AGGAATTTGAACTGAGCAAGCTGCAGCAGCGCCTGGGGCGGGAGGTGGAGGAGAAGATCAAGCAGACCCACCGTAAGTACCTGCTGCAGG AGCAGCTAAAGATCATCAAGAAGGAGCTGGGCCTGGAGAAGGACGACAAGGATGCCATCGAGGAGAAGTTCCGGGAGCGCCTGAAGGAGC TCGTGGTCCCCAAGCACGTCATGGATGTTGTGGACGAGGAGCTGAGCAAGCTGGGCCTGCTGGACAACCACTCCTCGGAGTTCAAAACTG TAATTAAGAAGGAAGAGAAGATTGAGAAGAAGGAGGAAAAAAAGCCTGAAGACATTAAGAAGGAAGAAAAAGACCAGGATGAGCTGAAAC CCGGACCTACAAATCGGTCTAGAGTCACCAAATCAGGAAGCAGAGGAATGGAGCGGACGGTCGTGATGGATAAATCGAAAGGAGAGCCCG TCATTAGCGTGAAAACCACAAGCAGGTCCAAAGAGAGAAGCTCCAAGAGTCAGGATCGCAAGTCAGAAAGCAAAGAAAAGAGAGACATCT TGTCGTTTGATAAAATCAAAGAACAAAGGGAGAGAGAGCGCCAGAGGCAGCGGGAACGGGAGATCCGCGAAACGGAGAGGCGGCGGGAGC GCGAGCAGCGGGAGCGGGAGCAACGCCTCGAGGCCTTCCATGAGCGGAAGGAGAAGGCCCGGCTACAGCGGGAACGCCTGCAGCTCGAGT GCCAGCGCCAGCGGCTGGAGCGGGAGCGCATGGAGCGGGAGCGGCTGGAGCGCGAGCGCATGCGCGTGGAGCGTGAGCGCAGGAAGGAGC AGGAGCGCATCCACCGCGAGCGCGAGGAGCTGCGGCGCCAGCAGGAGCAGCTGCGTTACGAGCAGGAGCGGCGGCCCGGGCGGAGGCCCT ACGACCTGGACCGACGAGATGATGCCTATTGGCCAGAAGGAAAGCGTGTGGCAATGGAGGACCGATATCGTGCAGACTTTCCCCGGCCAG ACCACCGCTTTCACGACTTCGATCATCGAGACCGGGGCCAGTACCAGGACCACGCCATCGACAGGCGGGAGGGTTCGAGGCCAATGATGG GAGACCACCGGGATGGGCAGCACTATGGAGATGACCGCCATGGCCACGGAGGACCCCCAGAGCGCCACGGCCGGGACTCCCGTGATGGCT GGGGGGGCTACGGCTCCGACAAGAGGCTGAGTGAAGGCCGGGGGCTGCCCCCTCCCCCCAGGGGTGGCCGTGACTGGGGAGAGCACAACC AGCGGCTAGAGGAGCACCAGGCACGCGCCTGGCAGGGTGCCATGGACGCAGGCGCGGCTAGCCGGGAGCACGCCAGGTGGCAAGGTGGCG AGAGGGGCCTGTCTGGGCCCTCGGGGCCGGGGCACATGGCAAGCCGCGGTGGAGTGGCGGGGCGAGGCGGCTTTGCACAAGGTGGACATT CCCAGGGCCACGTGGTGCCAGGTGGCGGACTGGAAGGTGGCGGAGTGGCCAGCCAGGACCGGGGCAGCAGAGTCCCTCACCCACACCCTC ATCCCCCCCCGTACCCCCACTTCACCCGCCGCTACTAAGTCCCACTCGCTGCGAGTTTTCGGGTGGGCAGACGCACTGTTGAATCTGGTA GCCAGGGTTCCCTCGAACTTGGGGGATCTTTTTAAAAGCAAAGTAAATCCTGCCACCATGTTGTAGCTCAATACAATGTGAACTCACTTT TTTTTTTTTTTTAAATAAATGTGTTCTTGTTCTGCCATTTTTAAATCAAGGTTTCTGTTAACGAGGCATTCCATTTTCCATTAATAAAGT >In-frame_LONP1_ENST00000593119_chr19_5705783_-_SAFB2_ENST00000252542_chr19_5600271_-_2755nt GCGAGTTGTGTGAGCCGCCAGTATGGCCGGGCTATGGCGGCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTG CGGCGGCCGATGCTGGCCGCCGCCGGGGGGCGGGTTCCCACTGCAGCAGGAGCGTGGTTGCTCCGAGGCCCGGTCATAACGGCGCTCACG CCCATGACGATCCCCGATGTGTTTCCGCACCTGCCGCTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAG GTTAAAAATAAGAAGTTGGTTGAGCTGCTGAGAAGGAAAGTTCGTCTCGCCCAGCCTTATGTCGGCGTCTTTCTAAAGAGAGATGACAGC AATGAGTCGGATGTGGTCGAGAGCCTGGATGAAATCTACCACACGGGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGACAAG CTGCGCATGATCGTCATGGGACACAGAAGAGTCCATATCAGCAGACAGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCAC AAGCCCCGCAGGAAGTCAAAGCGGGGCAAGAAGGAGGCGGAGGACGAGCTGAGCGCCAGGCACCCGGCGGAGCTGGCGATGGAGCCCACC CCTGAGCTCCCGGCTGAGGTGCTCATGGTGGAGGTAGAGAACGTTGTCCACGAGGACTTCCAGGTCACGGAGGAGGTGAAAGCCCTGACT GCAGAGATCGTGAAGACCATCCGGGACATCATTGCCTTGAACCCTCTCTACAGGGAGTCAGTGCTGCAGATGATGCAGGCTGGCCAGCGG GTGGTGGACAACCCCATCTACCTGAGCGACATGGGCGCCGCGCTCACCGGGGCCGAGTCCCATGAGCTGCAGGACGTCCTGGAAGAGACC AATATTCCTAAGCGGCTGTACAAGGCCCTCTCCCTGCTGAAGAAGGAATTTGAACTGAGCAAGCTGCAGCAGCGCCTGGGGCGGGAGGTG GAGGAGAAGATCAAGCAGACCCACCGTAAGTACCTGCTGCAGGAGCAGCTAAAGATCATCAAGAAGGAGCTGGGCCTGGAGAAGGACGAC AAGGATGCCATCGAGGAGAAGTTCCGGGAGCGCCTGAAGGAGCTCGTGGTCCCCAAGCACGTCATGGATGTTGTGGACGAGGAGCTGAGC AAGCTGGGCCTGCTGGACAACCACTCCTCGGAGTTCAAAACTGTAATTAAGAAGGAAGAGAAGATTGAGAAGAAGGAGGAAAAAAAGCCT GAAGACATTAAGAAGGAAGAAAAAGACCAGGATGAGCTGAAACCCGGACCTACAAATCGGTCTAGAGTCACCAAATCAGGAAGCAGAGGA ATGGAGCGGACGGTCGTGATGGATAAATCGAAAGGAGAGCCCGTCATTAGCGTGAAAACCACAAGCAGGTCCAAAGAGAGAAGCTCCAAG AGTCAGGATCGCAAGTCAGAAAGCAAAGAAAAGAGAGACATCTTGTCGTTTGATAAAATCAAAGAACAAAGGGAGAGAGAGCGCCAGAGG CAGCGGGAACGGGAGATCCGCGAAACGGAGAGGCGGCGGGAGCGCGAGCAGCGGGAGCGGGAGCAACGCCTCGAGGCCTTCCATGAGCGG AAGGAGAAGGCCCGGCTACAGCGGGAACGCCTGCAGCTCGAGTGCCAGCGCCAGCGGCTGGAGCGGGAGCGCATGGAGCGGGAGCGGCTG GAGCGCGAGCGCATGCGCGTGGAGCGTGAGCGCAGGAAGGAGCAGGAGCGCATCCACCGCGAGCGCGAGGAGCTGCGGCGCCAGCAGGAG CAGCTGCGTTACGAGCAGGAGCGGCGGCCCGGGCGGAGGCCCTACGACCTGGACCGACGAGATGATGCCTATTGGCCAGAAGGAAAGCGT GTGGCAATGGAGGACCGATATCGTGCAGACTTTCCCCGGCCAGACCACCGCTTTCACGACTTCGATCATCGAGACCGGGGCCAGTACCAG GACCACGCCATCGACAGGCGGGAGGGTTCGAGGCCAATGATGGGAGACCACCGGGATGGGCAGCACTATGGAGATGACCGCCATGGCCAC GGAGGACCCCCAGAGCGCCACGGCCGGGACTCCCGTGATGGCTGGGGGGGCTACGGCTCCGACAAGAGGCTGAGTGAAGGCCGGGGGCTG CCCCCTCCCCCCAGGGGTGGCCGTGACTGGGGAGAGCACAACCAGCGGCTAGAGGAGCACCAGGCACGCGCCTGGCAGGGTGCCATGGAC GCAGGCGCGGCTAGCCGGGAGCACGCCAGGTGGCAAGGTGGCGAGAGGGGCCTGTCTGGGCCCTCGGGGCCGGGGCACATGGCAAGCCGC GGTGGAGTGGCGGGGCGAGGCGGCTTTGCACAAGGTGGACATTCCCAGGGCCACGTGGTGCCAGGTGGCGGACTGGAAGGTGGCGGAGTG GCCAGCCAGGACCGGGGCAGCAGAGTCCCTCACCCACACCCTCATCCCCCCCCGTACCCCCACTTCACCCGCCGCTACTAAGTCCCACTC GCTGCGAGTTTTCGGGTGGGCAGACGCACTGTTGAATCTGGTAGCCAGGGTTCCCTCGAACTTGGGGGATCTTTTTAAAAGCAAAGTAAA TCCTGCCACCATGTTGTAGCTCAATACAATGTGAACTCACTTTTTTTTTTTTTTTAAATAAATGTGTTCTTGTTCTGCCATTTTTAAATC >In-frame_LONP1_ENST00000540670_chr19_5705783_-_SAFB2_ENST00000252542_chr19_5600271_-_2839nt AGACGAATCCCGGGAAGCCCGAATCCGCGCACCCCAAAGTGCGCTCAGAGCCTGAGTATGCGCACCCGGCCACCCGTGGCCAGTCTAGAG TCTGAGCATGCGCATGTTGTCCGCGCGCCTAAGCATGTGCACAGGCTGCTCATGAGTTCCTAAACGTTGCGTTTGCAACACTACCAGTGT TTTGTACGGGCGCTGGCGCCTGCTCACAGCCTTCCACGTGACCGGAAAAGGCCTTCAGCGCATAAAGTGGGAGACCGGAAGAGGCGGAGA CGATCCGATGCTCGAACTCCGCCCCCTCTTCTCCGCGTAGGCCCAGCTCCCTGAAGCGGCTGTTTCGAGCCACGCGCCCATCGGGTTAAA AATAAGAAGTTGGTTGAGCTGCTGAGAAGGAAAGTTCGTCTCGCCCAGCCTTATGTCGGCGTCTTTCTAAAGAGAGATGACAGCAATGAG TCGGATGTGGTCGAGAGCCTGGATGAAATCTACCACACGGGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGACAAGCTGCGC ATGATCGTCATGGGACACAGAAGAGTCCATATCAGCAGACAGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCACAAGCCC CGCAGGAAGTCAAAGCGGGGCAAGAAGGAGGCGGAGGACGAGCTGAGCGCCAGGCACCCGGCGGAGCTGGCGATGGAGCCCACCCCTGAG CTCCCGGCTGAGGTGCTCATGGTGGAGGTAGAGAACGTTGTCCACGAGGACTTCCAGGTCACGGAGGAGGTGAAAGCCCTGACTGCAGAG ATCGTGAAGACCATCCGGGACATCATTGCCTTGAACCCTCTCTACAGGGAGTCAGTGCTGCAGATGATGCAGGCTGGCCAGCGGGTGGTG GACAACCCCATCTACCTGAGCGACATGGGCGCCGCGCTCACCGGGGCCGAGTCCCATGAGCTGCAGGACGTCCTGGAAGAGACCAATATT CCTAAGCGGCTGTACAAGGCCCTCTCCCTGCTGAAGAAGGAATTTGAACTGAGCAAGCTGCAGCAGCGCCTGGGGCGGGAGGTGGAGGAG AAGATCAAGCAGACCCACCGTAAGTACCTGCTGCAGGAGCAGCTAAAGATCATCAAGAAGGAGCTGGGCCTGGAGAAGGACGACAAGGAT GCCATCGAGGAGAAGTTCCGGGAGCGCCTGAAGGAGCTCGTGGTCCCCAAGCACGTCATGGATGTTGTGGACGAGGAGCTGAGCAAGCTG GGCCTGCTGGACAACCACTCCTCGGAGTTCAAAACTGTAATTAAGAAGGAAGAGAAGATTGAGAAGAAGGAGGAAAAAAAGCCTGAAGAC ATTAAGAAGGAAGAAAAAGACCAGGATGAGCTGAAACCCGGACCTACAAATCGGTCTAGAGTCACCAAATCAGGAAGCAGAGGAATGGAG CGGACGGTCGTGATGGATAAATCGAAAGGAGAGCCCGTCATTAGCGTGAAAACCACAAGCAGGTCCAAAGAGAGAAGCTCCAAGAGTCAG GATCGCAAGTCAGAAAGCAAAGAAAAGAGAGACATCTTGTCGTTTGATAAAATCAAAGAACAAAGGGAGAGAGAGCGCCAGAGGCAGCGG GAACGGGAGATCCGCGAAACGGAGAGGCGGCGGGAGCGCGAGCAGCGGGAGCGGGAGCAACGCCTCGAGGCCTTCCATGAGCGGAAGGAG AAGGCCCGGCTACAGCGGGAACGCCTGCAGCTCGAGTGCCAGCGCCAGCGGCTGGAGCGGGAGCGCATGGAGCGGGAGCGGCTGGAGCGC GAGCGCATGCGCGTGGAGCGTGAGCGCAGGAAGGAGCAGGAGCGCATCCACCGCGAGCGCGAGGAGCTGCGGCGCCAGCAGGAGCAGCTG CGTTACGAGCAGGAGCGGCGGCCCGGGCGGAGGCCCTACGACCTGGACCGACGAGATGATGCCTATTGGCCAGAAGGAAAGCGTGTGGCA ATGGAGGACCGATATCGTGCAGACTTTCCCCGGCCAGACCACCGCTTTCACGACTTCGATCATCGAGACCGGGGCCAGTACCAGGACCAC GCCATCGACAGGCGGGAGGGTTCGAGGCCAATGATGGGAGACCACCGGGATGGGCAGCACTATGGAGATGACCGCCATGGCCACGGAGGA CCCCCAGAGCGCCACGGCCGGGACTCCCGTGATGGCTGGGGGGGCTACGGCTCCGACAAGAGGCTGAGTGAAGGCCGGGGGCTGCCCCCT CCCCCCAGGGGTGGCCGTGACTGGGGAGAGCACAACCAGCGGCTAGAGGAGCACCAGGCACGCGCCTGGCAGGGTGCCATGGACGCAGGC GCGGCTAGCCGGGAGCACGCCAGGTGGCAAGGTGGCGAGAGGGGCCTGTCTGGGCCCTCGGGGCCGGGGCACATGGCAAGCCGCGGTGGA GTGGCGGGGCGAGGCGGCTTTGCACAAGGTGGACATTCCCAGGGCCACGTGGTGCCAGGTGGCGGACTGGAAGGTGGCGGAGTGGCCAGC CAGGACCGGGGCAGCAGAGTCCCTCACCCACACCCTCATCCCCCCCCGTACCCCCACTTCACCCGCCGCTACTAAGTCCCACTCGCTGCG AGTTTTCGGGTGGGCAGACGCACTGTTGAATCTGGTAGCCAGGGTTCCCTCGAACTTGGGGGATCTTTTTAAAAGCAAAGTAAATCCTGC CACCATGTTGTAGCTCAATACAATGTGAACTCACTTTTTTTTTTTTTTTAAATAAATGTGTTCTTGTTCTGCCATTTTTAAATCAAGGTT >In-frame_LONP1_ENST00000590729_chr19_5705783_-_SAFB2_ENST00000252542_chr19_5600271_-_2583nt GCGGCGCGGGGGGCAGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCGCACCTGC CGCTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGGTTAAAAATAAGAAGTTGGTTGAGCTGCTGAGAA GGAAAGTTCGTCTCGCCCAGCCTTATGTCGGCGTCTTTCTAAAGAGAGATGACAGCAATGAGTCGGATGTGGTCGAGAGCCTGGATGAAA TCTACCACACGGGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGACAAGCTGCGCATGATCGTCATGGGACACAGAAGAGTCC ATATCAGCAGACAGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCACAAGCCCCGCAGGAAGTCAAAGCGGGGCAAGAAGG AGGCGGAGGACGAGCTGAGCGCCAGGCACCCGGCGGAGCTGGCGATGGAGCCCACCCCTGAGCTCCCGGCTGAGGTGCTCATGGTGGAGG CCCTGACTGCAGAGATCGTGAAGACCATCCGGGACATCATTGCCTTGAACCCTCTCTACAGGGAGTCAGTGCTGCAGATGATGCAGGCTG GCCAGCGGGTGGTGGACAACCCCATCTACCTGAGCGACATGGGCGCCGCGCTCACCGGGGCCGAGTCCCATGAGCTGCAGGACGTCCTGG AAGAGACCAATATTCCTAAGCGGCTGTACAAGGCCCTCTCCCTGCTGAAGAAGGAATTTGAACTGAGCAAGCTGCAGCAGCGCCTGGGGC GGGAGGTGGAGGAGAAGATCAAGCAGACCCACCGTAAGTACCTGCTGCAGGAGCAGCTAAAGATCATCAAGAAGGAGCTGGGCCTGGAGA AGGACGACAAGGATGCCATCGAGGAGAAGTTCCGGGAGCGCCTGAAGGAGCTCGTGGTCCCCAAGCACGTCATGGATGTTGTGGACGAGG AGCTGAGCAAGCTGGGCCTGCTGGACAACCACTCCTCGGAGTTCAAAACTGTAATTAAGAAGGAAGAGAAGATTGAGAAGAAGGAGGAAA AAAAGCCTGAAGACATTAAGAAGGAAGAAAAAGACCAGGATGAGCTGAAACCCGGACCTACAAATCGGTCTAGAGTCACCAAATCAGGAA GCAGAGGAATGGAGCGGACGGTCGTGATGGATAAATCGAAAGGAGAGCCCGTCATTAGCGTGAAAACCACAAGCAGGTCCAAAGAGAGAA GCTCCAAGAGTCAGGATCGCAAGTCAGAAAGCAAAGAAAAGAGAGACATCTTGTCGTTTGATAAAATCAAAGAACAAAGGGAGAGAGAGC GCCAGAGGCAGCGGGAACGGGAGATCCGCGAAACGGAGAGGCGGCGGGAGCGCGAGCAGCGGGAGCGGGAGCAACGCCTCGAGGCCTTCC ATGAGCGGAAGGAGAAGGCCCGGCTACAGCGGGAACGCCTGCAGCTCGAGTGCCAGCGCCAGCGGCTGGAGCGGGAGCGCATGGAGCGGG AGCGGCTGGAGCGCGAGCGCATGCGCGTGGAGCGTGAGCGCAGGAAGGAGCAGGAGCGCATCCACCGCGAGCGCGAGGAGCTGCGGCGCC AGCAGGAGCAGCTGCGTTACGAGCAGGAGCGGCGGCCCGGGCGGAGGCCCTACGACCTGGACCGACGAGATGATGCCTATTGGCCAGAAG GAAAGCGTGTGGCAATGGAGGACCGATATCGTGCAGACTTTCCCCGGCCAGACCACCGCTTTCACGACTTCGATCATCGAGACCGGGGCC AGTACCAGGACCACGCCATCGACAGGCGGGAGGGTTCGAGGCCAATGATGGGAGACCACCGGGATGGGCAGCACTATGGAGATGACCGCC ATGGCCACGGAGGACCCCCAGAGCGCCACGGCCGGGACTCCCGTGATGGCTGGGGGGGCTACGGCTCCGACAAGAGGCTGAGTGAAGGCC GGGGGCTGCCCCCTCCCCCCAGGGGTGGCCGTGACTGGGGAGAGCACAACCAGCGGCTAGAGGAGCACCAGGCACGCGCCTGGCAGGGTG CCATGGACGCAGGCGCGGCTAGCCGGGAGCACGCCAGGTGGCAAGGTGGCGAGAGGGGCCTGTCTGGGCCCTCGGGGCCGGGGCACATGG CAAGCCGCGGTGGAGTGGCGGGGCGAGGCGGCTTTGCACAAGGTGGACATTCCCAGGGCCACGTGGTGCCAGGTGGCGGACTGGAAGGTG GCGGAGTGGCCAGCCAGGACCGGGGCAGCAGAGTCCCTCACCCACACCCTCATCCCCCCCCGTACCCCCACTTCACCCGCCGCTACTAAG TCCCACTCGCTGCGAGTTTTCGGGTGGGCAGACGCACTGTTGAATCTGGTAGCCAGGGTTCCCTCGAACTTGGGGGATCTTTTTAAAAGC AAAGTAAATCCTGCCACCATGTTGTAGCTCAATACAATGTGAACTCACTTTTTTTTTTTTTTTAAATAAATGTGTTCTTGTTCTGCCATT |
Top |
FusionGenePPI for LONP1_SAFB2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LONP1 | USP2, ATG101, GBAS, MYC, ICT1, MME, PSMA3, SIRT7, CUL1, A2M, CDC37, CYP2C8, ECSIT, IFIT3, IFIT5, LOXL4, MAST1, RNF32, APOE, DYNC1H1, C1QBP, ITGA4, SOX2, ADRB2, LATS2, ILK, TUBG1, CUL7, EGFR, C9orf173, GCAT, CLPX, PSMC4, PSMC5, SF3B1, TATDN1, NTRK1, CEP162, OFD1, CEP164, CNTRL, RPGRIP1L, DCTN1, NDUFS7, LRPPRC, ATL3, MTMR11, KLHDC8A, C19orf45, RASL10B, DCAF12L2, MRPL4, DCAF4, NEU4, FOXRED1, UPF3A, C9orf24, MRPS24, MKLN1, COQ2, TRIM25 | SAFB2 | SAFB, ESR1, SORBS3, CHGB, MAP1LC3A, RB1CC1, NCOR1, HDAC3, TOPORS, CUL3, COPS5, CAND1, SRCAP, IK, APOA1, FNTA, FUS, GIT2, ZSCAN18, MOV10, CUL7, OBSL1, EZH2, SUZ12, EED, BMI1, TP53, RSPH9, RBMX, FNDC4, ZFP41, HNRNPUL1, CCAR1, SSB, HNRNPA1, MYO1C, PPP1CB, PPP1CC, EMC2, MATR3, MPHOSPH8, CAMKK1, MEX3C, ELAVL2, DHPS, TRIP6, APOBEC3D, CAPN13, CIZ1, CLK3, COX15, VDAC1, G3BP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | SAFB2 | chr19:5705783 | chr19:5600271 | ENST00000252542 | - | 10 | 21 | 600_953 | 519 | 954 | SAFB1 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LONP1_SAFB2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LONP1_SAFB2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | LONP1 | C1838180 | CODAS syndrome | 2 | ORPHANET;UNIPROT |
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