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Fusion gene ID: 19954 |
FusionGeneSummary for LONP1_RAD51 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LONP1_RAD51 | Fusion gene ID: 19954 | Hgene | Tgene | Gene symbol | LONP1 | RAD51 | Gene ID | 9361 | 5888 |
| Gene name | lon peptidase 1, mitochondrial | RAD51 recombinase | |
| Synonyms | CODASS|LON|LONP|LonHS|PIM1|PRSS15|hLON | BRCC5|FANCR|HRAD51|HsRad51|HsT16930|MRMV2|RAD51A|RECA | |
| Cytomap | 19p13.3 | 15q15.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lon protease homolog, mitochondrialhLON ATP-dependent proteaselon protease-like proteinmitochondrial ATP-dependent protease Lonmitochondrial lon protease-like proteinserine protease 15 | DNA repair protein RAD51 homolog 1BRCA1/BRCA2-containing complex, subunit 5RAD51 homolog ARecA, E. coli, homolog ofRecA-like proteinrecombination protein A | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | P36776 | Q06609 | |
| Ensembl transtripts involved in fusion gene | ENST00000360614, ENST00000585374, ENST00000593119, ENST00000540670, ENST00000590729, ENST00000590511, | ENST00000423169, ENST00000267868, ENST00000557850, ENST00000532743, ENST00000382643, ENST00000530766, | |
| Fusion gene scores | * DoF score | 14 X 10 X 11=1540 | 3 X 3 X 3=27 |
| # samples | 15 | 3 | |
| ** MAII score | log2(15/1540*10)=-3.35989594508638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: LONP1 [Title/Abstract] AND RAD51 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LONP1 | GO:0034599 | cellular response to oxidative stress | 17420247 |
| Hgene | LONP1 | GO:0051260 | protein homooligomerization | 14739292 |
| Hgene | LONP1 | GO:0051603 | proteolysis involved in cellular protein catabolic process | 8248235|17420247 |
| Tgene | RAD51 | GO:0000724 | double-strand break repair via homologous recombination | 16428451 |
| Tgene | RAD51 | GO:0006268 | DNA unwinding involved in DNA replication | 7988572 |
| Tgene | RAD51 | GO:0006974 | cellular response to DNA damage stimulus | 23509288|25585578 |
| Tgene | RAD51 | GO:0010569 | regulation of double-strand break repair via homologous recombination | 23754376 |
| Tgene | RAD51 | GO:0031297 | replication fork processing | 25585578 |
| Tgene | RAD51 | GO:0051106 | positive regulation of DNA ligation | 8929543 |
| Tgene | RAD51 | GO:0071479 | cellular response to ionizing radiation | 23509288|23754376 |
| Tgene | RAD51 | GO:0072757 | cellular response to camptothecin | 23509288 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | CESC | TCGA-EA-A50E-01A | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000360614 | ENST00000423169 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| In-frame | ENST00000360614 | ENST00000267868 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| Frame-shift | ENST00000360614 | ENST00000557850 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| Frame-shift | ENST00000360614 | ENST00000532743 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| Frame-shift | ENST00000360614 | ENST00000382643 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| 5CDS-3UTR | ENST00000360614 | ENST00000530766 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| Frame-shift | ENST00000585374 | ENST00000423169 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| Frame-shift | ENST00000585374 | ENST00000267868 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| Frame-shift | ENST00000585374 | ENST00000557850 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| Frame-shift | ENST00000585374 | ENST00000532743 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| Frame-shift | ENST00000585374 | ENST00000382643 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| 5CDS-3UTR | ENST00000585374 | ENST00000530766 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| Frame-shift | ENST00000593119 | ENST00000423169 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| In-frame | ENST00000593119 | ENST00000267868 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| Frame-shift | ENST00000593119 | ENST00000557850 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| Frame-shift | ENST00000593119 | ENST00000532743 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| Frame-shift | ENST00000593119 | ENST00000382643 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| 5CDS-3UTR | ENST00000593119 | ENST00000530766 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| Frame-shift | ENST00000540670 | ENST00000423169 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| In-frame | ENST00000540670 | ENST00000267868 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| Frame-shift | ENST00000540670 | ENST00000557850 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| Frame-shift | ENST00000540670 | ENST00000532743 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| Frame-shift | ENST00000540670 | ENST00000382643 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| 5CDS-3UTR | ENST00000540670 | ENST00000530766 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| Frame-shift | ENST00000590729 | ENST00000423169 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| In-frame | ENST00000590729 | ENST00000267868 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| Frame-shift | ENST00000590729 | ENST00000557850 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| Frame-shift | ENST00000590729 | ENST00000532743 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| Frame-shift | ENST00000590729 | ENST00000382643 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| 5CDS-3UTR | ENST00000590729 | ENST00000530766 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| intron-3CDS | ENST00000590511 | ENST00000423169 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| intron-3CDS | ENST00000590511 | ENST00000267868 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| intron-3CDS | ENST00000590511 | ENST00000557850 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| intron-3CDS | ENST00000590511 | ENST00000532743 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| intron-3CDS | ENST00000590511 | ENST00000382643 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
| intron-3UTR | ENST00000590511 | ENST00000530766 | LONP1 | chr19 | 5700800 | - | RAD51 | chr15 | 41023253 | + |
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FusionProtFeatures for LONP1_RAD51 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LONP1 | RAD51 |
| ATP-dependent serine protease that mediates theselective degradation of misfolded, unassembled or oxidativelydamaged polypeptides as well as certain short-lived regulatoryproteins in the mitochondrial matrix. May also have a chaperonefunction in the assembly of inner membrane protein complexes.Participates in the regulation of mitochondrial gene expressionand in the maintenance of the integrity of the mitochondrialgenome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulatemitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation ofregulatory proteins binding to adjacent sites in mitochondrialpromoters (PubMed:12198491, PubMed:15870080, PubMed:17420247,PubMed:8248235). Endogenous substrates include mitochondrialsteroidogenic acute regulatory (StAR) protein, helicase Twinkle(TWNK) and the large ribosomal subunit protein bL32m. bL32m isprotected from degradation by LONP1 when it is bound to a nucleicacid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575).{ECO:0000255|HAMAP-Rule:MF_03120, ECO:0000269|PubMed:12198491,ECO:0000269|PubMed:15870080, ECO:0000269|PubMed:17420247,ECO:0000269|PubMed:17579211, ECO:0000269|PubMed:28377575,ECO:0000269|PubMed:8248235}. | Plays an important role in homologous strand exchange, akey step in DNA repair through homologous recombination (HR)(PubMed:28575658). Binds to single and double-stranded DNA andexhibits DNA-dependent ATPase activity. Catalyzes the recognitionof homology and strand exchange between homologous DNA partners toform a joint molecule between a processed DNA break and the repairtemplate. Binds to single-stranded DNA in an ATP-dependent mannerto form nucleoprotein filaments which are essential for thehomology search and strand exchange (PubMed:26681308). Part of aPALB2-scaffolded HR complex containing BRCA2 and RAD51C and whichis thought to play a role in DNA repair by HR. Plays a role inregulating mitochondrial DNA copy number under conditions ofoxidative stress in the presence of RAD51C and XRCC3. Alsoinvolved in interstrand cross-link repair (PubMed:26253028).{ECO:0000269|PubMed:12205100, ECO:0000269|PubMed:12442171,ECO:0000269|PubMed:18417535, ECO:0000269|PubMed:20231364,ECO:0000269|PubMed:20348101, ECO:0000269|PubMed:20413593,ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:23754376,ECO:0000269|PubMed:26253028, ECO:0000269|PubMed:26681308,ECO:0000269|PubMed:28575658}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LONP1_RAD51 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_LONP1_ENST00000360614_chr19_5700800_-_RAD51_ENST00000267868_chr15_41023253_+_543aa MAASTGYVRLWGAARCWVLRRPMLAAAGGRVPTAAGAWLLRGQRTCDASPPWALWGRGPAIGGQWRGFWEASSRGGGAFSGGEDASEGGA EEGAGGAGGSAGAGEGPVITALTPMTIPDVFPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVE SLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSKRGKKEAEDELSARHPAELAMEPTPELPAEV LMVEVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLY KALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDN HSSEFNVTRNYLDWLTSIPWGKYSNENLDLARAQAVLEEDHYGMEDVKKRILIVSEERKRGNQNLQNLRLSLSSXSXSYVRHXCRWSGRC >In-frame_LONP1_ENST00000593119_chr19_5700800_-_RAD51_ENST00000267868_chr15_41023253_+_479aa MAASTGYVRLWGAARCWVLRRPMLAAAGGRVPTAAGAWLLRGPVITALTPMTIPDVFPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLR RKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSKRGKK EAEDELSARHPAELAMEPTPELPAEVLMVEVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDM GAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFRER LKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLTSIPWGKYSNENLDLARAQAVLEEDHYGMEDVKKRILIVSEERKRGNQN >In-frame_LONP1_ENST00000540670_chr19_5700800_-_RAD51_ENST00000267868_chr15_41023253_+_347aa MQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSKRGKKEAEDELSARHPAELAMEPTPELPAEVLMVEVENVVHEDFQVT EEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQ QRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLT >In-frame_LONP1_ENST00000590729_chr19_5700800_-_RAD51_ENST00000267868_chr15_41023253_+_413aa MTIPDVFPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKL RMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSKRGKKEAEDELSARHPAELAMEPTPELPAEVLMVEALTAEIVKTIRDIIALNPLY RESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQL KIIKKELGLEKDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLTSIPWGKYSNENLDLARAQAVLEED |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_LONP1_ENST00000360614_chr19_5700800_-_RAD51_ENST00000267868_chr15_41023253_+_1630nt ATGGCGGCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCGATGCTGGCCGCCGCCGGGGGGCGG GTTCCCACTGCAGCAGGAGCGTGGTTGCTCCGAGGCCAGCGGACCTGCGACGCCTCTCCTCCTTGGGCACTGTGGGGCCGAGGCCCGGCA ATTGGGGGCCAATGGCGGGGGTTTTGGGAAGCGAGCAGCCGCGGCGGAGGCGCATTCTCGGGGGGCGAGGACGCCTCCGAGGGCGGCGCG GAGGAAGGAGCCGGCGGCGCGGGGGGCAGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTG TTTCCGCACCTGCCGCTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGGTTAAAAATAAGAAGTTGGTT GAGCTGCTGAGAAGGAAAGTTCGTCTCGCCCAGCCTTATGTCGGCGTCTTTCTAAAGAGAGATGACAGCAATGAGTCGGATGTGGTCGAG AGCCTGGATGAAATCTACCACACGGGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGACAAGCTGCGCATGATCGTCATGGGA CACAGAAGAGTCCATATCAGCAGACAGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCACAAGCCCCGCAGGAAGTCAAAG CGGGGCAAGAAGGAGGCGGAGGACGAGCTGAGCGCCAGGCACCCGGCGGAGCTGGCGATGGAGCCCACCCCTGAGCTCCCGGCTGAGGTG CTCATGGTGGAGGTAGAGAACGTTGTCCACGAGGACTTCCAGGTCACGGAGGAGGTGAAAGCCCTGACTGCAGAGATCGTGAAGACCATC CGGGACATCATTGCCTTGAACCCTCTCTACAGGGAGTCAGTGCTGCAGATGATGCAGGCTGGCCAGCGGGTGGTGGACAACCCCATCTAC CTGAGCGACATGGGCGCCGCGCTCACCGGGGCCGAGTCCCATGAGCTGCAGGACGTCCTGGAAGAGACCAATATTCCTAAGCGGCTGTAC AAGGCCCTCTCCCTGCTGAAGAAGGAATTTGAACTGAGCAAGCTGCAGCAGCGCCTGGGGCGGGAGGTGGAGGAGAAGATCAAGCAGACC CACCGTAAGTACCTGCTGCAGGAGCAGCTAAAGATCATCAAGAAGGAGCTGGGCCTGGAGAAGGACGACAAGGATGCCATCGAGGAGAAG TTCCGGGAGCGCCTGAAGGAGCTCGTGGTCCCCAAGCACGTCATGGATGTTGTGGACGAGGAGCTGAGCAAGCTGGGCCTGCTGGACAAC CACTCCTCGGAGTTCAATGTCACCCGCAACTACCTAGACTGGCTCACGTCCATCCCTTGGGGCAAGTACAGCAACGAGAACCTGGACCTG GCGCGGGCACAGGCAGTGCTGGAGGAAGACCACTACGGCATGGAGGACGTCAAGAAACGCATCCTGATTGTATCTGAGGAAAGGAAGAGG GGAAACCAGAATCTGCAAAATCTACGACTCTCCCTGTCTTCCTGAAGCTGAAGCTATGTTCGCCATTAATGCAGATGGAGTGGGAGATGC >In-frame_LONP1_ENST00000593119_chr19_5700800_-_RAD51_ENST00000267868_chr15_41023253_+_1438nt ATGGCGGCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCGATGCTGGCCGCCGCCGGGGGGCGG GTTCCCACTGCAGCAGGAGCGTGGTTGCTCCGAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCGCACCTG CCGCTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGGTTAAAAATAAGAAGTTGGTTGAGCTGCTGAGA AGGAAAGTTCGTCTCGCCCAGCCTTATGTCGGCGTCTTTCTAAAGAGAGATGACAGCAATGAGTCGGATGTGGTCGAGAGCCTGGATGAA ATCTACCACACGGGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGACAAGCTGCGCATGATCGTCATGGGACACAGAAGAGTC CATATCAGCAGACAGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCACAAGCCCCGCAGGAAGTCAAAGCGGGGCAAGAAG GAGGCGGAGGACGAGCTGAGCGCCAGGCACCCGGCGGAGCTGGCGATGGAGCCCACCCCTGAGCTCCCGGCTGAGGTGCTCATGGTGGAG GTAGAGAACGTTGTCCACGAGGACTTCCAGGTCACGGAGGAGGTGAAAGCCCTGACTGCAGAGATCGTGAAGACCATCCGGGACATCATT GCCTTGAACCCTCTCTACAGGGAGTCAGTGCTGCAGATGATGCAGGCTGGCCAGCGGGTGGTGGACAACCCCATCTACCTGAGCGACATG GGCGCCGCGCTCACCGGGGCCGAGTCCCATGAGCTGCAGGACGTCCTGGAAGAGACCAATATTCCTAAGCGGCTGTACAAGGCCCTCTCC CTGCTGAAGAAGGAATTTGAACTGAGCAAGCTGCAGCAGCGCCTGGGGCGGGAGGTGGAGGAGAAGATCAAGCAGACCCACCGTAAGTAC CTGCTGCAGGAGCAGCTAAAGATCATCAAGAAGGAGCTGGGCCTGGAGAAGGACGACAAGGATGCCATCGAGGAGAAGTTCCGGGAGCGC CTGAAGGAGCTCGTGGTCCCCAAGCACGTCATGGATGTTGTGGACGAGGAGCTGAGCAAGCTGGGCCTGCTGGACAACCACTCCTCGGAG TTCAATGTCACCCGCAACTACCTAGACTGGCTCACGTCCATCCCTTGGGGCAAGTACAGCAACGAGAACCTGGACCTGGCGCGGGCACAG GCAGTGCTGGAGGAAGACCACTACGGCATGGAGGACGTCAAGAAACGCATCCTGATTGTATCTGAGGAAAGGAAGAGGGGAAACCAGAAT >In-frame_LONP1_ENST00000540670_chr19_5700800_-_RAD51_ENST00000267868_chr15_41023253_+_1042nt ATGCAGGACCTTGGGGACAAGCTGCGCATGATCGTCATGGGACACAGAAGAGTCCATATCAGCAGACAGCTGGAGGTGGAGCCCGAGGAG CCGGAGGCGGAGAACAAGCACAAGCCCCGCAGGAAGTCAAAGCGGGGCAAGAAGGAGGCGGAGGACGAGCTGAGCGCCAGGCACCCGGCG GAGCTGGCGATGGAGCCCACCCCTGAGCTCCCGGCTGAGGTGCTCATGGTGGAGGTAGAGAACGTTGTCCACGAGGACTTCCAGGTCACG GAGGAGGTGAAAGCCCTGACTGCAGAGATCGTGAAGACCATCCGGGACATCATTGCCTTGAACCCTCTCTACAGGGAGTCAGTGCTGCAG ATGATGCAGGCTGGCCAGCGGGTGGTGGACAACCCCATCTACCTGAGCGACATGGGCGCCGCGCTCACCGGGGCCGAGTCCCATGAGCTG CAGGACGTCCTGGAAGAGACCAATATTCCTAAGCGGCTGTACAAGGCCCTCTCCCTGCTGAAGAAGGAATTTGAACTGAGCAAGCTGCAG CAGCGCCTGGGGCGGGAGGTGGAGGAGAAGATCAAGCAGACCCACCGTAAGTACCTGCTGCAGGAGCAGCTAAAGATCATCAAGAAGGAG CTGGGCCTGGAGAAGGACGACAAGGATGCCATCGAGGAGAAGTTCCGGGAGCGCCTGAAGGAGCTCGTGGTCCCCAAGCACGTCATGGAT GTTGTGGACGAGGAGCTGAGCAAGCTGGGCCTGCTGGACAACCACTCCTCGGAGTTCAATGTCACCCGCAACTACCTAGACTGGCTCACG TCCATCCCTTGGGGCAAGTACAGCAACGAGAACCTGGACCTGGCGCGGGCACAGGCAGTGCTGGAGGAAGACCACTACGGCATGGAGGAC GTCAAGAAACGCATCCTGATTGTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTCTCCCTGTCTTCCTGAAGC >In-frame_LONP1_ENST00000590729_chr19_5700800_-_RAD51_ENST00000267868_chr15_41023253_+_1240nt ATGACGATCCCCGATGTGTTTCCGCACCTGCCGCTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGGTT AAAAATAAGAAGTTGGTTGAGCTGCTGAGAAGGAAAGTTCGTCTCGCCCAGCCTTATGTCGGCGTCTTTCTAAAGAGAGATGACAGCAAT GAGTCGGATGTGGTCGAGAGCCTGGATGAAATCTACCACACGGGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGACAAGCTG CGCATGATCGTCATGGGACACAGAAGAGTCCATATCAGCAGACAGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCACAAG CCCCGCAGGAAGTCAAAGCGGGGCAAGAAGGAGGCGGAGGACGAGCTGAGCGCCAGGCACCCGGCGGAGCTGGCGATGGAGCCCACCCCT GAGCTCCCGGCTGAGGTGCTCATGGTGGAGGCCCTGACTGCAGAGATCGTGAAGACCATCCGGGACATCATTGCCTTGAACCCTCTCTAC AGGGAGTCAGTGCTGCAGATGATGCAGGCTGGCCAGCGGGTGGTGGACAACCCCATCTACCTGAGCGACATGGGCGCCGCGCTCACCGGG GCCGAGTCCCATGAGCTGCAGGACGTCCTGGAAGAGACCAATATTCCTAAGCGGCTGTACAAGGCCCTCTCCCTGCTGAAGAAGGAATTT GAACTGAGCAAGCTGCAGCAGCGCCTGGGGCGGGAGGTGGAGGAGAAGATCAAGCAGACCCACCGTAAGTACCTGCTGCAGGAGCAGCTA AAGATCATCAAGAAGGAGCTGGGCCTGGAGAAGGACGACAAGGATGCCATCGAGGAGAAGTTCCGGGAGCGCCTGAAGGAGCTCGTGGTC CCCAAGCACGTCATGGATGTTGTGGACGAGGAGCTGAGCAAGCTGGGCCTGCTGGACAACCACTCCTCGGAGTTCAATGTCACCCGCAAC TACCTAGACTGGCTCACGTCCATCCCTTGGGGCAAGTACAGCAACGAGAACCTGGACCTGGCGCGGGCACAGGCAGTGCTGGAGGAAGAC CACTACGGCATGGAGGACGTCAAGAAACGCATCCTGATTGTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_LONP1_ENST00000360614_chr19_5700800_-_RAD51_ENST00000267868_chr15_41023253_+_2766nt CGAACTCCGCCCCCTCTTCTCCGCGTAGGCCCAGCTCCCTGAAGCGGCTGTTTCGAGCCACGCGCCCATCGGGTACCGAGGCACGCGCCG GGCGTCACGTGCGTTTCGCGGCGAGCGGAAATGACGCGAGTTGTGTGAGCCGCCAGTATGGCCGGGCTATGGCGGCGAGCACTGGCTACG TGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCGATGCTGGCCGCCGCCGGGGGGCGGGTTCCCACTGCAGCAGGAGCGT GGTTGCTCCGAGGCCAGCGGACCTGCGACGCCTCTCCTCCTTGGGCACTGTGGGGCCGAGGCCCGGCAATTGGGGGCCAATGGCGGGGGT TTTGGGAAGCGAGCAGCCGCGGCGGAGGCGCATTCTCGGGGGGCGAGGACGCCTCCGAGGGCGGCGCGGAGGAAGGAGCCGGCGGCGCGG GGGGCAGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCGCACCTGCCGCTCATCG CCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGGTTAAAAATAAGAAGTTGGTTGAGCTGCTGAGAAGGAAAGTTC GTCTCGCCCAGCCTTATGTCGGCGTCTTTCTAAAGAGAGATGACAGCAATGAGTCGGATGTGGTCGAGAGCCTGGATGAAATCTACCACA CGGGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGACAAGCTGCGCATGATCGTCATGGGACACAGAAGAGTCCATATCAGCA GACAGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCACAAGCCCCGCAGGAAGTCAAAGCGGGGCAAGAAGGAGGCGGAGG ACGAGCTGAGCGCCAGGCACCCGGCGGAGCTGGCGATGGAGCCCACCCCTGAGCTCCCGGCTGAGGTGCTCATGGTGGAGGTAGAGAACG TTGTCCACGAGGACTTCCAGGTCACGGAGGAGGTGAAAGCCCTGACTGCAGAGATCGTGAAGACCATCCGGGACATCATTGCCTTGAACC CTCTCTACAGGGAGTCAGTGCTGCAGATGATGCAGGCTGGCCAGCGGGTGGTGGACAACCCCATCTACCTGAGCGACATGGGCGCCGCGC TCACCGGGGCCGAGTCCCATGAGCTGCAGGACGTCCTGGAAGAGACCAATATTCCTAAGCGGCTGTACAAGGCCCTCTCCCTGCTGAAGA AGGAATTTGAACTGAGCAAGCTGCAGCAGCGCCTGGGGCGGGAGGTGGAGGAGAAGATCAAGCAGACCCACCGTAAGTACCTGCTGCAGG AGCAGCTAAAGATCATCAAGAAGGAGCTGGGCCTGGAGAAGGACGACAAGGATGCCATCGAGGAGAAGTTCCGGGAGCGCCTGAAGGAGC TCGTGGTCCCCAAGCACGTCATGGATGTTGTGGACGAGGAGCTGAGCAAGCTGGGCCTGCTGGACAACCACTCCTCGGAGTTCAATGTCA CCCGCAACTACCTAGACTGGCTCACGTCCATCCCTTGGGGCAAGTACAGCAACGAGAACCTGGACCTGGCGCGGGCACAGGCAGTGCTGG AGGAAGACCACTACGGCATGGAGGACGTCAAGAAACGCATCCTGATTGTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATC TACGACTCTCCCTGTCTTCCTGAAGCTGAAGCTATGTTCGCCATTAATGCAGATGGAGTGGGAGATGCCAAAGACTGAATCATTGGGTTT TTCCTCTGTTAAAAACCTTAAGTGCTGCAGCCTAATGAGAGTGCACTGCTCCCTGGGGTTCTCTACAGGCCTCTTCCTGTTGTGACTGCC AGGATAAAGCTTCCGGGAAAACAGCTATTATATCAGCTTTTCTGATGGTATAAACAGGAGACAGGTCAGTAGTCACAAACTGATCTAAAA TGTTTATTCCTTCTGTAGTGTATTAATCTCTGTGTGTTTTCTTTGGTTTTGGAGGAGGGGTATGAAGTATCTTTGACATGGTGCCTTAGG AATGACTTGGGTTTAACAAGCTGTCTACTGGACAATCTTATGTTTCCAAGAGAACTAAAGCTGGAGAGACCTGACCCTTCTCTCACTTCT AAATTAATGGTAAAATAAAATGCCTCAGCTATGTAGCAAAGGGAATGGGTCTGCACAGATTCTTTTTTTCTGTCAGTAAAACTCTCAAGC AGGTTTTTAAGTTGTCTGTCTGAATGATCTTGTGTAAGGTTTTGGTTATGGAGTCTTGTGCCAAACCTACTAGGCCATTAGCCCTTCACC ATCTACCTGCTTGGTCTTTCATTGCTAAGACTAACTCAAGATAATCCTAGAGTCTTAAAGCATTTCAGGCCAGTGTGGTGTCTTGCGCCT GTACTCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCGCTTGAGCCCAGGAGTTTTAAGTCCAGCTTGGCCAAGGTGGTGAAATCCCAT CTCTACAAAAAATGCAGAACTTAATCTGGACACACTGTTACACGTGCCTGTAGTCCCAGCTACTCGATAGCCTGAGGTGGGAGAATCACT TAAGCCTGGAAGGTGGAAGTTGCAGTGAGTCGAGATTGCACTGCTGCATTCCAGCCAGGGTGACAGAGTGAGACCATGTTTCAAACAAGA >In-frame_LONP1_ENST00000593119_chr19_5700800_-_RAD51_ENST00000267868_chr15_41023253_+_2449nt GCGAGTTGTGTGAGCCGCCAGTATGGCCGGGCTATGGCGGCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTG CGGCGGCCGATGCTGGCCGCCGCCGGGGGGCGGGTTCCCACTGCAGCAGGAGCGTGGTTGCTCCGAGGCCCGGTCATAACGGCGCTCACG CCCATGACGATCCCCGATGTGTTTCCGCACCTGCCGCTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAG GTTAAAAATAAGAAGTTGGTTGAGCTGCTGAGAAGGAAAGTTCGTCTCGCCCAGCCTTATGTCGGCGTCTTTCTAAAGAGAGATGACAGC AATGAGTCGGATGTGGTCGAGAGCCTGGATGAAATCTACCACACGGGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGACAAG CTGCGCATGATCGTCATGGGACACAGAAGAGTCCATATCAGCAGACAGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCAC AAGCCCCGCAGGAAGTCAAAGCGGGGCAAGAAGGAGGCGGAGGACGAGCTGAGCGCCAGGCACCCGGCGGAGCTGGCGATGGAGCCCACC CCTGAGCTCCCGGCTGAGGTGCTCATGGTGGAGGTAGAGAACGTTGTCCACGAGGACTTCCAGGTCACGGAGGAGGTGAAAGCCCTGACT GCAGAGATCGTGAAGACCATCCGGGACATCATTGCCTTGAACCCTCTCTACAGGGAGTCAGTGCTGCAGATGATGCAGGCTGGCCAGCGG GTGGTGGACAACCCCATCTACCTGAGCGACATGGGCGCCGCGCTCACCGGGGCCGAGTCCCATGAGCTGCAGGACGTCCTGGAAGAGACC AATATTCCTAAGCGGCTGTACAAGGCCCTCTCCCTGCTGAAGAAGGAATTTGAACTGAGCAAGCTGCAGCAGCGCCTGGGGCGGGAGGTG GAGGAGAAGATCAAGCAGACCCACCGTAAGTACCTGCTGCAGGAGCAGCTAAAGATCATCAAGAAGGAGCTGGGCCTGGAGAAGGACGAC AAGGATGCCATCGAGGAGAAGTTCCGGGAGCGCCTGAAGGAGCTCGTGGTCCCCAAGCACGTCATGGATGTTGTGGACGAGGAGCTGAGC AAGCTGGGCCTGCTGGACAACCACTCCTCGGAGTTCAATGTCACCCGCAACTACCTAGACTGGCTCACGTCCATCCCTTGGGGCAAGTAC AGCAACGAGAACCTGGACCTGGCGCGGGCACAGGCAGTGCTGGAGGAAGACCACTACGGCATGGAGGACGTCAAGAAACGCATCCTGATT GTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTCTCCCTGTCTTCCTGAAGCTGAAGCTATGTTCGCCATTAA TGCAGATGGAGTGGGAGATGCCAAAGACTGAATCATTGGGTTTTTCCTCTGTTAAAAACCTTAAGTGCTGCAGCCTAATGAGAGTGCACT GCTCCCTGGGGTTCTCTACAGGCCTCTTCCTGTTGTGACTGCCAGGATAAAGCTTCCGGGAAAACAGCTATTATATCAGCTTTTCTGATG GTATAAACAGGAGACAGGTCAGTAGTCACAAACTGATCTAAAATGTTTATTCCTTCTGTAGTGTATTAATCTCTGTGTGTTTTCTTTGGT TTTGGAGGAGGGGTATGAAGTATCTTTGACATGGTGCCTTAGGAATGACTTGGGTTTAACAAGCTGTCTACTGGACAATCTTATGTTTCC AAGAGAACTAAAGCTGGAGAGACCTGACCCTTCTCTCACTTCTAAATTAATGGTAAAATAAAATGCCTCAGCTATGTAGCAAAGGGAATG GGTCTGCACAGATTCTTTTTTTCTGTCAGTAAAACTCTCAAGCAGGTTTTTAAGTTGTCTGTCTGAATGATCTTGTGTAAGGTTTTGGTT ATGGAGTCTTGTGCCAAACCTACTAGGCCATTAGCCCTTCACCATCTACCTGCTTGGTCTTTCATTGCTAAGACTAACTCAAGATAATCC TAGAGTCTTAAAGCATTTCAGGCCAGTGTGGTGTCTTGCGCCTGTACTCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCGCTTGAGCC CAGGAGTTTTAAGTCCAGCTTGGCCAAGGTGGTGAAATCCCATCTCTACAAAAAATGCAGAACTTAATCTGGACACACTGTTACACGTGC CTGTAGTCCCAGCTACTCGATAGCCTGAGGTGGGAGAATCACTTAAGCCTGGAAGGTGGAAGTTGCAGTGAGTCGAGATTGCACTGCTGC ATTCCAGCCAGGGTGACAGAGTGAGACCATGTTTCAAACAAGAAACATTTCAGAGGGTAAGTAAACAGATTTGATTGTGAGGCTTCTAAT >In-frame_LONP1_ENST00000540670_chr19_5700800_-_RAD51_ENST00000267868_chr15_41023253_+_2533nt AGACGAATCCCGGGAAGCCCGAATCCGCGCACCCCAAAGTGCGCTCAGAGCCTGAGTATGCGCACCCGGCCACCCGTGGCCAGTCTAGAG TCTGAGCATGCGCATGTTGTCCGCGCGCCTAAGCATGTGCACAGGCTGCTCATGAGTTCCTAAACGTTGCGTTTGCAACACTACCAGTGT TTTGTACGGGCGCTGGCGCCTGCTCACAGCCTTCCACGTGACCGGAAAAGGCCTTCAGCGCATAAAGTGGGAGACCGGAAGAGGCGGAGA CGATCCGATGCTCGAACTCCGCCCCCTCTTCTCCGCGTAGGCCCAGCTCCCTGAAGCGGCTGTTTCGAGCCACGCGCCCATCGGGTTAAA AATAAGAAGTTGGTTGAGCTGCTGAGAAGGAAAGTTCGTCTCGCCCAGCCTTATGTCGGCGTCTTTCTAAAGAGAGATGACAGCAATGAG TCGGATGTGGTCGAGAGCCTGGATGAAATCTACCACACGGGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGACAAGCTGCGC ATGATCGTCATGGGACACAGAAGAGTCCATATCAGCAGACAGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCACAAGCCC CGCAGGAAGTCAAAGCGGGGCAAGAAGGAGGCGGAGGACGAGCTGAGCGCCAGGCACCCGGCGGAGCTGGCGATGGAGCCCACCCCTGAG CTCCCGGCTGAGGTGCTCATGGTGGAGGTAGAGAACGTTGTCCACGAGGACTTCCAGGTCACGGAGGAGGTGAAAGCCCTGACTGCAGAG ATCGTGAAGACCATCCGGGACATCATTGCCTTGAACCCTCTCTACAGGGAGTCAGTGCTGCAGATGATGCAGGCTGGCCAGCGGGTGGTG GACAACCCCATCTACCTGAGCGACATGGGCGCCGCGCTCACCGGGGCCGAGTCCCATGAGCTGCAGGACGTCCTGGAAGAGACCAATATT CCTAAGCGGCTGTACAAGGCCCTCTCCCTGCTGAAGAAGGAATTTGAACTGAGCAAGCTGCAGCAGCGCCTGGGGCGGGAGGTGGAGGAG AAGATCAAGCAGACCCACCGTAAGTACCTGCTGCAGGAGCAGCTAAAGATCATCAAGAAGGAGCTGGGCCTGGAGAAGGACGACAAGGAT GCCATCGAGGAGAAGTTCCGGGAGCGCCTGAAGGAGCTCGTGGTCCCCAAGCACGTCATGGATGTTGTGGACGAGGAGCTGAGCAAGCTG GGCCTGCTGGACAACCACTCCTCGGAGTTCAATGTCACCCGCAACTACCTAGACTGGCTCACGTCCATCCCTTGGGGCAAGTACAGCAAC GAGAACCTGGACCTGGCGCGGGCACAGGCAGTGCTGGAGGAAGACCACTACGGCATGGAGGACGTCAAGAAACGCATCCTGATTGTATCT GAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTCTCCCTGTCTTCCTGAAGCTGAAGCTATGTTCGCCATTAATGCAGA TGGAGTGGGAGATGCCAAAGACTGAATCATTGGGTTTTTCCTCTGTTAAAAACCTTAAGTGCTGCAGCCTAATGAGAGTGCACTGCTCCC TGGGGTTCTCTACAGGCCTCTTCCTGTTGTGACTGCCAGGATAAAGCTTCCGGGAAAACAGCTATTATATCAGCTTTTCTGATGGTATAA ACAGGAGACAGGTCAGTAGTCACAAACTGATCTAAAATGTTTATTCCTTCTGTAGTGTATTAATCTCTGTGTGTTTTCTTTGGTTTTGGA GGAGGGGTATGAAGTATCTTTGACATGGTGCCTTAGGAATGACTTGGGTTTAACAAGCTGTCTACTGGACAATCTTATGTTTCCAAGAGA ACTAAAGCTGGAGAGACCTGACCCTTCTCTCACTTCTAAATTAATGGTAAAATAAAATGCCTCAGCTATGTAGCAAAGGGAATGGGTCTG CACAGATTCTTTTTTTCTGTCAGTAAAACTCTCAAGCAGGTTTTTAAGTTGTCTGTCTGAATGATCTTGTGTAAGGTTTTGGTTATGGAG TCTTGTGCCAAACCTACTAGGCCATTAGCCCTTCACCATCTACCTGCTTGGTCTTTCATTGCTAAGACTAACTCAAGATAATCCTAGAGT CTTAAAGCATTTCAGGCCAGTGTGGTGTCTTGCGCCTGTACTCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCGCTTGAGCCCAGGAG TTTTAAGTCCAGCTTGGCCAAGGTGGTGAAATCCCATCTCTACAAAAAATGCAGAACTTAATCTGGACACACTGTTACACGTGCCTGTAG TCCCAGCTACTCGATAGCCTGAGGTGGGAGAATCACTTAAGCCTGGAAGGTGGAAGTTGCAGTGAGTCGAGATTGCACTGCTGCATTCCA GCCAGGGTGACAGAGTGAGACCATGTTTCAAACAAGAAACATTTCAGAGGGTAAGTAAACAGATTTGATTGTGAGGCTTCTAATAAAGTA >In-frame_LONP1_ENST00000590729_chr19_5700800_-_RAD51_ENST00000267868_chr15_41023253_+_2277nt GCGGCGCGGGGGGCAGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCGCACCTGC CGCTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGGTTAAAAATAAGAAGTTGGTTGAGCTGCTGAGAA GGAAAGTTCGTCTCGCCCAGCCTTATGTCGGCGTCTTTCTAAAGAGAGATGACAGCAATGAGTCGGATGTGGTCGAGAGCCTGGATGAAA TCTACCACACGGGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGACAAGCTGCGCATGATCGTCATGGGACACAGAAGAGTCC ATATCAGCAGACAGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCACAAGCCCCGCAGGAAGTCAAAGCGGGGCAAGAAGG AGGCGGAGGACGAGCTGAGCGCCAGGCACCCGGCGGAGCTGGCGATGGAGCCCACCCCTGAGCTCCCGGCTGAGGTGCTCATGGTGGAGG CCCTGACTGCAGAGATCGTGAAGACCATCCGGGACATCATTGCCTTGAACCCTCTCTACAGGGAGTCAGTGCTGCAGATGATGCAGGCTG GCCAGCGGGTGGTGGACAACCCCATCTACCTGAGCGACATGGGCGCCGCGCTCACCGGGGCCGAGTCCCATGAGCTGCAGGACGTCCTGG AAGAGACCAATATTCCTAAGCGGCTGTACAAGGCCCTCTCCCTGCTGAAGAAGGAATTTGAACTGAGCAAGCTGCAGCAGCGCCTGGGGC GGGAGGTGGAGGAGAAGATCAAGCAGACCCACCGTAAGTACCTGCTGCAGGAGCAGCTAAAGATCATCAAGAAGGAGCTGGGCCTGGAGA AGGACGACAAGGATGCCATCGAGGAGAAGTTCCGGGAGCGCCTGAAGGAGCTCGTGGTCCCCAAGCACGTCATGGATGTTGTGGACGAGG AGCTGAGCAAGCTGGGCCTGCTGGACAACCACTCCTCGGAGTTCAATGTCACCCGCAACTACCTAGACTGGCTCACGTCCATCCCTTGGG GCAAGTACAGCAACGAGAACCTGGACCTGGCGCGGGCACAGGCAGTGCTGGAGGAAGACCACTACGGCATGGAGGACGTCAAGAAACGCA TCCTGATTGTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTCTCCCTGTCTTCCTGAAGCTGAAGCTATGTTC GCCATTAATGCAGATGGAGTGGGAGATGCCAAAGACTGAATCATTGGGTTTTTCCTCTGTTAAAAACCTTAAGTGCTGCAGCCTAATGAG AGTGCACTGCTCCCTGGGGTTCTCTACAGGCCTCTTCCTGTTGTGACTGCCAGGATAAAGCTTCCGGGAAAACAGCTATTATATCAGCTT TTCTGATGGTATAAACAGGAGACAGGTCAGTAGTCACAAACTGATCTAAAATGTTTATTCCTTCTGTAGTGTATTAATCTCTGTGTGTTT TCTTTGGTTTTGGAGGAGGGGTATGAAGTATCTTTGACATGGTGCCTTAGGAATGACTTGGGTTTAACAAGCTGTCTACTGGACAATCTT ATGTTTCCAAGAGAACTAAAGCTGGAGAGACCTGACCCTTCTCTCACTTCTAAATTAATGGTAAAATAAAATGCCTCAGCTATGTAGCAA AGGGAATGGGTCTGCACAGATTCTTTTTTTCTGTCAGTAAAACTCTCAAGCAGGTTTTTAAGTTGTCTGTCTGAATGATCTTGTGTAAGG TTTTGGTTATGGAGTCTTGTGCCAAACCTACTAGGCCATTAGCCCTTCACCATCTACCTGCTTGGTCTTTCATTGCTAAGACTAACTCAA GATAATCCTAGAGTCTTAAAGCATTTCAGGCCAGTGTGGTGTCTTGCGCCTGTACTCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCG CTTGAGCCCAGGAGTTTTAAGTCCAGCTTGGCCAAGGTGGTGAAATCCCATCTCTACAAAAAATGCAGAACTTAATCTGGACACACTGTT ACACGTGCCTGTAGTCCCAGCTACTCGATAGCCTGAGGTGGGAGAATCACTTAAGCCTGGAAGGTGGAAGTTGCAGTGAGTCGAGATTGC ACTGCTGCATTCCAGCCAGGGTGACAGAGTGAGACCATGTTTCAAACAAGAAACATTTCAGAGGGTAAGTAAACAGATTTGATTGTGAGG |
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FusionGenePPI for LONP1_RAD51 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LONP1 | USP2, ATG101, GBAS, MYC, ICT1, MME, PSMA3, SIRT7, CUL1, A2M, CDC37, CYP2C8, ECSIT, IFIT3, IFIT5, LOXL4, MAST1, RNF32, APOE, DYNC1H1, C1QBP, ITGA4, SOX2, ADRB2, LATS2, ILK, TUBG1, CUL7, EGFR, C9orf173, GCAT, CLPX, PSMC4, PSMC5, SF3B1, TATDN1, NTRK1, CEP162, OFD1, CEP164, CNTRL, RPGRIP1L, DCTN1, NDUFS7, LRPPRC, ATL3, MTMR11, KLHDC8A, C19orf45, RASL10B, DCAF12L2, MRPL4, DCAF4, NEU4, FOXRED1, UPF3A, C9orf24, MRPS24, MKLN1, COQ2, TRIM25 | RAD51 | BRCA2, RAD51AP1, DMC1, EIF2D, CAB39, TIMM13, H2AFX, BRCA1, BARD1, BRE, BRCC3, TP53, ABL1, RAD52, BLM, RAD51, RAD51B, RAD51C, RAD51D, XRCC2, XRCC3, ATM, VIM, CHD3, RAD54B, ATRX, DNAJA3, SUMO1, UBE2I, RPA1, MSH4, RAD18, MCPH1, SP1, MDC1, PALB2, MORF4L1, POLN, WRN, UHRF2, MSH2, MSH6, TERF2IP, PML, SWI5, SFR1, RECQL5, CHEK1, SWSAP1, AICDA, RPA3, PFN1, FBXO18, UGDH, NXF1, HNRNPA2B1, HNRNPC, ZDHHC17, TEAD1, PDS5B, CDH13, CST6, FAM84B, IL24, ITIH5, NAT2, ST14, TFF1, WHSC1L1, NELFB, CSNK2B, HSP90AA1, MAPK8IP3, PCSK1N, SIRT2, UMPS, USP10, CDC42, IGBP1, MYH11, PPP3CB, RAB5C, LRP8, CBX4, SLC33A1, HMG20A, RNASEH2A, TUBGCP2, POLK, RTEL1, KIF21A, UGGT1, CDC73, CXXC4, ELMSAN1, NAF1, SGOL1, HMGXB4, CASP3, TUBG1, ESR1, FANCD2, PCNA, ERCC5, SHFM1, UCHL3, DUSP21, FIGNL1, SNX32, DNA2, HSFY1, PARPBP, TUBA1A, LMNB1, FANCA, SPTA1, WDR48, KEAP1, BCR, RFWD3, USP21, RNF115 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LONP1_RAD51 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LONP1_RAD51 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | LONP1 | C1838180 | CODAS syndrome | 2 | ORPHANET;UNIPROT |
| Tgene | RAD51 | C0006142 | Malignant neoplasm of breast | 1 | UNIPROT |
| Tgene | RAD51 | C0018671 | Head and Neck Neoplasms | 1 | CTD_human |
| Tgene | RAD51 | C1449861 | Micronuclei, Chromosome-Defective | 1 | CTD_human |
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