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Fusion gene ID: 19939 |
FusionGeneSummary for LNX1_USP46 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LNX1_USP46 | Fusion gene ID: 19939 | Hgene | Tgene | Gene symbol | LNX1 | USP46 | Gene ID | 84708 | 64854 |
| Gene name | ligand of numb-protein X 1 | ubiquitin specific peptidase 46 | |
| Synonyms | LNX|MPDZ|PDZRN2 | - | |
| Cytomap | 4q12 | 4q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase LNXPDZ domain-containing ring finger protein 2RING-type E3 ubiquitin transferase LNXligand of numb-protein X 1, E3 ubiquitin protein ligasemulti-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNXnumb-binding pr | ubiquitin carboxyl-terminal hydrolase 46deubiquitinating enzyme 46ubiquitin thioesterase 46ubiquitin thiolesterase 46ubiquitin-specific-processing protease 46 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q8TBB1 | P62068 | |
| Ensembl transtripts involved in fusion gene | ENST00000306888, ENST00000263925, ENST00000504605, | ENST00000441222, ENST00000451218, ENST00000508499, ENST00000504078, | |
| Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 2 X 2 X 2=8 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: LNX1 [Title/Abstract] AND USP46 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | USP46 | GO:0016579 | protein deubiquitination | 14715245|19075014 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-26-5134-01A | LNX1 | chr4 | 54373484 | - | USP46 | chr4 | 53494330 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000306888 | ENST00000441222 | LNX1 | chr4 | 54373484 | - | USP46 | chr4 | 53494330 | - |
| Frame-shift | ENST00000306888 | ENST00000451218 | LNX1 | chr4 | 54373484 | - | USP46 | chr4 | 53494330 | - |
| Frame-shift | ENST00000306888 | ENST00000508499 | LNX1 | chr4 | 54373484 | - | USP46 | chr4 | 53494330 | - |
| 5CDS-intron | ENST00000306888 | ENST00000504078 | LNX1 | chr4 | 54373484 | - | USP46 | chr4 | 53494330 | - |
| In-frame | ENST00000263925 | ENST00000441222 | LNX1 | chr4 | 54373484 | - | USP46 | chr4 | 53494330 | - |
| In-frame | ENST00000263925 | ENST00000451218 | LNX1 | chr4 | 54373484 | - | USP46 | chr4 | 53494330 | - |
| In-frame | ENST00000263925 | ENST00000508499 | LNX1 | chr4 | 54373484 | - | USP46 | chr4 | 53494330 | - |
| 5CDS-intron | ENST00000263925 | ENST00000504078 | LNX1 | chr4 | 54373484 | - | USP46 | chr4 | 53494330 | - |
| intron-3CDS | ENST00000504605 | ENST00000441222 | LNX1 | chr4 | 54373484 | - | USP46 | chr4 | 53494330 | - |
| intron-3CDS | ENST00000504605 | ENST00000451218 | LNX1 | chr4 | 54373484 | - | USP46 | chr4 | 53494330 | - |
| intron-3CDS | ENST00000504605 | ENST00000508499 | LNX1 | chr4 | 54373484 | - | USP46 | chr4 | 53494330 | - |
| intron-intron | ENST00000504605 | ENST00000504078 | LNX1 | chr4 | 54373484 | - | USP46 | chr4 | 53494330 | - |
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FusionProtFeatures for LNX1_USP46 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LNX1 | USP46 |
| E3 ubiquitin-protein ligase that mediates ubiquitinationand subsequent proteasomal degradation of NUMB. E3 ubiquitinligases accept ubiquitin from an E2 ubiquitin-conjugating enzymein the form of a thioester and then directly transfers theubiquitin to targeted substrates. Mediates ubiquitination ofisoform p66 and isoform p72 of NUMB, but not that of isoform p71or isoform p65. {ECO:0000250|UniProtKB:O70263}. Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.{ECO:0000250|UniProtKB:O70263}. | Deubiquitinating enzyme that plays a role in behavior,possibly by regulating GABA action. May act by mediating thedeubiquitination of GAD1/GAD67 (By similarity). Has almost nodeubiquitinating activity by itself and requires the interactionwith WDR48 to have a high activity (PubMed:19075014,PubMed:26388029). Not involved in deubiquitination ofmonoubiquitinated FANCD2 (PubMed:19075014).{ECO:0000250|UniProtKB:P62069, ECO:0000269|PubMed:19075014,ECO:0000269|PubMed:26388029}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LNX1_USP46 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_LNX1_ENST00000263925_chr4_54373484_-_USP46_ENST00000441222_chr4_53494330_-_586aa MNQPESANDPEPLCAVCGQAHSLEENHFYSYPEEVDDDLICHICLQALLDPLDTPCGHTYCTLCLTNFLVEKDFCPMDRKPLVLQHCKKS SILVNKLLNKLLVTCPFREHCTQVLQRCDLEHHFQTSCKGASHYGLTKDRKRRSQDGCPDGCASLTATAPSPEVSAAATISLMTDEPGLD NPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTIRSRSFKKINRALSVLRRTKSGSAVANHADQGRENSENTTAPEVWKHMLLXLRAS GIVLLPSIPGECVGIQGPAKEEGKLADVPGGPFPQHCHTEEEGWRHPTKEVHFKAEKREXSLXXLHAAGCSXIFKLFAKHYCGHPSGGEE TGKTKWKIKKWQHERTCGKXXTRTHLGPXDFSGNAYQXNSMLELXNCXXQRXRFSXPFCXCGAEYIHYPLSKRLQQHRNTVXXTKILLXN MLQQTRSPEKDEGKKAAHDLGPAPKAVQVHGAAAQIHQAVLPCGLPSGTPALQHLQXCSEPGPHVXLGCGGRSLWQWSXSWALYHYCEKS >In-frame_LNX1_ENST00000263925_chr4_54373484_-_USP46_ENST00000451218_chr4_53494330_-_586aa MNQPESANDPEPLCAVCGQAHSLEENHFYSYPEEVDDDLICHICLQALLDPLDTPCGHTYCTLCLTNFLVEKDFCPMDRKPLVLQHCKKS SILVNKLLNKLLVTCPFREHCTQVLQRCDLEHHFQTSCKGASHYGLTKDRKRRSQDGCPDGCASLTATAPSPEVSAAATISLMTDEPGLD NPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTIRSRSFKKINRALSVLRRTKSGSAVANHADQGRENSENTTAPEVWKHMLLXLRAS GIVLLPSIPGECVGIQGPAKEEGKLADVPGGPFPQHCHTEEEGWRHPTKEVHFKAEKREXSLXXLHAAGCSXIFKLFAKHYCGHPSGGEE TGKTKWKIKKWQHERTCGKXXTRTHLGPXDFSGNAYQXNSMLELXNCXXQRXRFSXPFCXCGAEYIHYPLSKRLQQHRNTVXXTKILLXN MLQQTRSPEKDEGKKAAHDLGPAPKAVQVHGAAAQIHQAVLPCGLPSGTPALQHLQXCSEPGPHVXLGCGGRSLWQWSXSWALYHYCEKS >In-frame_LNX1_ENST00000263925_chr4_54373484_-_USP46_ENST00000508499_chr4_53494330_-_586aa MNQPESANDPEPLCAVCGQAHSLEENHFYSYPEEVDDDLICHICLQALLDPLDTPCGHTYCTLCLTNFLVEKDFCPMDRKPLVLQHCKKS SILVNKLLNKLLVTCPFREHCTQVLQRCDLEHHFQTSCKGASHYGLTKDRKRRSQDGCPDGCASLTATAPSPEVSAAATISLMTDEPGLD NPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTIRSRSFKKINRALSVLRRTKSGSAVANHADQGRENSENTTAPEVWKHMLLXLRAS GIVLLPSIPGECVGIQGPAKEEGKLADVPGGPFPQHCHTEEEGWRHPTKEVHFKAEKREXSLXXLHAAGCSXIFKLFAKHYCGHPSGGEE TGKTKWKIKKWQHERTCGKXXTRTHLGPXDFSGNAYQXNSMLELXNCXXQRXRFSXPFCXCGAEYIHYPLSKRLQQHRNTVXXTKILLXN MLQQTRSPEKDEGKKAAHDLGPAPKAVQVHGAAAQIHQAVLPCGLPSGTPALQHLQXCSEPGPHVXLGCGGRSLWQWSXSWALYHYCEKS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_LNX1_ENST00000263925_chr4_54373484_-_USP46_ENST00000441222_chr4_53494330_-_1759nt ATGAACCAGCCAGAGTCTGCCAACGATCCTGAACCCCTGTGTGCAGTGTGTGGCCAAGCCCACTCCTTGGAGGAAAACCACTTCTACAGC TATCCAGAGGAAGTGGATGATGACCTCATCTGCCACATCTGCCTGCAGGCTTTGCTGGACCCCCTGGACACTCCGTGTGGACACACCTAC TGCACCCTCTGCCTCACCAACTTCCTGGTGGAGAAGGACTTCTGTCCCATGGACCGCAAGCCTCTGGTTCTGCAGCACTGCAAGAAGTCC AGCATCCTGGTCAACAAACTCCTCAACAAGCTACTGGTGACCTGCCCATTCAGGGAGCACTGCACCCAGGTGTTGCAGCGCTGTGACCTC GAGCATCACTTTCAAACCAGCTGTAAAGGTGCCTCCCACTACGGCCTGACCAAAGATAGGAAGAGGCGCTCACAAGATGGCTGTCCAGAC GGCTGTGCGAGCCTCACAGCCACGGCTCCCTCCCCAGAGGTTTCTGCAGCTGCCACCATCTCCTTAATGACAGACGAGCCTGGCCTAGAC AACCCTGCCTACGTGTCCTCGGCAGAGGACGGGCAGCCAGCAATCAGCCCAGTGGACTCTGGCCGGAGCAACCGAACTAGGGCACGGCCC TTTGAGAGATCCACTATTAGAAGCAGATCATTTAAAAAAATAAATCGAGCTTTGAGTGTTCTTCGAAGGACAAAGAGCGGGAGTGCAGTT GCCAACCATGCCGACCAGGGCAGGGAAAATTCTGAAAACACCACTGCCCCTGAAGTTTGGAAACACATGCTACTGTAACTCCGTGCTTCA GGCATTGTACTTCTGCCGTCCATTCCGGGAGAATGTGTTGGCATACAAGGCCCAGCAAAAGAAGAAGGAAAACTTGCTGACGTGCCTGGC GGACCTTTTCCACAGCATTGCCACACAGAAGAAGAAGGTTGGCGTCATCCCACCAAAGAAGTTCATTTCAAGGCTGAGAAAAGAGAATGA TCTCTTTGATAACTACATGCAGCAGGATGCTCATGAATTTTTAAATTATTTGCTAAACACTATTGCGGACATCCTTCAGGAGGAGAAGAA ACAGGAAAAACAAAATGGAAAATTAAAAAATGGCAACATGAACGAACCTGCGGAAAATAATAAACCAGAACTCACCTGGGTCCATGAGAT TTTTCAGGGAACGCTTACCAATGAAACTCGATGCTTGAACTGTGAAACTGTTAGTAGCAAAGATGAAGATTTTCTTGACCTTTCTGTTGA TGTGGAGCAGAATACATCCATTACCCACTGTCTAAGAGACTTCAGCAACACAGAAACACTGTGTAGTGAACAAAAATATTATTGTGAAAC ATGCTGCAGCAAACAAGAAGCCCAGAAAAGGATGAGGGTAAAAAAGCTGCCCATGATCTTGGCCCTGCACCTAAAGCGGTTCAAGTACAT GGAGCAGCTGCACAGATACACCAAGCTGTCTTACCGTGTGGTCTTCCCTCTGGAACTCCGGCTCTTCAACACCTCCAGTGATGCAGTGAA CCTGGACCGCATGTATGACTTGGTTGCGGTGGTCGTTCACTGTGGCAGTGGTCCTAATCGTGGGCATTATATCACTATTGTGAAAAGTCA CGGCTTCTGGCTTTTGTTTGATGATGACATTGTAGAGAAAATAGATGCTCAAGCTATTGAAGAATTCTATGGCCTGACGTCAGATATATC >In-frame_LNX1_ENST00000263925_chr4_54373484_-_USP46_ENST00000451218_chr4_53494330_-_1759nt ATGAACCAGCCAGAGTCTGCCAACGATCCTGAACCCCTGTGTGCAGTGTGTGGCCAAGCCCACTCCTTGGAGGAAAACCACTTCTACAGC TATCCAGAGGAAGTGGATGATGACCTCATCTGCCACATCTGCCTGCAGGCTTTGCTGGACCCCCTGGACACTCCGTGTGGACACACCTAC TGCACCCTCTGCCTCACCAACTTCCTGGTGGAGAAGGACTTCTGTCCCATGGACCGCAAGCCTCTGGTTCTGCAGCACTGCAAGAAGTCC AGCATCCTGGTCAACAAACTCCTCAACAAGCTACTGGTGACCTGCCCATTCAGGGAGCACTGCACCCAGGTGTTGCAGCGCTGTGACCTC GAGCATCACTTTCAAACCAGCTGTAAAGGTGCCTCCCACTACGGCCTGACCAAAGATAGGAAGAGGCGCTCACAAGATGGCTGTCCAGAC GGCTGTGCGAGCCTCACAGCCACGGCTCCCTCCCCAGAGGTTTCTGCAGCTGCCACCATCTCCTTAATGACAGACGAGCCTGGCCTAGAC AACCCTGCCTACGTGTCCTCGGCAGAGGACGGGCAGCCAGCAATCAGCCCAGTGGACTCTGGCCGGAGCAACCGAACTAGGGCACGGCCC TTTGAGAGATCCACTATTAGAAGCAGATCATTTAAAAAAATAAATCGAGCTTTGAGTGTTCTTCGAAGGACAAAGAGCGGGAGTGCAGTT GCCAACCATGCCGACCAGGGCAGGGAAAATTCTGAAAACACCACTGCCCCTGAAGTTTGGAAACACATGCTACTGTAACTCCGTGCTTCA GGCATTGTACTTCTGCCGTCCATTCCGGGAGAATGTGTTGGCATACAAGGCCCAGCAAAAGAAGAAGGAAAACTTGCTGACGTGCCTGGC GGACCTTTTCCACAGCATTGCCACACAGAAGAAGAAGGTTGGCGTCATCCCACCAAAGAAGTTCATTTCAAGGCTGAGAAAAGAGAATGA TCTCTTTGATAACTACATGCAGCAGGATGCTCATGAATTTTTAAATTATTTGCTAAACACTATTGCGGACATCCTTCAGGAGGAGAAGAA ACAGGAAAAACAAAATGGAAAATTAAAAAATGGCAACATGAACGAACCTGCGGAAAATAATAAACCAGAACTCACCTGGGTCCATGAGAT TTTTCAGGGAACGCTTACCAATGAAACTCGATGCTTGAACTGTGAAACTGTTAGTAGCAAAGATGAAGATTTTCTTGACCTTTCTGTTGA TGTGGAGCAGAATACATCCATTACCCACTGTCTAAGAGACTTCAGCAACACAGAAACACTGTGTAGTGAACAAAAATATTATTGTGAAAC ATGCTGCAGCAAACAAGAAGCCCAGAAAAGGATGAGGGTAAAAAAGCTGCCCATGATCTTGGCCCTGCACCTAAAGCGGTTCAAGTACAT GGAGCAGCTGCACAGATACACCAAGCTGTCTTACCGTGTGGTCTTCCCTCTGGAACTCCGGCTCTTCAACACCTCCAGTGATGCAGTGAA CCTGGACCGCATGTATGACTTGGTTGCGGTGGTCGTTCACTGTGGCAGTGGTCCTAATCGTGGGCATTATATCACTATTGTGAAAAGTCA CGGCTTCTGGCTTTTGTTTGATGATGACATTGTAGAGAAAATAGATGCTCAAGCTATTGAAGAATTCTATGGCCTGACGTCAGATATATC >In-frame_LNX1_ENST00000263925_chr4_54373484_-_USP46_ENST00000508499_chr4_53494330_-_1759nt ATGAACCAGCCAGAGTCTGCCAACGATCCTGAACCCCTGTGTGCAGTGTGTGGCCAAGCCCACTCCTTGGAGGAAAACCACTTCTACAGC TATCCAGAGGAAGTGGATGATGACCTCATCTGCCACATCTGCCTGCAGGCTTTGCTGGACCCCCTGGACACTCCGTGTGGACACACCTAC TGCACCCTCTGCCTCACCAACTTCCTGGTGGAGAAGGACTTCTGTCCCATGGACCGCAAGCCTCTGGTTCTGCAGCACTGCAAGAAGTCC AGCATCCTGGTCAACAAACTCCTCAACAAGCTACTGGTGACCTGCCCATTCAGGGAGCACTGCACCCAGGTGTTGCAGCGCTGTGACCTC GAGCATCACTTTCAAACCAGCTGTAAAGGTGCCTCCCACTACGGCCTGACCAAAGATAGGAAGAGGCGCTCACAAGATGGCTGTCCAGAC GGCTGTGCGAGCCTCACAGCCACGGCTCCCTCCCCAGAGGTTTCTGCAGCTGCCACCATCTCCTTAATGACAGACGAGCCTGGCCTAGAC AACCCTGCCTACGTGTCCTCGGCAGAGGACGGGCAGCCAGCAATCAGCCCAGTGGACTCTGGCCGGAGCAACCGAACTAGGGCACGGCCC TTTGAGAGATCCACTATTAGAAGCAGATCATTTAAAAAAATAAATCGAGCTTTGAGTGTTCTTCGAAGGACAAAGAGCGGGAGTGCAGTT GCCAACCATGCCGACCAGGGCAGGGAAAATTCTGAAAACACCACTGCCCCTGAAGTTTGGAAACACATGCTACTGTAACTCCGTGCTTCA GGCATTGTACTTCTGCCGTCCATTCCGGGAGAATGTGTTGGCATACAAGGCCCAGCAAAAGAAGAAGGAAAACTTGCTGACGTGCCTGGC GGACCTTTTCCACAGCATTGCCACACAGAAGAAGAAGGTTGGCGTCATCCCACCAAAGAAGTTCATTTCAAGGCTGAGAAAAGAGAATGA TCTCTTTGATAACTACATGCAGCAGGATGCTCATGAATTTTTAAATTATTTGCTAAACACTATTGCGGACATCCTTCAGGAGGAGAAGAA ACAGGAAAAACAAAATGGAAAATTAAAAAATGGCAACATGAACGAACCTGCGGAAAATAATAAACCAGAACTCACCTGGGTCCATGAGAT TTTTCAGGGAACGCTTACCAATGAAACTCGATGCTTGAACTGTGAAACTGTTAGTAGCAAAGATGAAGATTTTCTTGACCTTTCTGTTGA TGTGGAGCAGAATACATCCATTACCCACTGTCTAAGAGACTTCAGCAACACAGAAACACTGTGTAGTGAACAAAAATATTATTGTGAAAC ATGCTGCAGCAAACAAGAAGCCCAGAAAAGGATGAGGGTAAAAAAGCTGCCCATGATCTTGGCCCTGCACCTAAAGCGGTTCAAGTACAT GGAGCAGCTGCACAGATACACCAAGCTGTCTTACCGTGTGGTCTTCCCTCTGGAACTCCGGCTCTTCAACACCTCCAGTGATGCAGTGAA CCTGGACCGCATGTATGACTTGGTTGCGGTGGTCGTTCACTGTGGCAGTGGTCCTAATCGTGGGCATTATATCACTATTGTGAAAAGTCA CGGCTTCTGGCTTTTGTTTGATGATGACATTGTAGAGAAAATAGATGCTCAAGCTATTGAAGAATTCTATGGCCTGACGTCAGATATATC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_LNX1_ENST00000263925_chr4_54373484_-_USP46_ENST00000441222_chr4_53494330_-_8742nt TTTCAATCCCTAAGGTCTCAGCAATGCTTTATCTGTCGGGGCTTCCGTGATGTCACCCATTTCCTGGTCTGGAGCGACCAATGCCGTCCT CCTTCCTCCAGGCACCTGTTCACCGAAGTTGAGGCTGGTCACAACTCCGGCGGCCCAAGGAGCTGCTCGGTTCACCCACAAGGAATGAGA GCTGCCTGCCTGCTGCTGCTTGGAGAGCCCCAGACAGTCGCTTGAAGAGGTGTGTGGATGTCTCCTAGATCTTGACTTGCTCCTGAGGAA ATATTGTGTGACTGAGTTTCCTGTTATACTGCTCTCCAATCCATCATGAACCAGCCAGAGTCTGCCAACGATCCTGAACCCCTGTGTGCA GTGTGTGGCCAAGCCCACTCCTTGGAGGAAAACCACTTCTACAGCTATCCAGAGGAAGTGGATGATGACCTCATCTGCCACATCTGCCTG CAGGCTTTGCTGGACCCCCTGGACACTCCGTGTGGACACACCTACTGCACCCTCTGCCTCACCAACTTCCTGGTGGAGAAGGACTTCTGT CCCATGGACCGCAAGCCTCTGGTTCTGCAGCACTGCAAGAAGTCCAGCATCCTGGTCAACAAACTCCTCAACAAGCTACTGGTGACCTGC CCATTCAGGGAGCACTGCACCCAGGTGTTGCAGCGCTGTGACCTCGAGCATCACTTTCAAACCAGCTGTAAAGGTGCCTCCCACTACGGC CTGACCAAAGATAGGAAGAGGCGCTCACAAGATGGCTGTCCAGACGGCTGTGCGAGCCTCACAGCCACGGCTCCCTCCCCAGAGGTTTCT GCAGCTGCCACCATCTCCTTAATGACAGACGAGCCTGGCCTAGACAACCCTGCCTACGTGTCCTCGGCAGAGGACGGGCAGCCAGCAATC AGCCCAGTGGACTCTGGCCGGAGCAACCGAACTAGGGCACGGCCCTTTGAGAGATCCACTATTAGAAGCAGATCATTTAAAAAAATAAAT CGAGCTTTGAGTGTTCTTCGAAGGACAAAGAGCGGGAGTGCAGTTGCCAACCATGCCGACCAGGGCAGGGAAAATTCTGAAAACACCACT GCCCCTGAAGTTTGGAAACACATGCTACTGTAACTCCGTGCTTCAGGCATTGTACTTCTGCCGTCCATTCCGGGAGAATGTGTTGGCATA CAAGGCCCAGCAAAAGAAGAAGGAAAACTTGCTGACGTGCCTGGCGGACCTTTTCCACAGCATTGCCACACAGAAGAAGAAGGTTGGCGT CATCCCACCAAAGAAGTTCATTTCAAGGCTGAGAAAAGAGAATGATCTCTTTGATAACTACATGCAGCAGGATGCTCATGAATTTTTAAA TTATTTGCTAAACACTATTGCGGACATCCTTCAGGAGGAGAAGAAACAGGAAAAACAAAATGGAAAATTAAAAAATGGCAACATGAACGA ACCTGCGGAAAATAATAAACCAGAACTCACCTGGGTCCATGAGATTTTTCAGGGAACGCTTACCAATGAAACTCGATGCTTGAACTGTGA AACTGTTAGTAGCAAAGATGAAGATTTTCTTGACCTTTCTGTTGATGTGGAGCAGAATACATCCATTACCCACTGTCTAAGAGACTTCAG CAACACAGAAACACTGTGTAGTGAACAAAAATATTATTGTGAAACATGCTGCAGCAAACAAGAAGCCCAGAAAAGGATGAGGGTAAAAAA GCTGCCCATGATCTTGGCCCTGCACCTAAAGCGGTTCAAGTACATGGAGCAGCTGCACAGATACACCAAGCTGTCTTACCGTGTGGTCTT CCCTCTGGAACTCCGGCTCTTCAACACCTCCAGTGATGCAGTGAACCTGGACCGCATGTATGACTTGGTTGCGGTGGTCGTTCACTGTGG CAGTGGTCCTAATCGTGGGCATTATATCACTATTGTGAAAAGTCACGGCTTCTGGCTTTTGTTTGATGATGACATTGTAGAGAAAATAGA TGCTCAAGCTATTGAAGAATTCTATGGCCTGACGTCAGATATATCAAAAAATTCAGAATCTGGATATATTTTATTCTATCAGTCAAGAGA GTAACTGAAAGACCTGCGGGACTGATTCACGTGGGGAGAATGTTCACAGCACTGTCACCCGGCTTCTCCGCAGGCTTTCCTCTTCCCCAG TGGCCCACTAATGGTATCACTCCGAGTCTCAATGGTCTGGCTGTGTTAGACTCTCTCCTTTTGTGTTTTTACATGCAGCACTACTCTTGG TTTTATTTCAGTCTGACATAGAGTTAACTGCAATCAGATTGTAGTCTGATTTATATGAATAACGGTTGCTAATTTTAGGACTGGGTGAAA GCTATGCCATTCATTATGTCTGGCTGTATTAGAATGACATTTCCTATGAATGTCTACGGTCTGTTTTAGGTGTTTGCTAAACTTCTATGG CTTCCAGGGTCTTCTTACAATGCATTCCTTTAACTTGTCCCTGGAAGCATTGCTACCCATTTTCAGCTTCTCTGCCTCTCTTCTGATACA AGGACAGAAGAATTGGGTAGATATTCACCTTTTAGGGGTGCAAGTATAGCTTTAAGTTTGTGCAAGTGAAAATGTTGAAAAGTGAGTAAC CTCGATATTAAAATCATCCTTGACATGAAACAGGGTGAAGAGAAGCTGTCCGTGGCGGCTGGTGTTGGCTGGCATTGGCACTGGGCTGTG CTGACCTAGCCATTACAATTCCAGGGGCTAAGAAGGCTCAGGGCAGACAAAGTCAAGAGGAGGAAGTTTTTGTGGACAATGAAAAGTTAT TTTCGTACCTTTCTACCAAAACCAAGTTTCAGGAAAATAACTCTATGTTGTTTATTTTCAGTGACACTTATGTAAGGCCCTGTGAGTTGT ATTTATCCTGTATCCGGCACTGCTAAGCTTTTCAAGGTATCTTTCCAATCCTGCTGATGTGGCAGTCAATGGCTGCAGGGCTGGCAAACC TCCCCTTAGCCAGTCAGCACGGCATTGTTCCTTATCAGGAATAACAAAGGTACTACATCTTTCCAGCCATCAGCACGTTGTACAACTTAA CTTTTTAACATAGTCCGTCTGTTTACTGAGGCACTGGCGAGTCCCAGGGCTGATACAGAACCTTCCCTAGAGGGAATACCAGAGTTAGCT GGGTATAGAGGTGGCTCAAAGGAAGTGTCCGTGGGCAGGGGGAGGAATGAACAAAATGGCGCTGTTTCTTTGGCTCAGACTCCTAGAATG CTTGACAAGACAGAATTTTTTTGGAAGAACCTCATCTCACTATAGTTACTTTTTTCACTTTTGTTATATATGTATTTATTAGAGCATTTG AATATTGGTACCTTTAAAAGGGTCATTTGGTGTTTTGCTGTTGAGCTGGTTTTTGAGTCATAGATCTTGGCTTCCTTTAGAAGCCACTTA ACTTCCATACACTATAATAAACTGTGAACATATTTTTGTTACCTAATGCATCCACTGATGAACATGCAAACTTTGGGCATAATGTGAACT AAAATTGAAATGGAAAATGTTAGTGGCCATTTTGCAACAATGAAGAGGATAGCACTTTATCTAGATGAAAACTGGATTTCTTATCTTTGA AATATCTTGAACTGTTTATTGCTCAGAACTTAAGTAAGCATGCCAACATTTCGTTTGTTTATGCTTGAAGTGAAATGTTTTACTTTTCAC TGGAGAAGACAAAACAGGGTGATCTTCATGTTATTGTTTTATACAAGTGATGGAAATGTACCTTGCCTTGTTTAGAGGCAATTTCACATT TATAAATATTTTTTTTTCCTCCATGAAACTTACGCAGTAATCACTACCTGGAAGGTGAGTTTTGATCTCTTTTTAAGGAGAGGCACTTTC CAACTGAAGGTGATTGATGTAGGGAAATGTTTGTACTATATAGAATCCATATATTTGACTGCAAGTTACAAAGTTTTAAGAACATGATGG TTGGTCTCTAATATATTTGGAACTGATTCATAAGAAAAGTTATTAAAATTATCTTTGAAACACCTCTTGAAGCTAATTTATTAGAAAAAA TATTTCAGTTGGAAGGCTGTAGAAGTAATGTTTAAATGCTAAGTCATAAGTTCAGGATATTTCTTTTCTATTTGGTTGTGCAAAATGTTT TTCCCAGTTATTTAATCGAAGTAATTCCTTTTAATAGAAAGAGTCAGTTAAAATTCAGCATTCATGGATAGATTTTTGGAACGAAAAAGG GTAAGTATAAGAAAATATTGCAAACACATTAAAACAGTTGTATGGTGCAGGAAAAGAAGATTGGAAAAAGACCAAAACACACTTCTCCAG CAACACTCCATCAGCTTTTTAAAATTTAGAGCTATCTGCTAATTTTTTCCCTCTTCCTTCTCAATAAATGAAACAAACACTGGGCAGCTG CAGGTTTCTCCCAATCATGTCTCTTTATGTAAAGACAGTAACATGCAAACACTTTTAGTTTACATCCCTCATTCACAGTGTAAAGCAGGA AATGGTGTGGGAGATGTGAGACCATTCTGAGGTCAGCGATAGCCCAAAGGCTCTGCAGTATTCCCTCCAATGGCCAAGGATTCCGTGTGT CATCTGCAGGAGTGAGTAGGCCTGCTGTATTTCTTGTAACTGCTGGGTGTTACAAAATAAGTTACAATGTTTTACACTTTAAAAAAAAAA CAGAAGGAACATTTGCTTTATTGGTTACTTACTAGTTTAGCCTCTAGGTTATGGCACAGCATGCTAAAAAATCATGTGTTTAAAAGTAAA TGTTGGTAAAATGCTGGCATCTGGTCCTATTGTGTTGATGCATTTTCACTTCTGTGGTCATAGGAAATGGACTGGTCTAAAGAGAGTGAG GCACAACACAAGCAGGGCATTAGTTTGAATAGGAAGTCAATCATATTTGGTTTTATGGCCTGGTGTATTTTGGGTTTAAGATAAAATAGG GAAAAATGTCAGAAATGATCCCTATGCATTTATTTTCATGGATACCCTTAATTTCATGGGCATGCCTAATAATGATCTATGTTCTAACTG GAGCTTAGGGCTTATTTTAGATATTGGAGTGTAGCTTTATTACAGATGGATTTTATCTTTCAACATTGCATTTTGATCAACTTTGTATAT TCACGTGTATTAAAATATTGTGCACTAAATGTTTTGCCCTTGTTTGCTATTATATGGTCAAGGCATTTATCAGCACTATTGTAATGAACT CATGTAAGTGGCATGGGTCAGGGAAAATTATTTCCTACTTTTCTGCCTAATTAAATTTCTGTTTTCCAGTATTACATTAATTTATTTTTG GCTTCCATTTCTGTATAACCAAAATAGTTACTGTATTTGTGTGGCATTCCTATTATTTTGTTGCTAAAAATATTGTAGTTTTTATTTAAA ATAATCTGTACCTTAATTTTTTAAAATGTAACCAATTCAAGCACTTTAAGCAATAATGTCAATCTTGTGAAATTTTAATCAGTTTAACAC CCTGCCTCTAAAATTGTTTGCAAAAAATAAATAAATGAATAAAATGGGAATTCTCTTTCTAGAGAATTATATCCGGGTAATGCTACACAC ATGGACTTAAAATCCTTTTTATAAAGTGTGAGTCAGTGGCAGGTCTTATGTCCAAGTAATTATTACAAACAATTTTGAAGCAGTGGAAAT GTACAGAACATTCTGATCATTATAATATATAAAGGCAGTATTACTCTCAAGGTTGATAAAAATCAATGTTCTGGAGATAACTCATCACTT TTTTTGAGTGAAAAAGATCAACAGAATTTAATTCAGGAAATGGTATCTGGAGAATAGCAAATTGAGAATATCAGTGAAAAGAATTTAGGG ATAGTTAACTAGGCATCACAGTGAATTTATTTTTGGGGACTTTGCATATAAAATCCTTTTAACCAGTTATGAAATGAAAGATCCATTCCC CAAATAAGAAGGCAGCTTCCAGTATCTGGTTTCTAGGAAGGAGTAGGACTGTGATTGGTCCCTGGTGCCCTGACTTCTGGGCCTGTTTCT GAGCCATGGGGGACCCCCCAGCTTCAGAAATACTCACGTGGGTTCACACCACTCCCTGCCCCAGAAGGAGGGCAGGCACAGGTCCATGCC ATGTGGCCTCAGTGAAGCCTACAGTAACTATGGGTAGGGCTGCTTTTCCCTGTCAATCACCCAGGGCACCTGTGGGTGGACAGAAGATTG TCATCGGAATACATGCTTGGGCCCAATTATGGGAATAAAACCTCATAGACCAAGAGCAGGGAATGTGCCAGTAAGTGTTGAGTCTCCCAG CTGCTGTCCATCTTCTCGGGGCAGTGCAGTTGAACCTGACTGAGCTGGAACAGAGACTGTTGGGAAGGTCACTTCTGTCTGCCACGAAGG CCAAAGGCAGAGAAGACCTTCTTGGGACTGTGTTTTTCTTTCCTAGGCCTCACTTTGTCCTGGGATTTATAGGACAGGCCTGTCACTACC AAGGTGACACAAATTCTAGAGAATGTATTTTCCCATTTCTTCAAATTTCCTTTCCTCTCTTTTTATTGATACTTAAAATACCTTTACTAA AAAAATGAAGCCTTCCATTTCCATTCCCTTATATTTACATGAAGATAAAAATACTTACTAAGTCGTTGTATTTGTCCATTCTGGCAGTGC TATAAAGACATACCTGAGCGTGGGTCATTTCTGAAGAAAAGAGGTTTAATTGGCTCATGGTTTTATGGGCTGTACAGGCTTCTGTTCTGG GGGAGGCCTCAGGAAACTTACAATCAGCAGAAGGCAAAGGGAAAGCAAGCCCATCTTACATGGCAGGAGCAAGAGGAAGAGAGCAAAGGG GGAGGGGTTACACACTTTTCTTTCCTTTTTTTTTTTTAAGATGGAGTCTCACTGTCACCCAGGCTGGAGTGCAGTGATGAGATCTCAGCT CACTGCAACCTCTGCCTCCCGAGTTCAAGCGATTCTTCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCACTATACCCGG GTAATTTTTGTATTTTCAGTAGATACAAAGTTTTCTCATATTGGCCAAGCTGGTCTGGAACTCCTGACTTCAGGTGCCTCAGCCTCCCAA AGTGCTGGGATTACAGGCAAGAGCCACCTTGCTCGGCTGGGGTTACACACTTTTAAACAACCAGATCTCGTGAGAACTCAGTCATGAGGC AGTACTAGGGGGATGGTGCTTAACCACCTATGATGCAATCACCTCCCACCAGGCCCCACCTCCAACACTGGGGATTACAATTCAACATGG GATTTGGGTGGAGACACAGAGCCAAACCGTATCAGTCATTTTTCTTTTACTGAAGGAAAATTTTGGTTGTGGGGTTAGTACTAAAGATAG CCCATGTAGACTTTTTCTGAAGATACCCCAAGTGGAGAGATTTTTAATTAGGCATTTATTTGGCACCTATTGCATTCTAGGCATTGTGAT AGGAGCTGGGGGATAAAAAGGTGACACAGATTGGGTCCCTCTTATGGACTCGTTTTTTGTCTCAGAAGACAAGTCTGGGTGAGAAAGAAA TTTAAAATTTAAGTTGTGGAAATAACACGTGTGGGGGAAACTCCTTGCAATTCAGCACAGTTTGGTATTCAGCCCCAGCCTCAACATGCA GATGGCACTGTTGGATGAAGCCACACCATCTTTTTTCCTGGGAGCCCCACACTCTTCCCAGCCTGCCTTCTAGCTCAGGGACAACACATT TTGAAAAACAAAGTATAAATCGATTATGTTGCAACAATGAACTTCACGTTTTGCCTCTTCTCATGTTAAAAGAGCCAGTATCATGAAAGC CTCAACAGTGAGCTTTATGAATCAAATATCTGTTATTTCTAAACAATCTGTTTACATTATGACCAAATAATTAGAGCCTATCTAGACTTA CCAAAATAAGATAGGGCATAAGCGATTTATTGGTGCATCAGCCTTTGTTTGCTTTTTAAGGTTCCTTTATGTTTTAAAGGGATTTGAACA AAAGACATCAGGAGCTTACAAAGGAAAAATAGCTTCATTTTGGTTATGAGATACCAGAGTCAGAAATGACATTAGATTGTATAGAAAAGA CTTCTAATTGTGTGCTTACTTCCCACATGATTATAATAAACTATATATTAACAACCTTGGGATCGTACTCAGGTTGTCAATTACACGGAT GCATCTTTCACTTTTTTCTTTCCCAAGAGTGAGAGAAAGAGTGAGGTTGTGCTTAAGGCAGTGTGGAATTCTACAGAAGCTCTTCTTGGA AAAGGAGTTCAGGCACTTGTGTTGTAGACTGCAGTCTGATTCTGTTCTTACTTCCTCTCAGCATAAGGGAGCTTTGAAAAGAAAACTCAG ACTTGTATCCGACTTGACCAGAAGCAAAATAACTTGATCATTGAAGCCACTATTTCTGTGTATTTGATCAAGTCCTCCTCTGGAATCCAA TGCAGCCATATTCATATTTCGGTCTCTCTTAATGGACCTTGCTGGAAAGAACATTCTGTGCTAAGAAAATGGAAAATAAACGTGAGAAAA CTTTAAGAATGAGCCTTCACACCTCCTGCAGCAGGTGATAGCTCTGTACTTCAGAGCTTGTCTCCAGGTTGAGAATTACCTGTTTTCCAC TCTGAGGGGATTAGAAAGATACTGTTTTAATGGGTTATAAAACTTGTGTGAAGAAGATTGGCCTTCTCCACCTCTCCTGTGAAATAAATT >In-frame_LNX1_ENST00000263925_chr4_54373484_-_USP46_ENST00000451218_chr4_53494330_-_5536nt TTTCAATCCCTAAGGTCTCAGCAATGCTTTATCTGTCGGGGCTTCCGTGATGTCACCCATTTCCTGGTCTGGAGCGACCAATGCCGTCCT CCTTCCTCCAGGCACCTGTTCACCGAAGTTGAGGCTGGTCACAACTCCGGCGGCCCAAGGAGCTGCTCGGTTCACCCACAAGGAATGAGA GCTGCCTGCCTGCTGCTGCTTGGAGAGCCCCAGACAGTCGCTTGAAGAGGTGTGTGGATGTCTCCTAGATCTTGACTTGCTCCTGAGGAA ATATTGTGTGACTGAGTTTCCTGTTATACTGCTCTCCAATCCATCATGAACCAGCCAGAGTCTGCCAACGATCCTGAACCCCTGTGTGCA GTGTGTGGCCAAGCCCACTCCTTGGAGGAAAACCACTTCTACAGCTATCCAGAGGAAGTGGATGATGACCTCATCTGCCACATCTGCCTG CAGGCTTTGCTGGACCCCCTGGACACTCCGTGTGGACACACCTACTGCACCCTCTGCCTCACCAACTTCCTGGTGGAGAAGGACTTCTGT CCCATGGACCGCAAGCCTCTGGTTCTGCAGCACTGCAAGAAGTCCAGCATCCTGGTCAACAAACTCCTCAACAAGCTACTGGTGACCTGC CCATTCAGGGAGCACTGCACCCAGGTGTTGCAGCGCTGTGACCTCGAGCATCACTTTCAAACCAGCTGTAAAGGTGCCTCCCACTACGGC CTGACCAAAGATAGGAAGAGGCGCTCACAAGATGGCTGTCCAGACGGCTGTGCGAGCCTCACAGCCACGGCTCCCTCCCCAGAGGTTTCT GCAGCTGCCACCATCTCCTTAATGACAGACGAGCCTGGCCTAGACAACCCTGCCTACGTGTCCTCGGCAGAGGACGGGCAGCCAGCAATC AGCCCAGTGGACTCTGGCCGGAGCAACCGAACTAGGGCACGGCCCTTTGAGAGATCCACTATTAGAAGCAGATCATTTAAAAAAATAAAT CGAGCTTTGAGTGTTCTTCGAAGGACAAAGAGCGGGAGTGCAGTTGCCAACCATGCCGACCAGGGCAGGGAAAATTCTGAAAACACCACT GCCCCTGAAGTTTGGAAACACATGCTACTGTAACTCCGTGCTTCAGGCATTGTACTTCTGCCGTCCATTCCGGGAGAATGTGTTGGCATA CAAGGCCCAGCAAAAGAAGAAGGAAAACTTGCTGACGTGCCTGGCGGACCTTTTCCACAGCATTGCCACACAGAAGAAGAAGGTTGGCGT CATCCCACCAAAGAAGTTCATTTCAAGGCTGAGAAAAGAGAATGATCTCTTTGATAACTACATGCAGCAGGATGCTCATGAATTTTTAAA TTATTTGCTAAACACTATTGCGGACATCCTTCAGGAGGAGAAGAAACAGGAAAAACAAAATGGAAAATTAAAAAATGGCAACATGAACGA ACCTGCGGAAAATAATAAACCAGAACTCACCTGGGTCCATGAGATTTTTCAGGGAACGCTTACCAATGAAACTCGATGCTTGAACTGTGA AACTGTTAGTAGCAAAGATGAAGATTTTCTTGACCTTTCTGTTGATGTGGAGCAGAATACATCCATTACCCACTGTCTAAGAGACTTCAG CAACACAGAAACACTGTGTAGTGAACAAAAATATTATTGTGAAACATGCTGCAGCAAACAAGAAGCCCAGAAAAGGATGAGGGTAAAAAA GCTGCCCATGATCTTGGCCCTGCACCTAAAGCGGTTCAAGTACATGGAGCAGCTGCACAGATACACCAAGCTGTCTTACCGTGTGGTCTT CCCTCTGGAACTCCGGCTCTTCAACACCTCCAGTGATGCAGTGAACCTGGACCGCATGTATGACTTGGTTGCGGTGGTCGTTCACTGTGG CAGTGGTCCTAATCGTGGGCATTATATCACTATTGTGAAAAGTCACGGCTTCTGGCTTTTGTTTGATGATGACATTGTAGAGAAAATAGA TGCTCAAGCTATTGAAGAATTCTATGGCCTGACGTCAGATATATCAAAAAATTCAGAATCTGGATATATTTTATTCTATCAGTCAAGAGA GTAACTGAAAGACCTGCGGGACTGATTCACGTGGGGAGAATGTTCACAGCACTGTCACCCGGCTTCTCCGCAGGCTTTCCTCTTCCCCAG TGGCCCACTAATGGTATCACTCCGAGTCTCAATGGTCTGGCTGTGTTAGACTCTCTCCTTTTGTGTTTTTACATGCAGCACTACTCTTGG TTTTATTTCAGTCTGACATAGAGTTAACTGCAATCAGATTGTAGTCTGATTTATATGAATAACGGTTGCTAATTTTAGGACTGGGTGAAA GCTATGCCATTCATTATGTCTGGCTGTATTAGAATGACATTTCCTATGAATGTCTACGGTCTGTTTTAGGTGTTTGCTAAACTTCTATGG CTTCCAGGGTCTTCTTACAATGCATTCCTTTAACTTGTCCCTGGAAGCATTGCTACCCATTTTCAGCTTCTCTGCCTCTCTTCTGATACA AGGACAGAAGAATTGGGTAGATATTCACCTTTTAGGGGTGCAAGTATAGCTTTAAGTTTGTGCAAGTGAAAATGTTGAAAAGTGAGTAAC CTCGATATTAAAATCATCCTTGACATGAAACAGGGTGAAGAGAAGCTGTCCGTGGCGGCTGGTGTTGGCTGGCATTGGCACTGGGCTGTG CTGACCTAGCCATTACAATTCCAGGGGCTAAGAAGGCTCAGGGCAGACAAAGTCAAGAGGAGGAAGTTTTTGTGGACAATGAAAAGTTAT TTTCGTACCTTTCTACCAAAACCAAGTTTCAGGAAAATAACTCTATGTTGTTTATTTTCAGTGACACTTATGTAAGGCCCTGTGAGTTGT ATTTATCCTGTATCCGGCACTGCTAAGCTTTTCAAGGTATCTTTCCAATCCTGCTGATGTGGCAGTCAATGGCTGCAGGGCTGGCAAACC TCCCCTTAGCCAGTCAGCACGGCATTGTTCCTTATCAGGAATAACAAAGGTACTACATCTTTCCAGCCATCAGCACGTTGTACAACTTAA CTTTTTAACATAGTCCGTCTGTTTACTGAGGCACTGGCGAGTCCCAGGGCTGATACAGAACCTTCCCTAGAGGGAATACCAGAGTTAGCT GGGTATAGAGGTGGCTCAAAGGAAGTGTCCGTGGGCAGGGGGAGGAATGAACAAAATGGCGCTGTTTCTTTGGCTCAGACTCCTAGAATG CTTGACAAGACAGAATTTTTTTGGAAGAACCTCATCTCACTATAGTTACTTTTTTCACTTTTGTTATATATGTATTTATTAGAGCATTTG AATATTGGTACCTTTAAAAGGGTCATTTGGTGTTTTGCTGTTGAGCTGGTTTTTGAGTCATAGATCTTGGCTTCCTTTAGAAGCCACTTA ACTTCCATACACTATAATAAACTGTGAACATATTTTTGTTACCTAATGCATCCACTGATGAACATGCAAACTTTGGGCATAATGTGAACT AAAATTGAAATGGAAAATGTTAGTGGCCATTTTGCAACAATGAAGAGGATAGCACTTTATCTAGATGAAAACTGGATTTCTTATCTTTGA AATATCTTGAACTGTTTATTGCTCAGAACTTAAGTAAGCATGCCAACATTTCGTTTGTTTATGCTTGAAGTGAAATGTTTTACTTTTCAC TGGAGAAGACAAAACAGGGTGATCTTCATGTTATTGTTTTATACAAGTGATGGAAATGTACCTTGCCTTGTTTAGAGGCAATTTCACATT TATAAATATTTTTTTTTCCTCCATGAAACTTACGCAGTAATCACTACCTGGAAGGTGAGTTTTGATCTCTTTTTAAGGAGAGGCACTTTC CAACTGAAGGTGATTGATGTAGGGAAATGTTTGTACTATATAGAATCCATATATTTGACTGCAAGTTACAAAGTTTTAAGAACATGATGG TTGGTCTCTAATATATTTGGAACTGATTCATAAGAAAAGTTATTAAAATTATCTTTGAAACACCTCTTGAAGCTAATTTATTAGAAAAAA TATTTCAGTTGGAAGGCTGTAGAAGTAATGTTTAAATGCTAAGTCATAAGTTCAGGATATTTCTTTTCTATTTGGTTGTGCAAAATGTTT TTCCCAGTTATTTAATCGAAGTAATTCCTTTTAATAGAAAGAGTCAGTTAAAATTCAGCATTCATGGATAGATTTTTGGAACGAAAAAGG GTAAGTATAAGAAAATATTGCAAACACATTAAAACAGTTGTATGGTGCAGGAAAAGAAGATTGGAAAAAGACCAAAACACACTTCTCCAG CAACACTCCATCAGCTTTTTAAAATTTAGAGCTATCTGCTAATTTTTTCCCTCTTCCTTCTCAATAAATGAAACAAACACTGGGCAGCTG CAGGTTTCTCCCAATCATGTCTCTTTATGTAAAGACAGTAACATGCAAACACTTTTAGTTTACATCCCTCATTCACAGTGTAAAGCAGGA AATGGTGTGGGAGATGTGAGACCATTCTGAGGTCAGCGATAGCCCAAAGGCTCTGCAGTATTCCCTCCAATGGCCAAGGATTCCGTGTGT CATCTGCAGGAGTGAGTAGGCCTGCTGTATTTCTTGTAACTGCTGGGTGTTACAAAATAAGTTACAATGTTTTACACTTTAAAAAAAAAA CAGAAGGAACATTTGCTTTATTGGTTACTTACTAGTTTAGCCTCTAGGTTATGGCACAGCATGCTAAAAAATCATGTGTTTAAAAGTAAA TGTTGGTAAAATGCTGGCATCTGGTCCTATTGTGTTGATGCATTTTCACTTCTGTGGTCATAGGAAATGGACTGGTCTAAAGAGAGTGAG GCACAACACAAGCAGGGCATTAGTTTGAATAGGAAGTCAATCATATTTGGTTTTATGGCCTGGTGTATTTTGGGTTTAAGATAAAATAGG GAAAAATGTCAGAAATGATCCCTATGCATTTATTTTCATGGATACCCTTAATTTCATGGGCATGCCTAATAATGATCTATGTTCTAACTG GAGCTTAGGGCTTATTTTAGATATTGGAGTGTAGCTTTATTACAGATGGATTTTATCTTTCAACATTGCATTTTGATCAACTTTGTATAT TCACGTGTATTAAAATATTGTGCACTAAATGTTTTGCCCTTGTTTGCTATTATATGGTCAAGGCATTTATCAGCACTATTGTAATGAACT CATGTAAGTGGCATGGGTCAGGGAAAATTATTTCCTACTTTTCTGCCTAATTAAATTTCTGTTTTCCAGTATTACATTAATTTATTTTTG GCTTCCATTTCTGTATAACCAAAATAGTTACTGTATTTGTGTGGCATTCCTATTATTTTGTTGCTAAAAATATTGTAGTTTTTATTTAAA ATAATCTGTACCTTAATTTTTTAAAATGTAACCAATTCAAGCACTTTAAGCAATAATGTCAATCTTGTGAAATTTTAATCAGTTTAACAC >In-frame_LNX1_ENST00000263925_chr4_54373484_-_USP46_ENST00000508499_chr4_53494330_-_2133nt TTTCAATCCCTAAGGTCTCAGCAATGCTTTATCTGTCGGGGCTTCCGTGATGTCACCCATTTCCTGGTCTGGAGCGACCAATGCCGTCCT CCTTCCTCCAGGCACCTGTTCACCGAAGTTGAGGCTGGTCACAACTCCGGCGGCCCAAGGAGCTGCTCGGTTCACCCACAAGGAATGAGA GCTGCCTGCCTGCTGCTGCTTGGAGAGCCCCAGACAGTCGCTTGAAGAGGTGTGTGGATGTCTCCTAGATCTTGACTTGCTCCTGAGGAA ATATTGTGTGACTGAGTTTCCTGTTATACTGCTCTCCAATCCATCATGAACCAGCCAGAGTCTGCCAACGATCCTGAACCCCTGTGTGCA GTGTGTGGCCAAGCCCACTCCTTGGAGGAAAACCACTTCTACAGCTATCCAGAGGAAGTGGATGATGACCTCATCTGCCACATCTGCCTG CAGGCTTTGCTGGACCCCCTGGACACTCCGTGTGGACACACCTACTGCACCCTCTGCCTCACCAACTTCCTGGTGGAGAAGGACTTCTGT CCCATGGACCGCAAGCCTCTGGTTCTGCAGCACTGCAAGAAGTCCAGCATCCTGGTCAACAAACTCCTCAACAAGCTACTGGTGACCTGC CCATTCAGGGAGCACTGCACCCAGGTGTTGCAGCGCTGTGACCTCGAGCATCACTTTCAAACCAGCTGTAAAGGTGCCTCCCACTACGGC CTGACCAAAGATAGGAAGAGGCGCTCACAAGATGGCTGTCCAGACGGCTGTGCGAGCCTCACAGCCACGGCTCCCTCCCCAGAGGTTTCT GCAGCTGCCACCATCTCCTTAATGACAGACGAGCCTGGCCTAGACAACCCTGCCTACGTGTCCTCGGCAGAGGACGGGCAGCCAGCAATC AGCCCAGTGGACTCTGGCCGGAGCAACCGAACTAGGGCACGGCCCTTTGAGAGATCCACTATTAGAAGCAGATCATTTAAAAAAATAAAT CGAGCTTTGAGTGTTCTTCGAAGGACAAAGAGCGGGAGTGCAGTTGCCAACCATGCCGACCAGGGCAGGGAAAATTCTGAAAACACCACT GCCCCTGAAGTTTGGAAACACATGCTACTGTAACTCCGTGCTTCAGGCATTGTACTTCTGCCGTCCATTCCGGGAGAATGTGTTGGCATA CAAGGCCCAGCAAAAGAAGAAGGAAAACTTGCTGACGTGCCTGGCGGACCTTTTCCACAGCATTGCCACACAGAAGAAGAAGGTTGGCGT CATCCCACCAAAGAAGTTCATTTCAAGGCTGAGAAAAGAGAATGATCTCTTTGATAACTACATGCAGCAGGATGCTCATGAATTTTTAAA TTATTTGCTAAACACTATTGCGGACATCCTTCAGGAGGAGAAGAAACAGGAAAAACAAAATGGAAAATTAAAAAATGGCAACATGAACGA ACCTGCGGAAAATAATAAACCAGAACTCACCTGGGTCCATGAGATTTTTCAGGGAACGCTTACCAATGAAACTCGATGCTTGAACTGTGA AACTGTTAGTAGCAAAGATGAAGATTTTCTTGACCTTTCTGTTGATGTGGAGCAGAATACATCCATTACCCACTGTCTAAGAGACTTCAG CAACACAGAAACACTGTGTAGTGAACAAAAATATTATTGTGAAACATGCTGCAGCAAACAAGAAGCCCAGAAAAGGATGAGGGTAAAAAA GCTGCCCATGATCTTGGCCCTGCACCTAAAGCGGTTCAAGTACATGGAGCAGCTGCACAGATACACCAAGCTGTCTTACCGTGTGGTCTT CCCTCTGGAACTCCGGCTCTTCAACACCTCCAGTGATGCAGTGAACCTGGACCGCATGTATGACTTGGTTGCGGTGGTCGTTCACTGTGG CAGTGGTCCTAATCGTGGGCATTATATCACTATTGTGAAAAGTCACGGCTTCTGGCTTTTGTTTGATGATGACATTGTAGAGAAAATAGA TGCTCAAGCTATTGAAGAATTCTATGGCCTGACGTCAGATATATCAAAAAATTCAGAATCTGGATATATTTTATTCTATCAGTCAAGAGA 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FusionGenePPI for LNX1_USP46 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LNX1 | MAGEA11, DCTD, LDOC1, CUTC, CALCOCO2, SRSF1, NADK, ENOX1, RBMX, RPIA, TRAF2, KHDRBS3, CCDC85B, PAFAH1B3, KLHL12, TRIP13, TIFA, CEP72, RABAC1, PCBD1, KRTAP4-12, NAGK, KCTD13, MAGEB18, AIMP2, APIP, KCTD17, DDX17, FHL3, TRIM23, NECAB2, SAT1, TSC22D4, ZBTB43, AKIRIN2, KXD1, KRT15, DVL3, EHMT2, PAICS, RAD54B, FBP1, ZBTB8A, NUMB, RHOC, CD8A, SRC, AMMECR1L, AURKB, AURKC, FAM212B, CAMK2N2, DAPK1, DEPTOR, EBF4, EPHB3, KIAA1598, MRPS24, MUSTN1, NKD2, PLEKHG5, PPID, RASL11B, SCLT1, SNCB, ZADH2, WWP1, SAPCD1, TMEM14C, WAC, STX5, PAK6, PBK, TYK2, KCNA4, PRKCA, SDK1, INSC, NRCAM, ABCB1, KALRN, CLDN17, GPR142, EXOC8, DOCK9, LRRC3B, GRIN1, ARHGAP6, LNX2, SSTR3, ADRA1D, SLC6A15, LGR6, TYRO3, CITED1, CGN, PTGIR, SLC6A5, HUNK, GIPR, ARVCF, CTNND2, PKP4, GAS2L2, CLDN1, TSC2, GJD4, TNFRSF18, CLDN2, ILF3, CTSO, VRK2, WNT8A, STRN, ARHGEF16, PQBP1, CDC42EP4, ORMDL3, BPIFA1, ABR, JOSD1, NUP37, BCR, HTR2B, PKDREJ, PDZRN3, PDZRN4, CXADR, ABCA1, SNW1, COIL, UBE2D2, APP, HSP90AA1, NACAP1, PRPH, IL3RA, ULK2, SUV39H1, SUV39H2, IGSF5, SPHKAP, CTBP1, ACAT2, ALDOC, BLVRA, CA8, CDA, CIRBP, CLK2, DAB1, GDI1, GRB2, HSBP1, PKM, PPIA, MAPK9, PTS, RAD51D, RBMY1A1, DPF2, SNRPF, TPM4, VCP, EIF4H, NCK2, SSNA1, RFPL3, NEK6, RUVBL2, MTUS2, ISCU, DNPEP, OSBP2, NME7, OSGIN1, ZNF593, MEMO1, ZNF581, PRR13, ROPN1, ZCCHC10, FBXL12, FAM118A, TRMT12, GOLPH3L, POMGNT1, ZFP64, NXT2, TRIM39, LGALS14, AGTRAP, TRIM54, HOMEZ, LSM2, PBLD, ROBO3, AIDA, MTMR9, HMBOX1, SNRNP25, CCDC102B, THAP7, APOL4, TSSK3, KRTAP9-2, ATRIP, DCUN1D5, LNX1, KRTAP4-2, MVB12B, ATPAF2, ACY3, CCDC114, CCDC101, C1QTNF1, MRFAP1L1, CIB3, METTL21A, FAM9B, KCTD6, TBCEL, FAM124A, ALKBH3, CPNE2, LCLAT1, NUDT14, CATSPERD, KCTD1, RUFY4, STAC2, NOTCH2NL, JAK3, PTPN11, SH2D2A, SOCS6, LRFN4, NXF2B | USP46 | ALDH9A1, DMWD, MYL6, SET, YWHAH, IQGAP1, PJA2, RAD51AP1, PHLPP2, ERP44, PHLPP1, WDR48, PPP1R9B, WDR20, USP12, EIF2AK4, HIST2H2AC, WDR26, WDR77, HIST2H2BE, UBA52, HSPA8, ACTB, SNX6, SNX2, PTGER3, IFI30, MAPK8IP2, XPO1, GRIA1, UBB, TSPYL6, GORASP1, RNF19B, THUMPD3, CHRM3, IGFBP1, USH1C |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LNX1_USP46 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LNX1_USP46 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | USP46 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | USP46 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | USP46 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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