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Fusion gene ID: 19934 |
FusionGeneSummary for LNPEP_PPIP5K2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LNPEP_PPIP5K2 | Fusion gene ID: 19934 | Hgene | Tgene | Gene symbol | LNPEP | PPIP5K2 | Gene ID | 4012 | 23262 |
| Gene name | leucyl and cystinyl aminopeptidase | diphosphoinositol pentakisphosphate kinase 2 | |
| Synonyms | CAP|IRAP|P-LAP|PLAP | CFAP160|HISPPD1|IP7K2|VIP2 | |
| Cytomap | 5q15 | 5q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | leucyl-cystinyl aminopeptidaseAT (4) receptorangiotensin IV receptorcystinyl aminopeptidaseinsulin-regulated aminopeptidaseinsulin-regulated membrane aminopeptidaseinsulin-responsive aminopeptidaseotaseoxytocinaseplacental leucine aminopeptidase | inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2VIP1 homolog 2histidine acid phosphatase domain-containing protein 1inositol heptaphosphate kinase 2insP6 and PP-IP5 kinase 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UIQ6 | O43314 | |
| Ensembl transtripts involved in fusion gene | ENST00000231368, ENST00000395770, ENST00000395784, | ENST00000321521, ENST00000358359, ENST00000513500, ENST00000414217, | |
| Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 2 X 2 X 2=8 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: LNPEP [Title/Abstract] AND PPIP5K2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-XK-AAJ3-01A | LNPEP | chr5 | 96322374 | + | PPIP5K2 | chr5 | 102537223 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000231368 | ENST00000321521 | LNPEP | chr5 | 96322374 | + | PPIP5K2 | chr5 | 102537223 | + |
| In-frame | ENST00000231368 | ENST00000358359 | LNPEP | chr5 | 96322374 | + | PPIP5K2 | chr5 | 102537223 | + |
| 5CDS-3UTR | ENST00000231368 | ENST00000513500 | LNPEP | chr5 | 96322374 | + | PPIP5K2 | chr5 | 102537223 | + |
| 5CDS-3UTR | ENST00000231368 | ENST00000414217 | LNPEP | chr5 | 96322374 | + | PPIP5K2 | chr5 | 102537223 | + |
| Frame-shift | ENST00000395770 | ENST00000321521 | LNPEP | chr5 | 96322374 | + | PPIP5K2 | chr5 | 102537223 | + |
| In-frame | ENST00000395770 | ENST00000358359 | LNPEP | chr5 | 96322374 | + | PPIP5K2 | chr5 | 102537223 | + |
| 5CDS-3UTR | ENST00000395770 | ENST00000513500 | LNPEP | chr5 | 96322374 | + | PPIP5K2 | chr5 | 102537223 | + |
| 5CDS-3UTR | ENST00000395770 | ENST00000414217 | LNPEP | chr5 | 96322374 | + | PPIP5K2 | chr5 | 102537223 | + |
| intron-3CDS | ENST00000395784 | ENST00000321521 | LNPEP | chr5 | 96322374 | + | PPIP5K2 | chr5 | 102537223 | + |
| intron-3CDS | ENST00000395784 | ENST00000358359 | LNPEP | chr5 | 96322374 | + | PPIP5K2 | chr5 | 102537223 | + |
| intron-3UTR | ENST00000395784 | ENST00000513500 | LNPEP | chr5 | 96322374 | + | PPIP5K2 | chr5 | 102537223 | + |
| intron-3UTR | ENST00000395784 | ENST00000414217 | LNPEP | chr5 | 96322374 | + | PPIP5K2 | chr5 | 102537223 | + |
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FusionProtFeatures for LNPEP_PPIP5K2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LNPEP | PPIP5K2 |
| Release of an N-terminal amino acid, cleaves beforecysteine, leucine as well as other amino acids. Degrades peptidehormones such as oxytocin, vasopressin and angiotensin III, andplays a role in maintaining homeostasis during pregnancy. May beinvolved in the inactivation of neuronal peptides in the brain.Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and maybe the angiotensin IV receptor in the brain.{ECO:0000269|PubMed:11389728, ECO:0000269|PubMed:11707427,ECO:0000269|PubMed:1731608}. | Bifunctional inositol kinase that acts in concert withthe IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize thediphosphate group-containing inositol pyrophosphatesdiphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and(PP)2-InsP4, also respectively called InsP7 and InsP8, regulate avariety of cellular processes, including apoptosis, vesicletrafficking, cytoskeletal dynamics, exocytosis, insulin signalingand neutrophil activation. Phosphorylates inositolhexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4.Alternatively, phosphorylates at position 1 or 3 PP-InsP5,produced by IP6Ks from InsP6, to produce (PP)2-InsP4.{ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LNPEP_PPIP5K2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_LNPEP_ENST00000231368_chr5_96322374_+_PPIP5K2_ENST00000358359_chr5_102537223_+_414aa MEPFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGEHEMEEDEEDYESSAKLLGMSFMNRSSGLRN SATGYRQSPDGACSVPSARTMVVCAFVIVVAVSVIMVIYLLPRCTFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELS LHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSS YYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVA >In-frame_LNPEP_ENST00000395770_chr5_96322374_+_PPIP5K2_ENST00000358359_chr5_102537223_+_400aa MIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGEHEMEEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGACS VPSARTMVVCAFVIVVAVSVIMVIYLLPRCTFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSV TISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESN EKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDVN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_LNPEP_ENST00000231368_chr5_96322374_+_PPIP5K2_ENST00000358359_chr5_102537223_+_1244nt ATGGAGCCCTTCACCAATGATCGGCTTCAGCTCCCCAGGAATATGATTGAAAACAGCATGTTTGAGGAAGAACCAGATGTGGTGGATTTA GCCAAAGAGCCTTGTTTACATCCTCTAGAGCCTGATGAGGTGGAATATGAGCCCCGGGGTTCCCGACTGCTGGTGCGGGGTCTTGGTGAG CATGAGATGGAGGAGGATGAAGAGGATTATGAGTCATCAGCAAAGCTGCTGGGCATGTCCTTCATGAATAGAAGCTCAGGCCTTCGGAAC AGTGCAACTGGTTACAGGCAGAGCCCAGATGGGGCTTGTTCAGTACCCTCTGCAAGGACCATGGTGGTCTGTGCTTTTGTCATCGTGGTT GCTGTTTCTGTAATCATGGTGATTTACTTACTGCCCAGATGTACCTTTACCAAAGAAGGCTGCCATAAAAAAAACCAGTCAATTGGACTA ATTCAGCCATTTGCAACAAATGGGAAATTGTTTCCATGGGCACAGATCAGGCTTCCCACTGCCGTTGTGCCACTACGCTATGAACTCAGC CTACACCCGAACCTAACCTCGATGACATTCAGGGGTTCTGTGACAATTTCAGTTCAGGCTCTTCAGGTCACATGGAATATCATTCTTCAT AGCACAGGTCATAATATTTCAAGAGTGACCTTTATGTCAGCAGTTTCAAGCCAAGAAAAACAAGCTGAGATCCTGGAATATGCATATCAT GGACAGATCGCCATTGTTGCCCCCGAAGCCCTTCTAGCAGGGCACAATTATACGTTGAAGATAGAGTACTCGGCAAATATATCTAGTTCT TATTATGGGTTTTATGGCTTCTCCTACACAGATGAAAGTAATGAGAAAAAGTACTTTGCAGCAACTCAGTTTGAACCCCTGGCAGCAAGA TCTGCTTTTCCTTGTTTTGATGAACCAGCATTTAAAGCCACTTTTATCATCAAGATCATAAGGGATGAGCAATACACCGCTTTATCAAAT ATGCCTAAGAAGTCATCAGTCGTTCTAGATGATGGACTTGTTCAGGATGAGTTTTCTGAGAGTGTGAAGATGAGCACTTACTTGGTTGCT TTCATTGTGGGAGAGATGAAGAACCTGAGTCAGGACGTAAATGGAACCCTGCTACAAGTGGACCTTCTAGTGCAGTTGTTCCTAATACCT >In-frame_LNPEP_ENST00000395770_chr5_96322374_+_PPIP5K2_ENST00000358359_chr5_102537223_+_1202nt ATGATTGAAAACAGCATGTTTGAGGAAGAACCAGATGTGGTGGATTTAGCCAAAGAGCCTTGTTTACATCCTCTAGAGCCTGATGAGGTG GAATATGAGCCCCGGGGTTCCCGACTGCTGGTGCGGGGTCTTGGTGAGCATGAGATGGAGGAGGATGAAGAGGATTATGAGTCATCAGCA AAGCTGCTGGGCATGTCCTTCATGAATAGAAGCTCAGGCCTTCGGAACAGTGCAACTGGTTACAGGCAGAGCCCAGATGGGGCTTGTTCA GTACCCTCTGCAAGGACCATGGTGGTCTGTGCTTTTGTCATCGTGGTTGCTGTTTCTGTAATCATGGTGATTTACTTACTGCCCAGATGT ACCTTTACCAAAGAAGGCTGCCATAAAAAAAACCAGTCAATTGGACTAATTCAGCCATTTGCAACAAATGGGAAATTGTTTCCATGGGCA CAGATCAGGCTTCCCACTGCCGTTGTGCCACTACGCTATGAACTCAGCCTACACCCGAACCTAACCTCGATGACATTCAGGGGTTCTGTG ACAATTTCAGTTCAGGCTCTTCAGGTCACATGGAATATCATTCTTCATAGCACAGGTCATAATATTTCAAGAGTGACCTTTATGTCAGCA GTTTCAAGCCAAGAAAAACAAGCTGAGATCCTGGAATATGCATATCATGGACAGATCGCCATTGTTGCCCCCGAAGCCCTTCTAGCAGGG CACAATTATACGTTGAAGATAGAGTACTCGGCAAATATATCTAGTTCTTATTATGGGTTTTATGGCTTCTCCTACACAGATGAAAGTAAT GAGAAAAAGTACTTTGCAGCAACTCAGTTTGAACCCCTGGCAGCAAGATCTGCTTTTCCTTGTTTTGATGAACCAGCATTTAAAGCCACT TTTATCATCAAGATCATAAGGGATGAGCAATACACCGCTTTATCAAATATGCCTAAGAAGTCATCAGTCGTTCTAGATGATGGACTTGTT CAGGATGAGTTTTCTGAGAGTGTGAAGATGAGCACTTACTTGGTTGCTTTCATTGTGGGAGAGATGAAGAACCTGAGTCAGGACGTAAAT GGAACCCTGCTACAAGTGGACCTTCTAGTGCAGTTGTTCCTAATACCTCATCTCGGAAAAAGAATATAACTAGCAAAACAGAAACGCATG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_LNPEP_ENST00000231368_chr5_96322374_+_PPIP5K2_ENST00000358359_chr5_102537223_+_3508nt TCCGCGGCCAACCTCCCCAGGGAAACCAGCGATTCGCGGTTCAGATAGCGACCTTCGCCCGCAGGTTCCTGCTCTGCCTTCAGACTTCGG CTTCAGTGGCACCTGCTCAGCGAGGCCTCGTCTAACCAAGCCATCCGAATTAACTACCCACTCACTCGCCATCACATCACCCCGATTTAA TTCGCAGCGGGGCACTGACTTTACACTCGTGTGTCTTCTGTGTTTATTTATGGTCTGTTTCTGGAATGTCCGCTCCTGGGACTGGGACCA TGATTTTCTGGCGCAGTGCGGGTGTCTCGGCGTCCGGGATCGGGCGGGTCGCAGTAGGGCTCCACATTTGTTGAGTGACTGAACACCGTT CCCGGCCGGGGAGAGCGCCGCAGCCGGGTCCACTTCAGGTAGGGGCTGGGCTTTCCCGGCCCCGCCTAGGCCCCGCCCCCAGCGCGAACC CGCTCCCACCTCGCCTGTCCACGGAGCAGCAGGGGGTTTGACTGTGCTTTTCCCTCTTGCTTCCCTCGCTCTTTCTGCAGCTGCCACGAA AACCCGGAACGGCGGAGCGGCGCCGCCCCTCGCGGCACCTCCCTGGCAGCCCTTGGAGGCCGCGCTGGGCATGCTCAGTCAGCTGGGCCG CCTCAGCTCTCGGAGTAGGAAGCTCGGGCGCTCCGGCTGTAAGGAGCCGCGGCGGGGGGAAAATGGAGCCCTTCACCAATGATCGGCTTC AGCTCCCCAGGAATATGATTGAAAACAGCATGTTTGAGGAAGAACCAGATGTGGTGGATTTAGCCAAAGAGCCTTGTTTACATCCTCTAG AGCCTGATGAGGTGGAATATGAGCCCCGGGGTTCCCGACTGCTGGTGCGGGGTCTTGGTGAGCATGAGATGGAGGAGGATGAAGAGGATT ATGAGTCATCAGCAAAGCTGCTGGGCATGTCCTTCATGAATAGAAGCTCAGGCCTTCGGAACAGTGCAACTGGTTACAGGCAGAGCCCAG ATGGGGCTTGTTCAGTACCCTCTGCAAGGACCATGGTGGTCTGTGCTTTTGTCATCGTGGTTGCTGTTTCTGTAATCATGGTGATTTACT TACTGCCCAGATGTACCTTTACCAAAGAAGGCTGCCATAAAAAAAACCAGTCAATTGGACTAATTCAGCCATTTGCAACAAATGGGAAAT TGTTTCCATGGGCACAGATCAGGCTTCCCACTGCCGTTGTGCCACTACGCTATGAACTCAGCCTACACCCGAACCTAACCTCGATGACAT TCAGGGGTTCTGTGACAATTTCAGTTCAGGCTCTTCAGGTCACATGGAATATCATTCTTCATAGCACAGGTCATAATATTTCAAGAGTGA CCTTTATGTCAGCAGTTTCAAGCCAAGAAAAACAAGCTGAGATCCTGGAATATGCATATCATGGACAGATCGCCATTGTTGCCCCCGAAG CCCTTCTAGCAGGGCACAATTATACGTTGAAGATAGAGTACTCGGCAAATATATCTAGTTCTTATTATGGGTTTTATGGCTTCTCCTACA CAGATGAAAGTAATGAGAAAAAGTACTTTGCAGCAACTCAGTTTGAACCCCTGGCAGCAAGATCTGCTTTTCCTTGTTTTGATGAACCAG CATTTAAAGCCACTTTTATCATCAAGATCATAAGGGATGAGCAATACACCGCTTTATCAAATATGCCTAAGAAGTCATCAGTCGTTCTAG ATGATGGACTTGTTCAGGATGAGTTTTCTGAGAGTGTGAAGATGAGCACTTACTTGGTTGCTTTCATTGTGGGAGAGATGAAGAACCTGA GTCAGGACGTAAATGGAACCCTGCTACAAGTGGACCTTCTAGTGCAGTTGTTCCTAATACCTCATCTCGGAAAAAGAATATAACTAGCAA AACAGAAACGCATGAACACAAAAAAAACACTGGGAAAAAGAAATGAAATCTTAGCAGAAGCTGGAACTTTTTATACTTATAAAAATAGTA TGTTCTTATGTTTCTCCTTATGCATTTATGTGTTCACTTAAAAATGTTTTTAAATCTAAGGTTTTCTTTGTTTATGTTCAGGTAAGGAAC TGTTGTCATGATCTGGAAATGTTTAAAACAATGTTTGTTAGCATTCTGTGAGCAGCAAAACTTATAGTGATAAAAATCGATTGTTGTTAA TATGATGTTTACCATGTGCACATAGTAATGAAAAGGAACATAAAAGCCCAGCAGGCTCGTACCAAAGTCACAGCAGTAATGCTATGTACT GCAGAGTCTGATGAGCTGGCCTTTGTGCACACTTTTATTTTCATGGGATTGCATCTTAGCTGTTAAAACTTCTAGATTGAAATTTGACAG CCAGGGTTACATATTGGGGACTTTTAAAGTGTCTTTCCAAAGAGATTTCATTAACCGTTTAGATTAGAATATCTTTCCCAATTGTTACAG TGACATATATGCTGCAATATTTAACAACTGGAGTATTAGCCACATGGGTTATTTTTTCAATCTGTGTTTTGAATTTTTTTATTGTGTGTT ATTTAAAATATTACATATGCAGCTGGGAGAACTACACCTTTGTGCACATAGATTTATATATTAATTTGTAGAAAATATTTTCTTTATATA TTTCCTTACCATACAAGGTGCCTTGTTCATCAGGAAAACTTTTGTTTTGTATTTTGACAAGAAAGGCACCTTCAGAGTTTCTTTTTAAGT ATAGTTGACAAGTGTATAAATGTTACACTTACTTTCAGAGTTCTTTTTAGATCTAAAGAAGTCAGTTCAAAAATGGAAATCAACAATGTT AGGAGAAATCTGAATTCTGTTAAGTTAGTAAGTATTATGTATAGCATCTGTTTTTAACCATTTCCATTCTTATCCCTAGTGTATCAGTTG ATCACACTAAGAAAGCTTAAAGATTGAGCATTTGAAATAAATGCTCTTTATAAATGATTAGATTTTTGAAGGGATATTGAAATCATTGCG CTGTGATTTCATCTGTGATGTGAAAAATCAATTTATTATCCTTGGTGCTTTCCCCCCCACCAATGCACAAATAATTGTGAACAGCTTGAA ATGACTTAAACTGTAATCCAAATGGGACAATCTGATAAGAATTTCATGCATTGGTAGTTAAATAACTTAAATTGCTAAAGCTTTAGCTTG AAATTTATGTTTAGAAAAACTATTGATTTCCCATGGTATGAATATAACTATTGTAATTCTTCAAATGAGACTCTTCTCACCTTAAATAGT CATATATTAATTAACTTATAGGAAATAAGCATACTATATGTTAGCTGTTTTAAAAGGTACCAGATGTAAGAGTCATAAATATATGCAATT AAAGAAGTTCATAGATTTCACATGAATGTAAATGTGTTATATGGAGACATGTCTTGTAAACAGTTGAATGTATGTAAGTTTTCTGTTTGT >In-frame_LNPEP_ENST00000395770_chr5_96322374_+_PPIP5K2_ENST00000358359_chr5_102537223_+_3123nt GCTCCTAACTCCACTAAGTACAGAAGTGGAGCCGTACAGCCATGAATGTCAGGCATGTTGTGGGGACTAGTTGTATTAGTTTTCTATTGC CACCATAACAAATTACCACAAACTTAAGCAATATAGTACAAATTTATCTTAAAGTTATTGGCAGGTCAGAAGCCTGATACGGATCTCATT GGGCTAAAACGAAGGAGTTGGCAGGGCTGTGTGTTCCTTTCTGTAGGCTCTGGGCAGGATCCATTTCCTGCACTTTTTTGGCTTTTGGAG GTCGTCCACATTCCTTGGCTCCTGGCCCTGCTCCTTCATCTTCAAAGCTACCAAAGATCGGCTTCAGCTCCCCAGGAATATGATTGAAAA CAGCATGTTTGAGGAAGAACCAGATGTGGTGGATTTAGCCAAAGAGCCTTGTTTACATCCTCTAGAGCCTGATGAGGTGGAATATGAGCC CCGGGGTTCCCGACTGCTGGTGCGGGGTCTTGGTGAGCATGAGATGGAGGAGGATGAAGAGGATTATGAGTCATCAGCAAAGCTGCTGGG CATGTCCTTCATGAATAGAAGCTCAGGCCTTCGGAACAGTGCAACTGGTTACAGGCAGAGCCCAGATGGGGCTTGTTCAGTACCCTCTGC AAGGACCATGGTGGTCTGTGCTTTTGTCATCGTGGTTGCTGTTTCTGTAATCATGGTGATTTACTTACTGCCCAGATGTACCTTTACCAA AGAAGGCTGCCATAAAAAAAACCAGTCAATTGGACTAATTCAGCCATTTGCAACAAATGGGAAATTGTTTCCATGGGCACAGATCAGGCT TCCCACTGCCGTTGTGCCACTACGCTATGAACTCAGCCTACACCCGAACCTAACCTCGATGACATTCAGGGGTTCTGTGACAATTTCAGT TCAGGCTCTTCAGGTCACATGGAATATCATTCTTCATAGCACAGGTCATAATATTTCAAGAGTGACCTTTATGTCAGCAGTTTCAAGCCA AGAAAAACAAGCTGAGATCCTGGAATATGCATATCATGGACAGATCGCCATTGTTGCCCCCGAAGCCCTTCTAGCAGGGCACAATTATAC GTTGAAGATAGAGTACTCGGCAAATATATCTAGTTCTTATTATGGGTTTTATGGCTTCTCCTACACAGATGAAAGTAATGAGAAAAAGTA CTTTGCAGCAACTCAGTTTGAACCCCTGGCAGCAAGATCTGCTTTTCCTTGTTTTGATGAACCAGCATTTAAAGCCACTTTTATCATCAA GATCATAAGGGATGAGCAATACACCGCTTTATCAAATATGCCTAAGAAGTCATCAGTCGTTCTAGATGATGGACTTGTTCAGGATGAGTT TTCTGAGAGTGTGAAGATGAGCACTTACTTGGTTGCTTTCATTGTGGGAGAGATGAAGAACCTGAGTCAGGACGTAAATGGAACCCTGCT ACAAGTGGACCTTCTAGTGCAGTTGTTCCTAATACCTCATCTCGGAAAAAGAATATAACTAGCAAAACAGAAACGCATGAACACAAAAAA AACACTGGGAAAAAGAAATGAAATCTTAGCAGAAGCTGGAACTTTTTATACTTATAAAAATAGTATGTTCTTATGTTTCTCCTTATGCAT TTATGTGTTCACTTAAAAATGTTTTTAAATCTAAGGTTTTCTTTGTTTATGTTCAGGTAAGGAACTGTTGTCATGATCTGGAAATGTTTA AAACAATGTTTGTTAGCATTCTGTGAGCAGCAAAACTTATAGTGATAAAAATCGATTGTTGTTAATATGATGTTTACCATGTGCACATAG TAATGAAAAGGAACATAAAAGCCCAGCAGGCTCGTACCAAAGTCACAGCAGTAATGCTATGTACTGCAGAGTCTGATGAGCTGGCCTTTG TGCACACTTTTATTTTCATGGGATTGCATCTTAGCTGTTAAAACTTCTAGATTGAAATTTGACAGCCAGGGTTACATATTGGGGACTTTT AAAGTGTCTTTCCAAAGAGATTTCATTAACCGTTTAGATTAGAATATCTTTCCCAATTGTTACAGTGACATATATGCTGCAATATTTAAC AACTGGAGTATTAGCCACATGGGTTATTTTTTCAATCTGTGTTTTGAATTTTTTTATTGTGTGTTATTTAAAATATTACATATGCAGCTG GGAGAACTACACCTTTGTGCACATAGATTTATATATTAATTTGTAGAAAATATTTTCTTTATATATTTCCTTACCATACAAGGTGCCTTG TTCATCAGGAAAACTTTTGTTTTGTATTTTGACAAGAAAGGCACCTTCAGAGTTTCTTTTTAAGTATAGTTGACAAGTGTATAAATGTTA CACTTACTTTCAGAGTTCTTTTTAGATCTAAAGAAGTCAGTTCAAAAATGGAAATCAACAATGTTAGGAGAAATCTGAATTCTGTTAAGT TAGTAAGTATTATGTATAGCATCTGTTTTTAACCATTTCCATTCTTATCCCTAGTGTATCAGTTGATCACACTAAGAAAGCTTAAAGATT GAGCATTTGAAATAAATGCTCTTTATAAATGATTAGATTTTTGAAGGGATATTGAAATCATTGCGCTGTGATTTCATCTGTGATGTGAAA AATCAATTTATTATCCTTGGTGCTTTCCCCCCCACCAATGCACAAATAATTGTGAACAGCTTGAAATGACTTAAACTGTAATCCAAATGG GACAATCTGATAAGAATTTCATGCATTGGTAGTTAAATAACTTAAATTGCTAAAGCTTTAGCTTGAAATTTATGTTTAGAAAAACTATTG ATTTCCCATGGTATGAATATAACTATTGTAATTCTTCAAATGAGACTCTTCTCACCTTAAATAGTCATATATTAATTAACTTATAGGAAA TAAGCATACTATATGTTAGCTGTTTTAAAAGGTACCAGATGTAAGAGTCATAAATATATGCAATTAAAGAAGTTCATAGATTTCACATGA ATGTAAATGTGTTATATGGAGACATGTCTTGTAAACAGTTGAATGTATGTAAGTTTTCTGTTTGTGAAAATGTAGTTAATGTACTCACTG |
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FusionGenePPI for LNPEP_PPIP5K2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LNPEP | FHOD1, TNKS2, TNKS, FBXO6, AP2B1, PRDX3, REL, TCF4, FATE1, CD3E, HLA-DRA, LGALS3, HLA-DPA1, LGALS8, LGALS9, BTNL8, SIAE, TNF, GPHA2, EWSR1, TMEM17, TMEM216, CANX, DROSHA, NDUFA13, HEATR3, GCC1, TMEM263, PPM1H, LMAN2L, C5orf28, SCGB1D4, EDNRB, ST8SIA4, GPR107, CCL22, NAPRT, SCGB1D1, GLRA2 | PPIP5K2 | THOC7, VAC14, WDR74, WDR6, ZC3H15, ZBTB8B, NTRK1, CETN1, IL17RA, DEF8, CELA3A, PLEC, AAK1, SEC24B, CCDC88A, LUZP1, NUP88, URGCP, EYA4, UBE2D2, ARFGAP3, AHNAK |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LNPEP_PPIP5K2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LNPEP_PPIP5K2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | LNPEP | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Hgene | LNPEP | C0025261 | Memory Disorders | 1 | CTD_human |
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