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Fusion gene ID: 19931 |
FusionGeneSummary for LNPEP_FLT4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LNPEP_FLT4 | Fusion gene ID: 19931 | Hgene | Tgene | Gene symbol | LNPEP | FLT4 | Gene ID | 4012 | 2324 |
| Gene name | leucyl and cystinyl aminopeptidase | fms related tyrosine kinase 4 | |
| Synonyms | CAP|IRAP|P-LAP|PLAP | FLT-4|FLT41|LMPH1A|PCL|VEGFR-3|VEGFR3 | |
| Cytomap | 5q15 | 5q35.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | leucyl-cystinyl aminopeptidaseAT (4) receptorangiotensin IV receptorcystinyl aminopeptidaseinsulin-regulated aminopeptidaseinsulin-regulated membrane aminopeptidaseinsulin-responsive aminopeptidaseotaseoxytocinaseplacental leucine aminopeptidase | vascular endothelial growth factor receptor 3fms-like tyrosine kinase 4tyrosine-protein kinase receptor FLT4 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UIQ6 | P35916 | |
| Ensembl transtripts involved in fusion gene | ENST00000231368, ENST00000395770, ENST00000395784, | ENST00000261937, ENST00000393347, ENST00000502649, ENST00000424276, | |
| Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 5 X 4 X 3=60 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LNPEP [Title/Abstract] AND FLT4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | FLT4 | GO:0018108 | peptidyl-tyrosine phosphorylation | 7898938 |
| Tgene | FLT4 | GO:0035924 | cellular response to vascular endothelial growth factor stimulus | 9435229 |
| Tgene | FLT4 | GO:0038084 | vascular endothelial growth factor signaling pathway | 23878260 |
| Tgene | FLT4 | GO:0046777 | protein autophosphorylation | 7675451|9435229|23878260 |
| Tgene | FLT4 | GO:0048010 | vascular endothelial growth factor receptor signaling pathway | 9012504 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-D3-A8GN-06A | LNPEP | chr5 | 96271878 | + | FLT4 | chr5 | 180048904 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000231368 | ENST00000261937 | LNPEP | chr5 | 96271878 | + | FLT4 | chr5 | 180048904 | - |
| In-frame | ENST00000231368 | ENST00000393347 | LNPEP | chr5 | 96271878 | + | FLT4 | chr5 | 180048904 | - |
| In-frame | ENST00000231368 | ENST00000502649 | LNPEP | chr5 | 96271878 | + | FLT4 | chr5 | 180048904 | - |
| 5CDS-5UTR | ENST00000231368 | ENST00000424276 | LNPEP | chr5 | 96271878 | + | FLT4 | chr5 | 180048904 | - |
| intron-3CDS | ENST00000395770 | ENST00000261937 | LNPEP | chr5 | 96271878 | + | FLT4 | chr5 | 180048904 | - |
| intron-3CDS | ENST00000395770 | ENST00000393347 | LNPEP | chr5 | 96271878 | + | FLT4 | chr5 | 180048904 | - |
| intron-3CDS | ENST00000395770 | ENST00000502649 | LNPEP | chr5 | 96271878 | + | FLT4 | chr5 | 180048904 | - |
| intron-5UTR | ENST00000395770 | ENST00000424276 | LNPEP | chr5 | 96271878 | + | FLT4 | chr5 | 180048904 | - |
| 3UTR-3CDS | ENST00000395784 | ENST00000261937 | LNPEP | chr5 | 96271878 | + | FLT4 | chr5 | 180048904 | - |
| 3UTR-3CDS | ENST00000395784 | ENST00000393347 | LNPEP | chr5 | 96271878 | + | FLT4 | chr5 | 180048904 | - |
| 3UTR-3CDS | ENST00000395784 | ENST00000502649 | LNPEP | chr5 | 96271878 | + | FLT4 | chr5 | 180048904 | - |
| 3UTR-5UTR | ENST00000395784 | ENST00000424276 | LNPEP | chr5 | 96271878 | + | FLT4 | chr5 | 180048904 | - |
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FusionProtFeatures for LNPEP_FLT4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LNPEP | FLT4 |
| Release of an N-terminal amino acid, cleaves beforecysteine, leucine as well as other amino acids. Degrades peptidehormones such as oxytocin, vasopressin and angiotensin III, andplays a role in maintaining homeostasis during pregnancy. May beinvolved in the inactivation of neuronal peptides in the brain.Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and maybe the angiotensin IV receptor in the brain.{ECO:0000269|PubMed:11389728, ECO:0000269|PubMed:11707427,ECO:0000269|PubMed:1731608}. | Tyrosine-protein kinase that acts as a cell-surfacereceptor for VEGFC and VEGFD, and plays an essential role in adultlymphangiogenesis and in the development of the vascular networkand the cardiovascular system during embryonic development.Promotes proliferation, survival and migration of endothelialcells, and regulates angiogenic sprouting. Signaling by activatedFLT4 leads to enhanced production of VEGFC, and to a lesser degreeVEGFA, thereby creating a positive feedback loop that enhancesFLT4 signaling. Modulates KDR signaling by forming heterodimers.The secreted isoform 3 may function as a decoy receptor for VEGFCand/or VEGFD and play an important role as a negative regulator ofVEGFC-mediated lymphangiogenesis and angiogenesis. Binding ofvascular growth factors to isoform 1 or isoform 2 leads to theactivation of several signaling cascades; isoform 2 seems to beless efficient in signal transduction, because it has a truncatedC-terminus and therefore lacks several phosphorylation sites.Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signalingpathway, of MAPK8 and the JUN signaling pathway, and of the AKT1signaling pathway. Phosphorylates SHC1. Mediates phosphorylationof PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:11532940,ECO:0000269|PubMed:15102829, ECO:0000269|PubMed:15474514,ECO:0000269|PubMed:16076871, ECO:0000269|PubMed:16452200,ECO:0000269|PubMed:17210781, ECO:0000269|PubMed:19610651,ECO:0000269|PubMed:19779139, ECO:0000269|PubMed:20224550,ECO:0000269|PubMed:20431062, ECO:0000269|PubMed:20445537,ECO:0000269|PubMed:21273538, ECO:0000269|PubMed:7675451,ECO:0000269|PubMed:8700872, ECO:0000269|PubMed:9435229}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >FLT4 | chr5:96271878 | chr5:180048904 | ENST00000261937 | - | 11 | 30 | 555_671 | 552 | 1364 | Domain | Note=Ig-like C2-type 6 |
| Tgene | >FLT4 | chr5:96271878 | chr5:180048904 | ENST00000261937 | - | 11 | 30 | 678_764 | 552 | 1364 | Domain | Note=Ig-like C2-type 7 |
| Tgene | >FLT4 | chr5:96271878 | chr5:180048904 | ENST00000261937 | - | 11 | 30 | 845_1173 | 552 | 1364 | Domain | Protein kinase |
| Tgene | >FLT4 | chr5:96271878 | chr5:180048904 | ENST00000393347 | - | 11 | 30 | 555_671 | 552 | 1299 | Domain | Note=Ig-like C2-type 6 |
| Tgene | >FLT4 | chr5:96271878 | chr5:180048904 | ENST00000393347 | - | 11 | 30 | 678_764 | 552 | 1299 | Domain | Note=Ig-like C2-type 7 |
| Tgene | >FLT4 | chr5:96271878 | chr5:180048904 | ENST00000393347 | - | 11 | 30 | 845_1173 | 552 | 1299 | Domain | Protein kinase |
| Tgene | >FLT4 | chr5:96271878 | chr5:180048904 | ENST00000261937 | - | 11 | 30 | 851_859 | 552 | 1364 | Nucleotide binding | ATP |
| Tgene | >FLT4 | chr5:96271878 | chr5:180048904 | ENST00000393347 | - | 11 | 30 | 851_859 | 552 | 1299 | Nucleotide binding | ATP |
| Tgene | >FLT4 | chr5:96271878 | chr5:180048904 | ENST00000261937 | - | 11 | 30 | 797_1363 | 552 | 1364 | Topological domain | Cytoplasmic |
| Tgene | >FLT4 | chr5:96271878 | chr5:180048904 | ENST00000393347 | - | 11 | 30 | 797_1363 | 552 | 1299 | Topological domain | Cytoplasmic |
| Tgene | >FLT4 | chr5:96271878 | chr5:180048904 | ENST00000261937 | - | 11 | 30 | 776_796 | 552 | 1364 | Transmembrane | Helical |
| Tgene | >FLT4 | chr5:96271878 | chr5:180048904 | ENST00000393347 | - | 11 | 30 | 776_796 | 552 | 1299 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >LNPEP | chr5:96271878 | chr5:180048904 | ENST00000231368 | + | 1 | 18 | 53_54 | 6 | 1026 | Motif | Dileucine internalization motif |
| Hgene | >LNPEP | chr5:96271878 | chr5:180048904 | ENST00000231368 | + | 1 | 18 | 76_77 | 6 | 1026 | Motif | Dileucine internalization motif |
| Hgene | >LNPEP | chr5:96271878 | chr5:180048904 | ENST00000395770 | + | 1 | 18 | 53_54 | -117 | 1012 | Motif | Dileucine internalization motif |
| Hgene | >LNPEP | chr5:96271878 | chr5:180048904 | ENST00000395770 | + | 1 | 18 | 76_77 | -117 | 1012 | Motif | Dileucine internalization motif |
| Hgene | >LNPEP | chr5:96271878 | chr5:180048904 | ENST00000231368 | + | 1 | 18 | 428_432 | 6 | 1026 | Region | Substrate binding |
| Hgene | >LNPEP | chr5:96271878 | chr5:180048904 | ENST00000231368 | + | 1 | 18 | 96_101 | 6 | 1026 | Region | Note=Tankyrase binding |
| Hgene | >LNPEP | chr5:96271878 | chr5:180048904 | ENST00000395770 | + | 1 | 18 | 428_432 | -117 | 1012 | Region | Substrate binding |
| Hgene | >LNPEP | chr5:96271878 | chr5:180048904 | ENST00000395770 | + | 1 | 18 | 96_101 | -117 | 1012 | Region | Note=Tankyrase binding |
| Hgene | >LNPEP | chr5:96271878 | chr5:180048904 | ENST00000231368 | + | 1 | 18 | 132_1025 | 6 | 1026 | Topological domain | Extracellular |
| Hgene | >LNPEP | chr5:96271878 | chr5:180048904 | ENST00000231368 | + | 1 | 18 | 1_110 | 6 | 1026 | Topological domain | Cytoplasmic |
| Hgene | >LNPEP | chr5:96271878 | chr5:180048904 | ENST00000395770 | + | 1 | 18 | 132_1025 | -117 | 1012 | Topological domain | Extracellular |
| Hgene | >LNPEP | chr5:96271878 | chr5:180048904 | ENST00000395770 | + | 1 | 18 | 1_110 | -117 | 1012 | Topological domain | Cytoplasmic |
| Hgene | >LNPEP | chr5:96271878 | chr5:180048904 | ENST00000231368 | + | 1 | 18 | 111_131 | 6 | 1026 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Hgene | >LNPEP | chr5:96271878 | chr5:180048904 | ENST00000395770 | + | 1 | 18 | 111_131 | -117 | 1012 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Tgene | FLT4 | chr5:96271878 | chr5:180048904 | ENST00000261937 | - | 11 | 30 | 151_213 | 552 | 1364 | Domain | Note=Ig-like C2-type 2 |
| Tgene | FLT4 | chr5:96271878 | chr5:180048904 | ENST00000261937 | - | 11 | 30 | 219_326 | 552 | 1364 | Domain | Note=Ig-like C2-type 3 |
| Tgene | FLT4 | chr5:96271878 | chr5:180048904 | ENST00000261937 | - | 11 | 30 | 30_127 | 552 | 1364 | Domain | Note=Ig-like C2-type 1 |
| Tgene | FLT4 | chr5:96271878 | chr5:180048904 | ENST00000261937 | - | 11 | 30 | 331_415 | 552 | 1364 | Domain | Note=Ig-like C2-type 4 |
| Tgene | FLT4 | chr5:96271878 | chr5:180048904 | ENST00000261937 | - | 11 | 30 | 422_552 | 552 | 1364 | Domain | Note=Ig-like C2-type 5 |
| Tgene | FLT4 | chr5:96271878 | chr5:180048904 | ENST00000393347 | - | 11 | 30 | 151_213 | 552 | 1299 | Domain | Note=Ig-like C2-type 2 |
| Tgene | FLT4 | chr5:96271878 | chr5:180048904 | ENST00000393347 | - | 11 | 30 | 219_326 | 552 | 1299 | Domain | Note=Ig-like C2-type 3 |
| Tgene | FLT4 | chr5:96271878 | chr5:180048904 | ENST00000393347 | - | 11 | 30 | 30_127 | 552 | 1299 | Domain | Note=Ig-like C2-type 1 |
| Tgene | FLT4 | chr5:96271878 | chr5:180048904 | ENST00000393347 | - | 11 | 30 | 331_415 | 552 | 1299 | Domain | Note=Ig-like C2-type 4 |
| Tgene | FLT4 | chr5:96271878 | chr5:180048904 | ENST00000393347 | - | 11 | 30 | 422_552 | 552 | 1299 | Domain | Note=Ig-like C2-type 5 |
| Tgene | FLT4 | chr5:96271878 | chr5:180048904 | ENST00000261937 | - | 11 | 30 | 25_775 | 552 | 1364 | Topological domain | Extracellular |
| Tgene | FLT4 | chr5:96271878 | chr5:180048904 | ENST00000393347 | - | 11 | 30 | 25_775 | 552 | 1299 | Topological domain | Extracellular |
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FusionGeneSequence for LNPEP_FLT4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_LNPEP_ENST00000231368_chr5_96271878_+_FLT4_ENST00000261937_chr5_180048904_-_818aa MEPFTNAIPDGFTIESKPSEELLEGQPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATL SLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEKSGVDL ADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSII MDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNH LNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRAS PDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESI FDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGR GLQEEEEVCMAPRSSQSSEEGSFSQVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVSFPGCLARGAETRGSSRMKTFEEFPMTPTTYK GSVDNQTDSGMVLASEEFEQIESRHRQESGFSCKGPGQNVAVTRAHPDSQGRRRRPERGARGGQVFYNSEYGELSEPSEEDHCSPSARVT >In-frame_LNPEP_ENST00000231368_chr5_96271878_+_FLT4_ENST00000393347_chr5_180048904_-_753aa MEPFTNAIPDGFTIESKPSEELLEGQPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATL SLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEKSGVDL ADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSII MDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNH LNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRAS PDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESI FDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGR GLQEEEEVCMAPRSSQSSEEGSFSQVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVSFPGCLARGAETRGSSRMKTFEEFPMTPTTYK >In-frame_LNPEP_ENST00000231368_chr5_96271878_+_FLT4_ENST00000502649_chr5_180048904_-_761aa MEPFTNAIPDGFTIESKPSEELLEGQPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATL SLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEKSGVDL ADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSII MDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNH LNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRAS PDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESI FDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGR GLQEEEEVCMAPRSSQSSEEGSFSQVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVSFPGCLARGAETRGSSRMKTFEEFPMTPTTYK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_LNPEP_ENST00000231368_chr5_96271878_+_FLT4_ENST00000261937_chr5_180048904_-_2454nt ATGGAGCCCTTCACCAATGCCATCCCCGACGGCTTCACCATCGAATCCAAGCCATCCGAGGAGCTACTAGAGGGCCAGCCGGTGCTCCTG AGCTGCCAAGCCGACAGCTACAAGTACGAGCATCTGCGCTGGTACCGCCTCAACCTGTCCACGCTGCACGATGCGCACGGGAACCCGCTT CTGCTCGACTGCAAGAACGTGCATCTGTTCGCCACCCCTCTGGCCGCCAGCCTGGAGGAGGTGGCACCTGGGGCGCGCCACGCCACGCTC AGCCTGAGTATCCCCCGCGTCGCGCCCGAGCACGAGGGCCACTATGTGTGCGAAGTGCAAGACCGGCGCAGCCATGACAAGCACTGCCAC AAGAAGTACCTGTCGGTGCAGGCCCTGGAAGCCCCTCGGCTCACGCAGAACTTGACCGACCTCCTGGTGAACGTGAGCGACTCGCTGGAG ATGCAGTGCTTGGTGGCCGGAGCGCACGCGCCCAGCATCGTGTGGTACAAAGACGAGAGGCTGCTGGAGGAAAAGTCTGGAGTCGACTTG GCGGACTCCAACCAGAAGCTGAGCATCCAGCGCGTGCGCGAGGAGGATGCGGGACGCTATCTGTGCAGCGTGTGCAACGCCAAGGGCTGC GTCAACTCCTCCGCCAGCGTGGCCGTGGAAGGCTCCGAGGATAAGGGCAGCATGGAGATCGTGATCCTTGTCGGTACCGGCGTCATCGCT GTCTTCTTCTGGGTCCTCCTCCTCCTCATCTTCTGTAACATGAGGAGGCCGGCCCACGCAGACATCAAGACGGGCTACCTGTCCATCATC ATGGACCCCGGGGAGGTGCCTCTGGAGGAGCAATGCGAATACCTGTCCTACGATGCCAGCCAGTGGGAATTCCCCCGAGAGCGGCTGCAC CTGGGGAGAGTGCTCGGCTACGGCGCCTTCGGGAAGGTGGTGGAAGCCTCCGCTTTCGGCATCCACAAGGGCAGCAGCTGTGACACCGTG GCCGTGAAAATGCTGAAAGAGGGCGCCACGGCCAGCGAGCACCGCGCGCTGATGTCGGAGCTCAAGATCCTCATTCACATCGGCAACCAC CTCAACGTGGTCAACCTCCTCGGGGCGTGCACCAAGCCGCAGGGCCCCCTCATGGTGATCGTGGAGTTCTGCAAGTACGGCAACCTCTCC AACTTCCTGCGCGCCAAGCGGGACGCCTTCAGCCCCTGCGCGGAGAAGTCTCCCGAGCAGCGCGGACGCTTCCGCGCCATGGTGGAGCTC GCCAGGCTGGATCGGAGGCGGCCGGGGAGCAGCGACAGGGTCCTCTTCGCGCGGTTCTCGAAGACCGAGGGCGGAGCGAGGCGGGCTTCT CCAGACCAAGAAGCTGAGGACCTGTGGCTGAGCCCGCTGACCATGGAAGATCTTGTCTGCTACAGCTTCCAGGTGGCCAGAGGGATGGAG TTCCTGGCTTCCCGAAAGTGCATCCACAGAGACCTGGCTGCTCGGAACATTCTGCTGTCGGAAAGCGACGTGGTGAAGATCTGTGACTTT GGCCTTGCCCGGGACATCTACAAAGACCCCGACTACGTCCGCAAGGGCAGTGCCCGGCTGCCCCTGAAGTGGATGGCCCCTGAAAGCATC TTCGACAAGGTGTACACCACGCAGAGTGACGTGTGGTCCTTTGGGGTGCTTCTCTGGGAGATCTTCTCTCTGGGGGCCTCCCCGTACCCT GGGGTGCAGATCAATGAGGAGTTCTGCCAGCGGCTGAGAGACGGCACAAGGATGAGGGCCCCGGAGCTGGCCACTCCCGCCATACGCCGC ATCATGCTGAACTGCTGGTCCGGAGACCCCAAGGCGAGACCTGCATTCTCGGAGCTGGTGGAGATCCTGGGGGACCTGCTCCAGGGCAGG GGCCTGCAAGAGGAAGAGGAGGTCTGCATGGCCCCGCGCAGCTCTCAGAGCTCAGAAGAGGGCAGCTTCTCGCAGGTGTCCACCATGGCC CTACACATCGCCCAGGCTGACGCTGAGGACAGCCCGCCAAGCCTGCAGCGCCACAGCCTGGCCGCCAGGTATTACAACTGGGTGTCCTTT CCCGGGTGCCTGGCCAGAGGGGCTGAGACCCGTGGTTCCTCCAGGATGAAGACATTTGAGGAATTCCCCATGACCCCAACGACCTACAAA GGCTCTGTGGACAACCAGACAGACAGTGGGATGGTGCTGGCCTCGGAGGAGTTTGAGCAGATAGAGAGCAGGCATAGACAAGAAAGCGGC TTCAGCTGTAAAGGACCTGGCCAGAATGTGGCTGTGACCAGGGCACACCCTGACTCCCAAGGGAGGCGGCGGCGGCCTGAGCGGGGGGCC CGAGGAGGCCAGGTGTTTTACAACAGCGAGTATGGGGAGCTGTCGGAGCCAAGCGAGGAGGACCACTGCTCCCCGTCTGCCCGCGTGACT >In-frame_LNPEP_ENST00000231368_chr5_96271878_+_FLT4_ENST00000393347_chr5_180048904_-_2259nt ATGGAGCCCTTCACCAATGCCATCCCCGACGGCTTCACCATCGAATCCAAGCCATCCGAGGAGCTACTAGAGGGCCAGCCGGTGCTCCTG AGCTGCCAAGCCGACAGCTACAAGTACGAGCATCTGCGCTGGTACCGCCTCAACCTGTCCACGCTGCACGATGCGCACGGGAACCCGCTT CTGCTCGACTGCAAGAACGTGCATCTGTTCGCCACCCCTCTGGCCGCCAGCCTGGAGGAGGTGGCACCTGGGGCGCGCCACGCCACGCTC AGCCTGAGTATCCCCCGCGTCGCGCCCGAGCACGAGGGCCACTATGTGTGCGAAGTGCAAGACCGGCGCAGCCATGACAAGCACTGCCAC AAGAAGTACCTGTCGGTGCAGGCCCTGGAAGCCCCTCGGCTCACGCAGAACTTGACCGACCTCCTGGTGAACGTGAGCGACTCGCTGGAG ATGCAGTGCTTGGTGGCCGGAGCGCACGCGCCCAGCATCGTGTGGTACAAAGACGAGAGGCTGCTGGAGGAAAAGTCTGGAGTCGACTTG GCGGACTCCAACCAGAAGCTGAGCATCCAGCGCGTGCGCGAGGAGGATGCGGGACGCTATCTGTGCAGCGTGTGCAACGCCAAGGGCTGC GTCAACTCCTCCGCCAGCGTGGCCGTGGAAGGCTCCGAGGATAAGGGCAGCATGGAGATCGTGATCCTTGTCGGTACCGGCGTCATCGCT GTCTTCTTCTGGGTCCTCCTCCTCCTCATCTTCTGTAACATGAGGAGGCCGGCCCACGCAGACATCAAGACGGGCTACCTGTCCATCATC ATGGACCCCGGGGAGGTGCCTCTGGAGGAGCAATGCGAATACCTGTCCTACGATGCCAGCCAGTGGGAATTCCCCCGAGAGCGGCTGCAC CTGGGGAGAGTGCTCGGCTACGGCGCCTTCGGGAAGGTGGTGGAAGCCTCCGCTTTCGGCATCCACAAGGGCAGCAGCTGTGACACCGTG GCCGTGAAAATGCTGAAAGAGGGCGCCACGGCCAGCGAGCACCGCGCGCTGATGTCGGAGCTCAAGATCCTCATTCACATCGGCAACCAC CTCAACGTGGTCAACCTCCTCGGGGCGTGCACCAAGCCGCAGGGCCCCCTCATGGTGATCGTGGAGTTCTGCAAGTACGGCAACCTCTCC AACTTCCTGCGCGCCAAGCGGGACGCCTTCAGCCCCTGCGCGGAGAAGTCTCCCGAGCAGCGCGGACGCTTCCGCGCCATGGTGGAGCTC GCCAGGCTGGATCGGAGGCGGCCGGGGAGCAGCGACAGGGTCCTCTTCGCGCGGTTCTCGAAGACCGAGGGCGGAGCGAGGCGGGCTTCT CCAGACCAAGAAGCTGAGGACCTGTGGCTGAGCCCGCTGACCATGGAAGATCTTGTCTGCTACAGCTTCCAGGTGGCCAGAGGGATGGAG TTCCTGGCTTCCCGAAAGTGCATCCACAGAGACCTGGCTGCTCGGAACATTCTGCTGTCGGAAAGCGACGTGGTGAAGATCTGTGACTTT GGCCTTGCCCGGGACATCTACAAAGACCCCGACTACGTCCGCAAGGGCAGTGCCCGGCTGCCCCTGAAGTGGATGGCCCCTGAAAGCATC TTCGACAAGGTGTACACCACGCAGAGTGACGTGTGGTCCTTTGGGGTGCTTCTCTGGGAGATCTTCTCTCTGGGGGCCTCCCCGTACCCT GGGGTGCAGATCAATGAGGAGTTCTGCCAGCGGCTGAGAGACGGCACAAGGATGAGGGCCCCGGAGCTGGCCACTCCCGCCATACGCCGC ATCATGCTGAACTGCTGGTCCGGAGACCCCAAGGCGAGACCTGCATTCTCGGAGCTGGTGGAGATCCTGGGGGACCTGCTCCAGGGCAGG GGCCTGCAAGAGGAAGAGGAGGTCTGCATGGCCCCGCGCAGCTCTCAGAGCTCAGAAGAGGGCAGCTTCTCGCAGGTGTCCACCATGGCC CTACACATCGCCCAGGCTGACGCTGAGGACAGCCCGCCAAGCCTGCAGCGCCACAGCCTGGCCGCCAGGTATTACAACTGGGTGTCCTTT CCCGGGTGCCTGGCCAGAGGGGCTGAGACCCGTGGTTCCTCCAGGATGAAGACATTTGAGGAATTCCCCATGACCCCAACGACCTACAAA GGCTCTGTGGACAACCAGACAGACAGTGGGATGGTGCTGGCCTCGGAGGAGTTTGAGCAGATAGAGAGCAGGCATAGACAAGAAAGCGGC >In-frame_LNPEP_ENST00000231368_chr5_96271878_+_FLT4_ENST00000502649_chr5_180048904_-_2283nt ATGGAGCCCTTCACCAATGCCATCCCCGACGGCTTCACCATCGAATCCAAGCCATCCGAGGAGCTACTAGAGGGCCAGCCGGTGCTCCTG AGCTGCCAAGCCGACAGCTACAAGTACGAGCATCTGCGCTGGTACCGCCTCAACCTGTCCACGCTGCACGATGCGCACGGGAACCCGCTT CTGCTCGACTGCAAGAACGTGCATCTGTTCGCCACCCCTCTGGCCGCCAGCCTGGAGGAGGTGGCACCTGGGGCGCGCCACGCCACGCTC AGCCTGAGTATCCCCCGCGTCGCGCCCGAGCACGAGGGCCACTATGTGTGCGAAGTGCAAGACCGGCGCAGCCATGACAAGCACTGCCAC AAGAAGTACCTGTCGGTGCAGGCCCTGGAAGCCCCTCGGCTCACGCAGAACTTGACCGACCTCCTGGTGAACGTGAGCGACTCGCTGGAG ATGCAGTGCTTGGTGGCCGGAGCGCACGCGCCCAGCATCGTGTGGTACAAAGACGAGAGGCTGCTGGAGGAAAAGTCTGGAGTCGACTTG GCGGACTCCAACCAGAAGCTGAGCATCCAGCGCGTGCGCGAGGAGGATGCGGGACGCTATCTGTGCAGCGTGTGCAACGCCAAGGGCTGC GTCAACTCCTCCGCCAGCGTGGCCGTGGAAGGCTCCGAGGATAAGGGCAGCATGGAGATCGTGATCCTTGTCGGTACCGGCGTCATCGCT GTCTTCTTCTGGGTCCTCCTCCTCCTCATCTTCTGTAACATGAGGAGGCCGGCCCACGCAGACATCAAGACGGGCTACCTGTCCATCATC ATGGACCCCGGGGAGGTGCCTCTGGAGGAGCAATGCGAATACCTGTCCTACGATGCCAGCCAGTGGGAATTCCCCCGAGAGCGGCTGCAC CTGGGGAGAGTGCTCGGCTACGGCGCCTTCGGGAAGGTGGTGGAAGCCTCCGCTTTCGGCATCCACAAGGGCAGCAGCTGTGACACCGTG GCCGTGAAAATGCTGAAAGAGGGCGCCACGGCCAGCGAGCACCGCGCGCTGATGTCGGAGCTCAAGATCCTCATTCACATCGGCAACCAC CTCAACGTGGTCAACCTCCTCGGGGCGTGCACCAAGCCGCAGGGCCCCCTCATGGTGATCGTGGAGTTCTGCAAGTACGGCAACCTCTCC AACTTCCTGCGCGCCAAGCGGGACGCCTTCAGCCCCTGCGCGGAGAAGTCTCCCGAGCAGCGCGGACGCTTCCGCGCCATGGTGGAGCTC GCCAGGCTGGATCGGAGGCGGCCGGGGAGCAGCGACAGGGTCCTCTTCGCGCGGTTCTCGAAGACCGAGGGCGGAGCGAGGCGGGCTTCT CCAGACCAAGAAGCTGAGGACCTGTGGCTGAGCCCGCTGACCATGGAAGATCTTGTCTGCTACAGCTTCCAGGTGGCCAGAGGGATGGAG TTCCTGGCTTCCCGAAAGTGCATCCACAGAGACCTGGCTGCTCGGAACATTCTGCTGTCGGAAAGCGACGTGGTGAAGATCTGTGACTTT GGCCTTGCCCGGGACATCTACAAAGACCCCGACTACGTCCGCAAGGGCAGTGCCCGGCTGCCCCTGAAGTGGATGGCCCCTGAAAGCATC TTCGACAAGGTGTACACCACGCAGAGTGACGTGTGGTCCTTTGGGGTGCTTCTCTGGGAGATCTTCTCTCTGGGGGCCTCCCCGTACCCT GGGGTGCAGATCAATGAGGAGTTCTGCCAGCGGCTGAGAGACGGCACAAGGATGAGGGCCCCGGAGCTGGCCACTCCCGCCATACGCCGC ATCATGCTGAACTGCTGGTCCGGAGACCCCAAGGCGAGACCTGCATTCTCGGAGCTGGTGGAGATCCTGGGGGACCTGCTCCAGGGCAGG GGCCTGCAAGAGGAAGAGGAGGTCTGCATGGCCCCGCGCAGCTCTCAGAGCTCAGAAGAGGGCAGCTTCTCGCAGGTGTCCACCATGGCC CTACACATCGCCCAGGCTGACGCTGAGGACAGCCCGCCAAGCCTGCAGCGCCACAGCCTGGCCGCCAGGTATTACAACTGGGTGTCCTTT CCCGGGTGCCTGGCCAGAGGGGCTGAGACCCGTGGTTCCTCCAGGATGAAGACATTTGAGGAATTCCCCATGACCCCAACGACCTACAAA GGCTCTGTGGACAACCAGACAGACAGTGGGATGGTGCTGGCCTCGGAGGAGTTTGAGCAGATAGAGAGCAGGCATAGACAAGAAAGCGGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_LNPEP_ENST00000231368_chr5_96271878_+_FLT4_ENST00000261937_chr5_180048904_-_4832nt TCCGCGGCCAACCTCCCCAGGGAAACCAGCGATTCGCGGTTCAGATAGCGACCTTCGCCCGCAGGTTCCTGCTCTGCCTTCAGACTTCGG CTTCAGTGGCACCTGCTCAGCGAGGCCTCGTCTAACCAAGCCATCCGAATTAACTACCCACTCACTCGCCATCACATCACCCCGATTTAA TTCGCAGCGGGGCACTGACTTTACACTCGTGTGTCTTCTGTGTTTATTTATGGTCTGTTTCTGGAATGTCCGCTCCTGGGACTGGGACCA TGATTTTCTGGCGCAGTGCGGGTGTCTCGGCGTCCGGGATCGGGCGGGTCGCAGTAGGGCTCCACATTTGTTGAGTGACTGAACACCGTT CCCGGCCGGGGAGAGCGCCGCAGCCGGGTCCACTTCAGGTAGGGGCTGGGCTTTCCCGGCCCCGCCTAGGCCCCGCCCCCAGCGCGAACC CGCTCCCACCTCGCCTGTCCACGGAGCAGCAGGGGGTTTGACTGTGCTTTTCCCTCTTGCTTCCCTCGCTCTTTCTGCAGCTGCCACGAA AACCCGGAACGGCGGAGCGGCGCCGCCCCTCGCGGCACCTCCCTGGCAGCCCTTGGAGGCCGCGCTGGGCATGCTCAGTCAGCTGGGCCG CCTCAGCTCTCGGAGTAGGAAGCTCGGGCGCTCCGGCTGTAAGGAGCCGCGGCGGGGGGAAAATGGAGCCCTTCACCAATGCCATCCCCG ACGGCTTCACCATCGAATCCAAGCCATCCGAGGAGCTACTAGAGGGCCAGCCGGTGCTCCTGAGCTGCCAAGCCGACAGCTACAAGTACG AGCATCTGCGCTGGTACCGCCTCAACCTGTCCACGCTGCACGATGCGCACGGGAACCCGCTTCTGCTCGACTGCAAGAACGTGCATCTGT TCGCCACCCCTCTGGCCGCCAGCCTGGAGGAGGTGGCACCTGGGGCGCGCCACGCCACGCTCAGCCTGAGTATCCCCCGCGTCGCGCCCG AGCACGAGGGCCACTATGTGTGCGAAGTGCAAGACCGGCGCAGCCATGACAAGCACTGCCACAAGAAGTACCTGTCGGTGCAGGCCCTGG AAGCCCCTCGGCTCACGCAGAACTTGACCGACCTCCTGGTGAACGTGAGCGACTCGCTGGAGATGCAGTGCTTGGTGGCCGGAGCGCACG CGCCCAGCATCGTGTGGTACAAAGACGAGAGGCTGCTGGAGGAAAAGTCTGGAGTCGACTTGGCGGACTCCAACCAGAAGCTGAGCATCC AGCGCGTGCGCGAGGAGGATGCGGGACGCTATCTGTGCAGCGTGTGCAACGCCAAGGGCTGCGTCAACTCCTCCGCCAGCGTGGCCGTGG AAGGCTCCGAGGATAAGGGCAGCATGGAGATCGTGATCCTTGTCGGTACCGGCGTCATCGCTGTCTTCTTCTGGGTCCTCCTCCTCCTCA TCTTCTGTAACATGAGGAGGCCGGCCCACGCAGACATCAAGACGGGCTACCTGTCCATCATCATGGACCCCGGGGAGGTGCCTCTGGAGG AGCAATGCGAATACCTGTCCTACGATGCCAGCCAGTGGGAATTCCCCCGAGAGCGGCTGCACCTGGGGAGAGTGCTCGGCTACGGCGCCT TCGGGAAGGTGGTGGAAGCCTCCGCTTTCGGCATCCACAAGGGCAGCAGCTGTGACACCGTGGCCGTGAAAATGCTGAAAGAGGGCGCCA CGGCCAGCGAGCACCGCGCGCTGATGTCGGAGCTCAAGATCCTCATTCACATCGGCAACCACCTCAACGTGGTCAACCTCCTCGGGGCGT GCACCAAGCCGCAGGGCCCCCTCATGGTGATCGTGGAGTTCTGCAAGTACGGCAACCTCTCCAACTTCCTGCGCGCCAAGCGGGACGCCT TCAGCCCCTGCGCGGAGAAGTCTCCCGAGCAGCGCGGACGCTTCCGCGCCATGGTGGAGCTCGCCAGGCTGGATCGGAGGCGGCCGGGGA GCAGCGACAGGGTCCTCTTCGCGCGGTTCTCGAAGACCGAGGGCGGAGCGAGGCGGGCTTCTCCAGACCAAGAAGCTGAGGACCTGTGGC TGAGCCCGCTGACCATGGAAGATCTTGTCTGCTACAGCTTCCAGGTGGCCAGAGGGATGGAGTTCCTGGCTTCCCGAAAGTGCATCCACA GAGACCTGGCTGCTCGGAACATTCTGCTGTCGGAAAGCGACGTGGTGAAGATCTGTGACTTTGGCCTTGCCCGGGACATCTACAAAGACC CCGACTACGTCCGCAAGGGCAGTGCCCGGCTGCCCCTGAAGTGGATGGCCCCTGAAAGCATCTTCGACAAGGTGTACACCACGCAGAGTG ACGTGTGGTCCTTTGGGGTGCTTCTCTGGGAGATCTTCTCTCTGGGGGCCTCCCCGTACCCTGGGGTGCAGATCAATGAGGAGTTCTGCC AGCGGCTGAGAGACGGCACAAGGATGAGGGCCCCGGAGCTGGCCACTCCCGCCATACGCCGCATCATGCTGAACTGCTGGTCCGGAGACC CCAAGGCGAGACCTGCATTCTCGGAGCTGGTGGAGATCCTGGGGGACCTGCTCCAGGGCAGGGGCCTGCAAGAGGAAGAGGAGGTCTGCA TGGCCCCGCGCAGCTCTCAGAGCTCAGAAGAGGGCAGCTTCTCGCAGGTGTCCACCATGGCCCTACACATCGCCCAGGCTGACGCTGAGG ACAGCCCGCCAAGCCTGCAGCGCCACAGCCTGGCCGCCAGGTATTACAACTGGGTGTCCTTTCCCGGGTGCCTGGCCAGAGGGGCTGAGA CCCGTGGTTCCTCCAGGATGAAGACATTTGAGGAATTCCCCATGACCCCAACGACCTACAAAGGCTCTGTGGACAACCAGACAGACAGTG GGATGGTGCTGGCCTCGGAGGAGTTTGAGCAGATAGAGAGCAGGCATAGACAAGAAAGCGGCTTCAGCTGTAAAGGACCTGGCCAGAATG TGGCTGTGACCAGGGCACACCCTGACTCCCAAGGGAGGCGGCGGCGGCCTGAGCGGGGGGCCCGAGGAGGCCAGGTGTTTTACAACAGCG AGTATGGGGAGCTGTCGGAGCCAAGCGAGGAGGACCACTGCTCCCCGTCTGCCCGCGTGACTTTCTTCACAGACAACAGCTACTAAGCAG CATCGGACAAGACCCCCAGCACTTGGGGGTTCAGGCCCGGCAGGGCGGGCAGAGGGCTGGAGGCCCAGGCTGGGAACTCATCTGGTTGAA CTCTGGTGGCACAGGAGTGTCCTCTTCCCTCTCTGCAGACTTCCCAGCTAGGAAGAGCAGGACTCCAGGCCCAAGGCTCCCGGAATTCCG TCACCACGACTGGCCAGGGCCACGCTCCAGCTGCCCCGGCCCCTCCCCCTGAGATTCAGATGTCATTTAGTTCAGCATCCGCAGGTGCTG GTCCCGGGGCCAGCACTTCCATGGGAATGTCTCTTTGGCGACCTCCTTTCATCACACTGGGTGGTGGCCTGGTCCCTGTTTTCCCACGAG GAATCTGTGGGTCTGGGAGTCACACAGTGTTGGAGGTTAAGGCATACGAGAGCAGAGGTCTCCCAAACGCCCTTTCCTCCTCAGGCACAC AGCTACTCTCCCCACGAGGGCTGGCTGGCCTCACCCACCCCTGCACAGTTGAAGGGAGGGGCTGTGTTTCCATCTCAAAGAAGGCATTTG CAGGGTCCTCTTCTGGGCCTGACCAAACAGCCAACTAGCCCCTGGGGTGGCCACCAGTATGACAGTATTATACGCTGGCAACACAGAGGC AGCCCGCACACCTGCGCCTGGGTGTTGAGAGCCATCCTGCAAGTCTTTTTCAACAGAACTTCACAGACTGTTAGAGCTGCTGAGAAGAAT TTGCTTTCCGAATTCAGCCTGGAAGGCGCCCAGGGACAGCTGTACTGAGTCTAGATGACTCTGACCCCCGCCCCAGGTCAAGGCCAGCAG AGCAGTCAGTGCCTCTGGAGAAGGCCCTTGCTCTCCCACCTGGCCCAGACTCCGAGGAGCCTGGGTCTGGAGCTGCCGGTCTGGTTCTTC CCTTTAGAGCCCGGATCTGCCACCTGCGGCCCCTCCCAAGCCGTGAACCAGCTCATGAGAGATGAACACTGTGGGATCCACTCAGGAAGG CTCGGGGCTGGCACAAAGGACCACCCAGCATTGCCCTGTGCCACCCAGCACTCAGTGGACATTCTGGGGACCTGCCTTCAGCCTTTTCCT GCCCTGTGCCTGACATCAGCACCCTGGCTGGTCAGAATGCCGCCCTCCCAGAGGAGCAGCCGAGAGATCCCCTGAAGGCTGGAGGCATTC TGCTCAGGACCCCTATCCCAGCTCACAGTGCCCAACCATCTCACCAGGAGAAAGAGCCACATCCCCACGTTAGGACCACGGAGACTGACC ACCACCCTGACCCCCCAAACCCACGCACCAGACGCTTGCAGGACAGGCGCCGCGCAGCGGGCAGGGGCTTGCCCGGCCGACCCTCCCCTC CCCACCTCCCCCACTGCGCGTTACTCCAGGATATGCCGAGTGCACGTATAAGGTCATCTTCGTCGTCCCCGTGGACCTCCCCCTTCCTCT GCACGTCGTCCAACGTGGGACTGGCGTGTCAGGCTTCCCTGGGAGGATCTGGAGGTTGTTCTCTGCAGAGAACCAGCCTGGCTCCTGGCG CGCACCTCTGCTCCCTTCTCCTCACTACCCACCCACGCATGTACCGGGAAAAAAACTACTATGCCCTTCTAGACCATGTTCTGAGAAAAG >In-frame_LNPEP_ENST00000231368_chr5_96271878_+_FLT4_ENST00000393347_chr5_180048904_-_3267nt TCCGCGGCCAACCTCCCCAGGGAAACCAGCGATTCGCGGTTCAGATAGCGACCTTCGCCCGCAGGTTCCTGCTCTGCCTTCAGACTTCGG CTTCAGTGGCACCTGCTCAGCGAGGCCTCGTCTAACCAAGCCATCCGAATTAACTACCCACTCACTCGCCATCACATCACCCCGATTTAA TTCGCAGCGGGGCACTGACTTTACACTCGTGTGTCTTCTGTGTTTATTTATGGTCTGTTTCTGGAATGTCCGCTCCTGGGACTGGGACCA TGATTTTCTGGCGCAGTGCGGGTGTCTCGGCGTCCGGGATCGGGCGGGTCGCAGTAGGGCTCCACATTTGTTGAGTGACTGAACACCGTT CCCGGCCGGGGAGAGCGCCGCAGCCGGGTCCACTTCAGGTAGGGGCTGGGCTTTCCCGGCCCCGCCTAGGCCCCGCCCCCAGCGCGAACC CGCTCCCACCTCGCCTGTCCACGGAGCAGCAGGGGGTTTGACTGTGCTTTTCCCTCTTGCTTCCCTCGCTCTTTCTGCAGCTGCCACGAA AACCCGGAACGGCGGAGCGGCGCCGCCCCTCGCGGCACCTCCCTGGCAGCCCTTGGAGGCCGCGCTGGGCATGCTCAGTCAGCTGGGCCG CCTCAGCTCTCGGAGTAGGAAGCTCGGGCGCTCCGGCTGTAAGGAGCCGCGGCGGGGGGAAAATGGAGCCCTTCACCAATGCCATCCCCG ACGGCTTCACCATCGAATCCAAGCCATCCGAGGAGCTACTAGAGGGCCAGCCGGTGCTCCTGAGCTGCCAAGCCGACAGCTACAAGTACG AGCATCTGCGCTGGTACCGCCTCAACCTGTCCACGCTGCACGATGCGCACGGGAACCCGCTTCTGCTCGACTGCAAGAACGTGCATCTGT TCGCCACCCCTCTGGCCGCCAGCCTGGAGGAGGTGGCACCTGGGGCGCGCCACGCCACGCTCAGCCTGAGTATCCCCCGCGTCGCGCCCG AGCACGAGGGCCACTATGTGTGCGAAGTGCAAGACCGGCGCAGCCATGACAAGCACTGCCACAAGAAGTACCTGTCGGTGCAGGCCCTGG AAGCCCCTCGGCTCACGCAGAACTTGACCGACCTCCTGGTGAACGTGAGCGACTCGCTGGAGATGCAGTGCTTGGTGGCCGGAGCGCACG CGCCCAGCATCGTGTGGTACAAAGACGAGAGGCTGCTGGAGGAAAAGTCTGGAGTCGACTTGGCGGACTCCAACCAGAAGCTGAGCATCC AGCGCGTGCGCGAGGAGGATGCGGGACGCTATCTGTGCAGCGTGTGCAACGCCAAGGGCTGCGTCAACTCCTCCGCCAGCGTGGCCGTGG AAGGCTCCGAGGATAAGGGCAGCATGGAGATCGTGATCCTTGTCGGTACCGGCGTCATCGCTGTCTTCTTCTGGGTCCTCCTCCTCCTCA TCTTCTGTAACATGAGGAGGCCGGCCCACGCAGACATCAAGACGGGCTACCTGTCCATCATCATGGACCCCGGGGAGGTGCCTCTGGAGG AGCAATGCGAATACCTGTCCTACGATGCCAGCCAGTGGGAATTCCCCCGAGAGCGGCTGCACCTGGGGAGAGTGCTCGGCTACGGCGCCT TCGGGAAGGTGGTGGAAGCCTCCGCTTTCGGCATCCACAAGGGCAGCAGCTGTGACACCGTGGCCGTGAAAATGCTGAAAGAGGGCGCCA CGGCCAGCGAGCACCGCGCGCTGATGTCGGAGCTCAAGATCCTCATTCACATCGGCAACCACCTCAACGTGGTCAACCTCCTCGGGGCGT GCACCAAGCCGCAGGGCCCCCTCATGGTGATCGTGGAGTTCTGCAAGTACGGCAACCTCTCCAACTTCCTGCGCGCCAAGCGGGACGCCT TCAGCCCCTGCGCGGAGAAGTCTCCCGAGCAGCGCGGACGCTTCCGCGCCATGGTGGAGCTCGCCAGGCTGGATCGGAGGCGGCCGGGGA GCAGCGACAGGGTCCTCTTCGCGCGGTTCTCGAAGACCGAGGGCGGAGCGAGGCGGGCTTCTCCAGACCAAGAAGCTGAGGACCTGTGGC TGAGCCCGCTGACCATGGAAGATCTTGTCTGCTACAGCTTCCAGGTGGCCAGAGGGATGGAGTTCCTGGCTTCCCGAAAGTGCATCCACA GAGACCTGGCTGCTCGGAACATTCTGCTGTCGGAAAGCGACGTGGTGAAGATCTGTGACTTTGGCCTTGCCCGGGACATCTACAAAGACC CCGACTACGTCCGCAAGGGCAGTGCCCGGCTGCCCCTGAAGTGGATGGCCCCTGAAAGCATCTTCGACAAGGTGTACACCACGCAGAGTG ACGTGTGGTCCTTTGGGGTGCTTCTCTGGGAGATCTTCTCTCTGGGGGCCTCCCCGTACCCTGGGGTGCAGATCAATGAGGAGTTCTGCC AGCGGCTGAGAGACGGCACAAGGATGAGGGCCCCGGAGCTGGCCACTCCCGCCATACGCCGCATCATGCTGAACTGCTGGTCCGGAGACC CCAAGGCGAGACCTGCATTCTCGGAGCTGGTGGAGATCCTGGGGGACCTGCTCCAGGGCAGGGGCCTGCAAGAGGAAGAGGAGGTCTGCA TGGCCCCGCGCAGCTCTCAGAGCTCAGAAGAGGGCAGCTTCTCGCAGGTGTCCACCATGGCCCTACACATCGCCCAGGCTGACGCTGAGG ACAGCCCGCCAAGCCTGCAGCGCCACAGCCTGGCCGCCAGGTATTACAACTGGGTGTCCTTTCCCGGGTGCCTGGCCAGAGGGGCTGAGA CCCGTGGTTCCTCCAGGATGAAGACATTTGAGGAATTCCCCATGACCCCAACGACCTACAAAGGCTCTGTGGACAACCAGACAGACAGTG GGATGGTGCTGGCCTCGGAGGAGTTTGAGCAGATAGAGAGCAGGCATAGACAAGAAAGCGGCTTCAGGTAGCTGAAGCAGAGAGAGAGAA GGCAGCATACGTCAGCATTTTCTTCTCTGCACTTATAAGAAAGATCAAAGACTTTAAGACTTTCGCTATTTCTTCTACTGCTATCTACTA CAAACTTCAAAGAGGAACCAGGAGGACAAGAGGAGCATGAAAGTGGACAAGGAGTGTGACCACTGAAGCACCACAGGGAGGGGTTAGGCC TCCGGATGACTGCGGGCAGGCCTGGATAATATCCAGCCTCCCACAAGAAGCTGGTGGAGCAGAGTGTTCCCTGACTCCTCCAAGGAAAGG >In-frame_LNPEP_ENST00000231368_chr5_96271878_+_FLT4_ENST00000502649_chr5_180048904_-_3139nt TCCGCGGCCAACCTCCCCAGGGAAACCAGCGATTCGCGGTTCAGATAGCGACCTTCGCCCGCAGGTTCCTGCTCTGCCTTCAGACTTCGG CTTCAGTGGCACCTGCTCAGCGAGGCCTCGTCTAACCAAGCCATCCGAATTAACTACCCACTCACTCGCCATCACATCACCCCGATTTAA TTCGCAGCGGGGCACTGACTTTACACTCGTGTGTCTTCTGTGTTTATTTATGGTCTGTTTCTGGAATGTCCGCTCCTGGGACTGGGACCA TGATTTTCTGGCGCAGTGCGGGTGTCTCGGCGTCCGGGATCGGGCGGGTCGCAGTAGGGCTCCACATTTGTTGAGTGACTGAACACCGTT CCCGGCCGGGGAGAGCGCCGCAGCCGGGTCCACTTCAGGTAGGGGCTGGGCTTTCCCGGCCCCGCCTAGGCCCCGCCCCCAGCGCGAACC CGCTCCCACCTCGCCTGTCCACGGAGCAGCAGGGGGTTTGACTGTGCTTTTCCCTCTTGCTTCCCTCGCTCTTTCTGCAGCTGCCACGAA AACCCGGAACGGCGGAGCGGCGCCGCCCCTCGCGGCACCTCCCTGGCAGCCCTTGGAGGCCGCGCTGGGCATGCTCAGTCAGCTGGGCCG CCTCAGCTCTCGGAGTAGGAAGCTCGGGCGCTCCGGCTGTAAGGAGCCGCGGCGGGGGGAAAATGGAGCCCTTCACCAATGCCATCCCCG ACGGCTTCACCATCGAATCCAAGCCATCCGAGGAGCTACTAGAGGGCCAGCCGGTGCTCCTGAGCTGCCAAGCCGACAGCTACAAGTACG AGCATCTGCGCTGGTACCGCCTCAACCTGTCCACGCTGCACGATGCGCACGGGAACCCGCTTCTGCTCGACTGCAAGAACGTGCATCTGT TCGCCACCCCTCTGGCCGCCAGCCTGGAGGAGGTGGCACCTGGGGCGCGCCACGCCACGCTCAGCCTGAGTATCCCCCGCGTCGCGCCCG AGCACGAGGGCCACTATGTGTGCGAAGTGCAAGACCGGCGCAGCCATGACAAGCACTGCCACAAGAAGTACCTGTCGGTGCAGGCCCTGG AAGCCCCTCGGCTCACGCAGAACTTGACCGACCTCCTGGTGAACGTGAGCGACTCGCTGGAGATGCAGTGCTTGGTGGCCGGAGCGCACG CGCCCAGCATCGTGTGGTACAAAGACGAGAGGCTGCTGGAGGAAAAGTCTGGAGTCGACTTGGCGGACTCCAACCAGAAGCTGAGCATCC AGCGCGTGCGCGAGGAGGATGCGGGACGCTATCTGTGCAGCGTGTGCAACGCCAAGGGCTGCGTCAACTCCTCCGCCAGCGTGGCCGTGG AAGGCTCCGAGGATAAGGGCAGCATGGAGATCGTGATCCTTGTCGGTACCGGCGTCATCGCTGTCTTCTTCTGGGTCCTCCTCCTCCTCA TCTTCTGTAACATGAGGAGGCCGGCCCACGCAGACATCAAGACGGGCTACCTGTCCATCATCATGGACCCCGGGGAGGTGCCTCTGGAGG AGCAATGCGAATACCTGTCCTACGATGCCAGCCAGTGGGAATTCCCCCGAGAGCGGCTGCACCTGGGGAGAGTGCTCGGCTACGGCGCCT TCGGGAAGGTGGTGGAAGCCTCCGCTTTCGGCATCCACAAGGGCAGCAGCTGTGACACCGTGGCCGTGAAAATGCTGAAAGAGGGCGCCA CGGCCAGCGAGCACCGCGCGCTGATGTCGGAGCTCAAGATCCTCATTCACATCGGCAACCACCTCAACGTGGTCAACCTCCTCGGGGCGT GCACCAAGCCGCAGGGCCCCCTCATGGTGATCGTGGAGTTCTGCAAGTACGGCAACCTCTCCAACTTCCTGCGCGCCAAGCGGGACGCCT TCAGCCCCTGCGCGGAGAAGTCTCCCGAGCAGCGCGGACGCTTCCGCGCCATGGTGGAGCTCGCCAGGCTGGATCGGAGGCGGCCGGGGA GCAGCGACAGGGTCCTCTTCGCGCGGTTCTCGAAGACCGAGGGCGGAGCGAGGCGGGCTTCTCCAGACCAAGAAGCTGAGGACCTGTGGC TGAGCCCGCTGACCATGGAAGATCTTGTCTGCTACAGCTTCCAGGTGGCCAGAGGGATGGAGTTCCTGGCTTCCCGAAAGTGCATCCACA GAGACCTGGCTGCTCGGAACATTCTGCTGTCGGAAAGCGACGTGGTGAAGATCTGTGACTTTGGCCTTGCCCGGGACATCTACAAAGACC CCGACTACGTCCGCAAGGGCAGTGCCCGGCTGCCCCTGAAGTGGATGGCCCCTGAAAGCATCTTCGACAAGGTGTACACCACGCAGAGTG ACGTGTGGTCCTTTGGGGTGCTTCTCTGGGAGATCTTCTCTCTGGGGGCCTCCCCGTACCCTGGGGTGCAGATCAATGAGGAGTTCTGCC AGCGGCTGAGAGACGGCACAAGGATGAGGGCCCCGGAGCTGGCCACTCCCGCCATACGCCGCATCATGCTGAACTGCTGGTCCGGAGACC CCAAGGCGAGACCTGCATTCTCGGAGCTGGTGGAGATCCTGGGGGACCTGCTCCAGGGCAGGGGCCTGCAAGAGGAAGAGGAGGTCTGCA TGGCCCCGCGCAGCTCTCAGAGCTCAGAAGAGGGCAGCTTCTCGCAGGTGTCCACCATGGCCCTACACATCGCCCAGGCTGACGCTGAGG ACAGCCCGCCAAGCCTGCAGCGCCACAGCCTGGCCGCCAGGTATTACAACTGGGTGTCCTTTCCCGGGTGCCTGGCCAGAGGGGCTGAGA CCCGTGGTTCCTCCAGGATGAAGACATTTGAGGAATTCCCCATGACCCCAACGACCTACAAAGGCTCTGTGGACAACCAGACAGACAGTG GGATGGTGCTGGCCTCGGAGGAGTTTGAGCAGATAGAGAGCAGGCATAGACAAGAAAGCGGCTTCAGAGGAACCAGGAGGACAAGAGGAG CATGAAAGTGGACAAGGAGTGTGACCACTGAAGCACCACAGGGAGGGGTTAGGCCTCCGGATGACTGCGGGCAGGCCTGGATAATATCCA |
Top |
FusionGenePPI for LNPEP_FLT4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LNPEP | FHOD1, TNKS2, TNKS, FBXO6, AP2B1, PRDX3, REL, TCF4, FATE1, CD3E, HLA-DRA, LGALS3, HLA-DPA1, LGALS8, LGALS9, BTNL8, SIAE, TNF, GPHA2, EWSR1, TMEM17, TMEM216, CANX, DROSHA, NDUFA13, HEATR3, GCC1, TMEM263, PPM1H, LMAN2L, C5orf28, SCGB1D4, EDNRB, ST8SIA4, GPR107, CCL22, NAPRT, SCGB1D1, GLRA2 | FLT4 | VEGFC, SHC1, GRB2, ITGB1, IKBKG, NEDD4, FIGF, HSP90AA1, EPN1, LGALS3, LGALS8, VSIG4, PTGER3, TNF, LIPH, PLVAP, TMEM52B, MAS1, PCDHGB1, NPY2R, CHRM3, EEF1A2, DUSP19 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LNPEP_FLT4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | FLT4 | P35916 | DB06589 | Pazopanib | Vascular endothelial growth factor receptor 3 | small molecule | approved |
| Tgene | FLT4 | P35916 | DB08896 | Regorafenib | Vascular endothelial growth factor receptor 3 | small molecule | approved |
| Tgene | FLT4 | P35916 | DB09079 | Nintedanib | Vascular endothelial growth factor receptor 3 | small molecule | approved |
| Tgene | FLT4 | P35916 | DB00398 | Sorafenib | Vascular endothelial growth factor receptor 3 | small molecule | approved|investigational |
| Tgene | FLT4 | P35916 | DB01268 | Sunitinib | Vascular endothelial growth factor receptor 3 | small molecule | approved|investigational |
| Tgene | FLT4 | P35916 | DB06626 | Axitinib | Vascular endothelial growth factor receptor 3 | small molecule | approved|investigational |
| Tgene | FLT4 | P35916 | DB09078 | Lenvatinib | Vascular endothelial growth factor receptor 3 | small molecule | approved|investigational |
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RelatedDiseases for LNPEP_FLT4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | LNPEP | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Hgene | LNPEP | C0025261 | Memory Disorders | 1 | CTD_human |
| Tgene | FLT4 | C1704423 | Milroy Disease | 10 | ORPHANET;UNIPROT |
| Tgene | FLT4 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
| Tgene | FLT4 | C1865871 | HEMANGIOMA, CAPILLARY INFANTILE | 1 | CTD_human;UNIPROT |
| Tgene | FLT4 | C2931852 | Clear-cell metastatic renal cell carcinoma | 1 | CTD_human |
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