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Fusion gene ID: 1993 |
FusionGeneSummary for ANXA4_MEIG1 |
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Fusion gene information | Fusion gene name: ANXA4_MEIG1 | Fusion gene ID: 1993 | Hgene | Tgene | Gene symbol | ANXA4 | MEIG1 | Gene ID | 307 | 644890 |
Gene name | annexin A4 | meiosis/spermiogenesis associated 1 | |
Synonyms | ANX4|HEL-S-274|P32.5|PAP-II|PIG28|PP4-X|ZAP36 | SPATA39|bA2K17.3 | |
Cytomap | 2p13.3 | 10p13 | |
Type of gene | protein-coding | protein-coding | |
Description | annexin A435-beta calcimedinannexin IV (placental anticoagulant protein II)annexin-4carbohydrate-binding protein p33/p41chromobindin-4endonexin Iepididymis secretory protein Li 274lipocortin IVplacental anticoagulant protein IIproliferation-indu | meiosis expressed gene 1 protein homologlong meiosis expressed gene 1 protein isoformmeiosis expressed gene 1 homologspermatogenesis associated 39 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P09525 | Q5JSS6 | |
Ensembl transtripts involved in fusion gene | ENST00000418066, ENST00000409920, ENST00000394295, ENST00000536030, | ENST00000407572, ENST00000378240, ENST00000467536, | |
Fusion gene scores | * DoF score | 5 X 4 X 5=100 | 1 X 1 X 1=1 |
# samples | 5 | 1 | |
** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: ANXA4 [Title/Abstract] AND MEIG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ANXA4 | GO:0006357 | regulation of transcription by RNA polymerase II | 20237821 |
Hgene | ANXA4 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 20237821 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | ESCA | TCGA-IG-A8O2-01A | ANXA4 | chr2 | 70015273 | + | MEIG1 | chr10 | 15028795 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000418066 | ENST00000407572 | ANXA4 | chr2 | 70015273 | + | MEIG1 | chr10 | 15028795 | + |
intron-intron | ENST00000418066 | ENST00000378240 | ANXA4 | chr2 | 70015273 | + | MEIG1 | chr10 | 15028795 | + |
intron-3UTR | ENST00000418066 | ENST00000467536 | ANXA4 | chr2 | 70015273 | + | MEIG1 | chr10 | 15028795 | + |
5CDS-intron | ENST00000409920 | ENST00000407572 | ANXA4 | chr2 | 70015273 | + | MEIG1 | chr10 | 15028795 | + |
5CDS-intron | ENST00000409920 | ENST00000378240 | ANXA4 | chr2 | 70015273 | + | MEIG1 | chr10 | 15028795 | + |
5CDS-3UTR | ENST00000409920 | ENST00000467536 | ANXA4 | chr2 | 70015273 | + | MEIG1 | chr10 | 15028795 | + |
5CDS-intron | ENST00000394295 | ENST00000407572 | ANXA4 | chr2 | 70015273 | + | MEIG1 | chr10 | 15028795 | + |
5CDS-intron | ENST00000394295 | ENST00000378240 | ANXA4 | chr2 | 70015273 | + | MEIG1 | chr10 | 15028795 | + |
5CDS-3UTR | ENST00000394295 | ENST00000467536 | ANXA4 | chr2 | 70015273 | + | MEIG1 | chr10 | 15028795 | + |
intron-intron | ENST00000536030 | ENST00000407572 | ANXA4 | chr2 | 70015273 | + | MEIG1 | chr10 | 15028795 | + |
intron-intron | ENST00000536030 | ENST00000378240 | ANXA4 | chr2 | 70015273 | + | MEIG1 | chr10 | 15028795 | + |
intron-3UTR | ENST00000536030 | ENST00000467536 | ANXA4 | chr2 | 70015273 | + | MEIG1 | chr10 | 15028795 | + |
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FusionProtFeatures for ANXA4_MEIG1 |
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Hgene | Tgene |
ANXA4 | MEIG1 |
Calcium/phospholipid-binding protein which promotesmembrane fusion and is involved in exocytosis. {ECO:0000250}. | Essential for spermiogenesis. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ANXA4_MEIG1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ANXA4_MEIG1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ANXA4 | NFKB1, H2AFX, UCHL5, SMPD1, NMT2, TINF2, POT1, DNAJB11, ANXA7, MPST, ANXA3, ANXA1, PADI4, EZH2, RAB8A, RHOU, CDH1, SF3A3 | MEIG1 | POLR2J |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ANXA4_MEIG1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ANXA4_MEIG1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ANXA4 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Hgene | ANXA4 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Hgene | ANXA4 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | ANXA4 | C0023903 | Liver neoplasms | 1 | CTD_human |
Hgene | ANXA4 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | ANXA4 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | ANXA4 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Hgene | ANXA4 | C0032927 | Precancerous Conditions | 1 | CTD_human |
Hgene | ANXA4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | ANXA4 | C2239176 | Liver carcinoma | 1 | CTD_human |