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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19920

FusionGeneSummary for LMOD1_NPNT

check button Fusion gene summary
Fusion gene informationFusion gene name: LMOD1_NPNT
Fusion gene ID: 19920
HgeneTgene
Gene symbol

LMOD1

NPNT

Gene ID

25802

255743

Gene nameleiomodin 1nephronectin
Synonyms1D|64kD|D1|SM-LMOD|SMLMODEGFL6L|POEM
Cytomap

1q32.1

4q24

Type of geneprotein-codingprotein-coding
Descriptionleiomodin-164 kDa autoantigen 1D64 kDa autoantigen 1D364 kDa autoantigen D1leimodin 1 (smooth muscle)leiomodin 1 (smooth muscle)leiomodin, muscle formsmooth muscle leiomodinthyroid and eye muscle autoantigen D1 (64kD)thyroid-associated ophthalmopnephronectinpreosteoblast EGF-like repeat protein with MAM domain
Modification date2018052320180527
UniProtAcc

P29536

Q6UXI9

Ensembl transtripts involved in fusion geneENST00000367288, ENST00000379987, 
ENST00000453617, ENST00000427316, 
ENST00000514622, ENST00000305572, 
ENST00000506666, ENST00000513430, 
Fusion gene scores* DoF score2 X 2 X 1=42 X 2 X 1=4
# samples 22
** MAII scorelog2(2/4*10)=2.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: LMOD1 [Title/Abstract] AND NPNT [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLMOD1

GO:0030838

positive regulation of actin filament polymerization

26370058

HgeneLMOD1

GO:0045010

actin nucleation

26370058


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE835052LMOD1chr1

201867341

+NPNTchr4

106861267

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000367288ENST00000379987LMOD1chr1

201867341

+NPNTchr4

106861267

-
intron-3CDSENST00000367288ENST00000453617LMOD1chr1

201867341

+NPNTchr4

106861267

-
intron-3CDSENST00000367288ENST00000427316LMOD1chr1

201867341

+NPNTchr4

106861267

-
intron-3CDSENST00000367288ENST00000514622LMOD1chr1

201867341

+NPNTchr4

106861267

-
intron-3CDSENST00000367288ENST00000305572LMOD1chr1

201867341

+NPNTchr4

106861267

-
intron-3CDSENST00000367288ENST00000506666LMOD1chr1

201867341

+NPNTchr4

106861267

-
intron-intronENST00000367288ENST00000513430LMOD1chr1

201867341

+NPNTchr4

106861267

-

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FusionProtFeatures for LMOD1_NPNT


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LMOD1

P29536

NPNT

Q6UXI9

Mediates nucleation of actin filaments.{ECO:0000269|PubMed:26370058}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LMOD1_NPNT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LMOD1_NPNT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LMOD1_NPNT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LMOD1_NPNT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLMOD1C0014175Endometriosis1CTD_human