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Fusion gene ID: 1992 |
FusionGeneSummary for ANXA4_GKN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ANXA4_GKN1 | Fusion gene ID: 1992 | Hgene | Tgene | Gene symbol | ANXA4 | GKN1 | Gene ID | 307 | 56287 |
| Gene name | annexin A4 | gastrokine 1 | |
| Synonyms | ANX4|HEL-S-274|P32.5|PAP-II|PIG28|PP4-X|ZAP36 | AMP18|BRICD1|CA11|FOV|foveolin | |
| Cytomap | 2p13.3 | 2p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | annexin A435-beta calcimedinannexin IV (placental anticoagulant protein II)annexin-4carbohydrate-binding protein p33/p41chromobindin-4endonexin Iepididymis secretory protein Li 274lipocortin IVplacental anticoagulant protein IIproliferation-indu | gastrokine-118 kDa antrum mucosa proteinAMP-18BRICHOS domain containing 1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P09525 | Q9NS71 | |
| Ensembl transtripts involved in fusion gene | ENST00000418066, ENST00000409920, ENST00000394295, ENST00000536030, | ENST00000377938, | |
| Fusion gene scores | * DoF score | 5 X 4 X 5=100 | 2 X 1 X 2=4 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: ANXA4 [Title/Abstract] AND GKN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ANXA4 | GO:0006357 | regulation of transcription by RNA polymerase II | 20237821 |
| Hgene | ANXA4 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 20237821 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-DK-AA75-01A | ANXA4 | chr2 | 70008706 | + | GKN1 | chr2 | 69204627 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000418066 | ENST00000377938 | ANXA4 | chr2 | 70008706 | + | GKN1 | chr2 | 69204627 | + |
| In-frame | ENST00000409920 | ENST00000377938 | ANXA4 | chr2 | 70008706 | + | GKN1 | chr2 | 69204627 | + |
| In-frame | ENST00000394295 | ENST00000377938 | ANXA4 | chr2 | 70008706 | + | GKN1 | chr2 | 69204627 | + |
| 5UTR-3CDS | ENST00000536030 | ENST00000377938 | ANXA4 | chr2 | 70008706 | + | GKN1 | chr2 | 69204627 | + |
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FusionProtFeatures for ANXA4_GKN1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ANXA4 | GKN1 |
| Calcium/phospholipid-binding protein which promotesmembrane fusion and is involved in exocytosis. {ECO:0000250}. | Has mitogenic activity and may be involved inmaintaining the integrity of the gastric mucosal epithelium.{ECO:0000269|PubMed:12851218}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ANXA4_GKN1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ANXA4_ENST00000409920_chr2_70008706_+_GKN1_ENST00000377938_chr2_69204627_+_185aa MAMIVFAGLLGVFLAPALANYNINVNDDNNNAGSGQQSVSVNNEHNVANVDNNNGWDSWNSIWDYGNGFAATRLFQKKTCIVHKMNKEVM PSIQSLDALVKEKKLQGKGPGGPPPKGLMYSVNPNKVDDLSKFGKNIANMCRGIPTYMAEEMQEASLFFYSGTCYTTSVLWIVDISFCGD >In-frame_ANXA4_ENST00000394295_chr2_70008706_+_GKN1_ENST00000377938_chr2_69204627_+_185aa MAMIVFAGLLGVFLAPALANYNINVNDDNNNAGSGQQSVSVNNEHNVANVDNNNGWDSWNSIWDYGNGFAATRLFQKKTCIVHKMNKEVM PSIQSLDALVKEKKLQGKGPGGPPPKGLMYSVNPNKVDDLSKFGKNIANMCRGIPTYMAEEMQEASLFFYSGTCYTTSVLWIVDISFCGD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ANXA4_ENST00000409920_chr2_70008706_+_GKN1_ENST00000377938_chr2_69204627_+_555nt ATGGCCATGATTGTCTTTGCTGGACTTCTTGGAGTCTTTCTAGCTCCTGCCCTAGCTAACTATAATATCAACGTCAATGATGACAACAAC AATGCTGGAAGTGGGCAGCAGTCAGTGAGTGTCAACAATGAACACAATGTGGCCAATGTTGACAATAACAACGGATGGGACTCCTGGAAT TCCATCTGGGATTATGGAAATGGCTTTGCTGCAACCAGACTCTTTCAAAAGAAGACATGCATTGTGCACAAAATGAACAAGGAAGTCATG CCCTCCATTCAATCCCTTGATGCACTGGTCAAGGAAAAGAAGCTTCAGGGTAAGGGACCAGGAGGACCACCTCCCAAGGGCCTGATGTAC TCAGTCAACCCAAACAAAGTCGATGACCTGAGCAAGTTCGGAAAAAACATTGCAAACATGTGTCGTGGGATTCCAACATACATGGCTGAG GAGATGCAAGAGGCAAGCCTGTTTTTTTACTCAGGAACGTGCTACACGACCAGTGTACTATGGATTGTGGACATTTCCTTCTGTGGAGAC >In-frame_ANXA4_ENST00000394295_chr2_70008706_+_GKN1_ENST00000377938_chr2_69204627_+_555nt ATGGCCATGATTGTCTTTGCTGGACTTCTTGGAGTCTTTCTAGCTCCTGCCCTAGCTAACTATAATATCAACGTCAATGATGACAACAAC AATGCTGGAAGTGGGCAGCAGTCAGTGAGTGTCAACAATGAACACAATGTGGCCAATGTTGACAATAACAACGGATGGGACTCCTGGAAT TCCATCTGGGATTATGGAAATGGCTTTGCTGCAACCAGACTCTTTCAAAAGAAGACATGCATTGTGCACAAAATGAACAAGGAAGTCATG CCCTCCATTCAATCCCTTGATGCACTGGTCAAGGAAAAGAAGCTTCAGGGTAAGGGACCAGGAGGACCACCTCCCAAGGGCCTGATGTAC TCAGTCAACCCAAACAAAGTCGATGACCTGAGCAAGTTCGGAAAAAACATTGCAAACATGTGTCGTGGGATTCCAACATACATGGCTGAG GAGATGCAAGAGGCAAGCCTGTTTTTTTACTCAGGAACGTGCTACACGACCAGTGTACTATGGATTGTGGACATTTCCTTCTGTGGAGAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ANXA4_ENST00000409920_chr2_70008706_+_GKN1_ENST00000377938_chr2_69204627_+_954nt GCGCGGCCGTCCCGGCCCGGGGCCCCAGGTGCGCTTCCCCTAGAGAGGGATTTTCCGGTCTCGTGGGCAGAGGAACAACCAGGAACTTGG GCTCAGTCTCCACCCCACAGTGGGGCGGATCCGTCCCGGATAAGACCCGCTGTCTGGCCCTGAGTAGGGTGTGACCTCCGCAGCCGCAGA GGAGGAGCGCAGCCCGGCCTCGAAGAACTTCTGCTTGGGTGGCTGAACTCTGATCTTGACCTAGAGTCATGGCCATGATTGTCTTTGCTG GACTTCTTGGAGTCTTTCTAGCTCCTGCCCTAGCTAACTATAATATCAACGTCAATGATGACAACAACAATGCTGGAAGTGGGCAGCAGT CAGTGAGTGTCAACAATGAACACAATGTGGCCAATGTTGACAATAACAACGGATGGGACTCCTGGAATTCCATCTGGGATTATGGAAATG GCTTTGCTGCAACCAGACTCTTTCAAAAGAAGACATGCATTGTGCACAAAATGAACAAGGAAGTCATGCCCTCCATTCAATCCCTTGATG CACTGGTCAAGGAAAAGAAGCTTCAGGGTAAGGGACCAGGAGGACCACCTCCCAAGGGCCTGATGTACTCAGTCAACCCAAACAAAGTCG ATGACCTGAGCAAGTTCGGAAAAAACATTGCAAACATGTGTCGTGGGATTCCAACATACATGGCTGAGGAGATGCAAGAGGCAAGCCTGT TTTTTTACTCAGGAACGTGCTACACGACCAGTGTACTATGGATTGTGGACATTTCCTTCTGTGGAGACACGGTGGAGAACTAAACAATTT TTTAAAGCCACTATGGATTTAGTCATCTGAATATGCTGTGCAGAAAAAATATGGGCTCCAGTGGTTTTTACCATGTCATTCTGAAATTTT >In-frame_ANXA4_ENST00000394295_chr2_70008706_+_GKN1_ENST00000377938_chr2_69204627_+_954nt GCGCGGCCGTCCCGGCCCGGGGCCCCAGGTGCGCTTCCCCTAGAGAGGGATTTTCCGGTCTCGTGGGCAGAGGAACAACCAGGAACTTGG GCTCAGTCTCCACCCCACAGTGGGGCGGATCCGTCCCGGATAAGACCCGCTGTCTGGCCCTGAGTAGGGTGTGACCTCCGCAGCCGCAGA GGAGGAGCGCAGCCCGGCCTCGAAGAACTTCTGCTTGGGTGGCTGAACTCTGATCTTGACCTAGAGTCATGGCCATGATTGTCTTTGCTG GACTTCTTGGAGTCTTTCTAGCTCCTGCCCTAGCTAACTATAATATCAACGTCAATGATGACAACAACAATGCTGGAAGTGGGCAGCAGT CAGTGAGTGTCAACAATGAACACAATGTGGCCAATGTTGACAATAACAACGGATGGGACTCCTGGAATTCCATCTGGGATTATGGAAATG GCTTTGCTGCAACCAGACTCTTTCAAAAGAAGACATGCATTGTGCACAAAATGAACAAGGAAGTCATGCCCTCCATTCAATCCCTTGATG CACTGGTCAAGGAAAAGAAGCTTCAGGGTAAGGGACCAGGAGGACCACCTCCCAAGGGCCTGATGTACTCAGTCAACCCAAACAAAGTCG ATGACCTGAGCAAGTTCGGAAAAAACATTGCAAACATGTGTCGTGGGATTCCAACATACATGGCTGAGGAGATGCAAGAGGCAAGCCTGT TTTTTTACTCAGGAACGTGCTACACGACCAGTGTACTATGGATTGTGGACATTTCCTTCTGTGGAGACACGGTGGAGAACTAAACAATTT TTTAAAGCCACTATGGATTTAGTCATCTGAATATGCTGTGCAGAAAAAATATGGGCTCCAGTGGTTTTTACCATGTCATTCTGAAATTTT |
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FusionGenePPI for ANXA4_GKN1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ANXA4 | NFKB1, H2AFX, UCHL5, SMPD1, NMT2, TINF2, POT1, DNAJB11, ANXA7, MPST, ANXA3, ANXA1, PADI4, EZH2, RAB8A, RHOU, CDH1, SF3A3 | GKN1 | CDC27, UBR5, C6orf58, LYZL1, CST1, AMY1C, PIGR, CST4, ZG16B, MUC7, IGHA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ANXA4_GKN1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ANXA4_GKN1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ANXA4 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| Hgene | ANXA4 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Hgene | ANXA4 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | ANXA4 | C0023903 | Liver neoplasms | 1 | CTD_human |
| Hgene | ANXA4 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Hgene | ANXA4 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Hgene | ANXA4 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Hgene | ANXA4 | C0032927 | Precancerous Conditions | 1 | CTD_human |
| Hgene | ANXA4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | ANXA4 | C2239176 | Liver carcinoma | 1 | CTD_human |
| Tgene | GKN1 | C0001418 | Adenocarcinoma | 1 | CTD_human |
| Tgene | GKN1 | C0029927 | Ovarian Cysts | 1 | CTD_human |
| Tgene | GKN1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
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